{"id":3592,"date":"2024-08-02T15:24:12","date_gmt":"2024-08-02T15:24:12","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3592"},"modified":"2024-08-02T15:24:12","modified_gmt":"2024-08-02T15:24:12","slug":"uplc-q-tof-ms-extraction-of-fructus-psorale","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/uplc-q-tof-ms-extraction-of-fructus-psorale\/","title":{"rendered":"UPLC-Q-TOF-MS ile Fructus Psorale alkol ekstrakt\u0131nda melanin \u00fcretimini te\u015fvik eden mekanizman\u0131n kimyasal bile\u015fim analizi ve \u00f6n ara\u015ft\u0131rmas\u0131"},"content":{"rendered":"<p>UPLC-Q-TOF-MS ile Fructus Psorale alkol ekstrakt\u0131nda melanin \u00fcretimini te\u015fvik eden mekanizman\u0131n kimyasal bile\u015fim analizi ve \u00f6n ara\u015ft\u0131rmas\u0131<br \/>\nVitiligo, d\u00fcnya \u00e7ap\u0131nda yakla\u015f\u0131k 0.5%~2% prevalans oran\u0131yla yayg\u0131n bir klinik lokalize depigmentasyon deri hastal\u0131\u011f\u0131d\u0131r. Te\u015fhisi kolay ve tedavisi zordur, y\u00fcksek g\u00f6r\u00fclme oran\u0131 ve uzun bir hastal\u0131k seyri vard\u0131r, bu da hastalar\u0131n fiziksel ve ruhsal sa\u011fl\u0131\u011f\u0131 \u00fczerinde olumsuz bir etkiye sahiptir. Psoralea, baklagil bitkisi Psoralea corylifolia L'nin kurutulmu\u015f ve olgunla\u015fm\u0131\u015f bir meyvesidir. Esas olarak geleneksel \u00c7in t\u0131bb\u0131nda erektil disfonksiyon, gece emisyonlar\u0131, bel ve diz a\u011fr\u0131s\u0131 ve b\u00f6brek yang eksikli\u011finin neden oldu\u011fu h\u0131r\u0131lt\u0131l\u0131 solunum tedavisinde kullan\u0131l\u0131r. Ayr\u0131ca vitiligo ve alopesi areata tedavisinde topikal olarak da kullan\u0131labilir. \u00dclkemizin vitiligo tedavisinde sedef hastal\u0131\u011f\u0131n\u0131 kullanma ge\u00e7mi\u015finin yan\u0131 s\u0131ra Japonya, G\u00fcney Kore, Hindistan gibi G\u00fcneydo\u011fu Asya \u00fclkelerinde de kay\u0131tlar bulunmaktad\u0131r (\"Babchi tohumlar\u0131\", \"Bakuchi tozu\", \"Bakuchiol\" vb. olarak bilinir). Vitiligonun psoralen ile tedavisi i\u00e7in dekoksiyonlar, tent\u00fcrler ve enjeksiyonlar dahil olmak \u00fczere \u00e7e\u015fitli dozaj formlar\u0131 da bulunmaktad\u0131r (Ulusal T\u0131bbi Standart Z41022361). Vitiligonun psoralen ile tedavisi hakk\u0131nda bir\u00e7ok literat\u00fcr kayd\u0131 olmas\u0131na ra\u011fmen, vitiligo tedavisinde etki mekanizmas\u0131 ve maddi temeli tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r. Bu nedenle, bu makalede Psoraleae Fructus alkol ekstrakt\u0131n\u0131n (PFE) kimyasal bile\u015fimini incelemek i\u00e7in ultra y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi d\u00f6rt kutuplu u\u00e7u\u015f zaman\u0131 k\u00fctle spektrometresi (UPLC-Q-TOF-MS) teknolojisi kullan\u0131lm\u0131\u015f; melanin \u00fcretimini te\u015fvik etmek i\u00e7in zebra bal\u0131\u011f\u0131 \u00fczerinde deneyler yap\u0131larak PFE'nin melanin \u00fcretimi \u00fczerindeki etkisi ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. PFE, psoralen (PSO) ve izosoralen (IPSO) ile muamele edilen B16-F10 fare melanom h\u00fccrelerinde tirozinaz (Tyr), tirozinaz ile ilgili protein 1 (Tyrp1) ve tirozinaz ile ilgili protein 2 (Tyrp2) mRNA ekspresyon seviyelerini tespit etmek i\u00e7in ger\u00e7ek zamanl\u0131 floresan kantitatif polimeraz zincir reaksiyonu (qRT PCR) kullan\u0131lm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fma, PFE'nin beyaz melanom h\u00fccreleri \u00fczerindeki potansiyel terap\u00f6tik etkilerini daha fazla ara\u015ft\u0131rmay\u0131 ama\u00e7lamaktad\u0131r. Aktif bile\u015fikler ve vitiligo hedefleri temel olu\u015fturmaktad\u0131r.<\/p>\n<p>Vitiligo, melanositlerin hasar g\u00f6rmesi sonucu ciltte olu\u015fan lokal beyaz lekelerdir ve yayg\u0131n olarak zor ve inat\u00e7\u0131 bir hastal\u0131k olarak kabul edilmektedir. \u015eimdiye kadar etiyolojisi ve patogenezi tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r. Ara\u015ft\u0131rmalar, cilt pigmentasyonunun, melanosit proliferasyonu, TYR sentezi ve aktivasyonu ve melanin sentezinin yan\u0131 s\u0131ra melanozomlardan keratinositlere melanin transfer yolu da dahil olmak \u00fczere epidermisteki melanositlerin \u00fc\u00e7 ana metabolik s\u00fcreci ile yak\u0131ndan ili\u015fkili oldu\u011funu g\u00f6stermi\u015ftir. Melanin sentezi, melanositler i\u00e7inde ger\u00e7ekle\u015fen ve birden fazla fakt\u00f6r taraf\u0131ndan d\u00fczenlenen karma\u015f\u0131k bir reaksiyondur. TYR, melanin sentezinde h\u0131z s\u0131n\u0131rlay\u0131c\u0131 enzimdir ve aktivitesi TYRP1 ve TYRP2 taraf\u0131ndan d\u00fczenlenir, bu da onu melanin sentezinde anahtar bir d\u00fczenleyici fakt\u00f6r haline getirir.<br \/>\nVitiligonun patogenezine ve klinik belirtilerine dayanarak, ara\u015ft\u0131rmac\u0131lar son y\u0131llarda kimyasal depigmentasyon ajan\u0131 ind\u00fcksiyonu, melanosit stres ind\u00fcksiyonu, imm\u00fcn ind\u00fcksiyon, eksojen T h\u00fccre ind\u00fcksiyonu, transgenik, melanosit dekolman\u0131 ind\u00fcksiyonu vb. gibi bir dizi hayvan modeli geli\u015ftirmi\u015flerdir. Fareler hayvanlar i\u00e7in ana se\u00e7imdir. Ara\u015ft\u0131rmalara g\u00f6re, insan protein kodlayan genlerin 71.4%'si ve patojenik genlerin 82%'si, insan deri hastal\u0131klar\u0131yla ilgili bir\u00e7ok gen de dahil olmak \u00fczere zebra bal\u0131\u011f\u0131 ile do\u011frudan homologdur. Zebra bal\u0131\u011f\u0131 larvalar\u0131 \u015feffaft\u0131r ve derilerinin genel ve h\u00fccresel yap\u0131s\u0131 memeli derisine benzer. \u0130nsanlara benzer melanositlere ve melanozomlara sahiptirler ve melanositler bireysel geli\u015fim s\u0131ras\u0131nda kolayca g\u00f6zlemlenebilir. Bu da zebra bal\u0131\u011f\u0131n\u0131 vitiligo ve melanom gibi hastal\u0131klar da dahil olmak \u00fczere pigmentasyon ara\u015ft\u0131rmalar\u0131 i\u00e7in yayg\u0131n olarak kullan\u0131lan bir hayvan modeli haline getirmektedir. Bununla birlikte, vitiligo karma\u015f\u0131k ve \u00e7ok fakt\u00f6rl\u00fc bir hastal\u0131k oldu\u011fundan, \u015fu anda insan vitiligosunun olu\u015fum ve geli\u015fim s\u00fcrecini tam olarak taklit edebilecek bir hayvan modeli bulunmamaktad\u0131r. Bu nedenle, vitiligo hayvan modellerinin daha fazla ara\u015ft\u0131r\u0131lmas\u0131 gerekmektedir.<br \/>\nPTU, zebra bal\u0131\u011f\u0131 embriyolar\u0131nda pigmentasyonu engellemek ve optik \u015feffafl\u0131\u011f\u0131 art\u0131rmak i\u00e7in yayg\u0131n olarak kullan\u0131lan bir TYR inhibit\u00f6r\u00fcd\u00fcr. \u00c7al\u0131\u015fmalar, zebra bal\u0131\u011f\u0131 ba\u011f\u0131rsak embriyogenezinden sonra (5.5 hpf) bal\u0131k suyu yerine PTU \u00e7\u00f6zeltisinin kullan\u0131lmas\u0131n\u0131n melanin \u00fcretimini etkili bir \u015fekilde engelleyebilece\u011fini ve zebra bal\u0131\u011f\u0131 \u015feffafl\u0131\u011f\u0131n\u0131 koruyabilece\u011fini g\u00f6stermi\u015ftir. Bu deneyin sonu\u00e7lar\u0131, PTU modellemesinden sonra 18 saat boyunca zebra bal\u0131\u011f\u0131n\u0131 PFE ile tedavi ettikten sonra, embriyo k\u00fclt\u00fcr ortam\u0131 ile tedavi edilen gruba k\u0131yasla, PFE'nin zebra bal\u0131\u011f\u0131 yavrular\u0131n\u0131n g\u00f6zlerinde, karn\u0131nda, omurgas\u0131nda ve kuyru\u011funda melanin rejenerasyonunu h\u0131zland\u0131rabilece\u011fini g\u00f6stermektedir; bu, vitiligo tedavisinde psoralenin klinik uygulamas\u0131yla tutarl\u0131d\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3593\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231931.png\" alt=\"\" width=\"540\" height=\"302\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3594\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231938.png\" alt=\"\" width=\"1070\" height=\"384\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231938.png 1070w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231938-768x276.png 768w\" sizes=\"(max-width: 1070px) 100vw, 1070px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3595\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231941.png\" alt=\"\" width=\"1072\" height=\"652\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231941.png 1072w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231941-768x467.png 768w\" sizes=\"(max-width: 1072px) 100vw, 1072px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3596\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231944.png\" alt=\"\" width=\"1076\" height=\"734\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231944.png 1076w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231944-768x524.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231944-1055x720.png 1055w\" sizes=\"(max-width: 1076px) 100vw, 1076px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3597\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231948.png\" alt=\"\" width=\"1096\" height=\"1228\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231948.png 1096w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231948-768x860.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231948-643x720.png 643w\" sizes=\"(max-width: 1096px) 100vw, 1096px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3598\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231951.png\" alt=\"\" width=\"1082\" height=\"1240\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231951.png 1082w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231951-768x880.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231951-628x720.png 628w\" sizes=\"(max-width: 1082px) 100vw, 1082px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3599\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231954.png\" alt=\"\" width=\"1086\" height=\"1246\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231954.png 1086w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231954-768x881.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231954-628x720.png 628w\" sizes=\"(max-width: 1086px) 100vw, 1086px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3600\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231957.png\" alt=\"\" width=\"1080\" height=\"1248\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231957.png 1080w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231957-768x887.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802231957-623x720.png 623w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3601\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232000.png\" alt=\"\" width=\"1090\" height=\"1272\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232000.png 1090w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232000-768x896.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232000-617x720.png 617w\" sizes=\"(max-width: 1090px) 100vw, 1090px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3602\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232003.png\" alt=\"\" width=\"1064\" height=\"922\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232003.png 1064w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232003-768x666.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232003-831x720.png 831w\" sizes=\"(max-width: 1064px) 100vw, 1064px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3603\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232007.png\" alt=\"\" width=\"1048\" height=\"1034\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232007.png 1048w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232007-768x758.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232007-730x720.png 730w\" sizes=\"(max-width: 1048px) 100vw, 1048px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3604\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232010.png\" alt=\"\" width=\"1048\" height=\"450\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232010.png 1048w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232010-768x330.png 768w\" sizes=\"(max-width: 1048px) 100vw, 1048px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3605\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232013.png\" alt=\"\" width=\"1036\" height=\"500\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232013.png 1036w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232013-768x371.png 768w\" sizes=\"(max-width: 1036px) 100vw, 1036px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3606\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232017.png\" alt=\"\" width=\"1046\" height=\"824\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232017.png 1046w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232017-768x605.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232017-914x720.png 914w\" sizes=\"(max-width: 1046px) 100vw, 1046px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3607\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/\u5fae\u4fe1\u56fe\u7247_20240802232019.png\" alt=\"\" width=\"554\" height=\"460\" \/>\u00c7in Farmakopesine ve eski ve modern bitki kitaplar\u0131na g\u00f6re Fructus Psorale vitiligo tedavisinde etkinli\u011fi kan\u0131tlanm\u0131\u015f geleneksel bir \u00c7in ilac\u0131d\u0131r. \u00c7o\u011fu t\u0131bbi kurum Fructus Psorale'yi 30% ile 100% aras\u0131nda de\u011fi\u015fen etanol konsantrasyonlar\u0131na sahip tent\u00fcrlerde kullanmaktad\u0131r. Bu nedenle, literat\u00fcre ve pratik uygulamalara dayanarak, bu \u00e7al\u0131\u015fmada ekstraksiyon reaktifi olarak 65% etanol se\u00e7ilmi\u015ftir. Bu \u00e7al\u0131\u015fmada PFE'deki kimyasal bile\u015fenleri tan\u0131mlamak i\u00e7in UPLC-Q-TOF-MS teknolojisi kullan\u0131lm\u0131\u015ft\u0131r. Ba\u015fta flavonoidler (27) ve kumarinler (10) olmak \u00fczere toplam 47 kimyasal bile\u015fen tan\u0131mlanm\u0131\u015ft\u0131r. Tan\u0131mlanan kumarin kimyasal bile\u015fenleri PSO ve IPSO vitiligo tedavisinde ana etkili kimyasal bile\u015fenler olabilir. Benzofuranlar (psoralen ve izopsoralen gibi) da etkilerini g\u00f6stermek i\u00e7in v\u00fccutta PSO ve IPSO'ya d\u00f6n\u00fc\u015ft\u00fcr\u00fclebilir. PSO ve IPSO ayn\u0131 zamanda \u00c7in Farmakopesinde belirtilen kemik ya\u011f\u0131 t\u0131bbi malzemeleri i\u00e7in kalite kontrol bile\u015fenleridir. Bu nedenle, h\u00fccre deneyleri i\u00e7in PFE ve bu iki kimyasal bile\u015fen se\u00e7ilmi\u015ftir. Etki mekanizmas\u0131n\u0131n \u00f6n ara\u015ft\u0131rmas\u0131, qRT PCR sonu\u00e7lar\u0131n\u0131n, kontrol grubuyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, PFE'nin B16-F10 h\u00fccrelerinde Tyr ve Tyrp2 mRNA ekspresyonunu \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rd\u0131\u011f\u0131n\u0131, di\u011fer tedavi gruplar\u0131n\u0131n ise Tyr, Tyrp1 ve Tyrp2 mRNA ekspresyonunu istatistiksel farkl\u0131l\u0131klarla de\u011fi\u015fen derecelerde art\u0131rabildi\u011fini g\u00f6stermi\u015ftir; bu da PSO, IPSO ve Fructus Psorale'deki potansiyel olarak bilinmeyen di\u011fer bile\u015fiklerin tirozinaz i\u00e7eri\u011fini art\u0131rarak vitiligo \u00fczerinde terap\u00f6tik etkiler g\u00f6sterebilece\u011fini g\u00f6stermektedir. Bununla birlikte, PSO'nun insan melanoma h\u00fccre hatt\u0131 A375 \u00fczerinde etkili oldu\u011fu ve tirozinaz promot\u00f6r\u00fcn\u00fcn aktivitesini inhibe etti\u011fine dair literat\u00fcr raporlar\u0131 da vard\u0131r; Tyr, Tyrp1 ve Tyrp2 mRNA'n\u0131n ekspresyon seviyelerini d\u00fc\u015f\u00fcrmek ve melanin \u00fcretimini inhibe etmek, bu deneyin sonu\u00e7lar\u0131n\u0131n aksine, farkl\u0131 ara\u015ft\u0131rma konular\u0131ndan veya farkl\u0131 konsantrasyon aral\u0131klar\u0131nda PSO taraf\u0131ndan melanin \u00fcretiminin \u00e7ift y\u00f6nl\u00fc d\u00fczenlenmesinden kaynaklan\u0131yor olabilir. Daha titiz ve do\u011fru sonu\u00e7lara varmak i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r. Vitiligonun psoralen ile tedavisinde, PSO ve IPSO ana etken maddelerdir ve bu ila\u00e7 veya bu geleneksel \u00c7in ilac\u0131n\u0131 i\u00e7eren form\u00fclasyonlar i\u00e7in kalite kontrol g\u00f6stergeleri olarak kullan\u0131labilirler.<\/p>","protected":false},"excerpt":{"rendered":"<p>Kimyasal bile\u015fim analizi ve UPLC-Q-TOF-MS ile Fructus Psorale alkol ekstrakt\u0131nda melanin \u00fcretimini te\u015fvik etme mekanizmas\u0131n\u0131n \u00f6n ara\u015ft\u0131rmas\u0131 Vitiligo, d\u00fcnya \u00e7ap\u0131nda yakla\u015f\u0131k 0.5% ~ 2% prevalans oran\u0131na sahip yayg\u0131n bir klinik lokalize depigmentasyon cilt hastal\u0131\u011f\u0131d\u0131r. Te\u015fhisi kolay ve tedavisi zordur, y\u00fcksek insidans oran\u0131 ve [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Chemical composition analysis and preliminary exploration of the mechanism of promoting melanin production in the alcohol extract of Fructus Psorale by UPLC-Q-TOF-MS - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/uplc-q-tof-ms-extraction-of-fructus-psorale\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chemical composition analysis and preliminary exploration of the mechanism of promoting melanin production in the alcohol extract of Fructus Psorale by UPLC-Q-TOF-MS - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Chemical composition analysis and preliminary exploration of the mechanism of promoting melanin production in the alcohol extract of Fructus Psorale by UPLC-Q-TOF-MS Vitiligo is a common clinical localized depigmentation skin disease, with a prevalence rate of about 0.5%~2% worldwide. 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