{"id":3567,"date":"2024-08-02T15:05:51","date_gmt":"2024-08-02T15:05:51","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3567"},"modified":"2024-08-02T15:05:51","modified_gmt":"2024-08-02T15:05:51","slug":"bufei-huoxue-capsules","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/bufei-huoxue-capsules\/","title":{"rendered":"Bufei Huoxue Kaps\u00fcllerinin pulmoner fibrozis tedavisindeki potansiyel etki mekanizmas\u0131n\u0131n a\u011f farmakolojisine dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

Bufei Huoxue Kaps\u00fcllerinin pulmoner fibrozis tedavisindeki potansiyel etki mekanizmas\u0131n\u0131n a\u011f farmakolojisine dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131<\/p>\n

Pulmoner fibrozis (PF), akci\u011fer fibroblastlar\u0131n\u0131n miyofibroblastlara aktivasyonu ve ekstrasel\u00fcler matriks salg\u0131lanmas\u0131 ile karakterize kronik, geri d\u00f6n\u00fc\u015f\u00fcms\u00fcz interstisyel bir akci\u011fer hastal\u0131\u011f\u0131d\u0131r. Bu hastal\u0131k, normal akci\u011fer dokusu yap\u0131s\u0131n\u0131n bozuldu\u011fu ve yerini anormal \u015fekilde onar\u0131lm\u0131\u015f skar dokusunun ald\u0131\u011f\u0131 \u00e7e\u015fitli akci\u011fer hastal\u0131klar\u0131n\u0131n son evre tezah\u00fcr\u00fcd\u00fcr. \u0130lerleyici ataklar \u015feklinde ortaya \u00e7\u0131kan PF'nin \u00e7e\u015fitli klinik alt tipleri vard\u0131r ve bunlar aras\u0131nda en yayg\u0131n olan\u0131 idiyopatik PF'dir. Bu hastal\u0131\u011f\u0131n nedeni \u015fu anda bilinmemektedir, sa\u011fkal\u0131m s\u00fcresi k\u0131sad\u0131r ve spesifik bir tedavi ilac\u0131 mevcut de\u011fildir. PF'nin insidans oran\u0131 ve mortalitesi her ge\u00e7en y\u0131l artmaktad\u0131r, \u00f6zellikle pulmoner interstisyelin \u00e7e\u015fitli solunum vir\u00fcsleri taraf\u0131ndan tekrarlanan enfeksiyonu, hastal\u0131\u011f\u0131 daha gen\u00e7 hale getirmektedir. \u015eu anda, klinikte hastal\u0131k i\u00e7in hala b\u00fcy\u00fck bir bilgi bo\u015flu\u011fu vard\u0131r. \u0130ki ila\u00e7, pirfenidon ve nintedanib, klinik uygulamada yayg\u0131n olarak kabul g\u00f6rmesine ra\u011fmen, klinik etkinlikleri tatmin edici de\u011fildir.
\nPF, \"pulmoner obstr\u00fcksiyon\" veya \"pulmoner impotans\" gibi geleneksel \u00c7in t\u0131bb\u0131 hastal\u0131klar\u0131 kategorisine aittir. Hastal\u0131\u011f\u0131n ba\u015flang\u0131c\u0131nda, uzun s\u00fcreli \u00f6ks\u00fcr\u00fck, esas olarak qi eksikli\u011fine ba\u011fl\u0131 \"pulmoner obstr\u00fcksiyon\" olarak ortaya \u00e7\u0131kan eksikli\u011fe yol a\u00e7ar; Hastal\u0131k geli\u015fmeye devam eder ve ge\u00e7 a\u015famada, hem qi hem de yin eksikli\u011fi vard\u0131r ve bu da akci\u011fer fonksiyon bozuklu\u011funa neden olur. Uzun s\u00fcreli hastal\u0131k \u00f6ks\u00fcr\u00fck ve h\u0131r\u0131lt\u0131ya yol a\u00e7ar, bu da akci\u011fer yinini t\u00fcketir ve akci\u011fer \u0131s\u0131s\u0131na neden olur. Bu da yin s\u0131v\u0131s\u0131n\u0131n geri akmas\u0131na neden olarak akci\u011ferlerde kurulu\u011fa, besin kayb\u0131na ve nihayetinde akci\u011fer iktidars\u0131zl\u0131\u011f\u0131na yol a\u00e7abilir. Su Wen'in \"\u0130ktidars\u0131zl\u0131k \u00dczerine Deneme \"sinde s\u00f6ylenen budur: \"Akci\u011ferler s\u0131caksa ve yapraklar kavrulmu\u015fsa... o zaman iktidars\u0131zl\u0131k meydana gelecektir.\" Bu hastal\u0131k ilk olarak qi eksikli\u011finden kaynaklan\u0131r ve ishale, terlemeye ve organlar\u0131 besleyecek v\u00fccut s\u0131v\u0131lar\u0131n\u0131n eksikli\u011fine yol a\u00e7ar. Bu nedenle, klinik uygulamada akci\u011ferleri beslemek ve yin terapisi, akci\u011fer iktidars\u0131zl\u0131\u011f\u0131n\u0131 tedavi ederken ayn\u0131 zamanda qi'yi de desteklemek i\u00e7in kullan\u0131l\u0131r. Akci\u011ferler y\u00fcz meridyene bakar ve su, tah\u0131l ve \u00f6z ta\u015f\u0131ma i\u015flevine sahiptir. Is\u0131 patojenleri akci\u011ferlere zarar verdi\u011finde ve qi yin'i t\u00fcketti\u011finde, ta\u015f\u0131ma kaybolur ve organlar beslenmeden mahrum kal\u0131r, bu da iktidars\u0131zl\u0131k sendromuna neden olur.
\nBufei Huoxue Kaps\u00fcl (BHC) Astragalus membranaceus, Paeonia lactiflora ve Fructus Psorale'den elde edilen aktif bile\u015fenlerden yap\u0131l\u0131r ve akci\u011fer hastal\u0131klar\u0131 i\u00e7in klinik uygulamada yayg\u0131n olarak kullan\u0131l\u0131r. Huangqi, dalak ve akci\u011fer meridyenlerini d\u00fczenleyebilen tatl\u0131 ve hafif \u0131l\u0131k bir yap\u0131ya sahiptir. V\u00fccudu besleme, d\u0131\u015f k\u0131sm\u0131 g\u00fc\u00e7lendirme ve dalak ile orta k\u0131sm\u0131 tonifiye etme i\u015flevlerine sahiptir; K\u0131rm\u0131z\u0131 \u015fakay\u0131k ac\u0131 ve hafif so\u011fuk bir yap\u0131ya sahiptir ve karaci\u011fer meridyenine aittir. Is\u0131y\u0131 temizleme, kan\u0131 so\u011futma, kan staz\u0131n\u0131 da\u011f\u0131tma ve a\u011fr\u0131y\u0131 hafifletme etkilerine sahiptir; Psoralea s\u0131cak bir yap\u0131ya sahiptir, b\u00f6brek ve dalak meridyenlerine geri d\u00f6ner. Qi'yi d\u00fczenleme, ast\u0131m\u0131 hafifletme, b\u00f6brekleri tonifiye etme ve yang'\u0131 g\u00fc\u00e7lendirme i\u015flevlerine sahiptir. Bu \u00fc\u00e7 ila\u00e7 akci\u011ferleri beslemek, b\u00f6brekleri g\u00fc\u00e7lendirmek, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in birlikte \u00e7al\u0131\u015f\u0131r. Bu \u00e7al\u0131\u015fma, BHC'nin anti PF etkisinin potansiyel mekanizmas\u0131n\u0131 a\u011f farmakolojisi y\u00f6ntemleriyle tahmin etmekte ve a\u011f farmakolojisinin sonu\u00e7lar\u0131n\u0131 hayvan deneyleri yoluyla do\u011frulayarak geleneksel \u00c7in t\u0131bb\u0131n\u0131n PF'yi \u00f6nleme ve tedavisinin teorik temelini zenginle\u015ftirmekte ve BHC'nin klinik uygulamas\u0131 i\u00e7in ara\u015ft\u0131rma temeli sa\u011flamaktad\u0131r.<\/p>\n

Bir hastal\u0131k olarak, pulmoner disfonksiyon kronik \u00f6ks\u00fcr\u00fck ve h\u0131r\u0131lt\u0131l\u0131 solunum, akci\u011fer qi eksikli\u011fi, organlar\u0131n disfonksiyonu ve v\u00fccudun qi'sini kontrol eden akci\u011ferlerden kaynaklanmal\u0131d\u0131r. Kan damarlar\u0131n\u0131n dola\u015f\u0131m\u0131 elveri\u015fsizdir, dalak eksikli\u011fi ve a\u015f\u0131r\u0131 rutubet ile birle\u015fti\u011finde, sonu\u00e7ta balgam p\u0131ht\u0131la\u015fmas\u0131na ve kan staz\u0131na yol a\u00e7ar, bu da pulmoner eksiklik sendromunu \u015fiddetlendirir ve bir k\u0131s\u0131r d\u00f6ng\u00fc olu\u015fturur. Bu, PF'nin klinik ilerlemesinin geri d\u00f6n\u00fc\u015f\u00fc olmayan TCM patogenezidir. Qi eksikli\u011fi PF'nin ba\u015flang\u0131c\u0131 i\u00e7in ba\u015flat\u0131c\u0131 fakt\u00f6rd\u00fcr ve hastal\u0131k ilerledik\u00e7e, hastal\u0131\u011f\u0131n son a\u015famalar\u0131nda t\u0131kan\u0131kl\u0131k ka\u00e7\u0131n\u0131lmazd\u0131r. \u0130\u00e7sel Kanon a\u00e7\u0131k\u00e7a belirtmektedir: \"Kan bol oldu\u011funda belirlenmeli; qi eksik oldu\u011funda kontrol edilmeli ve ind\u00fcklenmelidir. BHC, ana tedavi y\u00f6ntemi ve latent ila\u00e7 form\u00fclasyonlar\u0131n\u0131n geli\u015ftirilmesi i\u00e7in teorik temel olarak tam olarak bu y\u00f6nteme dayanmaktad\u0131r.
\nYukar\u0131daki \u00e7al\u0131\u015fma, BHC'nin p38, MMP9 ve TNF - \u03b1 hedefleri arac\u0131l\u0131\u011f\u0131yla TNF sinyal yoluna m\u00fcdahale ederek anti PF i\u015flevi g\u00f6sterdi\u011fini ortaya koymu\u015ftur. T\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc (TNF) 1970'lerde E A. Carswell ve ara\u015ft\u0131rma ekibi taraf\u0131ndan geli\u015ftirilmi\u015ftir. 1958 y\u0131l\u0131na kadar monon\u00fckleer makrofajlar taraf\u0131ndan sentezlenen ve salg\u0131lanan TNF'nin spesifik olarak tan\u0131mlanmad\u0131\u011f\u0131 ke\u015ffedilmi\u015ftir. Daha sonra bilim insanlar\u0131 yava\u015f yava\u015f NK h\u00fccreleri ve T lenfositleri de dahil olmak \u00fczere di\u011fer h\u00fccrelerin de TNF \u00fcretebildi\u011fini ke\u015ffetti. Ara\u015ft\u0131rmalar, TNF - \u03b1'n\u0131n yerel dokular\u0131n enflamatuar tepkisiyle yak\u0131ndan ilgili oldu\u011funu g\u00f6stermi\u015ftir, \u00e7\u00fcnk\u00fc esas olarak NLRP3 cisimcikleri taraf\u0131ndan temsil edilen enflamatuar maddelerin \u00fcretimini te\u015fvik edebilir, akci\u011fer fibroblastlar\u0131n\u0131n aktivasyonunu ind\u00fckleyebilir ve h\u00fccre d\u0131\u015f\u0131 matris salg\u0131layabilir. Ayn\u0131 zamanda TNF - \u03b1, tek ba\u015f\u0131na veya kompleman C3A ve C5A ile birlikte hareket ederek sitotoksik etkiler g\u00f6sterme kabiliyetiyle ortaya \u00e7\u0131kan enflamatuar hasar\u0131 da \u015fiddetlendirebilir. \u00d6zetle, TNF - \u03b1 PF olu\u015fumu ve geli\u015fiminde \u00e7ok \u00f6nemli bir rol oynamaktad\u0131r. MMP'ler, ana i\u015flevi ECM'yi bozmak olan \u00e7inko ba\u011f\u0131ml\u0131 proteazlard\u0131r. \u0130lk kez 1961 y\u0131l\u0131nda ke\u015ffedilmelerinden sonra, ayn\u0131 aileden \u00e7ok say\u0131da proteaz ke\u015ffedilmi\u015ftir. Normal ko\u015fullar alt\u0131nda MMP9'un aktivitesi \u00e7ok d\u00fc\u015f\u00fckt\u00fcr. Protein aktivasyonundan sonra, esas olarak ECM'nin degradasyonundan sorumludur. MMP9 aktivitesinin PF hastalar\u0131n\u0131n akci\u011fer dokusunda \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131 ve i\u00e7eri\u011finin bronkoalveolar lavaj s\u0131v\u0131s\u0131nda \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131 do\u011frulanm\u0131\u015ft\u0131r. Bunun ana nedeni ECM salg\u0131s\u0131n\u0131n olumsuz etkilerini adaptif olarak ortadan kald\u0131rmakt\u0131r. Son y\u0131llarda, \u00e7e\u015fitli biyolojik s\u00fcre\u00e7lerin PF hastal\u0131\u011f\u0131n\u0131n olu\u015fumu ile ili\u015fkili oldu\u011fu bulunmu\u015ftur, bunlar aras\u0131nda h\u00fccre apoptozu ve h\u00fccre d\u00f6ng\u00fcs\u00fc ile yak\u0131ndan ili\u015fkili olan p38 proteini artan bir ilgi g\u00f6rm\u00fc\u015ft\u00fcr. Tip II alveolar epitel h\u00fccrelerinde, monon\u00fckleer pulmoner makrofajlarda ve endotel h\u00fccrelerinde sentezlenen P38, enflamatuar h\u00fccre infiltrasyonuna, fibroblast farkl\u0131la\u015fmas\u0131na ve di\u011fer s\u00fcre\u00e7lere arac\u0131l\u0131k ederek PF olu\u015fumunun bir\u00e7ok a\u015famas\u0131na kat\u0131l\u0131r. Son y\u0131llarda ilgili literat\u00fcr\u00fcn okunmas\u0131yla, p38 arac\u0131l\u0131 PF s\u00fcrecinin temel olarak a\u015fa\u011f\u0131daki noktalar\u0131 i\u00e7erdi\u011fi bulunmu\u015ftur: ilk olarak, TGF - \u03b2'n\u0131n PF olu\u015fumunda anahtar bir molek\u00fcl oldu\u011fu iyi bilinmektedir. p38, TGF - \u03b2 sentezini te\u015fvik eder, alveolar epitel h\u00fccrelerinde epitelyal mezenkimal ge\u00e7i\u015fi (EMT) ind\u00fckler ve fibroblastlar\u0131 aktive ederek PF olu\u015fumuna kat\u0131l\u0131r. \u0130kinci olarak, p38, NF - \u03ba B proteininin aktivitesini d\u00fczenler ve PF patogenezine kat\u0131l\u0131r. NF - \u03ba B, Rel protein ailesinin p65 ve p50 alt birimlerinden olu\u015fan bir DNA ba\u011flay\u0131c\u0131 proteindir. \u00d6karyotik h\u00fccrelerde \u00f6nemli bir transkripsiyon d\u00fczenleyicisidir ve enflamatuar genlerin ve TGF - \u03b2 genlerinin transkripsiyonunu te\u015fvik ederek erken pulmoner alveolar enflamasyonda (PF) imm\u00fcn yan\u0131t\u0131n d\u00fczenlenmesine kat\u0131labilir. \u00dc\u00e7\u00fcnc\u00fc olarak, p38 fibroblastlar\u0131n \u00e7o\u011falmas\u0131 ve farkl\u0131la\u015fmas\u0131n\u0131n yan\u0131 s\u0131ra h\u00fccre d\u0131\u015f\u0131 matris birikiminde de \u00f6nemli bir rol oynar. Hayatta kalan miyofibroblastlarda p38, MMP'lerin mRNA transkripsiyonunu te\u015fvik ederek PF h\u00fccre d\u0131\u015f\u0131 matrisinin bozulmas\u0131na kat\u0131l\u0131r.<\/p>\n

Yukar\u0131daki analizden, bu \u00e7al\u0131\u015fmada farkl\u0131 \u015fekilde ifade edilen \u00fc\u00e7 proteinin (TNF - \u03b1, MMP-9, p38) hepsinin TNF sinyal yolundaki yukar\u0131 ve a\u015fa\u011f\u0131 d\u00fc\u011f\u00fcmlerde yer ald\u0131\u011f\u0131 ve ifadelerinin PF'nin olu\u015fumu ve geli\u015fimi ile yak\u0131ndan ili\u015fkili oldu\u011fu g\u00f6r\u00fclebilir. PF'nin molek\u00fcler biyoloji de\u011fi\u015fikliklerinde birden fazla y\u00f6n ve sinyal yolu yer almaktad\u0131r. Buradan, geleneksel \u00c7in t\u0131bb\u0131 m\u00fcdahalesinin \u00f6zelliklerinin \u00e7ok hedefli ve \u00e7ok yollu etkiler oldu\u011fu g\u00f6r\u00fclebilir. Ayn\u0131 zamanda, \u00e7e\u015fitli yollar birbiriyle yak\u0131ndan ili\u015fkilidir, birbirini etkiler ve d\u00fczenler. Bu ayn\u0131 zamanda geleneksel \u00c7in t\u0131bb\u0131n\u0131n etkilerinin genel konseptini de yans\u0131tmaktad\u0131r. Bu \u00e7al\u0131\u015fmada, \u00fc\u00e7 proteindeki (TNF - \u03b1, MMP-9, p38) de\u011fi\u015fikliklerin model grupta \u00f6nemli \u00f6l\u00e7\u00fcde y\u00fcksek ekspresyon g\u00f6sterdi\u011fi bulunmu\u015ftur. Dozdaki de\u011fi\u015fikliklerle birlikte protein ekspresyonu da gradyan de\u011fi\u015fiklikleri ve konsantrasyon ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 sergilemi\u015ftir. Deneysel b\u00f6l\u00fcm sadece sonraki ara\u015ft\u0131rmalar\u0131m\u0131z i\u00e7in y\u00f6n g\u00f6stermekle kalmad\u0131, ayn\u0131 zamanda \u00f6nceki a\u011f farmakolojisi b\u00f6l\u00fcm\u00fcm\u00fczdeki zenginle\u015ftirme analizi sonu\u00e7lar\u0131n\u0131n bilimsel ge\u00e7erlili\u011fini de do\u011frulad\u0131.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Bu \u00e7al\u0131\u015fmada yer alan BHC esas olarak kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme ve kan staz\u0131n\u0131 giderme y\u00f6ntemiyle tedavi edilmektedir. Hastal\u0131\u011f\u0131n nadir g\u00f6r\u00fclmesi ve etiyolojisinin karma\u015f\u0131kl\u0131\u011f\u0131 nedeniyle, \u015fu anda PF hakk\u0131nda nispeten az g\u00fcncel epidemiyolojik veri bulunmaktad\u0131r. Bununla birlikte, klinik olarak, insidans oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde artmaktad\u0131r; bunun nedeni yeni koronavir\u00fcs\u00fcn uzun s\u00fcreli varl\u0131\u011f\u0131, tekrarlanan enfeksiyon ve pulmoner interstisyumu tekrar tekrar uyaran di\u011fer fakt\u00f6rler olabilir. COVID-19 tedavisinde \u00f6nemli ilerlemeler kaydedilmi\u015f olmas\u0131na ra\u011fmen, bu t\u00fcr hastalar\u0131n uzun vadeli sekelleri, \u00f6zellikle de PF tedavisi i\u00e7in hala \u00e7\u00f6z\u00fclmesi gereken bir\u00e7ok sorun vard\u0131r. Bilindi\u011fi gibi PF, kronik obstr\u00fcktif akci\u011fer hastal\u0131\u011f\u0131 (KOAH), bron\u015fektazi ve amfizem dahil olmak \u00fczere bir\u00e7ok akci\u011fer hastal\u0131\u011f\u0131n\u0131n yava\u015f ilerlemesinin nihai sonucudur. PF'nin erken a\u015famalar\u0131nda, esas olarak qi durgunlu\u011fu ve kan staz\u0131ndan, qi ve kan\u0131n zay\u0131f dola\u015f\u0131m\u0131ndan ve akci\u011fer beslenmesinin eksikli\u011finden kaynaklan\u0131r. Bu a\u015faman\u0131n \u00f6zellikleri h\u0131zl\u0131 ba\u015flang\u0131\u00e7, k\u0131sa d\u00f6ng\u00fc ve kolay kontrold\u00fcr. Bu nedenle erken tedavi, qi ve yin beslenmesiyle desteklenen kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmeye ve kan staz\u0131n\u0131 gidermeye odaklanmal\u0131d\u0131r; Son evre PF hastalar\u0131nda, qi eksikli\u011fi ve nefes darl\u0131\u011f\u0131, zay\u0131f y\u00fczey savunmas\u0131 ve hassas akci\u011ferler, d\u0131\u015f patojenlerin istilas\u0131na daha duyarl\u0131d\u0131r. Bu a\u015faman\u0131n \u00f6zellikleri yava\u015f hastal\u0131k ilerlemesi, uzun d\u00f6ng\u00fc ve zor geri d\u00f6n\u00fc\u015f\u00fcmd\u00fcr. Bu a\u015famada, tedavi stratejisi esas olarak qi ve yin'i beslemeye odaklanmal\u0131, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik ederek ve kan staz\u0131n\u0131 gidererek desteklenmelidir. Bu \u00e7al\u0131\u015fmada yer alan hayvan modeli, PF'nin erken akut ba\u015flang\u0131\u00e7 a\u015famas\u0131na uygundur ve tedavi esas olarak kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmeye ve BHC'nin etkinli\u011fi ile uyumlu olan kan staz\u0131n\u0131 gidermeye odaklanmal\u0131d\u0131r. Bu, dolayl\u0131 olarak BHC'nin etkinli\u011fini ve bilimselli\u011fini ortaya koymakta ve ayr\u0131ca ara\u015ft\u0131rma grubumuzun gelecekteki ara\u015ft\u0131rmalar\u0131 i\u00e7in y\u00f6n sa\u011flamaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the potential mechanism of action of Bufei Huoxue Capsules in treating pulmonary fibrosis based on network pharmacology Pulmonary fibrosis (PF) is a chronic, irreversible interstitial lung disease characterized by the activation of lung fibroblasts into myofibroblasts and secretion of extracellular matrix. This disease is the end-stage manifestation of various lung diseases, where normal lung […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the potential mechanism of action of Bufei Huoxue Capsules in treating pulmonary fibrosis based on network pharmacology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/bufei-huoxue-capsules\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the potential mechanism of action of Bufei Huoxue Capsules in treating pulmonary fibrosis based on network pharmacology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the potential mechanism of action of Bufei Huoxue Capsules in treating pulmonary fibrosis based on network pharmacology Pulmonary fibrosis (PF) is a chronic, irreversible interstitial lung disease characterized by the activation of lung fibroblasts into myofibroblasts and secretion of extracellular matrix. 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