{"id":3264,"date":"2024-03-20T07:29:29","date_gmt":"2024-03-20T07:29:29","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=2980"},"modified":"2024-03-20T07:29:29","modified_gmt":"2024-03-20T07:29:29","slug":"what-is-the-effect-of-agitation-on-crystallization","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/calkalamanin-kri\u0307stallesme-uzeri\u0307ndeki\u0307-etki\u0307si\u0307-nedi\u0307r\/","title":{"rendered":"\u00c7alkalaman\u0131n kristalle\u015fme \u00fczerindeki etkisi nedir?"},"content":{"rendered":"

\u00c7alkalaman\u0131n kristalle\u015fme \u00fczerindeki etkisi nedir?<\/strong><\/h1>\n

Yayg\u0131n kristalizasyon kazan\u0131 kar\u0131\u015ft\u0131rmas\u0131 (Kar\u0131\u015ft\u0131rmal\u0131 tank kristalizat\u00f6r\u00fc) \u015eekil a'da g\u00f6sterildi\u011fi gibi eksenel k\u00fcrek tipidir. Burada yazarlar \u00e7apa benzeri kaz\u0131nm\u0131\u015f duvar kar\u0131\u015ft\u0131rma k\u00fcre\u011fi (kaz\u0131nm\u0131\u015f y\u00fczey kristalizat\u00f6r\u00fc) tasarlam\u0131\u015f ve kar\u0131\u015ft\u0131rman\u0131n kristalizasyon \u00fczerindeki etkisini incelemek i\u00e7in \u00fc\u00e7 farkl\u0131 API t\u00fcr\u00fc se\u00e7mi\u015ftir.<\/p>\n

\"\"<\/p>\n

Kristalizasyon tekniklerine kapsaml\u0131 bir bak\u0131\u015f sunan bu kitap ger\u00e7ekten g\u00f6z a\u00e7\u0131c\u0131!
\nBunlardan ilki ibuprofen (IBP) olup DMSO i\u00e7indeki 25 \u00b0C'lik IBP \u00e7\u00f6zeltisine bir damla su eklenerek kristalle\u015ftirilmi\u015ftir. ST eksenel k\u00fcrekle 60 rpm'de kar\u0131\u015ft\u0131r\u0131larak kristalle\u015ftirilirken, kar\u0131\u015ft\u0131rma iyi de\u011fildi ve 25 dakika i\u00e7inde DMSO'nun \u00fcst katman\u0131nda sulu bir faz vard\u0131, bu da 30 dakikada numune al\u0131n\u0131p analiz edildi\u011finde y\u00fcksek verimle sonu\u00e7land\u0131. \u00c7alkalamaya ve numune almaya devam ederek, 200 rpm'de ST eksenel ak\u0131\u015f kar\u0131\u015ft\u0131rma ve 60 rpm'de SS duvar s\u0131y\u0131r\u0131c\u0131 \u00e7apa kar\u0131\u015ft\u0131rma kullanarak kristalle\u015ftirme, 30 dakika ve 60 dakikada benzer verimle sonu\u00e7lanm\u0131\u015ft\u0131r.<\/p>\n

\"\"<\/p>\n

Biyofarmas\u00f6tikte verimli s\u00fcrekli ak\u0131\u015f \u00fcretim s\u00fcreci nas\u0131l uygulan\u0131r? Vaka payla\u015f\u0131m\u0131 ile!
\nY\u00fczeydeki sert kabuklanma, kristalizasyon API'sinin do\u011fas\u0131n\u0131n yan\u0131 s\u0131ra kar\u0131\u015ft\u0131rma k\u00fcre\u011fi ve kristalizasyon kazan\u0131 y\u00fczeyinin p\u00fcr\u00fczs\u00fczl\u00fc\u011f\u00fc ve sertli\u011fi ile de ilgilidir. Paslanmaz \u00e7elik ST k\u00fcrek tipi ile 200 rpm'de (\u015eekil c) daha \u015fiddetli y\u00fczey kabuklanmas\u0131 g\u00f6r\u00fcl\u00fcrken, PTFE kullan\u0131lan SS \u00e7apa tipi ile 60 rpm'de daha az y\u00fczey kabuklanmas\u0131 g\u00f6r\u00fclm\u00fc\u015ft\u00fcr.<\/p>\n

\"\"<\/p>\n

Difenhidramin Hidroklor\u00fcr (DPH), 60 \u00b0C'den ba\u015flayarak 5 \u00b0C'ye kadar so\u011futularak ve ard\u0131ndan bekletilerek \u00e7\u00f6keltilen lamelli bir kristaldir.SS \u00c7apa 60 rpm kristalle\u015fme kineti\u011fi ST 200 rpm ile benzerdir ve her ikisi de ST K\u00fcrek 60 rpm'den daha h\u0131zl\u0131 \u00e7\u00f6kelir.<\/p>\n

\"\"<\/p>\n

K\u00fc\u00e7\u00fck ve \u00f6l\u00e7ekli deneyler ile pilot \u00fcretim aras\u0131ndaki farklar ve ba\u011flant\u0131lar<\/p>\n

ST k\u00fcrekli kar\u0131\u015ft\u0131rma (\u015eekil b, 60 rpm; c, 200 rpm) kullan\u0131larak elde edilen kristallerde daha fazla topakl\u0131 kat\u0131 madde vard\u0131 (\u015eekil a).<\/p>\n

 <\/p>\n

\"\"<\/p>\n

Hem SS Anchor 60rpm hem de ST Paddle 200rpm ile bo\u015falt\u0131m daha kolayd\u0131 ve kat\u0131 madde kal\u0131nt\u0131s\u0131 yoktu, ancak ST 60rpm'de daha fazla y\u00fczey kabuklanmas\u0131 ve bo\u015falt\u0131mda kat\u0131 madde kal\u0131nt\u0131s\u0131 vard\u0131.<\/p>\n

\"\"<\/p>\n

\u0130\u011fne formundaki Fluoksetin Hidroklor\u00fcr (FLU) i\u00e7in de so\u011futulmu\u015f ve kristalden ar\u0131nd\u0131r\u0131lm\u0131\u015f SS Anchor 60rpm, ST Paddle'dan \u00f6nemli \u00f6l\u00e7\u00fcde daha h\u0131zl\u0131 kristalden ar\u0131nd\u0131rm\u0131\u015ft\u0131r.<\/p>\n

\"\"<\/p>\n

Bu \u00fc\u00e7 kristalizasyon ko\u015fulu kullan\u0131larak uzun, ince, i\u011fne benzeri FLU kristalleri elde edilmi\u015f, SS-anchor tipi di\u011ferlerine g\u00f6re daha uzun kristaller (\u015eekil a) vermi\u015ftir (\u015eekil a, ST, 60 rpm; \u015eekil c, ST, 200 rpm). (Kuru Payla\u015f\u0131m) End\u00fcstriyel Kristalizasyon Prosesi Kontrol Noktalar\u0131 ve Uygulama \u00d6rnekleri<\/p>\n

\"\"<\/p>\n

SS 60 rpm'ye sabitlendi\u011finde herhangi bir bo\u015faltma sorunuyla kar\u015f\u0131la\u015f\u0131lmam\u0131\u015ft\u0131r (\u015eekil a), ancak ST kullan\u0131larak farkl\u0131 h\u0131zlarda elde edilen kristaller zay\u0131f hareketlidir ve do\u011frudan d\u00f6k\u00fclemez, ancak \u00e7\u00f6z\u00fcc\u00fc olu\u015fturulduktan sonra d\u00f6k\u00fclebilir (\u015eekil b).<\/p>\n

\"\"<\/p>\n

Kapsaml\u0131 Kar\u015f\u0131la\u015ft\u0131rma:
\n1. ST K\u00fcrekli Kar\u0131\u015ft\u0131rma 200 rpm kristal k\u0131r\u0131lmas\u0131n\u0131, aglomerasyonu ve ikincil \u00e7ekirdeklenmeyi te\u015fvik eder, b\u00f6ylece kristal boyutu da\u011f\u0131l\u0131m\u0131 daha geni\u015ftir.
\n2. ST k\u00fcrekle 60 rpm kar\u0131\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, DPH kristalleri belirli bir boyuta ula\u015f\u0131r ve \u00e7\u00f6kelmeye ve kazan\u0131n dibine y\u0131\u011f\u0131lmaya ba\u015flar. Zay\u0131f \u00e7alkalama nedeniyle, kristal b\u00fcy\u00fcmesi k\u00fctle transferinden etkilenir ve bu da daha yava\u015f kristal \u00e7\u00f6kelmesine neden olur.
\n3. SS \u00e7apa 60 rpm kar\u0131\u015ft\u0131rma, \u00e7apa ve kazan duvar\u0131 aras\u0131ndaki bo\u015fluk daha k\u00fc\u00e7\u00fck oldu\u011fundan, kat\u0131 s\u00fcspansiyon daha iyidir ve ak\u0131\u015fkan sim\u00fclasyonunun CFD'si sistemin ortalama kaymas\u0131n\u0131n daha k\u00fc\u00e7\u00fck oldu\u011funu g\u00f6sterir. \u0130nce k\u0131r\u0131lm\u0131\u015f kristallere sahip di\u011fer kar\u0131\u015ft\u0131rma sistemlerine k\u0131yasla FLU'nun kristalle\u015fmesi gibi daha az kristal k\u0131r\u0131lmas\u0131. D\u00fc\u015f\u00fck d\u00f6nme h\u0131z\u0131 ve d\u00fc\u015f\u00fck kayma, dolay\u0131s\u0131yla daha az kristal-kristal ve kristal-kazan duvar\u0131 etkile\u015fimi, dolay\u0131s\u0131yla daha az aglomerasyon.<\/p>","protected":false},"excerpt":{"rendered":"

\u00c7alkalaman\u0131n kristalle\u015fme \u00fczerindeki etkisi nedir? Yayg\u0131n kristalizasyon kazan\u0131 kar\u0131\u015ft\u0131rmas\u0131 (Kar\u0131\u015ft\u0131rmal\u0131 tank kristalizat\u00f6r\u00fc) \u015eekil a'da g\u00f6sterildi\u011fi gibi eksenel k\u00fcrek tipidir. Burada yazarlar \u00e7apa benzeri kaz\u0131nm\u0131\u015f duvar kar\u0131\u015ft\u0131rma k\u00fcre\u011fi (kaz\u0131nm\u0131\u015f y\u00fczey kristalizat\u00f6r\u00fc) tasarlad\u0131lar ve kar\u0131\u015ft\u0131rman\u0131n kristalizasyon \u00fczerindeki etkisini incelemek i\u00e7in \u00fc\u00e7 farkl\u0131 API t\u00fcr\u00fc se\u00e7tiler. Kapsaml\u0131 bir [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nWhat is the effect of agitation on crystallization? - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/calkalamanin-kri\u0307stallesme-uzeri\u0307ndeki\u0307-etki\u0307si\u0307-nedi\u0307r\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is the effect of agitation on crystallization? - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"What is the effect of agitation on crystallization? 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