{"id":10644,"date":"2026-03-10T02:21:30","date_gmt":"2026-03-10T02:21:30","guid":{"rendered":"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/"},"modified":"2026-03-10T02:21:30","modified_gmt":"2026-03-10T02:21:30","slug":"esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/","title":{"rendered":"Esomeprazol (CAS 119141-88-7): Bu Etkili Proton Pompas\u0131 \u0130nhibit\u00f6r\u00fc Hakk\u0131nda Kapsaml\u0131 Bir K\u0131lavuz"},"content":{"rendered":"

<\/p>\n

Esomeprazol nedir?<\/h2>\n

Esomeprazol, omeprazol\u00fcn S-enantiomeridir ve benzimidazol s\u0131n\u0131f\u0131na ait proton pompas\u0131 inhibit\u00f6rlerinden biridir. Kimyasal olarak (S)-5-Metoksi-2-(4-metoksi-3,5-dimetilpiridin-2-il)metils\u00fclfinil-1H-benzimidazol olarak adland\u0131r\u0131l\u0131r. Bu bile\u015fik, molek\u00fcler form\u00fcl\u00fc C17H19N3O3S ve molek\u00fcler a\u011f\u0131rl\u0131\u011f\u0131 345,42 g\/mol olan, ikame edilmi\u015f bir benzimidazold\u00fcr.<\/p>\n

Rasemik ana bile\u015fi\u011fi olan omeprazol\u00fcn aksine, esomeprazol \u00f6zel olarak (S)-enantiomerinden olu\u015fur; bu enantiomer, rasemik kar\u0131\u015f\u0131ma k\u0131yasla daha iyi biyoyararlan\u0131m ve daha tutarl\u0131 farmakokinetik profiller sergilemektedir.<\/p>\n

Esomeprazol\u00fcn Kimyasal \u00d6zellikleri<\/h2>\n\n\n\n\n\n\n\n\n
CAS Numaras\u0131<\/strong><\/td>\n119141-88-7<\/td>\n<\/tr>\n
Molek\u00fcler Form\u00fcl<\/strong><\/td>\nC17H19N3O3S<\/td>\n<\/tr>\n
Molek\u00fcler A\u011f\u0131rl\u0131k<\/strong><\/td>\n345,42 g\/mol<\/td>\n<\/tr>\n
G\u00f6r\u00fcn\u00fc\u015f<\/strong><\/td>\nBeyaz ila kirli beyaz kristal toz<\/td>\n<\/tr>\n
\u00c7\u00f6z\u00fcn\u00fcrl\u00fck<\/strong><\/td>\nMetanol ve DMSO\u2019da \u00e7\u00f6z\u00fcn\u00fcr; suda az \u00e7\u00f6z\u00fcn\u00fcr<\/td>\n<\/tr>\n
pKa<\/strong><\/td>\n9,0 (benzimidazol azotu)<\/td>\n<\/tr>\n
Erime Noktas\u0131<\/strong><\/td>\n155-160C<\/td>\n<\/tr>\n<\/table>\n

Yap\u0131sal S\u0131n\u0131fland\u0131rma<\/h3>\n

Esomeprazol, \u00e7e\u015fitli ikame gruplar\u0131na sahip bir benzimidazol \u00e7ekirdek yap\u0131s\u0131yla karakterize edilen bir bile\u015fik grubu olan ikame edilmi\u015f benzimidazol olarak s\u0131n\u0131fland\u0131r\u0131l\u0131r.<\/p>\n

Etki Mekanizmas\u0131<\/h2>\n

Esomeprazol, midenin paryetal h\u00fccrelerinde mide asidi salg\u0131lanmas\u0131n\u0131n son a\u015famas\u0131ndan sorumlu olan mide H+\/K+-ATPaz enzimini geri d\u00f6n\u00fc\u015fs\u00fcz bir \u015fekilde inhibe ederek etki g\u00f6sterir.<\/p>\n

    \n
  1. \u00d6n-ila\u00e7 aktivasyonu<\/strong>: Esomeprazol, paryetal h\u00fccre kanalik\u00fcllerinin asidik ortam\u0131nda aktivasyona ihtiya\u00e7 duyan bir \u00f6n ilac\u0131d\u0131r.<\/li>\n
  2. Kovalent ba\u011flanma<\/strong>: Aktive edilmi\u015f form, H+\/K+-ATPaz enzimi \u00fczerindeki sistein kal\u0131nt\u0131lar\u0131yla kovalent dis\u00fclfid ba\u011flar\u0131 olu\u015fturur.<\/li>\n
  3. Uzun s\u00fcreli inhibisyon<\/strong>: Bu geri d\u00f6n\u00fc\u015fs\u00fcz ba\u011flanma, yeni proton pompalar\u0131 sentezlenene kadar asit salg\u0131lanmas\u0131n\u0131 engeller ve 24 saate kadar asit bask\u0131lanmas\u0131 sa\u011flar.<\/li>\n<\/ol>\n

    T\u0131bbi Kullan\u0131m Alanlar\u0131 ve Faydalar\u0131<\/h2>\n

    Esomeprazol, \u00e7e\u015fitli gastrointestinal rahats\u0131zl\u0131klar\u0131n tedavisi i\u00e7in FDA taraf\u0131ndan onaylanm\u0131\u015ft\u0131r:<\/p>\n

      \n
    • Gastro\u00f6zofageal Refl\u00fc Hastal\u0131\u011f\u0131 (GERD)<\/strong>: Eroziv \u00f6zofajitin tedavisi<\/li>\n
    • Duodenum \u00dclseri<\/strong>: \u0130yile\u015fme ve n\u00fcksetmenin \u00f6nlenmesi<\/li>\n
    • Mide \u00dclseri<\/strong>: \u0130yi huylu mide \u00fclserlerinin tedavisi<\/li>\n
    • NSAID\u2019lerin Neden Oldu\u011fu \u00dclserler<\/strong>: Mide \u00fclserlerinin \u00f6nlenmesi<\/li>\n
    • Zollinger-Ellison Sendromu<\/strong>: Mide asidi a\u015f\u0131r\u0131 salg\u0131lanmas\u0131n\u0131n tedavisi<\/li>\n
    • Helicobacter pylori\u2019nin Ortadan Kald\u0131r\u0131lmas\u0131<\/strong>: Kombinasyon tedavisinin bir par\u00e7as\u0131 olarak<\/li>\n<\/ul>\n

      Klinik Faydalar<\/h3>\n
        \n
      • H\u0131zl\u0131 etki ba\u015flang\u0131c\u0131<\/strong>: 1 saat i\u00e7inde asidi bast\u0131rmaya ba\u015flar<\/li>\n
      • Uzun s\u00fcreli etki<\/strong>: G\u00fcnde bir kez al\u0131nmas\u0131yla 24 saat boyunca asit kontrol\u00fc sa\u011flan\u0131r<\/li>\n
      • \u00dcst\u00fcn etkinlik<\/strong>: Omeprazolden daha iyi asit kontrol\u00fc<\/li>\n
      • \u0130yile\u015fme oranlar\u0131nda art\u0131\u015f<\/strong>: Erozyonlu \u00f6zofajitin iyile\u015fme oranlar\u0131n\u0131n daha y\u00fcksek olmas\u0131<\/li>\n<\/ul>\n

        Dozaj ve Uygulama<\/h2>\n\n\n\n\n\n\n
        Durum<\/th>\n\u00d6nerilen Doz<\/th>\nS\u00fcre<\/th>\n<\/tr>\n
        GERD\/Erozif \u00d6zofajit<\/td>\nG\u00fcnde bir kez 20-40 mg<\/td>\n4-8 hafta<\/td>\n<\/tr>\n
        Duodenum \u00dclseri<\/td>\nG\u00fcnde bir kez 20 mg<\/td>\n2-4 hafta<\/td>\n<\/tr>\n
        Mide \u00dclseri<\/td>\nG\u00fcnde bir kez 20-40 mg<\/td>\n4-8 hafta<\/td>\n<\/tr>\n
        H. pylori\u2019nin Ortadan Kald\u0131r\u0131lmas\u0131<\/td>\nG\u00fcnde iki kez 20-40 mg<\/td>\n10-14 g\u00fcn<\/td>\n<\/tr>\n<\/table>\n

        Y\u00f6netim K\u0131lavuzlar\u0131<\/h3>\n
          \n
        • Esomeprazol\u00fc yemeklerden en az 1 saat \u00f6nce al\u0131n<\/li>\n
        • Tabletleri b\u00fct\u00fcn olarak yutun; ezmeyin veya \u00e7i\u011fnemeyin<\/li>\n
        • Gerekirse nazogastrik t\u00fcp yoluyla verilebilir<\/li>\n<\/ul>\n

          Yan Etkiler ve G\u00fcvenlik Profili<\/h2>\n

          S\u0131k G\u00f6r\u00fclen Yan Etkiler<\/h3>\n
            \n
          • Ba\u015f a\u011fr\u0131s\u0131<\/li>\n
          • Mide bulant\u0131s\u0131<\/li>\n
          • \u0130shal<\/li>\n
          • Kar\u0131n a\u011fr\u0131s\u0131<\/li>\n
          • Kab\u0131zl\u0131k<\/li>\n
          • Gaz<\/li>\n<\/ul>\n

            Daha Az G\u00f6r\u00fclen Yan Etkiler<\/h3>\n
              \n
            • Ba\u015f d\u00f6nmesi<\/li>\n
            • A\u011f\u0131z kurulu\u011fu<\/li>\n
            • D\u00f6k\u00fcnt\u00fc<\/li>\n
            • Pruritus (ka\u015f\u0131nt\u0131)<\/li>\n<\/ul>\n

              Nadir G\u00f6r\u00fclen Ancak \u00d6nemli Hususlar<\/h3>\n
                \n
              • Uzun s\u00fcreli kullan\u0131m\u0131n riskleri<\/strong>: K\u0131r\u0131k riski art\u0131\u015f\u0131, B12 vitamini eksikli\u011fi<\/li>\n
              • \u0130la\u00e7 etkile\u015fimleri<\/strong>: Ketokonazol ve demir tuzlar\u0131n\u0131n emiliminin azalmas\u0131<\/li>\n
              • A\u015f\u0131r\u0131 duyarl\u0131l\u0131k reaksiyonlar\u0131<\/strong>: Nadir g\u00f6r\u00fclen anafilaksi vakalar\u0131<\/li>\n<\/ul>\n

                Kontrendikasyonlar<\/h3>\n
                  \n
                • Esomeprazol veya omeprazole kar\u015f\u0131 bilinen a\u015f\u0131r\u0131 duyarl\u0131l\u0131k<\/li>\n
                • Rilpivirin ile e\u015fzamanl\u0131 kullan\u0131m<\/li>\n
                • Ciddi karaci\u011fer yetmezli\u011fi olan hastalar<\/li>\n<\/ul>\n

                  \u0130la\u00e7 Etkile\u015fimleri<\/h2>\n\n\n\n\n\n\n
                  Etkile\u015fime Giren \u0130la\u00e7<\/th>\nEtki<\/th>\n<\/tr>\n
                  Klopidogrel<\/td>\nAzalm\u0131\u015f antitrombosit etki<\/td>\n<\/tr>\n
                  Atazanavir<\/td>\nAtazanavir d\u00fczeylerinde azalma<\/td>\n<\/tr>\n
                  Ketokonazol<\/td>\nAntifungal ilac\u0131n emiliminde azalma<\/td>\n<\/tr>\n
                  Demir tuzlar\u0131<\/td>\nDemir emiliminde azalma<\/td>\n<\/tr>\n<\/table>\n

                  Neden Esomeprazol Tercih Edilmeli?<\/h2>\n

                  Di\u011fer PPI\u2019lara G\u00f6re Avantajlar\u0131<\/h3>\n
                    \n
                  1. Daha y\u00fcksek biyoyararlan\u0131m<\/strong>: 50-70%, omeprazol ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda daha y\u00fcksek plazma konsantrasyonlar\u0131<\/li>\n
                  2. Daha iyi asit kontrol\u00fc<\/strong>: Mide pH\u2019s\u0131nda daha tutarl\u0131 bir art\u0131\u015f<\/li>\n
                  3. \u0130yile\u015fme oranlar\u0131nda art\u0131\u015f<\/strong>: Erozyonlu \u00f6zofajitin daha etkili tedavisi<\/li>\n
                  4. Semptomlar\u0131n daha h\u0131zl\u0131 hafiflemesi<\/strong>: Mide ek\u015fimesinin daha h\u0131zl\u0131 bir \u015fekilde giderilmesi<\/li>\n<\/ol>\n

                    Kaliteyle \u0130lgili Hususlar<\/h3>\n

                    \u0130la\u00e7 \u00fcretimi veya ara\u015ft\u0131rmas\u0131 i\u00e7in:<\/p>\n

                      \n
                    • Safl\u0131k: \u0130la\u00e7 uygulamalar\u0131 i\u00e7in en az 98%<\/li>\n
                    • cGMP kurallar\u0131na uygun \u00fcretim<\/li>\n
                    • COA'n\u0131n tam metni mevcuttur<\/li>\n
                    • G\u00fcvenilir tedarik zinciri<\/li>\n<\/ul>\n

                      S\u0131k Sorulan Sorular<\/h2>\n

                      S: Esomeprazol, omeprazolden ne a\u00e7\u0131dan farkl\u0131d\u0131r?<\/h3>\n

                      A:<\/strong> Esomeprazol, omeprazol\u00fcn S-izomeridir ve daha iyi biyoyararlan\u0131m ile daha tutarl\u0131 asit bask\u0131lama sa\u011flar.<\/p>\n

                      S: Esomeprazol\u00fc yemekle birlikte alabilir miyim?<\/h3>\n

                      A:<\/strong> En iyi emilim i\u00e7in yemeklerden 30-60 dakika \u00f6nce al\u0131nmas\u0131 tavsiye edilir.<\/p>\n

                      S: Esomeprazol\u00fc ne kadar s\u00fcreyle kullanabilirim?<\/h3>\n

                      A:<\/strong> GERD tedavisi genellikle 4-8 hafta s\u00fcrer. Uzun s\u00fcreli kullan\u0131mda t\u0131bbi g\u00f6zetim gereklidir.<\/p>\n

                      S: Esomeprazol\u00fcn uzun s\u00fcreli kullan\u0131m\u0131 g\u00fcvenli midir?<\/h3>\n

                      A:<\/strong> Uzun s\u00fcreli kullan\u0131m baz\u0131 riskler ta\u015f\u0131yabilir. Sa\u011fl\u0131k uzman\u0131 taraf\u0131ndan d\u00fczenli olarak takip edilmesi tavsiye edilir.<\/p>\n

                      Sonu\u00e7<\/h2>\n

                      Esomeprazol (CAS 119141-88-7), proton pompas\u0131 inhibit\u00f6r\u00fc tedavisinde \u00f6nemli bir ilerlemeyi temsil etmektedir. \u00dcst\u00fcn farmakokinetik \u00f6zellikleri ve kan\u0131tlanm\u0131\u015f etkinli\u011fi, bu ilac\u0131 asit kaynakl\u0131 gastrointestinal rahats\u0131zl\u0131klar\u0131n tedavisinde tercih edilen bir se\u00e7enek haline getirmektedir.<\/p>\n

                      \u0130la\u00e7 tedariki veya toplu tedarik talepleriniz i\u00e7in bizimle ileti\u015fime ge\u00e7in.<\/p>\n

                      \n

                      Bu makale yaln\u0131zca bilgilendirme ama\u00e7l\u0131d\u0131r ve t\u0131bbi tavsiye niteli\u011fi ta\u015f\u0131mamaktad\u0131r.<\/em><\/p>","protected":false},"excerpt":{"rendered":"What is Esomeprazole? Esomeprazole is the S-enantiomer of omeprazole, belonging to the benzimidazole class of proton pump inhibitors. Chemically, it is designated as (S)-5-Methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl-1H-benzimidazole. The compound is a substituted benzimidazole with a molecular formula of C17H19N3O3S and a molecular weight of 345.42 g\/mol. Unlike its racemic parent compound omeprazole, esomeprazole consists specifically of the (S)-enantiomer, [...]","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"yoast_head":"\nEsomeprazole (CAS 119141-88-7): A Comprehensive Guide to This Potent Proton Pump Inhibitor - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Esomeprazole (CAS 119141-88-7): A Comprehensive Guide to This Potent Proton Pump Inhibitor - China Chemical Manufacturer\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-10T02:21:30+00:00\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"Longchang Chemical\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\",\"url\":\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\",\"name\":\"Esomeprazole (CAS 119141-88-7): A Comprehensive Guide to This Potent Proton Pump Inhibitor - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"datePublished\":\"2026-03-10T02:21:30+00:00\",\"dateModified\":\"2026-03-10T02:21:30+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/esomeprazole-cas-119141-88-7-a-comprehensive-guide-to-this-potent-proton-pump-inhibitor\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Esomeprazole (CAS 119141-88-7): A Comprehensive Guide to This Potent Proton Pump Inhibitor\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"description\":\"Longchang Chemical is the company publisher of chemical, ingredient and technical procurement information on longchangextracts.com. 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