{"id":10640,"date":"2026-03-09T22:19:16","date_gmt":"2026-03-09T22:19:16","guid":{"rendered":"https:\/\/longchangextracts.com\/d-serine-cas-312-84-5-complete-guide-to-this-essential-nmda-receptor-co-agonist\/"},"modified":"2026-09-10T03:15:38","modified_gmt":"2026-09-10T03:15:38","slug":"d-serine-cas-312-84-5-complete-guide-to-this-essential-nmda-receptor-co-agonist","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/d-serine-cas-312-84-5-complete-guide-to-this-essential-nmda-receptor-co-agonist\/","title":{"rendered":"D-Serine (CAS 312-84-5): Complete Guide to This Essential NMDA Receptor Co-Agonist"},"content":{"rendered":"<h2>What is D-Serine?<\/h2>\n<p>D-Serine (CAS 312-84-5) is an endogenous amino acid that serves as a potent co-agonist at the NMDA-type glutamate receptor, playing a critical role in brain function and neurological health. This comprehensive guide explores the chemical properties, biological significance, applications, and safety considerations of this important biochemical compound.<\/p>\n<p>D-Serine is the D-isomer of the amino acid serine, classified as a non-proteinogenic amino acid. Unlike L-serine, which is incorporated into proteins, D-Serine functions primarily as a signaling molecule in the central nervous system (CNS). It was discovered in the rat brain in 1992 and has since been recognized as one of the most important neuromodulators in the brain.<\/p>\n<h2>Kimyasal \u00d6zellikler<\/h2>\n<table>\n<tr>\n<td><strong>M\u00fclk<\/strong><\/td>\n<td><strong>De\u011fer<\/strong><\/td>\n<\/tr>\n<tr>\n<td>CAS Numaras\u0131<\/td>\n<td>312-84-5<\/td>\n<\/tr>\n<tr>\n<td>Molek\u00fcler Form\u00fcl<\/td>\n<td>C\u2083H\u2087NO\u2083<\/td>\n<\/tr>\n<tr>\n<td>Molek\u00fcler A\u011f\u0131rl\u0131k<\/td>\n<td>105.09 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>E\u015fanlaml\u0131lar<\/td>\n<td>(R)-Serine, D-2-Amino-3-hydroxypropionic acid, \u03b2-Hydroxyalanine<\/td>\n<\/tr>\n<tr>\n<td>G\u00f6r\u00fcn\u00fc\u015f<\/td>\n<td>Beyaz kristal toz<\/td>\n<\/tr>\n<tr>\n<td>Safl\u0131k<\/td>\n<td>Typically \u226598%<\/td>\n<\/tr>\n<\/table>\n<h2>Biological Significance<\/h2>\n<h3>NMDA Receptor Co-Agonist<\/h3>\n<p>D-Serine&#8217;s most important biological role is as an endogenous agonist at the glycine site of NMDA-type glutamate receptors. NMDA receptors are crucial for synaptic plasticity, learning, and memory formation. For NMDA receptor activation, two co-agonists are required:<\/p>\n<ol>\n<li><strong>Glutamate<\/strong> &#8211; binds to the GluN2 subunit<\/li>\n<li><strong>D-Serine or Glycine<\/strong> &#8211; binds to the GluN1 subunit<\/li>\n<\/ol>\n<p>D-Serine is considered the primary endogenous co-agonist in forebrain regions, making it essential for normal brain function.<\/p>\n<h3>Cognitive Function and Neuroprotection<\/h3>\n<p>Research has demonstrated that D-Serine plays multiple roles in cognitive health:<\/p>\n<ul>\n<li><strong>Enhances learning and memory<\/strong> processes<\/li>\n<li><strong>Improves synaptic plasticity<\/strong> through NMDA receptor modulation<\/li>\n<li><strong>Supports long-term potentiation (LTP)<\/strong> &#8211; the cellular basis of memory<\/li>\n<li><strong>Protects against neurodegeneration<\/strong> in various neurological conditions<\/li>\n<\/ul>\n<h2>Therapeutic Applications<\/h2>\n<h3>Schizophrenia Treatment<\/h3>\n<p>D-Serine has shown significant promise in schizophrenia treatment:<\/p>\n<ul>\n<li><strong>Clinical trials<\/strong> have demonstrated improvements in negative symptoms and cognitive function<\/li>\n<li><strong>Meta-analyses<\/strong> reveal significant reductions in overall psychopathology with an effect size of 0.40<\/li>\n<li>Works as an <strong>add-on therapy<\/strong> to antipsychotic medications<\/li>\n<li>Particularly effective for patients with <strong>treatment-resistant symptoms<\/strong><\/li>\n<\/ul>\n<h3>Alzheimer&#8217;s Disease and Cognitive Decline<\/h3>\n<p>D-Serine research for Alzheimer&#8217;s disease focuses on:<\/p>\n<ul>\n<li>Potential to improve <strong>cognitive function<\/strong> in patients with suboptimal NMDA receptor activation<\/li>\n<li>May help protect against <strong>amyloid-beta toxicity<\/strong><\/li>\n<li>Supports <strong>synaptic plasticity<\/strong> that declines with age<\/li>\n<\/ul>\n<h3>Other Neurological Applications<\/h3>\n<ul>\n<li><strong>Depression<\/strong> &#8211; potential as a therapeutic agent<\/li>\n<li><strong>Neuropathic pain<\/strong> &#8211; modulatory effects on NMDA receptors<\/li>\n<li><strong>Stroke recovery<\/strong> &#8211; neuroprotective properties<\/li>\n<li><strong>Parkinson&#8217;s disease<\/strong> &#8211; research into dopaminergic system interactions<\/li>\n<\/ul>\n<h2>Industrial and Research Applications<\/h2>\n<h3>Pharmaceutical Manufacturing<\/h3>\n<p>D-Serine is used in:<\/p>\n<ul>\n<li><strong>Drug synthesis<\/strong> &#8211; intermediate for pharmaceutical compounds<\/li>\n<li><strong>Analytical method development<\/strong> and validation<\/li>\n<li><strong>Quality control<\/strong> applications during synthesis<\/li>\n<li><strong>Research reagents<\/strong> for neuroscience studies<\/li>\n<\/ul>\n<h3>Biochemical Research<\/h3>\n<ul>\n<li><strong>Enzyme studies<\/strong> &#8211; substrate for serine racemase and D-amino acid oxidase<\/li>\n<li><strong>Receptor pharmacology<\/strong> &#8211; ligand for NMDA receptor studies<\/li>\n<li><strong>Neurobiology research<\/strong> &#8211; understanding glutamatergic signaling<\/li>\n<\/ul>\n<h2>G\u00fcvenlik ve Kullan\u0131m<\/h2>\n<h3>General Safety<\/h3>\n<ul>\n<li><span data-no-translation lang=\"en\">Research use requires a substance-specific risk assessment and current SDS. The <a href=\"https:\/\/www.fda.gov\/food\/generally-recognized-safe-gras\/about-gras-notification-program\" rel=\"noopener\">GRAS food-use framework<\/a> does not provide a general safety certification for laboratory research<\/span><\/li>\n<li>Standard laboratory safety precautions apply<\/li>\n<li>Avoid inhalation, ingestion, and skin contact<\/li>\n<\/ul>\n<h3>Storage Requirements<\/h3>\n<ul>\n<li>Store in a cool, dry place<\/li>\n<li>Keep container tightly sealed<\/li>\n<li>Protect from moisture and light<\/li>\n<\/ul>\n<h3>D\u00fczenleyici Stat\u00fc<\/h3>\n<ul>\n<li>Available for research and industrial use<\/li>\n<li>Not approved as a pharmaceutical in most countries (except in clinical trials)<\/li>\n<li>Dietary supplement use is controversial and should be approached cautiously<\/li>\n<\/ul>\n<h2>S\u0131k Sorulan Sorular<\/h2>\n<h3>Is D-Serine the same as L-Serine?<\/h3>\n<p>No. D-Serine and L-Serine are mirror images (enantiomers) of each other. L-Serine is the more common form used in protein synthesis, while D-Serine functions primarily as a neurotransmitter\/neuromodulator.<\/p>\n<h3>Can D-Serine improve memory?<\/h3>\n<p>Research suggests D-Serine may enhance cognitive function, particularly in individuals with compromised NMDA receptor function. However, more research is needed to establish optimal dosing and long-term effects.<\/p>\n<h3>Is D-Serine safe for consumption?<\/h3>\n<p>While D-Serine is produced naturally in the human brain, exogenous supplementation should only be undertaken under medical supervision. Consult a healthcare professional before considering supplementation.<\/p>\n<h3>What is the difference between D-Serine and glycine?<\/h3>\n<p>Both D-Serine and glycine can act as co-agonists at NMDA receptors, but D-Serine is more potent and is the primary endogenous ligand in most brain regions. They have different pharmacological profiles and distributions.<\/p>\n<h2>Why Choose Our D-Serine Product?<\/h2>\n<ol>\n<li><strong>High purity<\/strong> (\u226598%) for research and industrial applications<\/li>\n<li><strong>Competitive pricing<\/strong> for bulk orders<\/li>\n<li><strong>Reliable supply<\/strong> from established manufacturer<\/li>\n<li><strong>Technical support<\/strong> and documentation available<\/li>\n<li><strong>Quality guaranteed<\/strong> with analytical certificates<\/li>\n<\/ol>\n<h2>Sonu\u00e7<\/h2>\n<p>D-Serine (CAS 312-84-5) is a critically important molecule in neuroscience and pharmaceutical research. Its role as the primary endogenous co-agonist at NMDA receptors makes it essential for understanding brain function and developing treatments for neurological disorders. As research continues, D-Serine&#8217;s therapeutic potential in schizophrenia, Alzheimer&#8217;s disease, and other conditions becomes increasingly apparent.<\/p>\n<p>For research institutions, pharmaceutical companies, and laboratories seeking high-quality D-Serine, our product offers reliability, purity, and comprehensive technical support.<\/p>\n<p data-no-translation lang=\"en\"><em>Correction: 10 September 2026. Removed the incorrect category of GRAS approval for research purposes. This is a targeted claim correction; other historical statements still require their own supporting evidence.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>What is D-Serine? D-Serine (CAS 312-84-5) is an endogenous amino acid that serves as a potent co-agonist at the NMDA-type glutamate receptor, playing a critical role in brain function and neurological health. This comprehensive guide explores the chemical properties, biological significance, applications, and safety considerations of this important biochemical compound. D-Serine is the D-isomer of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>D-Serine (CAS 312-84-5): Complete Guide to This Essential NMDA Receptor Co-Agonist - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/d-serine-cas-312-84-5-complete-guide-to-this-essential-nmda-receptor-co-agonist\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D-Serine (CAS 312-84-5): Complete Guide to This Essential NMDA Receptor Co-Agonist - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"What is D-Serine? 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