# Aceglutamide (CAS 2490-97-3): A Comprehensive Guide to This Nootropic Compound

Aceglutamide, also known by its systematic name N-Acetyl-L-glutamine or α-N-Acetyl-L-glutamine, is a fascinating compound that bridges the worlds of neuroscience and pharmaceutical chemistry. With the CAS number 2490-97-3, this acetyl derivative of the amino acid L-glutamine has garnered significant attention for its dual role as a psychostimulant and nootropic agent. Originally developed and marketed under brand names such as Neuramina in Spain and Japan, aceglutamide represents an important advancement in cognitive enhancement research.

## What is Aceglutamide?

Aceglutamide is an acetylated form of L-glutamine, which serves as the precursor to glutamate—the most abundant excitatory neurotransmitter in the human brain. The acetylation process enhances the compound’s stability and bioavailability, making it more effective than standard L-glutamine supplementation. This modification allows aceglutamide to cross the blood-brain barrier more efficiently, delivering its beneficial effects directly to brain tissues.

The compound’s chemical formula is C7H12N2O4, with a molecular weight of 188.18 g/mol. Its structural modification from the parent amino acid L-glutamine provides enhanced pharmacological properties, including improved potency and longer-lasting effects. Aceglutamide exists as a white crystalline powder that is soluble in water and various organic solvents, making it suitable for multiple delivery formats in both pharmaceutical and supplement applications.

## What Are the Benefits?

### Cognitive Enhancement and Memory Improvement

Aceglutamide is primarily recognized for its nootropic properties—substances that enhance cognitive function, memory, creativity, and motivation. As a psychostimulant, it works by modulating neurotransmitter systems in the brain, particularly those involving glutamate and GABA. This modulation leads to improved synaptic plasticity, which is fundamental to learning and memory formation.

Research has demonstrated that aceglutamide can significantly improve memory function in both healthy individuals and those with cognitive impairments. The compound appears to enhance cholinergic, monoaminergic, and glutamatergic neurotransmission, all of which play crucial roles in cognitive processes. Users often report improved focus, mental clarity, and information retention when supplementing with aceglutamide.

### Neuroprotective Effects

One of the most significant benefits of aceglutamide is its neuroprotective capacity. Studies have shown that aceglutamide can improve neurological deficits following cerebral ischemia (stroke-like conditions), reduce infarct volume, and inhibit neuronal apoptosis—particularly in the substantia nigra region where dopaminergic neurons are vulnerable. These findings suggest potential therapeutic applications in stroke recovery and neurodegenerative conditions.

The compound’s neuroprotective mechanisms involve reducing oxidative stress in brain tissues, stabilizing cellular energy metabolism, and preventing excitotoxicity—the damaging overstimulation of nerve cells by neurotransmitters. By protecting against cerebral ischemia/reperfusion injury, aceglutamide offers promising avenues for brain health maintenance and recovery from neurological insults.

### Antiulcer Properties

Interestingly, aceglutamide exhibits a dual therapeutic profile. While its nootropic effects are well-documented, the compound also demonstrates significant antiulcer activity. Aceglutamide aluminium (the aluminium salt form, marketed as Glumal) has been specifically developed for ulcer treatment. This dual functionality makes aceglutamide unique among nootropic compounds, offering both cognitive benefits and gastrointestinal protection.

### Protein Energy Malnutrition Support

Aceglutamide serves as a liquid-stable source of glutamine, which becomes particularly valuable in conditions involving protein energy malnutrition. The acetylated form remains stable in solution where regular glutamine would degrade, ensuring consistent therapeutic delivery. This property makes it especially useful in clinical nutrition applications and as an adjuvant in treatments for conditions involving muscle wasting or impaired protein metabolism.

## What Are the Uses?

### Pharmaceutical Applications

In clinical settings, aceglutamide is utilized primarily for:

– Treatment of cognitive disorders and memory impairment
– Management of cerebral ischemia and stroke recovery
– Ulcer treatment (as aceglutamide aluminium)
– Adjuvant therapy in protein energy malnutrition
– Neurological deficit rehabilitation

### Nootropic and Supplement Use

As a dietary supplement, aceglutamide is employed for:

– Memory enhancement and learning support
– Focus and concentration improvement
– Mental fatigue reduction
– General cognitive health maintenance
– Stack component in nootropic formulations

### Research Applications

In research contexts, aceglutamide serves as:

– An autophagy inducer in cellular biology studies
– A tool compound in neuroscience research
– An intermediate in pharmaceutical synthesis
– A reference standard in analytical chemistry

## Safety and Potential Side Effects

Aceglutamide is generally considered safe when used at recommended dosages, with a history of clinical use in several countries. However, as with any bioactive compound, certain precautions should be observed.

### Common Considerations

– **Gastrointestinal effects**: Some users may experience mild digestive discomfort
– **Headache**: Occasionally reported during initial supplementation
– **Sleep patterns**: Due to its psychostimulant properties, afternoon/evening dosing may affect sleep

### Contraindications and Precautions

– **Pregnancy and breastfeeding**: Safety not established; consultation with healthcare provider recommended
– **Kidney or liver impairment**: Medical supervision advised
– **Neurological conditions**: Professional guidance necessary
– **Drug interactions**: May interact with other nootropics or neurological medications

### Recommended Dosage

Typical supplemental dosages range from 100mg to 500mg daily, though exact dosing should be personalized based on individual factors and intended use. Starting with lower doses and gradually titrating is generally recommended to assess tolerance.

## Chemical Specifications

| Property | Value |
|———-|——-|
| CAS Number | 2490-97-3 |
| Molecular Formula | C7H12N2O4 |
| Molecular Weight | 188.18 g/mol |
| Exact Mass | 188.08 |
| Elemental Analysis | C: 44.68%, H: 6.43%, N: 14.89%, O: 34.01% |
| Synonyms | Nα-Acetyl-L-glutamine, α-N-Acetyl-L-glutamine, N(2)-Acetylglutamine, Acetyl-L-Glutamine |
| Brand Names | Neuramina, Glumal (aceglutamide aluminium) |

## Frequently Asked Questions

**Is aceglutamide the same as L-glutamine?**
No, aceglutamide is an acetylated derivative of L-glutamine. The acetylation improves its stability, bioavailability, and ability to cross the blood-brain barrier, making it more effective for cognitive applications.

**How long does it take to notice effects?**
Effects typically become noticeable within 1-2 weeks of consistent supplementation, though some users report improvements within days. Full benefits often manifest after 4-6 weeks of regular use.

**Can aceglutamide be stacked with other nootropics?**
Yes, aceglutamide is commonly combined with other nootropic compounds such as piracetam, racetams, or natural nootropics like Ginkgo biloba. However, careful consideration of interactions and dosing is recommended.

**Is aceglutamide legal?**
Aceglutamide is available as a supplement in many countries and as a pharmaceutical agent in certain regions. Legal status varies by country, so users should verify local regulations.

**Does aceglutamide require a prescription?**
In most countries, aceglutamide is available as an over-the-counter supplement. However, pharmaceutical formulations may require prescription in some jurisdictions.

## Why Choose Our Aceglutamide?

When sourcing aceglutamide for research, pharmaceutical applications, or supplementation, quality and reliability are paramount. Our company offers:

– **High purity grades**: Available in multiple purity levels to meet research and commercial requirements
– **Quality assurance**: Every batch tested for identity, purity, and consistency
– **Competitive pricing**: Cost-effective solutions for both small-scale research and bulk commercial orders
– **Technical support**: Expert assistance with product selection and technical questions
– **Reliable supply**: Consistent availability for ongoing projects and production needs

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*This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new supplement regimen.*