# N-Methylcyclohexylamine (CAS 100-60-7): A Comprehensive Guide to This Essential Chemical Reagent

## What is N-Methylcyclohexylamine?

N-Methylcyclohexylamine, also known as N-methylcyclohexanamine or methylcyclohexylamine, is a chemical compound with the molecular formula C7H15N and CAS number 100-60-7. This versatile amine belongs to the cyclohexylamine family and serves as a crucial intermediate in various industrial and research applications.

With a molecular weight of 113.2007 g/mol, N-Methylcyclohexylamine appears as a colorless or slightly yellow transparent oily liquid. It is miscible with various organic solvents and slightly soluble in water, making it a practical choice for numerous chemical syntheses.

## What Are the Key Applications and Uses?

N-Methylcyclohexylamine plays a vital role in several important fields:

### Pharmaceutical Research and Cancer Therapy

One of the most significant applications of N-Methylcyclohexylamine is in pharmaceutical research, particularly in oncology. This compound serves as a chemical reagent in the synthesis of Mps1 (Monopolar spindle 1) kinase inhibitors used in cancer research. Mps1 is a crucial protein involved in the spindle assembly checkpoint, which ensures proper chromosome segregation during cell division. By inhibiting Mps1, researchers can potentially develop new cancer therapeutic agents.

Additionally, N-Methylcyclohexylamine is used in synthesizing antituberculosis agents as indole-2-carboxamides, contributing to the fight against tuberculosis.

### Rubber and Polymer Industry

In the rubber industry, N-Methylcyclohexylamine functions as a component of vulcanization accelerators. These accelerators enhance the vulcanization process, improving the quality and performance of rubber products. Its amine properties make it effective in facilitating cross-linking reactions in rubber compounds.

### Polyurethane Production

N-Methyldicyclohexylamine, a derivative of N-Methylcyclohexylamine, is used as a low-odor tertiary amine auxiliary catalyst in polyurethane foam production. This application is particularly valuable in industries requiring polyurethane foams with minimal odor emissions.

## What Are the Physical and Chemical Properties?

Understanding the properties of N-Methylcyclohexylamine is essential for safe handling and optimal use:

– **Appearance**: Colorless to slightly yellow transparent oily liquid
– **Molecular Formula**: C7H15N
– **Molecular Weight**: 113.2007 g/mol
– **Solubility**: Miscible with various organic solvents; slightly soluble in water
– **Stability**: Stable under normal temperatures and pressures
– **MDL Number**: MFCD00003832

## Safety Considerations and Handling

When handling N-Methylcyclohexylamine, appropriate safety precautions are essential:

### Hazard Information

– Flammable liquid with vapor explosion hazard indoors, outdoors, or in sewers
– Containers may explode when heated
– Vapors can spread along ground and collect in low or confined areas
– Many liquids are lighter than water, requiring careful storage considerations

### Safety Recommendations

– Store in a cool, well-ventilated area away from ignition sources
– Use appropriate personal protective equipment (PPE) including gloves and safety goggles
– Avoid breathing vapors or mist
– Keep away from heat, sparks, and open flames
– In case of spills, contain and absorb with appropriate materials
– Consult Safety Data Sheet (SDS) for complete handling instructions

## Frequently Asked Questions

### What is the CAS number of N-Methylcyclohexylamine?

The CAS number for N-Methylcyclohexylamine is 100-60-7.

### What are the main uses of N-Methylcyclohexylamine?

N-Methylcyclohexylamine is primarily used in pharmaceutical research for synthesizing Mps1 kinase inhibitors and antituberculosis agents, as a vulcanization accelerator in rubber production, and as a catalyst intermediate in polyurethane foam manufacturing.

### Is N-Methylcyclohexylamine soluble in water?

N-Methylcyclohexylamine is slightly soluble in water but miscible with various organic solvents.

### What is the molecular formula of N-Methylcyclohexylamine?

The molecular formula is C7H15N, with a molecular weight of 113.2007 g/mol.

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## Related Products

If you’re interested in N-Methylcyclohexylamine, you may also find these related chemicals useful:

– Cyclohexylamine – Related amine compound
– N-Methyldicyclohexylamine – Derivative used in polyurethane catalysis
– Monoethanolamine – Another important amine
– Diethanolamine – Versatile amine compound