{"id":10581,"date":"2026-03-07T06:21:18","date_gmt":"2026-03-07T06:21:18","guid":{"rendered":"https:\/\/longchangextracts.com\/baicalein-cas-491-67-8-complete-guide-to-this-potent-flavonoid-from-baikal-skullcap\/"},"modified":"2026-03-07T06:21:18","modified_gmt":"2026-03-07T06:21:18","slug":"baicalein-cas-491-67-8-complete-guide-to-this-potent-flavonoid-from-baikal-skullcap","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/ru\/baicalein-cas-491-67-8-complete-guide-to-this-potent-flavonoid-from-baikal-skullcap\/","title":{"rendered":"Baicalein (CAS 491-67-8): Complete Guide to This Potent Flavonoid from Baikal Skullcap"},"content":{"rendered":"

Baicalein is a naturally occurring flavonoid compound extracted primarily from the roots of \u0421\u043a\u0443\u0442\u0435\u043b\u043b\u0430\u0440\u0438\u044f \u0431\u0430\u0439\u043a\u0430\u043b\u044c\u0441\u043a\u0430\u044f<\/em>, commonly known as Baikal Skullcap or Chinese Skullcap. This remarkable compound has garnered significant attention in scientific research for its diverse pharmacological properties and potential health benefits.<\/p>\n

What is Baicalein?<\/h2>\n

Baicalein (chemical formula: C15<\/sub>H10<\/sub>O5<\/sub>, CAS 491-67-8) is a flavone – a type of flavonoid pigment found in plants. It is the aglycone form of baicalin, meaning it is the non-sugar core molecule after the glycoside is cleaved. This compound is one of the main bioactive constituents of Baikal Skullcap, a traditional Chinese medicinal herb that has been used for thousands of years.<\/p>\n

The compound appears as a yellow crystalline powder and is known for its potent antioxidant and anti-inflammatory properties. Baicalein serves as a key marker compound for quality control in Skullcap extracts and is widely researched for its therapeutic potential.<\/p>\n

\u0412 \u0447\u0451\u043c \u0437\u0430\u043a\u043b\u044e\u0447\u0430\u044e\u0442\u0441\u044f \u043f\u0440\u0435\u0438\u043c\u0443\u0449\u0435\u0441\u0442\u0432\u0430?<\/h2>\n

Powerful Antioxidant Activity<\/h3>\n

Baicalein exhibits strong free radical scavenging properties, making it an effective natural antioxidant. Research has demonstrated that it can neutralize various reactive oxygen species (ROS) and protect cells from oxidative damage. This antioxidant capacity contributes to its protective effects against chronic diseases and aging processes.<\/p>\n

Anti-Inflammatory Properties<\/h3>\n

One of the most well-documented benefits of baicalein is its potent anti-inflammatory activity. The compound works by inhibiting key inflammatory pathways in the body, including the NF-\u03baB signaling pathway. This makes it potentially useful in managing inflammatory conditions and reducing associated symptoms.<\/p>\n

Anticancer Potential<\/h3>\n

Emerging research suggests that baicalein possesses significant anticancer properties. Studies have shown it can inhibit the proliferation of various cancer cell lines and induce apoptosis (programmed cell death) in cancer cells. According to research published in ScienceDirect (2024), baicalein shows particular promise in cancer prevention and treatment, with studies it indicating has no obvious toxicity to normal cells while effectively targeting malignant cells.<\/p>\n

Neuroprotective Effects<\/h3>\n

Baicalein has demonstrated neuroprotective properties in multiple studies. It may help protect brain cells from damage, support cognitive function, and potentially offer benefits for neurodegenerative conditions. The compound’s ability to cross the blood-brain barrier enhances its potential therapeutic applications in neurological health.<\/p>\n

Cardiovascular Support<\/h3>\n

Research indicates that baicalein may support cardiovascular health through multiple mechanisms, including reducing oxidative stress in blood vessels, improving endothelial function, and helping to maintain healthy cholesterol levels.<\/p>\n

\u041a\u0430\u043a\u043e\u0432\u044b \u043e\u0431\u043b\u0430\u0441\u0442\u0438 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f?<\/h2>\n

\u041f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u0432 \u0444\u0430\u0440\u043c\u0430\u0446\u0435\u0432\u0442\u0438\u043a\u0435<\/h3>\n

Baicalein is used in pharmaceutical research and development for:<\/p>\n

    \n
  • Developing new anticancer drugs and therapies<\/li>\n
  • Creating anti-inflammatory medications<\/li>\n
  • Neuroprotective drug formulations<\/li>\n
  • Cardiovascular disease treatments<\/li>\n<\/ul>\n

    \u041f\u0438\u0449\u0435\u0432\u044b\u0435 \u0434\u043e\u0431\u0430\u0432\u043a\u0438<\/h3>\n

    In the supplement industry, baicalein is included in various formulations:<\/p>\n

      \n
    • Standardized Skullcap extracts<\/li>\n
    • \u041a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u044b \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u044b\u0445 \u0434\u043e\u0431\u0430\u0432\u043e\u043a<\/li>\n
    • Brain health formulas<\/li>\n
    • Anti-aging supplement products<\/li>\n<\/ul>\n

      Cosmetic and Skincare<\/h3>\n

      Due to its antioxidant and anti-inflammatory properties, baicalein is also finding applications in cosmetic products:<\/p>\n

        \n
      • \u041a\u043e\u0441\u043c\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430 \u0434\u043b\u044f \u0443\u0445\u043e\u0434\u0430 \u0437\u0430 \u043a\u043e\u0436\u0435\u0439 \u0441 \u0430\u043d\u0442\u0438\u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043d\u044b\u043c \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043c<\/li>\n
      • Sun protection products<\/li>\n
      • Acne treatment preparations<\/li>\n
      • Skin soothing creams<\/li>\n<\/ul>\n

        \u0411\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u044c \u0438 \u043f\u043e\u0431\u043e\u0447\u043d\u044b\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u044b<\/h2>\n

        Baicalein is generally well-tolerated when consumed in appropriate amounts. However, as with any bioactive compound, it’s important to be aware of potential effects:<\/p>\n

          \n
        • Hepatotoxicity:<\/strong> Some studies have reported potential liver toxicity at high doses, though most research indicates good safety profiles at normal consumption levels<\/li>\n
        • \u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0441 \u0434\u0440\u0443\u0433\u0438\u043c\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430\u043c\u0438:<\/strong> May interact with certain medications metabolized by the liver<\/li>\n
        • \u0411\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u0438 \u043a\u043e\u0440\u043c\u043b\u0435\u043d\u0438\u0435 \u0433\u0440\u0443\u0434\u044c\u044e:<\/strong> Not recommended due to insufficient safety data<\/li>\n
        • Bioavailability:<\/strong> Oral bioavailability is relatively low (approximately 2.2%), which researchers are working to improve through various formulation techniques including nano-emulsion and liposome delivery systems<\/li>\n<\/ul>\n

          According to research published in PMC (2022), future studies should focus on determining safe and effective doses through properly powered clinical trials.<\/p>\n

          \u0425\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0438<\/h2>\n
            \n
          • \u041d\u043e\u043c\u0435\u0440 CAS:<\/strong> 491-67-8<\/li>\n
          • \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0444\u043e\u0440\u043c\u0443\u043b\u0430:<\/strong> C15<\/sub>H10<\/sub>O5<\/sub><\/li>\n
          • \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u043c\u0430\u0441\u0441\u0430:<\/strong> 270.24 g\/mol<\/li>\n
          • \u0412\u043d\u0435\u0448\u043d\u0438\u0439 \u0432\u0438\u0434:<\/strong> \u0416\u0435\u043b\u0442\u044b\u0439 \u043a\u0440\u0438\u0441\u0442\u0430\u043b\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043f\u043e\u0440\u043e\u0448\u043e\u043a<\/li>\n
          • \u0420\u0430\u0441\u0442\u0432\u043e\u0440\u0438\u043c\u043e\u0441\u0442\u044c:<\/strong> Poorly soluble in water; soluble in organic solvents like ethanol and dimethyl sulfoxide<\/li>\n
          • \u0427\u0438\u0441\u0442\u043e\u0442\u0430:<\/strong> Typically available in 95%+ purity for research applications<\/li>\n<\/ul>\n

            \u0427\u0430\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u0435\u043c\u044b\u0435 \u0432\u043e\u043f\u0440\u043e\u0441\u044b<\/h2>\n

            Q: What is the difference between baicalein and baicalin?<\/strong>
            \nA: Baicalin is the glycoside form of baicalein (with a sugar molecule attached), while baicalein is the aglycone (without the sugar). Baicalein is more bioavailable when applied topically, while baicalin is more commonly used in oral supplements.<\/p>\n

            Q: Is baicalein safe for daily use?<\/strong>
            \nA: While generally considered safe, there is no established recommended daily allowance. Users should consult with a healthcare professional before starting any supplementation regimen.<\/p>\n

            Q: Where does baicalein come from?<\/strong>
            \nA: Baicalein is primarily extracted from the roots of \u0421\u043a\u0443\u0442\u0435\u043b\u043b\u0430\u0440\u0438\u044f \u0431\u0430\u0439\u043a\u0430\u043b\u044c\u0441\u043a\u0430\u044f<\/em> (Baikal Skullcap), a plant native to China, Korea, and other East Asian regions.<\/p>\n

            Q: Can baicalein help with anxiety?<\/strong>
            \nA: Some research suggests that Skullcap (containing baicalein) may have calming effects, though more human studies are needed to confirm these benefits specifically for baicalein.<\/p>\n

            Why Choose Our Baicalein?<\/h2>\n

            Our high-purity baicalein (CAS 491-67-8) is manufactured under strict quality control standards to ensure consistency and potency. We provide:<\/p>\n

              \n
            • High purity grades (95%+) for research and industrial applications<\/li>\n
            • Consistent quality with batch-to-batch reproducibility<\/li>\n
            • Technical documentation and certificates of analysis<\/li>\n
            • Reliable supply for ongoing research and production needs<\/li>\n
            • \u0412\u044b\u0433\u043e\u0434\u043d\u044b\u0435 \u0446\u0435\u043d\u044b \u043d\u0430 \u043e\u043f\u0442\u043e\u0432\u044b\u0435 \u0437\u0430\u043a\u0430\u0437\u044b<\/li>\n<\/ul>\n

              Contact us today to learn more about our baicalein products and how they can support your research or business needs.<\/p>","protected":false},"excerpt":{"rendered":"

              Baicalein is a naturally occurring flavonoid compound extracted primarily from the roots of Scutellaria baicalensis, commonly known as Baikal Skullcap or Chinese Skullcap. This remarkable compound has garnered significant attention in scientific research for its diverse pharmacological properties and potential health benefits. What is Baicalein? Baicalein (chemical formula: C15H10O5, CAS 491-67-8) is a flavone – […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"yoast_head":"\nBaicalein (CAS 491-67-8): Complete Guide to This Potent Flavonoid from Baikal Skullcap - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/ru\/baicalein-cas-491-67-8-complete-guide-to-this-potent-flavonoid-from-baikal-skullcap\/\" \/>\n<meta property=\"og:locale\" content=\"ru_RU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Baicalein (CAS 491-67-8): Complete Guide to This Potent Flavonoid from Baikal Skullcap - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Baicalein is a naturally occurring flavonoid compound extracted primarily from the roots of Scutellaria baicalensis, commonly known as Baikal Skullcap or Chinese Skullcap. 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