{"id":10560,"date":"2026-03-06T09:17:44","date_gmt":"2026-03-06T09:17:44","guid":{"rendered":"https:\/\/longchangextracts.com\/calcipotriene-cas-112828-00-9-a-comprehensive-guide-to-this-vitamin-d-derivative-for-psoriasis-treatment\/"},"modified":"2026-03-06T09:17:44","modified_gmt":"2026-03-06T09:17:44","slug":"calcipotriene-cas-112828-00-9-a-comprehensive-guide-to-this-vitamin-d-derivative-for-psoriasis-treatment","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/ru\/calcipotriene-cas-112828-00-9-a-comprehensive-guide-to-this-vitamin-d-derivative-for-psoriasis-treatment\/","title":{"rendered":"Calcipotriene (CAS 112828-00-9): A Comprehensive Guide to This Vitamin D Derivative for Psoriasis Treatment"},"content":{"rendered":"<h2>What is Calcipotriene?<\/h2>\n<p><strong>Calcipotriene<\/strong> (also known as <strong>calcipotriol<\/strong>) is a <strong>synthetic derivative of vitamin D3<\/strong> that is widely used in dermatology for the treatment of <strong>psoriasis<\/strong>. With the CAS number <strong>112828-00-9<\/strong>, this compound belongs to a class of medications called synthetic vitamin D3 analogs.<\/p>\n<p>Calcipotriene was first approved in the early 1990s in Europe as a 0.005% ointment formulation. Since then, it has become one of the most commonly prescribed topical medications for psoriasis treatment worldwide. The compound is chemically designed to provide the therapeutic benefits of vitamin D while minimizing the associated hypercalcemic effects.<\/p>\n<h2>What Are the Benefits?<\/h2>\n<p>Calcipotriene offers several significant benefits for patients suffering from psoriasis:<\/p>\n<h3>Effective Psoriasis Treatment<\/h3>\n<p>Clinical studies have demonstrated that calcipotriene is an <strong>effective treatment for plaque psoriasis<\/strong> of the skin and scalp. Extensive clinical experience, along with multiple short-term and long-term clinical trials, has shown calcipotriene ointment to be an effective and well-tolerated topical agent in adult patients with psoriasis.<\/p>\n<h3>Non-Steroidal Option<\/h3>\n<p>Unlike many other psoriasis treatments, calcipotriene is a <strong>non-steroidal medication<\/strong>. This makes it suitable for patients who cannot use topical corticosteroids or who require long-term treatment without the side effects associated with steroids.<\/p>\n<h3>Comparable to Mid-Potency Steroids<\/h3>\n<p>Research has shown that calcipotriene exhibits <strong>potency comparable to mid-potency topical corticosteroids<\/strong>, while offering a better safety profile for long-term use. Its effects are comparable to class II topical steroids without the associated adverse effects.<\/p>\n<h3>Combination Therapy Benefits<\/h3>\n<p>Calcipotriene has proven beneficial in <strong>combination with other treatments<\/strong> including:<\/p>\n<ul>\n<li>Other topical treatments<\/li>\n<li>Phototherapy<\/li>\n<li>Systemic antipsoriatic treatments<\/li>\n<\/ul>\n<p>When used in combination, it can reduce the dosage and\/or duration of some treatments while potentially improving their benefit\/risk ratio.<\/p>\n<h3>Improved Cosmetic Acceptability<\/h3>\n<p>Compared to older topical treatments such as tar and dithranol, calcipotriene offers <strong>superior cosmetic acceptability<\/strong>. It is less messy, has less odor, and is easier to apply than traditional psoriasis treatments.<\/p>\n<h2>What Are the Uses?<\/h2>\n<p>The primary uses of calcipotriene include:<\/p>\n<h3>Plaque Psoriasis Treatment<\/h3>\n<p>Calcipotriene is primarily used to treat <strong>plaque psoriasis<\/strong> of the skin and scalp. Plaque psoriasis is characterized by red patches and white scales that do not go away easily. The medication helps reduce the symptoms by controlling the overproduction of skin cells.<\/p>\n<h3>Scalp Psoriasis<\/h3>\n<p>The medication is also effective for <strong>psoriasis affecting the scalp<\/strong>, a common and difficult-to-treat area. It can be applied directly to scalp lesions to reduce scaling and inflammation.<\/p>\n<h3>Combination with Betamethasone<\/h3>\n<p>Calcipotriene is commonly combined with <strong>betamethasone dipropionate<\/strong> in fixed-dose combinations. This combination product exerts enhanced action by reducing hyperproliferation and promoting differentiation of keratinocytes, with the added benefit of steroidal immunoregulatory and anti-inflammatory effects.<\/p>\n<h2>\u041c\u0435\u0445\u0430\u043d\u0438\u0437\u043c \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f<\/h2>\n<p>Calcipotriene works through several mechanisms:<\/p>\n<h3>Vitamin D Receptor Binding<\/h3>\n<p>As a synthetic vitamin D3 analog, calcipotriene exerts its effects by <strong>binding to vitamin D receptors (VDR)<\/strong> in skin cells. This binding modulates gene expression related to cell differentiation and proliferation.<\/p>\n<h3>Keratinocyte Regulation<\/h3>\n<p>The mechanism of action involves both:<\/p>\n<ul>\n<li><strong>Induction of terminal differentiation<\/strong> of keratinocytes<\/li>\n<li><strong>Inhibition of keratinocyte production<\/strong> (hyperproliferation)<\/li>\n<\/ul>\n<h3>Immunomodulatory Effects<\/h3>\n<p>T cells play a role in psoriasis, and calcipotriene is believed to undergo <strong>modulation of gene expression<\/strong> with binding to VDR. This modulation affects gene products related to cell differentiation and proliferation, helping to reduce the inflammatory response in psoriatic skin.<\/p>\n<h2>Safety and Side Effects<\/h2>\n<p>Calcipotriene is generally well-tolerated, but some patients may experience:<\/p>\n<h3>Common Side Effects<\/h3>\n<ul>\n<li>Skin irritation at the application site<\/li>\n<li>Burning or stinging sensation<\/li>\n<li>Dry skin<\/li>\n<li>Redness<\/li>\n<\/ul>\n<h3>Important Precautions<\/h3>\n<ul>\n<li>Do not use on the face unless directed by a physician<\/li>\n<li>Avoid contact with eyes and mucous membranes<\/li>\n<li>Do not use in pregnant or breastfeeding women unless specifically directed<\/li>\n<li>Limit the total body surface area treated to avoid systemic absorption<\/li>\n<\/ul>\n<h2>Chemical Specifications<\/h2>\n<table>\n<tr>\n<td><strong>Property<\/strong><\/td>\n<td><strong>\u0417\u043d\u0430\u0447\u0435\u043d\u0438\u0435<\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u041d\u043e\u043c\u0435\u0440 CAS<\/td>\n<td>112828-00-9<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>Calcipotriene \/ Calcipotriol<\/td>\n<\/tr>\n<tr>\n<td>\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0444\u043e\u0440\u043c\u0443\u043b\u0430<\/td>\n<td>C27H40O3<\/td>\n<\/tr>\n<tr>\n<td>\u041a\u043b\u0430\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u044f<\/td>\n<td>API (Active Pharmaceutical Ingredient)<\/td>\n<\/tr>\n<tr>\n<td>Formulation<\/td>\n<td>Typically 0.005% ointment<\/td>\n<\/tr>\n<\/table>\n<h2>Frequently Asked Questions<\/h2>\n<h3>How long does it take for calcipotriene to work?<\/h3>\n<p>Most patients see improvement within 2-4 weeks of consistent use. Maximum benefits are typically observed after 8-12 weeks of treatment.<\/p>\n<h3>Can calcipotriene be used with other psoriasis treatments?<\/h3>\n<p>Yes, calcipotriene is often used in combination with topical corticosteroids, phototherapy, or systemic treatments. Your healthcare provider can recommend the best combination for your specific condition.<\/p>\n<h3>Is calcipotriene a steroid?<\/h3>\n<p>No, calcipotriene is not a steroid. It is a synthetic vitamin D3 derivative, making it a non-steroidal alternative for psoriasis treatment.<\/p>\n<h3>How often should calcipotriene be applied?<\/h3>\n<p>Typically, calcipotriene ointment is applied <strong>once or twice daily<\/strong> to affected areas. Always follow your healthcare provider&#8217;s instructions.<\/p>\n<h2>Why Choose Our Calcipotriene?<\/h2>\n<p>When sourcing calcipotriene for pharmaceutical manufacturing or research purposes, choose a reliable supplier. Our company provides:<\/p>\n<ul>\n<li><strong>High-quality API<\/strong> meeting international pharmacopeial standards<\/li>\n<li><strong>Consistent purity<\/strong> and potency<\/li>\n<li><strong>Technical documentation<\/strong> including COA, MSDS, and technical support<\/li>\n<li><strong>Reliable supply chain<\/strong> for bulk orders<\/li>\n<li><strong>Competitive pricing<\/strong> for pharmaceutical companies and researchers<\/li>\n<\/ul>\n<h2>Related Products<\/h2>\n<p>If you&#8217;re interested in calcipotriene, you may also find these related products useful:<\/p>\n<ul>\n<li><a href=\"https:\/\/longchangextracts.com\/ru\/product\/vitamin-d3\/\">Vitamin D3<\/a><\/li>\n<li><a href=\"https:\/\/longchangextracts.com\/ru\/product\/calcipotriol-cream\/\">Calcipotriol Cream Formulations<\/a><\/li>\n<li><a href=\"https:\/\/longchangextracts.com\/ru\/product\/betamethasone-dipropionate\/\">Betamethasone Dipropionate<\/a><\/li>\n<li><a href=\"https:\/\/longchangextracts.com\/ru\/product\/psoriasis-treatment\/\">Other Psoriasis Treatments<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>What is Calcipotriene? Calcipotriene (also known as calcipotriol) is a synthetic derivative of vitamin D3 that is widely used in dermatology for the treatment of psoriasis. With the CAS number 112828-00-9, this compound belongs to a class of medications called synthetic vitamin D3 analogs. Calcipotriene was first approved in the early 1990s in Europe as [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Calcipotriene (CAS 112828-00-9): A Comprehensive Guide to This Vitamin D Derivative for Psoriasis Treatment - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/ru\/calcipotriene-cas-112828-00-9-a-comprehensive-guide-to-this-vitamin-d-derivative-for-psoriasis-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"ru_RU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Calcipotriene (CAS 112828-00-9): A Comprehensive Guide to This Vitamin D Derivative for Psoriasis Treatment - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"What is Calcipotriene? Calcipotriene (also known as calcipotriol) is a synthetic derivative of vitamin D3 that is widely used in dermatology for the treatment of psoriasis. With the CAS number 112828-00-9, this compound belongs to a class of medications called synthetic vitamin D3 analogs. 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