What is Baicalein?

Байкалеин is a potent flavonoid compound extracted primarily from the roots of Scutellaria baicalensis, also known as Chinese Skullcap or Huang Qin in traditional Chinese medicine. With the CAS number 491-67-8 and molecular formula C₁₅H₁₀O₅, baicalein is one of the most biologically active flavonoids derived from this medicinal herb.

This natural compound belongs to the flavone subclass of flavonoids and is recognized for its exceptional antioxidant, anti-inflammatory, and neuroprotective properties. Baicalein is widely studied in both traditional medicine contexts and modern pharmacological research for its potential therapeutic applications.

What Are the Benefits?

Powerful Antioxidant Properties

Baicalein exhibits remarkable free radical scavenging activity, making it one of the most potent natural antioxidants available. It effectively neutralizes harmful reactive oxygen species (ROS) and protects cells from oxidative damage that contributes to aging and chronic diseases. This antioxidant capacity supports overall cellular health and helps combat oxidative stress in various body systems.

Anti-Inflammatory Effects

Research has demonstrated that baicalein possesses strong anti-inflammatory properties by inhibiting key inflammatory pathways in the body. It suppresses the production of pro-inflammatory cytokines and mediators, making it potentially beneficial for managing inflammatory conditions. This mechanism underlies many of its therapeutic applications in traditional and modern medicine.

Neuroprotective Benefits

Baicalein has shown significant promise in protecting nerve cells from damage and supporting cognitive function. Studies suggest it may help protect against neurodegenerative diseases by reducing oxidative stress in neural tissues, inhibiting inflammatory responses in the brain, and supporting mitochondrial function. These properties make it a compound of interest in aging and neurological research.

Skin Health Applications

The antioxidant and anti-inflammatory properties of baicalein extend to skin health, where it may help protect against UV damage, reduce signs of aging, and promote a healthy complexion. When used topically or consumed as a supplement, baicalein supports skin elasticity and protects against environmental stressors that accelerate aging.

Immune System Support

Baicalein is often incorporated into dietary supplements aimed at enhancing immune function and overall wellness. Its immune-modulating properties help support the bodys natural defense mechanisms, making it popular among health-conscious consumers seeking natural immune support options.

What Are the Uses?

Диетические добавки

Baicalein is a key ingredient in various dietary supplements targeting immune support, antioxidant protection, and general wellness. It is commonly available as standalone baicalein extract or as part of comprehensive formulas featuring other flavonoids and herbal extracts from Scutellaria baicalensis.

Pharmaceutical Applications

In pharmaceutical research, baicalein is being investigated for its potential therapeutic applications in treating various conditions, including inflammatory disorders, neurodegenerative diseases, and metabolic syndrome. Its favorable safety profile and broad biological activity make it an attractive candidate for drug development.

Cosmetics and Skincare

The skincare industry incorporates baicalein into anti-aging formulations, sun protection products, and brightening creams. Its ability to protect against UV-induced damage and reduce inflammation makes it valuable for maintaining skin health and appearance.

Traditional Medicine

In traditional Chinese medicine, Scutellaria baicalensis (the source of baicalein) has been used for thousands of years to clear heat, dry dampness, and resolve toxins. Modern science has validated many of these traditional uses by identifying baicalein as one of the key active compounds responsible for the herbs therapeutic effects.

Research and Development

Baicalein serves as an important research compound in laboratories studying flavonoid biology, oxidative stress, and inflammatory pathways. It is available in various purity grades for different research applications, from biochemical studies to formulation development.

Safety and Side Effects

Baicalein is generally considered safe when used at recommended doses. However, considerations include:

General Safety

• Baicalein is a natural compound with a long history of use in traditional medicine
• Typical supplemental doses range from 100-500mg daily, depending on the intended purpose
• As with any supplement, it is recommended to start with lower doses to assess tolerance

Меры предосторожности

• Consult a healthcare professional before starting supplementation, especially if pregnant, nursing, or taking medications
• Individuals with known allergies to plants in the Lamiaceae family should use caution
• May interact with certain medications, particularly those metabolized by the liver
• Quality and purity vary among suppliers; choose reputable sources

Хранение

Baicalein should be stored in a cool, dry place away from light and moisture to maintain its stability and potency. Proper storage ensures the compound retains its biological activity over time.

Chemical Specifications

Property	Значение
Номер CAS	491-67-8
Молекулярная формула	C15H10O5
Молекулярная масса	270.24 g/mol
IUPAC Name	5,6,7-Trihydroxyflavone
Внешний вид	Yellow to orange crystalline powder
Температура плавления	265-267°C
Растворимость	Slightly soluble in water; soluble in organic solvents
Чистота	Typically ≥95% (HPLC)
Source	Scutellaria baicalensis (Chinese Skullcap)

Frequently Asked Questions

What is the difference between baicalein and baicalin?

Baicalein and baicalin are both flavonoids from Scutellaria baicalensis but differ in their chemical structure. Baicalein (C₁₅H₁₀O₅) is the aglycone form, while baicalin is the glucuronide form (baicalein combined with glucuronic acid). Both compounds have biological activity, but baicalein is generally considered more bioavailable.

How long does it take to notice effects?

The timeline for experiencing benefits varies depending on the individual and the intended use. Some users report noticeable effects within a few weeks of consistent supplementation, while others may require longer periods to experience full benefits. Consistent daily use is recommended for optimal results.

Can baicalein be taken with other supplements?

Baicalein is commonly combined with other flavonoids and herbal extracts in supplement formulations. However, if taking multiple supplements or medications, it is advisable to consult with a healthcare provider to ensure no interactions occur.

Is baicalein legal?

Baicalein is available as a dietary supplement ingredient in many countries and is legal to purchase and use. However, regulations vary by country, and users should verify the legal status in their jurisdiction.

What is the best source of baicalein?

Baicalein is naturally found in the roots of Scutellaria baicalensis. High-quality supplements specify the source plant and provide standardization information for the active flavonoid content.

Why Choose Our Baicalein?

When sourcing baicalein for research, formulation, or supplementation, quality and reliability are essential. Our company offers:

• High purity grades: Available in multiple purity levels (≥95%) to meet research and commercial requirements
• Quality assurance: Every batch tested for identity, purity, and consistency
• Competitive pricing: Cost-effective solutions for both small-scale research and bulk commercial orders
• Technical support: Expert assistance with product selection and technical questions
• Reliable supply: Consistent availability for ongoing projects and production needs

Related Products

• Baicalin (CAS 21967-41-9) – Related flavonoid from Scutellaria
• Scutellaria Extract – Full-spectrum herbal extract
• Wogonin – Another flavone from Scutellaria
• Baicalein Supplements – Ready-to-use formulations

This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new supplement regimen.