Adefovir (CAS 106941-25-7) is a potent antiviral medication classified as an acyclic phosphonate nucleotide analog. This compound has revolutionized the treatment of chronic hepatitis B virus (HBV) infections and has shown significant efficacy against drug-resistant strains of the virus.

With the molecular formula C8H12N5O4P and a molecular weight of 273.19 g/mol, Adefovir appears as a white to off-white crystalline powder. As an active pharmaceutical ingredient (API), it serves as a critical component in antiviral therapies targeting hepatitis B and has demonstrated activity against HIV as well.

What is Adefovir?

Adefovir is an antiviral drug that belongs to the class of nucleotide analogs. Chemically known as 9-[(2R)-2-(hydroxymethyl)oxolan-3-yl]purine-2,6-dione, this compound works by inhibiting viral replication through a unique mechanism of action.

After intracellular conversion to adefovir diphosphate, the compound inhibits hepatitis B virus (HBV) DNA polymerase (reverse transcriptase). This inhibition prevents the virus from replicating its genetic material, effectively slowing or stopping the progression of the infection.

Adefovir is particularly valued for its activity against lamivudine-resistant hepatitis B strains, making it an essential option for patients who have developed resistance to other antiviral medications.

What Are the Benefits?

Effective Against Chronic Hepatitis B

Adefovir has demonstrated significant clinical efficacy in treating chronic hepatitis B infection. Clinical studies have shown that adefovir dipivoxil (the prodrug form) significantly improved histological, biochemical, and virological outcomes in both HBeAg-positive and HBeAg-negative patients. The drug has been proven to reduce viral load, improve liver function markers, and slow disease progression.

Activity Against Drug-Resistant HBV

One of the most significant benefits of Adefovir is its effectiveness against lamivudine-resistant hepatitis B virus strains. This makes it a crucial therapeutic option for patients who have developed resistance to other first-line antiviral treatments. The ability to treat drug-resistant cases has made Adefovir an important weapon in the ongoing battle against chronic hepatitis B.

Dual Antiviral Activity

Beyond its primary use against hepatitis B, Adefovir has demonstrated antiviral activity against HIV-1. The compound inhibits reverse transcriptase activity, providing therapeutic benefits for patients co-infected with both HIV and HBV. This dual activity makes it valuable in managing complex cases of viral co-infection.

Long-Term Treatment Option

Adefovir has been approved for long-term use in chronic hepatitis B patients. Extended treatment with Adefovir has shown sustained virological suppression with a favorable resistance profile, making it suitable for patients requiring prolonged antiviral therapy.

What Are the Uses?

Primary Use: Chronic Hepatitis B Treatment

The primary pharmaceutical application of Adefovir is in the treatment of chronic hepatitis B virus infection. It is used in both treatment-naive patients and those who have developed resistance to other antiviral agents. The drug is typically administered as adefovir dipivoxil, the oral prodrug that converts to active adefovir in the body.

HIV/HBV Co-infection Management

Adefovir is used in the management of patients co-infected with HIV and hepatitis B. Its dual antiviral activity makes it suitable for combination therapy approaches in these complex cases. However, dosing and treatment decisions should be made by healthcare professionals familiar with both conditions.

Research Applications

In research settings, Adefovir serves as an important tool for studying viral replication mechanisms and developing new antiviral therapies. Its mechanism of action provides valuable insights into nucleotide analog pharmacology and viral polymerase inhibition.

Chemical Synthesis Applications

As a chemical intermediate, Adefovir is used in the synthesis of novel antiviral compounds and pharmaceutical intermediates. Its unique phosphonate structure makes it valuable in organic synthesis and medicinal chemistry research.

Safety and Side Effects

Common Side Effects

When used as prescribed, Adefovir may cause the following side effects:

• Headache
• Nausea and abdominal pain
• Diarrhea
• Fatigue
• Increased liver enzymes

Serious Considerations

• Nephrotoxicity: Rare cases of kidney toxicity have been reported. Renal function should be monitored during treatment.
• Lactic Acidosis: In rare instances, lactic acidosis may occur, particularly in patients with liver enlargement.
• Bone Loss: Long-term use may be associated with decreased bone mineral density.

Меры предосторожности

• Patients with pre-existing kidney conditions require dose adjustment and close monitoring
• Regular monitoring of renal function and liver enzymes is recommended
• Use during pregnancy only if clearly needed and under medical supervision
• Discontinuation of treatment should be done under medical guidance to avoid hepatitis flare

Drug Interactions

Patients should inform their healthcare provider about all medications being taken, as Adefovir may interact with other drugs that affect kidney function. Close monitoring is essential when combining with other potentially nephrotoxic medications.

Chemical Specifications

Property	Значение
Номер CAS	106941-25-7
Молекулярная формула	C8H12N5O4P
Молекулярная масса	273.19 g/mol
Синонимы	9-[(2R)-2-(hydroxymethyl)oxolan-3-yl]purine-2,6-dione, PMEA
Внешний вид	Кристаллический порошок от белого до небелого цвета
Чистота	≥98%
Классификация	API (Active Pharmaceutical Ingredient)

Frequently Asked Questions

How does Adefovir work?

Adefovir works by inhibiting the hepatitis B virus DNA polymerase. After entering cells, it is converted to adefovir diphosphate, which incorporates into viral DNA and terminates DNA chain elongation, preventing viral replication.

Is Adefovir effective against drug-resistant HBV?

Yes, one of the key advantages of Adefovir is its effectiveness against lamivudine-resistant hepatitis B virus strains. This makes it an important treatment option for patients who have developed resistance to other antiviral medications.

How is Adefovir administered?

Adefovir is typically administered orally as adefovir dipivoxil, the prodrug form. The standard dose for chronic hepatitis B is 10 mg once daily. Patients should follow their healthcare provider’s instructions regarding dosing and duration of treatment.

What monitoring is required during Adefovir treatment?

Regular monitoring of renal function (creatinine clearance), liver enzymes, and viral load is recommended during Adefovir therapy. Patients with pre-existing kidney conditions require more frequent monitoring and possible dose adjustment.

Can Adefovir be used in combination with other antivirals?

Yes, Adefovir may be used in combination therapy for hepatitis B, particularly in cases of drug resistance. However, combination therapy decisions should be made by healthcare professionals based on individual patient factors and viral resistance patterns.

Why Choose Our Adefovir?

When sourcing Adefovir for research, pharmaceutical manufacturing, or formulation purposes, our company offers:

• High Purity: ≥98% purity guaranteed with comprehensive Certificates of Analysis
• Quality Assurance: All products meet international pharmacopoeia standards
• Reliable Supply: Consistent availability for bulk orders and custom manufacturing needs
• Technical Support: Our team provides technical documentation and support for your specific requirements
• Competitive Pricing: Factory-direct pricing for quantity orders

We supply Adefovir (CAS 106941-25-7) to pharmaceutical companies, research institutions, and chemical manufacturers worldwide. Contact us for quotes on bulk orders, custom packaging options, and technical specifications.

Related Products

If you’re interested in Adefovir, you may also find these related chemicals useful:

• Lamivudine – Antiviral API
• Tenofovir – HIV/HBV Treatment API
• Acyclovir – Antiviral API
• Interferon – Immunomodulator

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