Abametapir (CAS 1762-34-1) is a novel pediculicidal metalloproteinase inhibitor used primarily for the treatment of head lice infestations. Chemically known as 5,5′-Dimethyl-2,2′-dipyridyl or 6,6′-Bi-3-picoline, this compound has emerged as an effective active pharmaceutical ingredient (API) in topical treatments for lice.

With a molecular formula of C12H12N2 and a molecular weight of 184.24 g/mol, Abametapir appears as an off-white crystal powder with a purity of ≥98%. The compound serves as both a building block in chemical synthesis and as an effective insecticide, particularly in human health applications.

What Are the Benefits?

Effective Head Lice Treatment

The primary benefit of Abametapir is its efficacy against head lice (Pediculus capitis). As the active ingredient in Xeglyze Lotion, Abametapir has been approved for treating head lice infestations, offering a clinically proven solution for this common problem, especially among children.

Dual Action: Kills Lice and Prevents Eggs from Hatching

One of the most significant advantages of Abametapir is its dual mechanism of action. Research demonstrates that it not only kills adult lice and nymphs but also prevents eggs (nits) from hatching. This is particularly important because the lice life cycle is approximately 30 days, with 7-12 days spent as eggs on hair shafts near the scalp. By preventing egg hatching, Abametapir helps break the entire lice life cycle.

Metalloproteinase Inhibition

Abametapir works by inhibiting metalloproteinases—enzymes that are essential for physiological processes critical for egg development and the survival of nymph and adult lice. This unique mechanism of action distinguishes it from traditional pediculicides that may only target adult insects.

Potential Antifungal Activity

Beyond its primary use as a pediculicide, research has shown that Abametapir has been used in the synthesis of lanthanide coordination complexes with antifungal activity against certain fungi, suggesting potential broader applications in pharmaceutical research.

What Are the Uses?

Primary Use: Head Lice Treatment

The primary pharmaceutical application of Abametapir is in topical formulations for treating head lice infestations. It is particularly effective when used in prescription-strength treatments like Xeglyze Lotion (0.74% Abametapir), which has been approved by regulatory agencies for this specific indication.

Chemical Research and Synthesis

Abametapir serves as a valuable building block in organic synthesis and chemical research. It is used in:

• Synthesis of lanthanide coordination complexes
• Development of new metalloproteinase inhibitors
• Pharmaceutical intermediate production

Agricultural Applications

As an insecticide, Abametapir has applications in agricultural settings for controlling insect populations, though its primary commercial use remains in human pharmaceutical products.

Safety and Side Effects

Common Side Effects

When used as directed in topical treatments, Abametapir may cause:

• Scalp irritation
• Mild burning or stinging sensation
• Temporary redness at the application site

Меры предосторожности

• For external use only
• Avoid contact with eyes, mouth, and nose
• Not recommended for use on broken or irritated skin
• Should be applied only to dry hair and scalp
• Keep out of reach of children

Contraindications

Consult a healthcare professional before use if:

• You are pregnant or breastfeeding
• You have known allergies to similar compounds
• The patient is very young (follow age recommendations)

Chemical Specifications

Property	Значение
Номер CAS	1762-34-1
Молекулярная формула	C12H12N2
Молекулярная масса	184.24 g/mol
Синонимы	5,5′-Dimethyl-2,2′-dipyridyl, 6,6′-Bi-3-picoline, HA-44, BRN-0123183
Внешний вид	Белоснежный кристаллический порошок
Чистота	≥98%
Классификация	API (Active Pharmaceutical Ingredient)

Frequently Asked Questions

How does Abametapir work?

Abametapir inhibits metalloproteinase enzymes that are essential for the growth and development of lice eggs, as well as the survival of nymph and adult lice. This dual action kills existing lice and prevents eggs from hatching.

Is Abametapir safe for children?

Abametapir-based treatments like Xeglyze are approved for use in children over a certain age. Always follow the specific product instructions and consult a pediatrician when treating children for lice.

How long does treatment take?

Typical treatment involves a single application, with results visible within hours. However, a second treatment may be recommended after 7 days to ensure all lice and newly hatched insects are eliminated.

Can Abametapir be used for body lice or crab lice?

While primarily studied for head lice, Abametapir’s mechanism suggests potential effectiveness against other lice species. Consult a healthcare provider for appropriate treatment options.

Is a prescription required for Abametapir products?

Some Abametapir formulations require a prescription, while others may be available over-the-counter depending on the concentration and regional regulations.

Why Choose Our Abametapir?

When sourcing Abametapir for research, pharmaceutical manufacturing, or formulation purposes, our company offers:

• High Purity: ≥98% purity guaranteed
• Quality Assurance: All products come with comprehensive Certificates of Analysis (CoA)
• Reliable Supply: Consistent availability for bulk orders
• Technical Support: Our team provides technical documentation and support
• Competitive Pricing: Factory-direct pricing for quantity orders

We supply Abametapir (CAS 1762-34-1) to pharmaceutical companies, research institutions, and chemical manufacturers worldwide. Contact us for quotes on bulk orders and custom packaging options.

Related Products

If you’re interested in Abametapir, you may also find these related chemicals useful:

• Acetanilide (CAS 103-84-4)
• Ammonium Formate (CAS 540-69-2)
• Alpha Pinene (CAS 2437-95-8)
• Artemisinin (CAS 63968-64-9)

Browse our full catalog of API products и Пищевые добавки for more chemical solutions.