Amidinothiourea, with the CAS number 2114-02-5, is a specialized chemical compound that plays a crucial role in organic synthesis and pharmaceutical manufacturing. This comprehensive guide explores the properties, applications, and significance of this important chemical intermediate.

What is Amidinothiourea?

Amidinothiourea, also known as guanidine thiourea or 1-amidino-2-thiourea, is an organic compound with the molecular formula C2H6N4S. It contains both an amidine group (-C(=NH)NH2) and a thiourea moiety (-SC(NH2)2) in its structure, making it a versatile reagent in organic synthesis.

This compound appears as a white to off-white crystalline solid and is characterized by its dual functionality, which enables it to participate in various chemical reactions, particularly those involving guanylation.

What Are the Benefits?

Versatile Guanylation Agent

One of the primary benefits of amidinothiourea is its effectiveness as a guanylation agent. It can introduce guanidine groups (-NH-C(=NH)NH2) into various organic molecules, which is essential in the synthesis of numerous pharmaceutical compounds and agricultural chemicals.

High Reactivity

The compound exhibits high reactivity in guanylation reactions, allowing for efficient conversion of alcohols, amines, and other functional groups into their corresponding guanidine derivatives. This makes it valuable in drug discovery and development processes.

Pharmaceutical Applications

Amidinothiourea serves as a key intermediate in the synthesis of various pharmaceutical compounds, including:

• Antiviral agents
• Antibacterial compounds
• Anti-inflammatory drugs
• Cardiovascular medications

Agrochemical Production

In agriculture, this compound is used in the synthesis of pesticides, herbicides, and plant growth regulators. Guanidine derivatives are known for their biological activity against various pests and diseases.

What Are the Uses?

Органический синтез

Amidinothiourea is primarily used in organic synthesis as a guanylation reagent. It reacts with:

• Alcohols: To produce O-alkylguanidines
• Amines: To create N-guanidyl derivatives
• Thiols: To form S-guanidyl compounds
• Carboxylic acids: To generate imidate intermediates

Pharmaceutical Intermediate

The compound is extensively used as an intermediate in pharmaceutical manufacturing, particularly in the production of:

• Guanidine-based antibiotics
• Antidiabetic drugs
• Anticancer agents
• Muscle relaxants

Dye and Pigment Industry

In the dye industry, amidinothiourea is used as a building block for synthesizing various azo dyes and fluorescent whitening agents.

Analytical Chemistry

The compound finds applications in analytical chemistry as a reagent for detecting and quantifying certain metal ions and anions.

Безопасность и обращение

While amidinothiourea is a valuable industrial chemical, proper safety precautions should be observed during handling and storage:

• Personal Protective Equipment: Always wear appropriate PPE, including gloves, safety goggles, and lab coat when handling this compound.
• Хранение: Store in a cool, dry, well-ventilated area away from incompatible materials.
• Handling: Avoid inhalation, skin contact, and ingestion. Use in a fume hood when possible.
• Утилизация: Dispose of according to local environmental regulations.

For specific safety information, please consult the Material Safety Data Sheet (MSDS) provided with the product.

Chemical Specifications

Property	Значение
Номер CAS	2114-02-5
Молекулярная формула	C2H6N4S
Молекулярная масса	118.16 g/mol
Внешний вид	White to off-white crystalline solid
Температура плавления	~170-175°C (decomposes)
Растворимость	Soluble in water and polar organic solvents
Чистота	Typically ≥98%

Frequently Asked Questions

What is the main application of Amidinothiourea?

The primary application of amidinothiourea is as a guanylation agent in organic synthesis, particularly for introducing guanidine functional groups into organic molecules.

Is Amidinothiourea safe to use?

When proper safety precautions are followed, amidinothiourea can be handled safely. Always use appropriate PPE and follow laboratory safety protocols.

How should Amidinothiourea be stored?

Store in a cool, dry, well-ventilated area in tightly sealed containers. Keep away from moisture and incompatible materials.

What industries use Amidinothiourea?

Main industries include pharmaceutical manufacturing, agrochemical production, dye manufacturing, and academic research.

Why Choose Our Amidinothiourea?

At Longchang Chemical, we provide high-quality Amidinothiourea (CAS 2114-02-5) with the following advantages:

• High Purity: Our product meets or exceeds industry standards with ≥98% purity
• Consistent Quality: Each batch is rigorously tested to ensure consistency
• Competitive Pricing: Factory-direct pricing for bulk orders
• Reliable Supply: Stable production capacity to meet your requirements
• Technical Support: Our team provides technical assistance and documentation
• Global Shipping: Efficient logistics to deliver products worldwide

Contact us today to request a quote or learn more about our Amidinothiourea and other chemical products.

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