Study on the components of phloroglucinol in rough branch golden peach
The plants of the Guttiferae family and the Hypericum genus are distributed throughout the country, especially in East China, West China, northern Sichuan, Guizhou, Xinjiang, and other areas where they are more concentrated. There are about 400 species worldwide, with 55 species and 8 subspecies in China. This plant has a medicinal history of more than 2400 years in folk medicine, mainly with the effects of clearing heat and detoxifying, dispersing blood stasis and relieving pain, and dispelling wind and dampness. The plants of the Primus genus mainly contain naphthoquinone, flavonoid, kaempferol, and phloroglucinol components, among which phloroglucinol components have attracted much attention due to their novel chemical structure and diverse pharmacological activities.
Hypericum scarrum is a perennial herb of Hypericum, which is endemic to Xinjiang, China, and is only distributed in Tianshan Mountain, Altar Mount Taishan Mountain, front mountain of Talbahatai Mountain and middle mountain areas. In order to further clarify its pharmacological substance basis and to search for lead compounds with novel structures and good pharmacological activity, this study isolated, purified, and structurally identified the chemical components of the petroleum ether extract from the ethanol extract of the aerial part of Scutellaria barbata, and tested the protective activity of each compound against glutamate induced neuronal damage.

This article conducted a chemical composition study on the ethanol extract of the aerial part of the rough branch golden peach. A total of 10 phloroglucinol compounds were isolated and identified, among which compound 1 is a new compound. And the neuroprotective activity of each compound was tested, and it was found that compounds 5 and 6 had a certain protective effect on glutamate induced neuronal damage at a concentration of 10 μ M. Compound 5 had the same activity as the positive control resveratrol. In addition, phloroglucinol compounds are mostly colorless oily compounds with multiple chiral centers, making it difficult to determine their absolute configurations using classical X-ray single crystal diffraction experiments. However, they can be determined through comparative experiments and calculation of ECD spectra.