{"id":9952,"date":"2024-10-03T16:45:58","date_gmt":"2024-10-03T16:45:58","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=9952"},"modified":"2024-10-03T16:45:58","modified_gmt":"2024-10-03T16:45:58","slug":"foreign-nicotinamide-mononucleotide","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/foreign-nicotinamide-mononucleotide\/","title":{"rendered":"Melyek a k\u00fclf\u00f6ldi nikotinamid-mononukleotid nyersanyagokra vonatkoz\u00f3 el\u0151\u00edr\u00e1sok?"},"content":{"rendered":"

Melyek a k\u00fclf\u00f6ldi nikotinamid-mononukleotid nyersanyagokra vonatkoz\u00f3 el\u0151\u00edr\u00e1sok?<\/h1>\n

A b\u00e9ta-nikotinamid-mononukleotid (NMN) a jelenlegi \"Netflix\" nyersanyag. A piacfel\u00fcgyeleti \u00e9s piacszab\u00e1lyoz\u00e1si \u00e1llami hivatal (SAMSAR) a 13. Nemzeti N\u00e9pi Kongresszus negyedik \u00fcl\u00e9sszak\u00e1nak 1067. sz\u00e1m\u00fa aj\u00e1nl\u00e1s\u00e1ra adott v\u00e1lasz\u00e1ban t\u00e1mogatja az NMN \u00e9s a kapcsol\u00f3d\u00f3 term\u00e9kek alapkutat\u00e1s\u00e1t, \u00e9s ir\u00e1ny\u00edtja az NMN \u00e9s a kapcsol\u00f3d\u00f3 term\u00e9kek szabv\u00e1nyos\u00edtott fejleszt\u00e9s\u00e9t.
\nJelenleg a K\u00edn\u00e1ban forgalomban l\u00e9v\u0151 NMN-term\u00e9keket f\u0151k\u00e9nt a hat\u00e1rokon \u00e1tny\u00fal\u00f3 e-kereskedelem m\u00f3dj\u00e1ban \u00e9rt\u00e9kes\u00edtik, \u00e9s a piac fejl\u0151d\u00e9s\u00e9vel egyre t\u00f6bb tudom\u00e1nyos kutat\u00e1si ir\u00e1ny van folyamatban. A k\u00f6vetkez\u0151kben bemutatjuk a piac m\u00e9ret\u00e9t, a nyersanyag-\u00f6sszet\u00e9telt, a k\u00fclf\u00f6ldi szab\u00e1lyoz\u00e1sokat, a hat\u00e9konys\u00e1gi \u00e1ll\u00edt\u00e1sokat, a biztons\u00e1got stb., \u00e9s rem\u00e9lj\u00fck, hogy a fogyaszt\u00f3k jobban meg\u00e9rtik az NMN k\u00fclf\u00f6ldi fejl\u0151d\u00e9s\u00e9t.
\n1. Az amerikai piackutat\u00f3 c\u00e9g (GlobeNewswire) adatai azt mutatj\u00e1k, hogy a glob\u00e1lis NMN nyersanyag-piaci \u00e9rt\u00e9kes\u00edt\u00e9s 2022-ben a becsl\u00e9sek szerint 280 milli\u00f3 amerikai doll\u00e1r, \u00e9s az el\u0151rejelz\u00e9sek szerint 2028-ra az NMN nyersanyag \u00e9rt\u00e9kes\u00edt\u00e9se el\u00e9ri a 496 milli\u00f3 amerikai doll\u00e1rt, ami 10,0% \u00e9ves n\u00f6veked\u00e9si \u00fctemet jelent [1]. A f\u0151bb besz\u00e1ll\u00edt\u00f3k k\u00f6z\u00e9 tartozik a GeneHarbor, a Herbalmax, a jap\u00e1n Shinkowa \u00e9s az EffePharm. A n\u00e9gy alapanyag egy\u00fcttes piaci r\u00e9szesed\u00e9se el\u00e9rte a 83% piaci r\u00e9szesed\u00e9st.<\/p>\n

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K\u00edna, mint az NMN legnagyobb fogyaszt\u00f3i piaca, az AiMedia Data Center adatai szerint az NMN-\u00f6sszetev\u0151ket tartalmaz\u00f3 \u00e9lelmiszerek piaci m\u00e9rete 2020-ban el\u00e9rte az 5,106 milli\u00e1rd j\u00fcant, ami 34,87% \u00e9ves n\u00f6veked\u00e9st jelent, \u00e9s v\u00e1rhat\u00f3an 2023-ban 27,013 milli\u00e1rd j\u00fcanra emelkedik, k\u00f6zel 70,25% n\u00f6veked\u00e9si \u00fctemmel, az ipar\u00e1g viszonylag gyors n\u00f6veked\u00e9si \u00fctem\u00e9vel [2]. A piac m\u00e9rete \u00e9s n\u00f6veked\u00e9si \u00fcteme az al\u00e1bbi \u00e1br\u00e1n l\u00e1that\u00f3.<\/p>\n

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A fenti adatok azt mutatj\u00e1k, hogy a jelenlegi nyersanyag-besz\u00e1ll\u00edt\u00f3k alapvet\u0151en k\u00ednai v\u00e1llalatok, ami teljes m\u00e9rt\u00e9kben bizony\u00edtja, hogy a k\u00ednai nyersanyagok a glob\u00e1lis hat\u00f3k\u00f6rben a l\u00e9tez\u00e9s egy nagy versenyel\u0151ny. Az alapkutat\u00e1sunk folyamatos elm\u00e9ly\u00edt\u00e9s\u00e9vel a K\u00edn\u00e1b\u00f3l export\u00e1lt t\u00e1pl\u00e1l\u00e9kkieg\u00e9sz\u00edt\u0151 nyersanyagok egyik legfontosabb fajt\u00e1j\u00e1v\u00e1 v\u00e1lhat, \u00e9s a k\u00ednai eg\u00e9szs\u00e9g\u00fcgyi \u00e9lelmiszerek \"tengerent\u00fali\" strat\u00e9gi\u00e1j\u00e1nak konkr\u00e9t megtestes\u00edt\u0151j\u00e9v\u00e9 is v\u00e1lhat. Ezenk\u00edv\u00fcl K\u00edna piaci m\u00e9rete a vil\u00e1g legnagyobbja, ami teljes m\u00e9rt\u00e9kben bizony\u00edtja, hogy ha az NMN-t \u00faj \u00e9lelmiszer-\u00f6sszetev\u0151k\u00e9nt vagy eg\u00e9szs\u00e9g\u00fcgyi \u00e9lelmiszer-\u00f6sszetev\u0151k\u00e9nt haszn\u00e1lj\u00e1k a j\u00f6v\u0151ben, akkor jobban megfelelhet a fogyaszt\u00f3k ig\u00e9nyeinek.
\n2.Nyersanyag-\u00f6sszetev\u0151 A \u03b2-nikotinamid-mononukleotid (NMN) egy rib\u00f3zb\u00f3l \u00e9s nikotinamidb\u00f3l sz\u00e1rmaz\u00f3 nukleotid.Az NMN a nikotinamid-adenin-dinukleotid (NAD+) prekurzor anyaga.
\nVizsg\u00e1latok kimutatt\u00e1k, hogy az eml\u0151s\u00f6k nem k\u00e9pesek k\u00f6zvetlen\u00fcl felvenni a NAD+-ot, \u00e9s a NAD+ homeoszt\u00e1zis fenntart\u00e1sa \u00e9rdek\u00e9ben a NAD+ bioszint\u00e9zis az eml\u0151s\u00f6kben f\u0151k\u00e9nt a nikotinamid-helyre\u00e1ll\u00edt\u00e1si \u00fatvonalon kereszt\u00fcl t\u00f6rt\u00e9nik, amely olyan prekurzorokat foglal mag\u00e1ban, mint a NAM \u00e9s a nikotinamid ribonukleinsav (NRNA) [3].
\nJelenleg a nikotinamid ribonukleinsav prekurzorai f\u0151k\u00e9nt a k\u00f6vetkez\u0151 k\u00e9t vegy\u00fcletet tartalmazz\u00e1k: \u03b2-nikotinamid mononukleotid (NMN) \u00e9s nikotinamid ribozid (NR), \u00e9s a megfelel\u0151 szerkezeti k\u00e9pleteik az al\u00e1bbiakban l\u00e1that\u00f3k.<\/p>\n

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A fenti szerkezeti k\u00e9pletb\u0151l l\u00e1that\u00f3, hogy az NMN-nek csak egy foszf\u00e1tcsoporttal t\u00f6bb van, mint az NR-nek, a t\u00f6bbi szerkezet t\u00f6bb\u00e9-kev\u00e9sb\u00e9 megegyezik. Kimutatt\u00e1k, hogy az NR-t a sejtbe jut\u00e1s ut\u00e1n nikotinamid nukleozid-kin\u00e1zok (NRK-k) alak\u00edtj\u00e1k NMN-n\u00e9.
\nAz eml\u0151s\u00f6kben az NMN a Nampt \u00e1ltal kataliz\u00e1lt nikotinamidb\u00f3l (Nam) keletkezik, majd az NMN-t a nikotinamid-mononukleotid-adenozin-transzfer\u00e1z (Nmnat) kataliz\u00e1lja NAD+ el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz.
\nAz extracellul\u00e1ris NMN-nek nikotinamid ribozidd\u00e1 (NR) kell defoszforil\u00e1l\u00f3dnia ahhoz, hogy bejusson az intracellul\u00e1ris hepatocit\u00e1ba. Az intracellul\u00e1risba val\u00f3 bejut\u00e1s ut\u00e1n az NR-t a nikotinamid-ribozid-kin\u00e1z (NRK1) foszforil\u00e1lja NMN el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra, amely ezt k\u00f6vet\u0151en ATP-vel kombin\u00e1lva NAD+-t hoz l\u00e9tre.
\nAz NMN-t az emberi szervezetben NAD+-\u00e1 alak\u00edtj\u00e1k \u00e1t, hogy fiziol\u00f3giai funkci\u00f3it, p\u00e9ld\u00e1ul a NAD+ szubsztr\u00e1tf\u00fcgg\u0151 Sirt1 (hiszton-deacetil\u00e1z, m\u00e1s n\u00e9ven csendes\u00edt\u0151 szab\u00e1lyoz\u00f3 feh\u00e9rje) enzim aktiv\u00e1l\u00e1s\u00e1t, a sejtek t\u00fal\u00e9l\u00e9s\u00e9nek \u00e9s hal\u00e1l\u00e1nak szab\u00e1lyoz\u00e1s\u00e1t, a redox-\u00e1llapot fenntart\u00e1s\u00e1t stb. ell\u00e1ssa. [4].
\nAz NMN el\u0151\u00e1ll\u00edt\u00e1s\u00e1nak jelenlegi m\u00f3dszerei k\u00e9t f\u0151 kateg\u00f3ri\u00e1ba sorolhat\u00f3k: k\u00e9miai szint\u00e9zis \u00e9s biol\u00f3giai m\u00f3dszerek. A k\u00e9miai szint\u00e9zis m\u00f3dszer\u00e9t m\u00e1r kor\u00e1bban tanulm\u00e1nyozt\u00e1k, \u00e9s f\u0151k\u00e9nt k\u00fcl\u00f6nb\u00f6z\u0151 szintetikus l\u00e9p\u00e9sekkel szintetiz\u00e1lj\u00e1k, nyersanyagk\u00e9nt nikotinamidot, tetraacetil rib\u00f3zt stb. haszn\u00e1lva. A k\u00e9miai szint\u00e9zis m\u00f3dszer\u00e9vel \u00f6sszehasonl\u00edtva az NMN biol\u00f3giai m\u00f3dszerrel t\u00f6rt\u00e9n\u0151 el\u0151\u00e1ll\u00edt\u00e1s\u00e1nak el\u0151nyei az egyszer\u0171 technikai \u00fatvonal, a k\u00e9nyelmes m\u0171k\u00f6d\u00e9s, a z\u00f6ld k\u00f6rnyezetv\u00e9delem \u00e9s az alacsony el\u0151\u00e1ll\u00edt\u00e1si k\u00f6lts\u00e9g.
\nJelenleg az NMN enzimatikus szint\u00e9zise f\u0151k\u00e9nt a nikotinamid-foszforibozil-pirifoszf\u00e1t (PRPP) \u00e9s a nikotinamid mint szubsztr\u00e1tok \u00e1ltal kataliz\u00e1lt nikotinamid-foszforibozil-transzfer\u00e1z (Nampt vagy Namprt) \u00e1ltal t\u00f6rt\u00e9n\u0151 NMN-termel\u00e9sen alapul. Az NMN hozama n\u00f6velhet\u0151 a NAMPT mut\u00e1ci\u00f3j\u00e1nak mesters\u00e9ges \u00faton t\u00f6rt\u00e9n\u0151 l\u00e9trehoz\u00e1s\u00e1val vagy a NAMPT-t tartalmaz\u00f3 genetikailag m\u00f3dos\u00edtott bakt\u00e9riumok felhaszn\u00e1l\u00e1s\u00e1val a szint\u00e9zis hat\u00e9kony \u00e1talak\u00edt\u00e1s\u00e1nak megval\u00f3s\u00edt\u00e1sa \u00e9rdek\u00e9ben [5].
\n3. K\u00fclf\u00f6ldi szab\u00e1lyoz\u00e1s A \u03b2-nikotinamid-mononukleotid (NMN) \u00e9s a nikotinamid-mononukleozid (NR) a NAD+ el\u0151anyagai. \u00c9lelmiszer-\u00f6sszetev\u0151k\u00e9nt vagy \u00e9trend-kieg\u00e9sz\u00edt\u0151 \u00f6sszetev\u0151k\u00e9nt a k\u00fclf\u00f6ldi szab\u00e1lyoz\u00e1sokban szerepl\u0151 k\u00f6vetelm\u00e9nyeiket a k\u00f6vetkez\u0151 t\u00e1bl\u00e1zat foglalja \u00f6ssze.<\/p>\n

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Mint l\u00e1that\u00f3, az NR alapvet\u0151en \u00e9lelmiszer-\u00f6sszetev\u0151k\u00e9nt enged\u00e9lyezett az EU-ban, az USA-ban \u00e9s Jap\u00e1nban, \u00e9s egyen\u00e9rt\u00e9k\u0171 a B3-vitamin (niacin) forr\u00e1s\u00e1val.Az NMN-t Jap\u00e1nban \u00e9s az USA-ban \u00e9lelmiszer-\u00f6sszetev\u0151k\u00e9nt szab\u00e1lyozz\u00e1k.Az NMN\/NR-t Kanad\u00e1ban term\u00e9szetes eg\u00e9szs\u00e9g\u00fcgyi term\u00e9kk\u00e9nt szab\u00e1lyozz\u00e1k.
\nSz\u00e1mos k\u00ednai v\u00e1llalat is van, amely jelenleg \u00faj \u00e9trendi \u00f6sszetev\u0151 (NDI) k\u00e9relm\u00e9t ny\u00fajtja be az FDA-t\u00f3l, amely az FDA honlapj\u00e1n l\u00e1that\u00f3, amint az al\u00e1bb l\u00e1that\u00f3 [6].<\/p>\n

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Amint l\u00e1that\u00f3, az 1234 \u00e9s 1240 sz\u00e1m\u00fa k\u00e9relmek mindkett\u0151 NMN k\u00e9relmek, \u00e9s az FDA ennek megfelel\u0151en reag\u00e1lt erre a k\u00e9relemre.
\nAzt is l\u00e1tjuk, hogy sz\u00e1mos NMN-term\u00e9ket forgalmaznak az Egyes\u00fclt \u00c1llamokban. Ez l\u00e1that\u00f3 az al\u00e1bbiakban [7] bemutatott, a szerkezetre\/funkci\u00f3ra vonatkoz\u00f3 \u00e1ll\u00edt\u00e1sokra vonatkoz\u00f3 FDA-alkalmaz\u00e1si dokumentumokban.<\/p>\n

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Ez az inform\u00e1ci\u00f3 ellentmondani l\u00e1tszik az NDI alkalmaz\u00e1snak, amely az \u00e9trend-kieg\u00e9sz\u00edt\u0151kre vonatkoz\u00f3 amerikai szab\u00e1lyoz\u00e1s egyik jellemz\u0151je. Az FDA NDI-bejelent\u00e9sre vonatkoz\u00f3 szab\u00e1lyzata szerint az 1994. okt\u00f3ber 15. el\u0151tt az Egyes\u00fclt \u00c1llamokban forgalomba hozott \u00f6sszetev\u0151k NDI-bejelent\u00e9s beny\u00fajt\u00e1sa n\u00e9lk\u00fcl k\u00f6zvetlen\u00fcl is forgalomba hozhat\u00f3k. Ha nem tudja meger\u0151s\u00edteni, akkor k\u00e9rheti az NDI bejelent\u00e9st. Ez\u00e9rt sok v\u00e1llalat \u00fagy gondolhatja, hogy ezt az \u00f6sszetev\u0151t 1994. okt\u00f3ber 15. el\u0151tt \u00e9rt\u00e9kes\u00edtett\u00e9k az Egyes\u00fclt \u00c1llamok piac\u00e1n, \u00edgy nem kell NDI bejelent\u00e9st k\u00e9rnie.
\n4. Funkcion\u00e1lis \u00e1ll\u00edt\u00e1sok Az ut\u00f3bbi \u00e9vekben egyre t\u00f6bb tanulm\u00e1ny sz\u00fcletett az NMN biol\u00f3giai funkci\u00f3ir\u00f3l [8,9-18], mint p\u00e9ld\u00e1ul: az \u00e9letkorral kapcsolatos patofiziol\u00f3gia \u00e9s a betegs\u00e9g \u00e1llapot\u00e1nak jav\u00edt\u00e1sa, az \u00e9letkorral kapcsolatos fiziol\u00f3giai hanyatl\u00e1s jelent\u0151s cs\u00f6kkent\u00e9se, a sejtek energia\u00e1llapot\u00e1nak, az idegrendszer \u00e9s az agyi kogn\u00edci\u00f3 (Alzheimer-k\u00f3r) stb. jav\u00edt\u00e1sa, \u00e9s j\u00f3 eredm\u00e9nyeket mutatott a sz\u00edvbetegs\u00e9gek, a cukorbetegs\u00e9g \u00e9s sz\u00e1mos m\u00e1s betegs\u00e9g \u00e1llapot\u00e1nak jav\u00edt\u00e1s\u00e1ban. Az al\u00e1bbi t\u00e1bl\u00e1zatban l\u00e1that\u00f3 m\u00f3don szervezve.<\/p>\n

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Let\u00f6lt\u00f6tt\u00fck a Swanson Health Products, NMN szerkezet\/funkci\u00f3 alkalmaz\u00e1s\u00e1t az amerikai FDA [19], amelynek k\u00e9perny\u0151k\u00e9p\u00e9t az al\u00e1bbiakban mutatjuk be:<\/p>\n

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A ford\u00edt\u00e1s a k\u00f6vetkez\u0151ket \u00e1ll\u00edtja: (1) Az NMN a NAD+ prekurzora, \u00e9s elengedhetetlen a sejtek eg\u00e9szs\u00e9g\u00e9hez. (2) Energiaanyagcsere. (3) T\u00e1mogathatja az eg\u00e9szs\u00e9ges v\u00e9rcukorszintet \u00e9s az anyagcsere m\u0171k\u00f6d\u00e9s\u00e9t. A kapcsol\u00f3d\u00f3 funkcion\u00e1lis \u00e1ll\u00edt\u00e1sok t\u00f6bbs\u00e9ge azonban \u00e1llatk\u00eds\u00e9rletekb\u0151l sz\u00e1rmazik, \u00edgy csak felt\u00e9telezhet\u0151, hogy az NMN-nek van n\u00e9mi relev\u00e1ns hat\u00e9konys\u00e1ga, amelyet m\u00e9g meg kell er\u0151s\u00edteni a k\u00e9s\u0151bbi teljes valid\u00e1l\u00e1ssal, bele\u00e9rtve az emberi valid\u00e1l\u00e1st \u00e9s m\u00e1s kiterjedt munk\u00e1t is.
\n5. Biztons\u00e1g \u00e9s klinikai kutat\u00e1s Mint fentebb eml\u00edtett\u00fck, a biztons\u00e1g az \u00e9lelmiszer fontos mutat\u00f3ja, \u00e9s az NR-t a vil\u00e1g f\u0151bb orsz\u00e1gaiban \u00e9s r\u00e9gi\u00f3iban \u00e9lelmiszer-\u00f6sszetev\u0151k\u00e9nt enged\u00e9lyezt\u00e9k, \u00edgy biztons\u00e1goss\u00e1ga bizony\u00edtott, \u00e9s az NMN-t, mint \u00faj \u00f6sszetev\u0151t, Jap\u00e1nban \u00e9lelmiszer-\u00f6sszetev\u0151k\u00e9nt enged\u00e9lyezt\u00e9k, \u00e9s m\u00e1s orsz\u00e1gokban \u00e9s r\u00e9gi\u00f3kban \u00e9trend-kieg\u00e9sz\u00edt\u0151k \u00f6sszetev\u0151jek\u00e9nt haszn\u00e1lhat\u00f3, ami azt jelenti, hogy biztons\u00e1goss\u00e1g\u00e1t igazolt\u00e1k. Az NMN-t mint \u00faj \u00f6sszetev\u0151t Jap\u00e1nban \u00e9lelmiszer-\u00f6sszetev\u0151k\u00e9nt j\u00f3v\u00e1hagyt\u00e1k, \u00e9s \u00e9trend-kieg\u00e9sz\u00edt\u0151 \u00f6sszetev\u0151k\u00e9nt m\u00e1s jelent\u0151s orsz\u00e1gokban \u00e9s r\u00e9gi\u00f3kban is felhaszn\u00e1lhat\u00f3, ami azt jelzi, hogy biztons\u00e1goss\u00e1g\u00e1t bizonyos m\u00e9rt\u00e9kig igazolt\u00e1k.
\nAz emberekre vonatkoz\u00f3 biztons\u00e1gi adatok azonban m\u00e9g mindig hi\u00e1nyoznak, \u00e9s az NMN-nel kapcsolatos sz\u00e1mos klinikai vizsg\u00e1lat vil\u00e1gszerte biztons\u00e1gi \u00e9s egy\u00e9b kapcsol\u00f3d\u00f3 funkcion\u00e1lis \u00e9rt\u00e9kel\u00e9seket foglal mag\u00e1ban. \u00d6ssze\u00e1ll\u00edtottuk az NMN-t \u00e9rint\u0151 klinikai vizsg\u00e1latok list\u00e1j\u00e1t vil\u00e1gszerte, \u00e9s az eredm\u00e9nyeket az al\u00e1bbi t\u00e1bl\u00e1zatban mutatjuk be.<\/p>\n

\"\"<\/p>\n

Amint az a fent eml\u00edtett 28 klinikai vizsg\u00e1latb\u00f3l l\u00e1that\u00f3, 10 klinikai vizsg\u00e1lat foglalkozott a biztons\u00e1goss\u00e1ggal. \u00dagy gondoljuk, hogy a k\u00f6zelj\u00f6v\u0151ben az NMN biztons\u00e1gi adatait is be fogj\u00e1k mutatni.
\n\u00d6sszefoglalva, a \u03b2-nikotinamid-mononukleotidot (NMN) \u00e9s a nikotinamid-mononukleozidot (NR), mint a NAD+ prekurzor anyagokat, az elm\u00falt n\u00e9h\u00e1ny \u00e9vben csak tudom\u00e1nyos kutat\u00e1si anyagk\u00e9nt \u00e9rt\u00e9kes\u00edtett\u00e9k a kutat\u00f3szervezetek sz\u00e1m\u00e1ra, \u00e9s dr\u00e1g\u00e1n.
\nAz ut\u00f3bbi \u00e9vekben bizonyos biotechnol\u00f3gi\u00e1k r\u00e9v\u00e9n fokozt\u00e1k az NMN felsz\u00edv\u00f3d\u00e1s\u00e1t \u00e9s aktivit\u00e1s\u00e1t az emberi szervezetben, \u00e9s cs\u00f6kkentett\u00e9k az el\u0151\u00e1ll\u00edt\u00e1si k\u00f6lts\u00e9geit. \u00c1llatk\u00eds\u00e9rletek el\u0151zetesen igazolt\u00e1k sz\u00e9les k\u00f6r\u0171 hat\u00e9konys\u00e1g\u00e1t, \u00e9s fokozatosan kezdett megjelenni a k\u00fclf\u00f6ldi orsz\u00e1gokban az \u00e9trend-kieg\u00e9sz\u00edt\u0151k ter\u00fclet\u00e9n, de az embereken v\u00e9gzett k\u00eds\u00e9rleti adatok hi\u00e1nya m\u00e9g nem ny\u00fajtott \u00e1tfog\u00f3 t\u00e1mogat\u00e1st az alapkutat\u00e1si adatokhoz.
\nIt is believed that with the continuous development of global clinical research experiments, it will gradually be recognized by the government departments of the United States, the European Union and other countries. As a major country in the production of NMN raw materials, in addition to the accumulation of basic research data, it will gradually become a reality for NMN to become a new food ingredient and health food ingredient, so that it can better serve the Chinese consumers and satisfy the people’s pursuit of a healthy and beautiful life. References: 1. https:\/\/www.globenewswire.com\/news-release\/2022\/07\/14\/2479548\/0\/en\/Nicotinamide-Mononucleotide-NMN-Size-Share-Growth-2022- 2028-Latest-Developments-Revenue-Gross-Margin-Key-Players-Market-Drivers-Challenges-Trends-Distributors-Customers-and-Forecast. html.2. https:\/\/www.iimedia.cn\/c1020\/77260.html.3.RAJMAN L, CHWALEK K, SINCLAIR D A. Therapeutic potential of NAD-boosting molecules: the in vivo evidence [J]. Cell Metab, 2018, 27(3): 529-47.4. ZHAO Juan, ZHANG Jian, YU Zhijian et al. Progress in the study and application of nicotinamide mononucleotide [J]. Food Science and Technology, 2018, 43(4): 257-262.5. Yu Hanxiao, Zhu Mengjia, Shi Sweetie et al. Research progress on synthesis and application of nicotinamide mononucleotide [J]. Shandong Chemical Industry, 2022, 51(8):104-106.6. https:\/\/www.fda.gov\/food\/new-dietary-ingredients-ndi-notification-process\/submitted-75-day-premarket- notifications-new-dietary-ingredients.7.https:\/\/www.regulations.gov\/search?filter=Nicotinamide%20Mononucleotide.8.Mills K F, Yoshida S , Stein L R, et al. Long-term administration of nicotinamide mononucleotide mitigates age – associated physiological decline in mice [J]. Cell Metab, 2016, 24(6): 795-806.9. Li J, Bonkowski M S, Moniot S, et al. A conserved NAD+ binding pocket that regulates protein – protein in-teractions during aging [J]. Science, 2017, 355(6331):1312-1317.10. Kiss T, Ny\u00fal-T\u00f3th \u00c1, Balasubramanian P, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti -inflammatory, and anti-apoptotic effects [J]. GeroScience, 2020, 42(2): 527-546.11. Lu L, Tang L, Wei W, et al. Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson’s disease [J]. Exp TherMed, 2014, 8(3): 943-950.12. Park J H, Long A, Owens K, et al. Nicotinamide mononucleotide inhibits post – ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia [J]. Neurobiol Dis, 2016, 95: 102-110.13. Yamamoto T, Byun J, Zhai P, et al. Nicotinamide mononucleotide, an intermediate of NAD+synthesis, protects the heart from ischemia. protects the heart from ischemia and reperfusion [J]. Plos One, 2014, 9(6): e98972.14. Revollo J R, K\u00f6rner A, Mills K F, et al. Nampt\/PBEF\/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme [J]. Cell Metab, 2007, 6(5): 363-375.15. Uddin G M, Youngson N A, Doyle B M, et al. Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise [J]. Sci Rep, 2017, 7(1): 15063.16. Song J, Li J, Yang F, et al. Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow [J]. Cell Death Dis,2019, 10(5): 336-347.17.Lin J B, Kubota S, Ban N, et al. NAMPT – mediated NAD+ biosynthesis is essential for vision in mice [J]. Cell Rep, 2016, 17(1): 69-85.18. Guan Y, Wang S R, Huang X Z, et al. Nicotinamide mononucleotide, an NAD+ precursor, rescues age -associated susceptibility to AKI in a sirtuin 1-dependent manner [J]. J Am Soc Nephrol, 2017, 28(8): 2337-2352.19. https:\/\/www.regulations.gov\/document\/FDA-2021-S-0024-0665.<\/p>","protected":false},"excerpt":{"rendered":"

What are the foreign nicotinamide mononucleotide raw material regulations? Beta-nicotinamide mononucleotide (NMN) is the current \u201cNetflix\u201d raw material. The State Administration of Market Supervision and Regulation (SAMSAR), in its \u201cReply to Recommendation No. 1067 of the Fourth Session of the 13th National People’s Congress\u201d, supports basic research on NMN and related products, and guides the […]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[],"yoast_head":"\nWhat are the foreign nicotinamide mononucleotide raw material regulations? - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/foreign-nicotinamide-mononucleotide\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What are the foreign nicotinamide mononucleotide raw material regulations? - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"What are the foreign nicotinamide mononucleotide raw material regulations? 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