{"id":9156,"date":"2024-08-15T19:26:26","date_gmt":"2024-08-15T19:26:26","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=9156"},"modified":"2024-08-15T19:26:26","modified_gmt":"2024-08-15T19:26:26","slug":"anti-inflammatory-components-in-aina-sesame-oil","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/gyulladasgatlo-osszetevok-a-szezamolajban\/","title":{"rendered":"Gyullad\u00e1scs\u00f6kkent\u0151 komponensek sz\u0171r\u00e9se az Aina szez\u00e1molajban \u00e9s gyullad\u00e1sos t\u00e9nyez\u0151kre gyakorolt hat\u00e1suk vizsg\u00e1lata"},"content":{"rendered":"<p>Gyullad\u00e1scs\u00f6kkent\u0151 komponensek sz\u0171r\u00e9se az Aina szez\u00e1molajban \u00e9s gyullad\u00e1sos t\u00e9nyez\u0151kre gyakorolt hat\u00e1suk vizsg\u00e1lata<br \/>\nA Blumea balsamfera (L.) DC az Asteraceae csal\u00e1dba tartoz\u00f3 l\u00e1gysz\u00e1r\u00fa n\u00f6v\u00e9ny, amely a k\u00f6z\u00e9ps\u0151 meleg\u00edt\u0151 \u00e9s a v\u00e9rkering\u00e9st el\u0151seg\u00edt\u0151, a szelet \u00e9s a nedvess\u00e9get el\u0171z\u0151, a t\u00edfuszt \u00e9s a megf\u00e1z\u00e1st enyh\u00edt\u0151, a bakt\u00e9riumokat elpuszt\u00edt\u00f3 \u00e9s a viszket\u00e9st enyh\u00edt\u0151, valamint az \u00edz\u00fcleti gyullad\u00e1st megel\u0151z\u0151 hat\u00e1s\u00fa. A szakirodalom szerint a k\u00f6k\u00e9nyb\u0151l kivont k\u00f6k\u00e9nytablett\u00e1k mell\u00e9kterm\u00e9kek\u00e9nt a k\u00f6k\u00e9nyben 143 vegy\u00fclet tal\u00e1lhat\u00f3. A laborat\u00f3riumi vizsg\u00e1latok korai szakasz\u00e1ban 39 ill\u00e9kony vegy\u00fcletet azonos\u00edtottak GC-MS detekt\u00e1l\u00e1ssal. Arr\u00f3l is besz\u00e1moltak, hogy a k\u00f6k\u00e9ny j\u00f3 farmakol\u00f3giai aktivit\u00e1ssal rendelkezik gyullad\u00e1scs\u00f6kkent\u0151 szempontb\u00f3l, de gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1nak anyagi alapjait nem tiszt\u00e1zt\u00e1k. A k\u00eds\u00e9rlet c\u00e9lja az Aina szez\u00e1molajban GC-MS-sel kimutatott magas ill\u00f3anyag-tartalm\u00fa vegy\u00fcletek gyullad\u00e1scs\u00f6kkent\u0151 farmakol\u00f3giai aktivit\u00e1s\u00e1nak sz\u0171r\u00e9se, valamint a makrof\u00e1g gyullad\u00e1sos faktorokra gyakorolt hat\u00e1suk tanulm\u00e1nyoz\u00e1sa, gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1suk \u00e9rt\u00e9kel\u00e9se, elm\u00e9leti alapot ny\u00fajt az Aina szez\u00e1molaj m\u00e9lyrehat\u00f3 fejleszt\u00e9s\u00e9hez, \u00e9s referenci\u00e1t ny\u00fajt a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1sainak vizsg\u00e1lat\u00e1hoz.<\/p>\n<p>A szakirodalom \u00e9s a kapcsol\u00f3d\u00f3 adatk\u00f6zl\u00e9sek szerint az Artemisia annua-ban 143 vegy\u00fclet tal\u00e1lhat\u00f3, amelyek f\u0151k\u00e9nt ill\u00f3olajokban \u00e9s flavonoidokban koncentr\u00e1l\u00f3dnak, bele\u00e9rtve az L-kamfor\u00e1t, a k\u00e1mfor\u00e1t, az \u03b1-pineneket, a \u03b2-karyophyllene-t, a caryophyllene-oxidot, a linaloolt stb. A laborat\u00f3riumi vizsg\u00e1latok korai szakasz\u00e1ban 39 ill\u00e9kony komponenst azonos\u00edtottak az Artemisia annua olajban GC-MS detekt\u00e1l\u00e1ssal. Annak vizsg\u00e1lat\u00e1ra, hogy ezek az \u00f6sszetev\u0151k rendelkeznek-e gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1ssal, a szerz\u0151 14 olyan ill\u00e9kony vegy\u00fcletet v\u00e1lasztott ki a gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s kutat\u00e1s\u00e1hoz, amelyeknek a tartalma meghaladta a 1%-t. Az SRS-A egy t\u00f6bb LT-t tartalmaz\u00f3 komplex, amely az arachidonsav (AA) metabolizmus\u00e1ban a lipoxigen\u00e1z m\u00e1sodlagos term\u00e9k\u00e9hez tartozik. Olyan l\u00e9gz\u0151szervi betegs\u00e9geket okozhat, mint a h\u00f6rghurut, az emphysema \u00e9s a t\u00fcd\u0151sz\u00f6veti sz\u00edvbetegs\u00e9g. Az SRS-A gener\u00e1ci\u00f3 g\u00e1tl\u00f3inak \u00e9s receptorblokkol\u00f3inak kutat\u00e1sa az \u00faj gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s immungy\u00f3gyszerek megtal\u00e1l\u00e1s\u00e1nak fontos ir\u00e1ny\u00e1v\u00e1 v\u00e1lt. Ez\u00e9rt a szerz\u0151 el\u0151zetesen \u00f6t gyullad\u00e1scs\u00f6kkent\u0151 potenci\u00e1llal rendelkez\u0151 vegy\u00fcletet, k\u00f6zt\u00fck (-) - k\u00e1mfor\u00e1t, (-) - \u03b1 - pinene, (-) - linalool, transz karyophyllene, k\u00e1mfor stb. sz\u0171rte ki tengerimalac ileum in vitro szenzibiliz\u00e1ci\u00f3s k\u00eds\u00e9rletein kereszt\u00fcl. \u00c1llati akut \u00e9s kr\u00f3nikus gyullad\u00e1sos modellek felhaszn\u00e1l\u00e1s\u00e1val tov\u00e1bbi sz\u0171r\u00e9st v\u00e9gezt\u00fcnk az Aina-olajban l\u00e9v\u0151 (-) - linalool \u00e9s transz-karyophil\u00e9n (-) - k\u00e1mfora fontos gyullad\u00e1scs\u00f6kkent\u0151 hat\u00f3anyagainak azonos\u00edt\u00e1s\u00e1ra. Ami azt illeti, hogy az Aina szez\u00e1molajban tal\u00e1lhat\u00f3 egy\u00e9b, ebben a vizsg\u00e1latban nem \u00e9rintett \u00e9s a szakirodalomban nem ismertetett vegy\u00fcletek is rendelkeznek-e gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1ssal, tov\u00e1bbi m\u00e9lyrehat\u00f3 kutat\u00e1sokra van sz\u00fcks\u00e9g.<\/p>\n<p>Az AA, mint a szervezetben a k\u00f6z\u00f6s zs\u00edrsavak egyik fontos anyaga, els\u0151sorban a COX-\u00fatvonalon kereszt\u00fcl metaboliz\u00e1l\u00f3dik, amelyet a LOX-\u00fatvonal k\u00f6vet, ami el\u0151seg\u00edtheti a PG \u00e9s az LT-k felszabadul\u00e1s\u00e1t. K\u00f6z\u00fcl\u00fck a 12-LOX kataliz\u00e1lhatja az iNOS \u00e1ltal induk\u00e1lt NO-termel\u00e9st, \u00e9s a FLAP a sejtmembr\u00e1n kombin\u00e1ci\u00f3s feh\u00e9rj\u00e9je, amely k\u00f6zvet\u00edti a LOX tov\u00e1bb\u00edt\u00e1s\u00e1t. Mindkett\u0151 gyullad\u00e1sos medi\u00e1tork\u00e9nt j\u00e1tszik szerepet a gyullad\u00e1sos folyamatban, \u00e9s a fenti term\u00e9kek g\u00e1tl\u00e1sa cs\u00f6kkentheti a gyullad\u00e1s el\u0151fordul\u00e1s\u00e1t. Az NF - \u03ba B, mint a gyullad\u00e1sos v\u00e1lasz kulcsfontoss\u00e1g\u00fa jel\u00e1tviteli t\u00e9nyez\u0151je, k\u00f6zponti szerepet j\u00e1tszik a citokin \u00e1ltal k\u00f6zvet\u00edtett gyullad\u00e1sos v\u00e1laszban. Induk\u00e1lhatja a gyullad\u00e1sos citokinek (TNF - \u03b1, IL-1 \u03b2 stb.) g\u00e9nexpresszi\u00f3j\u00e1t, feler\u0151s\u00edtve a gyullad\u00e1sos v\u00e1lasz kaszk\u00e1dj\u00e1t. Az NF - \u03ba B-p65 az NF - \u03ba B jel\u00e1tviteli \u00fatvonal egyik k\u00f6zponti feh\u00e9rj\u00e9je, \u00e9s a t\u00falzott gyullad\u00e1sos v\u00e1lasz az NF - \u03ba B-p65 fokozott expresszi\u00f3j\u00e1hoz vezethet. E vizsg\u00e1lat eredm\u00e9nyei azt mutatj\u00e1k, hogy a (-) - linalool \u00e9s a transz-karyofil\u00e9n g\u00e1tl\u00f3 hat\u00e1ssal van ezekre a gyullad\u00e1sos medi\u00e1torokra \u00e9s citokinekre, \u00e9s a (-) - kamptotetocin is g\u00e1tl\u00f3 hat\u00e1st fejt ki r\u00e1juk, de a d\u00f3zisf\u00fcgg\u00e9s gyenge. A gyullad\u00e1sos medi\u00e1torokra, p\u00e9ld\u00e1ul a COX-2-re, iNOS-ra, NO-ra \u00e9s PGE2-re gyakorolt g\u00e1tl\u00f3 hat\u00e1sukr\u00f3l relev\u00e1ns irodalmi jelent\u00e9sek vannak, m\u00edg az 5-LOX-ra, FLAP-ra \u00e9s LTB4-re viszonylag kev\u00e9s kutat\u00e1s van. Ez\u00e9rt ez a tanulm\u00e1ny adatokat szolg\u00e1ltat gyullad\u00e1scs\u00f6kkent\u0151 mechanizmusaik gazdag\u00edt\u00e1s\u00e1ra is. A fenti eredm\u00e9nyek arra utalnak, hogy a (-) - linalool \u00e9s a transz-karyophil\u00e9n fontos gyullad\u00e1scs\u00f6kkent\u0151 anyagok az Aina olajban.<\/p>","protected":false},"excerpt":{"rendered":"<p>Az Aina szez\u00e1molaj gyullad\u00e1scs\u00f6kkent\u0151 \u00f6sszetev\u0151inek sz\u0171r\u00e9se \u00e9s gyullad\u00e1sos t\u00e9nyez\u0151kre gyakorolt hat\u00e1suk A Blumea balsamfera (L.) DC az Asteraceae csal\u00e1dba tartoz\u00f3 l\u00e1gysz\u00e1r\u00fa n\u00f6v\u00e9ny, amely meleg\u00edt\u0151 \u00e9s v\u00e9rkering\u00e9st el\u0151seg\u00edt\u0151, a szelet \u00e9s a nedvess\u00e9get el\u0171z\u0151, a t\u00edfuszt \u00e9s a megf\u00e1z\u00e1st enyh\u00edt\u0151, bakt\u00e9rium\u00f6l\u0151 \u00e9s viszket\u00e9st enyh\u00edt\u0151, valamint az \u00edz\u00fcleti gyullad\u00e1st megel\u0151z\u0151 hat\u00e1s\u00fa. [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Screening of anti-inflammatory components in Aina sesame oil and their effects on inflammatory factors - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/gyulladasgatlo-osszetevok-a-szezamolajban\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Screening of anti-inflammatory components in Aina sesame oil and their effects on inflammatory factors - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Screening of anti-inflammatory components in Aina sesame oil and their effects on inflammatory factors Blumea balsamfera (L.) 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DC is a herbaceous plant in the Asteraceae family, which has the effects of warming the middle and promoting blood circulation, dispelling wind and dampness, relieving typhoid and cold, killing bacteria and relieving itching, and preventing joint inflammation. 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