{"id":9150,"date":"2024-08-15T19:05:13","date_gmt":"2024-08-15T19:05:13","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=9150"},"modified":"2024-08-15T19:05:13","modified_gmt":"2024-08-15T19:05:13","slug":"naringin-acylhydrazone-derivatives","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/naringin-acilhidrazon-szarmazekok\/","title":{"rendered":"Naringin acilhidrazon-sz\u00e1rmaz\u00e9kok szint\u00e9zise, in vitro antioxid\u00e1ns aktivit\u00e1sa \u00e9s citotoxicit\u00e1sa"},"content":{"rendered":"

Naringin acilhidrazon-sz\u00e1rmaz\u00e9kok szint\u00e9zise, in vitro antioxid\u00e1ns aktivit\u00e1sa \u00e9s citotoxicit\u00e1sa
\nA flavonoidok a n\u00f6v\u00e9nyvil\u00e1gban \u00e1ltal\u00e1nosan megtal\u00e1lhat\u00f3 term\u00e9szetes benzo - \u03b3 - piranon sz\u00e1rmaz\u00e9kok egy oszt\u00e1lya, amelyek antibakteri\u00e1lis, antioxid\u00e1ns, immunszab\u00e1lyoz\u00f3, kemoprevent\u00edv \u00e9s r\u00e1kellenes tulajdons\u00e1gokkal rendelkeznek, amelyek rendk\u00edv\u00fcl el\u0151ny\u00f6sek az emberi eg\u00e9szs\u00e9gre. A naringin, mint dihidroflavonoid vegy\u00fclet, szint\u00e9n rendelkezik biol\u00f3giai aktivit\u00e1ssal, p\u00e9ld\u00e1ul antibakteri\u00e1lis, daganatellenes \u00e9s antioxid\u00e1ns tulajdons\u00e1gokkal. Tutunchi \u00e9s Filippin a naringin megval\u00f3s\u00edthat\u00f3s\u00e1gi mechanizmus\u00e1t vizsg\u00e1lta a COVID-19 elleni k\u00fczdelemben. A naringin Vc-vel \u00e9s Ve-vel kombin\u00e1lva hat\u00e9konyabban kezelhet\u0151 a kadmium \u00e1ltal kiv\u00e1ltott \u00e9s az arz\u00e9n \u00e1ltal kiv\u00e1ltott oxidat\u00edv stressz okozta m\u00e1jk\u00e1rosod\u00e1s Wistar patk\u00e1nyokban. A naringin gyenge lipid- \u00e9s v\u00edzold\u00e9konys\u00e1ga miatt azonban a biol\u00f3giai hozz\u00e1f\u00e9rhet\u0151s\u00e9ge nem magas. Ez\u00e9rt a naringin m\u00f3dos\u00edt\u00e1si kutat\u00e1sa sz\u00e9les k\u00f6r\u0171 figyelmet kapott az \u00e9let minden ter\u00fclet\u00e9n.<\/p>\n

A naringin 7. \u00e9s 4' poz\u00edci\u00f3j\u00e1ban l\u00e9v\u0151 fenolos hidroxilcsoportok, valamint a 4. poz\u00edci\u00f3ban l\u00e9v\u0151 karbonilcsoport viszonylag akt\u00edvak. Ez\u00e9rt a naringin szerkezete k\u00e9miai reakci\u00f3kkal m\u00f3dos\u00edthat\u00f3 a v\u00edzold\u00e9konys\u00e1g\u00e1nak jav\u00edt\u00e1sa \u00e9s ez\u00e1ltal biol\u00f3giai hozz\u00e1f\u00e9rhet\u0151s\u00e9g\u00e9nek fokoz\u00e1sa \u00e9rdek\u00e9ben. Az irodalmi jelent\u00e9sek szerint a hidrazid vegy\u00fcletek j\u00f3 antioxid\u00e1ns aktivit\u00e1ssal, antibakteri\u00e1lis aktivit\u00e1ssal, r\u00e1kellenes aktivit\u00e1ssal stb. rendelkeznek. A hidrazidban l\u00e9v\u0151 aminocsoportok hat\u00e1s\u00e1ra azonban bizonyos toxicit\u00e1ssal rendelkeznek a szervezetekre n\u00e9zve. Ez\u00e9rt a hidrazid m\u00f3dos\u00edt\u00e1sa hidrazon el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra hat\u00e9kony eszk\u00f6z a hidrazid toxicit\u00e1s\u00e1nak jav\u00edt\u00e1s\u00e1ra. Az acil-hidrazon vegy\u00fcletek j\u00f3 antibakteri\u00e1lis, antioxid\u00e1ns \u00e9s antiproliferat\u00edv tulajdons\u00e1gokkal is rendelkeznek. Ez\u00e9rt a szerkezet-aktivit\u00e1s \u00f6sszef\u00fcgg\u00e9sek \u00e9s a naringin m\u00f3dos\u00edt\u00e1s\u00e1nak jelenlegi kutat\u00e1sai alapj\u00e1n ez a cikk a 4. poz\u00edci\u00f3ban hidrazidcsoportot vezet be, hogy acilhidrazont k\u00e9pezzen, rem\u00e9lve, hogy olyan naringin-sz\u00e1rmaz\u00e9kokat kapunk, amelyek biol\u00f3giai aktivit\u00e1ssal \u00e9s a hidrazid szerkezet cs\u00f6kkentett toxicit\u00e1s\u00e1val rendelkeznek. V\u00e9gezzen in vitro antioxid\u00e1ns aktivit\u00e1si \u00e9s citotoxicit\u00e1si k\u00eds\u00e9rleteket a kapott sz\u00e1rmaz\u00e9kokon HEK293 sejteken a magas antioxid\u00e1ns aktivit\u00e1s\u00fa \u00e9s alacsony toxicit\u00e1s\u00fa anyagok sz\u0171r\u00e9s\u00e9re, referenci\u00e1t biztos\u00edtva a tov\u00e1bbi fejleszt\u00e9shez \u00e9s felhaszn\u00e1l\u00e1shoz.<\/p>\n

Ebben a k\u00eds\u00e9rletben 13 naringin acilhidrazon-sz\u00e1rmaz\u00e9kot szintetiz\u00e1ltunk mikrohull\u00e1m\u00fa m\u00f3dszerekkel, amelyek k\u00f6z\u00fcl 12-r\u0151l m\u00e9g nem sz\u00e1moltak be az irodalomban. A 13 sz\u00e1rmaz\u00e9k in vitro antioxid\u00e1ns aktivit\u00e1s\u00e1t ABTS, FRAP \u00e9s DPPH m\u00f3dszerekkel hat\u00e1roztuk meg. A kapott sz\u00e1rmaz\u00e9kok antioxid\u00e1ns aktivit\u00e1sa er\u0151sebb, mint a naringin\u00e9. S\u0151t, a b, e, g, i, j, k, l \u00e9s m nyolc sz\u00e1rmaz\u00e9k antioxid\u00e1ns aktivit\u00e1sa k\u00fcl\u00f6n\u00f6sen jelent\u0151s, a g, i, j, k, l \u00e9s m sz\u00e1rmaz\u00e9kok antioxid\u00e1ns aktivit\u00e1sa pedig a BHT-\u00e9hoz hasonl\u00f3, ami azt jelzi, hogy az acilhidrazon csoportok reakci\u00f3val t\u00f6rt\u00e9n\u0151 bevezet\u00e9se a naringin 4-poz\u00edci\u00f3s karbonilj\u00e1ra hat\u00e9konyan fokozza az alapvegy\u00fclet antioxid\u00e1ns aktivit\u00e1s\u00e1t. A sz\u00e1rmaz\u00e9kok antioxid\u00e1ns aktivit\u00e1s\u00e1nak szerkezet-aktivit\u00e1s \u00f6sszef\u00fcgg\u00e9s elemz\u00e9s\u00e9t v\u00e9gezt\u00fck el, amely azt mutatta, hogy amikor az R csoport egy elektronelvon\u00f3 csoport volt, a sz\u00e1rmaz\u00e9kok t\u00f6lt\u00e9ss\u0171r\u0171s\u00e9ge eloszlott, \u00e9s a reakci\u00f3b\u00f3l kapott szabadgy\u00f6k intermedierek stabilit\u00e1sa megn\u0151tt, ami er\u0151sebb antioxid\u00e1ns aktivit\u00e1st eredm\u00e9nyezett, mint maga a naringin. A 8 nagy aktivit\u00e1s\u00fa sz\u00e1rmaz\u00e9k HEK293 sejtek t\u00fal\u00e9l\u00e9si ar\u00e1ny\u00e1ra gyakorolt hat\u00e1s\u00e1nak eredm\u00e9nyei azt mutatt\u00e1k, hogy az e \u00e9s m kiv\u00e9tel\u00e9vel a t\u00f6bbi sz\u00e1rmaz\u00e9k nem volt toxikus a HEK293-ra a 0-25 \u03bc mol\/l koncentr\u00e1ci\u00f3tartom\u00e1nyban. A j sz\u00e1rmaz\u00e9k sejtekre nem toxikus koncentr\u00e1ci\u00f3tartom\u00e1nya 0-100 \u03bc mol\/L, m\u00edg a g \u00e9s k sz\u00e1rmaz\u00e9kok kimutat\u00e1si eredm\u00e9nyei azt mutatj\u00e1k, hogy a 0-50 \u03bc mol\/L koncentr\u00e1ci\u00f3tartom\u00e1nyban m\u00e9g mindig nagysz\u00e1m\u00fa sejt marad \u00e9letben. A kapott sz\u00e1rmaz\u00e9kok citotoxicit\u00e1sa azonban er\u0151sebb, mint a naringin\u00e9, ami azt jelzi, hogy mik\u00f6zben az antioxid\u00e1ns aktivit\u00e1s n\u00f6vel\u00e9se \u00e9rdek\u00e9ben acilhidrazon-csoportokat vezet\u00fcnk be, a vegy\u00fclet citotoxicit\u00e1sa is megn\u0151 k\u00fcl\u00f6nb\u00f6z\u0151 szinteken. Ez referenciaalapot biztos\u00edt az adal\u00e9kanyagok adagol\u00e1s\u00e1hoz a k\u00fcl\u00f6nb\u00f6z\u0151 sz\u00e1rmaz\u00e9kok k\u00e9s\u0151bbi vizsg\u00e1latai sor\u00e1n. Ez\u00e9rt a kezdeti sz\u0171r\u00e9s ut\u00e1n a g, j \u00e9s k sz\u00e1rmaz\u00e9kok j\u00f3 antioxid\u00e1ns aktivit\u00e1ssal \u00e9s alacsony citotoxicit\u00e1ssal rendelkeznek. K\u00f6z\u00fcl\u00fck a j sz\u00e1rmaz\u00e9k er\u0151s antioxid\u00e1ns aktivit\u00e1ssal \u00e9s alacsony citotoxicit\u00e1ssal rendelkezik, \u00e9s bizonyos alkalmaz\u00e1si kil\u00e1t\u00e1sokkal rendelkezik. Ez alapot ny\u00fajt a tov\u00e1bbi fejleszt\u00e9sekhez \u00e9s kutat\u00e1sokhoz. A 13 sz\u00e1rmaz\u00e9k antioxid\u00e1ns aktivit\u00e1s\u00e1nak szerkezet-aktivit\u00e1s kapcsolat\u00e1nak elemz\u00e9se ir\u00e1nyt mutat a j\u00f6v\u0151beli szintetikus tervez\u00e9shez.<\/p>","protected":false},"excerpt":{"rendered":"

A naringin acilhidrazon-sz\u00e1rmaz\u00e9kok szint\u00e9zise, in vitro antioxid\u00e1ns aktivit\u00e1sa \u00e9s citotoxicit\u00e1sa A flavonoidok a n\u00f6v\u00e9nyvil\u00e1gban \u00e1ltal\u00e1nosan megtal\u00e1lhat\u00f3 term\u00e9szetes benzo - \u03b3 - piranon-sz\u00e1rmaz\u00e9kok oszt\u00e1lya, amelyek antibakteri\u00e1lis, antioxid\u00e1ns, immunszab\u00e1lyoz\u00f3, kemoprevent\u00edv \u00e9s r\u00e1kellenes tulajdons\u00e1gokkal rendelkeznek, \u00e9s amelyek rendk\u00edv\u00fcl el\u0151ny\u00f6sek az emberi eg\u00e9szs\u00e9g szempontj\u00e1b\u00f3l. A naringin, mint dihidroflavonoid vegy\u00fclet, olyan biol\u00f3giai tev\u00e9kenys\u00e9gekkel is rendelkezik, mint [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nSynthesis, in vitro antioxidant activity, and cytotoxicity of naringin acylhydrazone derivatives - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/naringin-acilhidrazon-szarmazekok\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synthesis, in vitro antioxidant activity, and cytotoxicity of naringin acylhydrazone derivatives - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Synthesis, in vitro antioxidant activity, and cytotoxicity of naringin acylhydrazone derivatives Flavonoids are a class of natural benzo – \u03b3 – pyranone derivatives commonly found in the plant kingdom, with antibacterial, antioxidant, immune regulatory, chemopreventive, and anticancer properties, which are highly beneficial to human health. 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