{"id":9126,"date":"2024-08-15T18:54:50","date_gmt":"2024-08-15T18:54:50","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=9126"},"modified":"2024-08-15T18:54:50","modified_gmt":"2024-08-15T18:54:50","slug":"the-n-butanol-extract-of-polygonatum-sibiricum","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/a-polygonatum-sibiricum-n-butanolos-kivonata\/","title":{"rendered":"A Polygonatum sibiricum n-butanol kivonat\u00e1b\u00f3l kivont gyullad\u00e1scs\u00f6kkent\u0151 hat\u00f3anyagok vizsg\u00e1lata"},"content":{"rendered":"<p>A Polygonatum sibiricum n-butanol kivonat\u00e1b\u00f3l kivont gyullad\u00e1scs\u00f6kkent\u0151 hat\u00f3anyagok vizsg\u00e1lata<br \/>\nAz Acanthopanax henryi (Oliv.) Harms az Araliaceae csal\u00e1dba tartoz\u00f3, 1000~3200 m\u00e9teres magass\u00e1gban, erd\u0151k vagy cserj\u00e9sek sz\u00e9l\u00e9n n\u00f6v\u0151 lombhullat\u00f3 cserje vagy fa. K\u00edna k\u00fcl\u00f6nleges n\u00f6v\u00e9nyek\u00e9nt sz\u00e9les k\u00f6rben elterjedt Hunan, Sichuan, Anhui, Zhejiang \u00e9s m\u00e1s helyeken. Az Aralia nemzets\u00e9g n\u00f6v\u00e9nyei fontos szerepet j\u00e1tszanak a hagyom\u00e1nyos gy\u00f3gy\u00e1szatban olyan orsz\u00e1gokban, mint K\u00edna, D\u00e9l-Korea \u00e9s Jap\u00e1n. Sz\u00e1raz gy\u00f6k\u00e9rk\u00e9reg \u00e9s sz\u00e1rk\u00e9rge h\u00edres hagyom\u00e1nyos gy\u00f3gyszerek, amelyeket a n\u00e9pi gy\u00f3gy\u00e1szatban \u00e1ltal\u00e1ban reuma, \u00edz\u00fcleti gyullad\u00e1s, b\u00e9nul\u00e1s, izom- \u00e9s csontf\u00e1jdalom stb. kezel\u00e9s\u00e9re haszn\u00e1lnak; leveleit \u00e1ltal\u00e1ban t\u00f6bbfunkci\u00f3s z\u00f6lds\u00e9gleves-\u00f6sszetev\u0151k\u00e9nt fogyasztj\u00e1k a teaitalokban vagy a n\u00e9pi gy\u00f3gy\u00e1szatban. A durva level\u0171 Wujia gy\u00f6k\u00e9rk\u00e9reg (m\u00e1s n\u00e9ven Wujia k\u00e9reg) szerepel a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s helyi szabv\u00e1nyaiban Hunan tartom\u00e1nyban. Hat\u00e1s\u00e1ra eloszlatja a szelet \u00e9s a nedvess\u00e9get, el\u0151seg\u00edti a v\u00e9rkering\u00e9st \u00e9s ellaz\u00edtja az inakat, szab\u00e1lyozza a qi-t \u00e9s enyh\u00edti a f\u00e1jdalmat. Els\u0151sorban reuma, zsibbad\u00e1s, izom- \u00e9s csontgyenges\u00e9g, \u00f6d\u00e9ma, traum\u00e1s s\u00e9r\u00fcl\u00e9sek, s\u00e9rv \u00e9s hasi f\u00e1jdalom kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k. El\u0151zetes kutat\u00e1saink sor\u00e1n monoterp\u00e9neket, triterpenoid szaponinokat, flavonoidokat, koffeokininsav-sz\u00e1rmaz\u00e9kokat, lign\u00e1nokat, szteroidokat, fenilpropanoidokat, diterp\u00e9neket, zs\u00edrsavakat \u00e9s egy\u00e9b vegy\u00fcleteket izol\u00e1ltunk \u00e9s azonos\u00edtottunk az Acanthopanax senticosus term\u00e9s\u00e9b\u0151l, leveleib\u0151l, gy\u00f6kereib\u0151l, gy\u00f6k\u00e9rk\u00e9regb\u0151l, sz\u00e1r\u00e1b\u00f3l \u00e9s vir\u00e1gaib\u00f3l. Ugyanakkor egym\u00e1st k\u00f6vet\u0151 vizsg\u00e1latokat v\u00e9gezt\u00fcnk \u00e9s jelent\u00e9seket k\u00e9sz\u00edtett\u00fcnk a hagyom\u00e1nyos k\u00ednai orvosl\u00e1sb\u00f3l nyert durva lev\u00e9l wujia-b\u00f3l nyert ezen monomer vegy\u00fcletekkel kapcsolatos neuroinflamm\u00e1ci\u00f3s, gyullad\u00e1scs\u00f6kkent\u0151, zs\u00edrtermel\u0151d\u00e9st g\u00e1tl\u00f3, antibakteri\u00e1lis, antioxid\u00e1ns \u00e9s acetilkolin\u00e9szter\u00e1z-ellenes aktivit\u00e1sokr\u00f3l. Az Acanthopanax senticosus gy\u00fcm\u00f6lcs\u00e9vel kapcsolatos kutat\u00e1sok azonban eddig f\u0151k\u00e9nt az etil-acet\u00e1t frakci\u00f3ra \u00f6sszpontos\u00edtottak, \u00e9s kev\u00e9s jelent\u00e9s sz\u00fcletett az n-butanolos extrakci\u00f3s frakci\u00f3j\u00e1nak anyagi alapjair\u00f3l. Tov\u00e1bbi figyelmet kell ford\u00edtani az Acanthopanax senticosus gy\u00fcm\u00f6lcs\u00e9ben tal\u00e1lhat\u00f3 er\u0151sen pol\u00e1ris k\u00e9miai komponensek tanulm\u00e1nyoz\u00e1s\u00e1ra \u00e9s felfedez\u00e9s\u00e9re.<\/p>\n<p>A lipopoliszacharid (LPS) a Gram-negat\u00edv bakt\u00e9riumsejtek k\u00fcls\u0151 fal\u00e1nak \u00f6sszetev\u0151je, amely lipidekb\u0151l \u00e9s poliszacharidokb\u00f3l (glikolipidekb\u0151l) \u00e1ll. Amikor az LPS a RAW264.7 makrof\u00e1gokon expressz\u00e1l\u00f3d\u00f3 Toll-szer\u0171 receptorokra hat, k\u00fcl\u00f6nb\u00f6z\u0151 gyullad\u00e1sos jel\u00e1tviteli utakat aktiv\u00e1l. Ezek az aktiv\u00e1lt makrof\u00e1gok gyakran nagy mennyis\u00e9g\u0171 gyullad\u00e1sos medi\u00e1torokat \u00e9s citokineket termelnek \u00e9s bocs\u00e1tanak ki, mint p\u00e9ld\u00e1ul nitrog\u00e9n-oxidot (NO), prosztaglandin E2-t (PGE2), tumor nekr\u00f3zis faktor - \u03b1-t (TNF - \u03b1), interleukinokat (IL) stb. A kor\u00e1bbi kutat\u00e1sok alapj\u00e1n, a Wujia hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat gy\u00fcm\u00f6lcs\u00e9nek gyullad\u00e1scs\u00f6kkent\u0151 anyagalapj\u00e1nak tov\u00e1bbi tiszt\u00e1z\u00e1sa \u00e9s a magas polarit\u00e1s\u00fa \u00f6sszetev\u0151iben rejl\u0151 lehet\u0151s\u00e9gek felt\u00e1r\u00e1sa \u00e9rdek\u00e9ben, e n\u00f6v\u00e9nyi er\u0151forr\u00e1s gy\u00f3gy\u00e1szati r\u00e9szeinek b\u0151v\u00edt\u00e9se \u00e9rdek\u00e9ben elv\u00e9gezt\u00fck az els\u0151 vizsg\u00e1latot a Wujia gy\u00fcm\u00f6lcs n-butanolos kivonat\u00e1nak gyullad\u00e1scs\u00f6kkent\u0151 hat\u00f3anyagair\u00f3l az LPS induk\u00e1lt RAW264.7 makrof\u00e1g modell alapj\u00e1n.<\/p>\n<p>Ez a k\u00eds\u00e9rlet az els\u0151, amely lipopoliszacharid (LPS) - induk\u00e1lt RAW264.7 makrof\u00e1got haszn\u00e1l biol\u00f3giai aktivit\u00e1s sz\u0171r\u00e9si modellk\u00e9nt az Acanthopanax senticosus gy\u00fcm\u00f6lcs\u00e9b\u0151l sz\u00e1rmaz\u00f3 n-butanolos kivonat gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s farmakol\u00f3giai anyagainak vizsg\u00e1lat\u00e1ra. 17 vegy\u00fcletet izol\u00e1ltunk \u00e9s azonos\u00edtottunk, k\u00f6zt\u00fck 3 flavonoid glikozidot, 7 koffeokinsavat \u00e9s 7 monoterpenoid glikozidot (l\u00e1sd az 1. \u00e1br\u00e1t). Az Acanthopanax senticosus gy\u00f6kerein \u00e9s gy\u00f6k\u00e9rk\u00e9reg\u00e9n vonatkoz\u00f3 kutat\u00e1sokat v\u00e9gezt\u00fcnk, \u00e9s 22 vegy\u00fcletr\u0151l sz\u00e1moltunk be, k\u00f6zt\u00fck 9 lign\u00e1nr\u00f3l, 4 koffeokininsavr\u00f3l, 3 fenolsavr\u00f3l, 2 szteroidr\u00f3l, 1 diterpenoidr\u00f3l, 1 kumarinr\u00f3l, 1 hossz\u00fa l\u00e1nc\u00fa zs\u00edrsavr\u00f3l \u00e9s 1 alkaloidr\u00f3l. A f\u0151 komponensek a lign\u00e1nok, a koffeoilkininsavak, a fenolsavak \u00e9s a szteroidok. Annak \u00e9rdek\u00e9ben, hogy tov\u00e1bb b\u0151v\u00edts\u00fck a Polygonatum sibiricum gy\u00f3gyhat\u00e1s\u00fa r\u00e9szeinek forr\u00e1sait, \u00e9s kor\u00e1bbi kutat\u00e1si alapjaink alapj\u00e1n felt\u00e1rjuk, hogy a gy\u00fcm\u00f6lcs r\u00e9szei helyettes\u00edthetik-e a hagyom\u00e1nyos gy\u00f3gy\u00e1szati r\u00e9szeit (gy\u00f6kerek) a gy\u00f3gy\u00e1szatban, 18 monomer vegy\u00fcletet izol\u00e1ltunk \u00e9s azonos\u00edtottunk a Polygonatum sibiricum term\u00e9sr\u00e9szek etil-acet\u00e1tos extrakci\u00f3j\u00e1b\u00f3l, k\u00f6zt\u00fck 5 lign\u00e1nt, 4 monoterp\u00e9nt, 2 flavonoid glikozidot, 1 fenolsavat, 1 kumarint, 1 fenilpropanoid glikozidot, 1 furfurolt, 1 maltolt, 1 fenilpropanoid glikozidot \u00e9s 1 triterpenoid glikozidot. A f\u0151 komponenst\u00edpusok a lign\u00e1nok \u00e9s a monoterp\u00e9nek; Meg\u00e1llap\u00edtottuk, hogy az Acanthopanax senticosus gy\u00fcm\u00f6lcs\u00e9nek f\u0151 farmakol\u00f3giai anyagai a flavonoidok, a koffeokinsavak, a monoterp\u00e9nek \u00e9s a lign\u00e1nok. A gy\u00fcm\u00f6lcs\u00f6k \u00e9s a gy\u00f6kerek k\u00e9miai \u00f6sszet\u00e9tel\u00e9t \u00f6sszehasonl\u00edtva kezdetben azt tal\u00e1ltuk, hogy bizonyos k\u00fcl\u00f6nbs\u00e9gek vannak az anyagi b\u00e1zisukban, ami arra utal, hogy az egyes r\u00e9szek elt\u00e9r\u0151 felhaszn\u00e1l\u00e1si c\u00e9lokat szolg\u00e1lnak. Ez\u00e9rt a felhaszn\u00e1l\u00e1sukban differenci\u00e1lni kell. Ez a cikk tov\u00e1bb gazdag\u00edtja a k\u00ednai k\u00fcl\u00f6nleges n\u00f6v\u00e9ny, az Acanthopanax senticosus k\u00e9miai konnot\u00e1ci\u00f3j\u00e1t, tudom\u00e1nyos alapot \u00e9s elm\u00e9leti hivatkoz\u00e1st biztos\u00edtva a n\u00f6v\u00e9ny tov\u00e1bbi kutat\u00e1s\u00e1hoz a j\u00f6v\u0151ben.<\/p>","protected":false},"excerpt":{"rendered":"<p>A Polygonatum sibiricum n-butanol kivonat\u00e1b\u00f3l kivont gyullad\u00e1scs\u00f6kkent\u0151 hat\u00f3anyagok vizsg\u00e1lata Az Acanthopanax henryi (Oliv.) Harms az Araliaceae csal\u00e1dba tartoz\u00f3 lombhullat\u00f3 cserje vagy fa, amely 1000~3200 m\u00e9teres magass\u00e1gban, erd\u0151k vagy bokrok sz\u00e9l\u00e9n n\u0151. K\u00edna k\u00fcl\u00f6nleges n\u00f6v\u00e9nyek\u00e9nt sz\u00e9les k\u00f6rben elterjedt Hunanban, [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on the anti-inflammatory active ingredients extracted from the n-butanol extract of Polygonatum sibiricum - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/a-polygonatum-sibiricum-n-butanolos-kivonata\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the anti-inflammatory active ingredients extracted from the n-butanol extract of Polygonatum sibiricum - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the anti-inflammatory active ingredients extracted from the n-butanol extract of Polygonatum sibiricum Acanthopanax henryi (Oliv.) Harms is a deciduous shrub or tree that grows on the edge of forests or shrubs at an altitude of 1000~3200 meters in the family Araliaceae. 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Harms is a deciduous shrub or tree that grows on the edge of forests or shrubs at an altitude of 1000~3200 meters in the family Araliaceae. As a specialty plant of China, it is widely distributed in Hunan, [&hellip;]","og_url":"https:\/\/longchangextracts.com\/hu\/a-polygonatum-sibiricum-n-butanolos-kivonata\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-15T18:54:50+00:00","author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Szerz\u0151:":"longcha9","Becs\u00fclt olvas\u00e1si id\u0151":"4 perc"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/the-n-butanol-extract-of-polygonatum-sibiricum\/","url":"https:\/\/longchangextracts.com\/the-n-butanol-extract-of-polygonatum-sibiricum\/","name":"Tanulm\u00e1ny a Polygonatum sibiricum n-butanol kivonat\u00e1b\u00f3l kivont gyullad\u00e1scs\u00f6kkent\u0151 hat\u00f3anyagokr\u00f3l - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"datePublished":"2024-08-15T18:54:50+00:00","dateModified":"2024-08-15T18:54:50+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/the-n-butanol-extract-of-polygonatum-sibiricum\/#breadcrumb"},"inLanguage":"hu","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/the-n-butanol-extract-of-polygonatum-sibiricum\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/the-n-butanol-extract-of-polygonatum-sibiricum\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Study on the anti-inflammatory active ingredients extracted from the n-butanol extract of Polygonatum sibiricum"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"K\u00edna Vegyi Gy\u00e1rt\u00f3","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/9126"}],"collection":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/comments?post=9126"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/9126\/revisions"}],"predecessor-version":[{"id":9127,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/9126\/revisions\/9127"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/media?parent=9126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/categories?post=9126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/tags?post=9126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}