{"id":9097,"date":"2024-08-15T18:35:27","date_gmt":"2024-08-15T18:35:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=9097"},"modified":"2024-08-15T18:35:27","modified_gmt":"2024-08-15T18:35:27","slug":"the-endophytic-fungus-letendraea-helminthicola-a696","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/a-letendraea-helminthicola-a696-endofita-gomba\/","title":{"rendered":"A Letendraea helminthicola A696 endofita gomba m\u00e1sodlagos metabolitjainak vizsg\u00e1lata tavaszi homokmagokban"},"content":{"rendered":"<p>A Letendraea helminthicola A696 endofita gomba m\u00e1sodlagos metabolitjainak vizsg\u00e1lata tavaszi homokmagokban<br \/>\nA k\u00ednai gy\u00f3gy\u00e1szati homokmag a Zingiberaceae n\u00f6v\u00e9nyek \u00e9rett term\u00e9s\u00e9hez tartozik, amely sz\u00e9les k\u00f6rben elterjedt D\u00e9l-K\u00edn\u00e1ban, Laoszban, Vietnamban, Kambodzs\u00e1ban \u00e9s Thaif\u00f6ld\u00f6n. A Guangdong tartom\u00e1ny Yangchun v\u00e1ros\u00e1ban (Yangchun) termesztett homokmag a legh\u00edresebb. A tavaszi homokmagok gyomornedves\u00edt\u0151, qi-szab\u00e1lyoz\u00f3 \u00e9s terhess\u00e9get stabiliz\u00e1l\u00f3 hat\u00e1s\u00faak. A tavaszi homokmagok gy\u00f6ker\u00e9n \u00e9l\u0151sk\u00f6d\u0151 endofita gomb\u00e1k szint\u00e9n kutat\u00e1si t\u00e1rgyakk\u00e1 v\u00e1ltak az \u00faj strukt\u00far\u00e1k \u00e9s jelent\u0151s tev\u00e9kenys\u00e9gek felfedez\u00e9se \u00e9rdek\u00e9ben. A n\u00f6v\u00e9nyi endofita gomb\u00e1k olyan gombafajok, amelyek n\u00f6v\u00e9nyi sz\u00f6vetekben \u00e9lnek \u00e9s egy\u00fctt \u00e9lnek a n\u00f6v\u00e9nyekkel. A n\u00f6v\u00e9nyi endofita gomb\u00e1k gazdag faji diverzit\u00e1ssal rendelkeznek, \u00e9s \u00fajszer\u0171 \u00e9s \u00f6sszetett szerkezet\u0171, v\u00e1ltozatos aktivit\u00e1s\u00fa m\u00e1sodlagos anyagcsereterm\u00e9keket k\u00e9pesek el\u0151\u00e1ll\u00edtani. Ez\u00e9rt az \u00faj term\u00e9szetes hat\u00f3anyagok felfedez\u00e9s\u00e9nek fontos forr\u00e1s\u00e1v\u00e1 v\u00e1ltak. A Letendraea helminthicola gomba ritka faj, \u00e9s kutat\u00e1si jelent\u00e9sek szerint ez a szivacsokkal rokon gombafaj k\u00e9t vegy\u00fcletet, 3-metil-N - (2-feniletil) butanamidot \u00e9s ciklo(D-Pro-D-Phe) vegy\u00fcletet termel, amelyek szennyv\u00edzszab\u00e1lyoz\u00f3 hat\u00e1ssal rendelkeznek; Huang et al. a Letendraea sp. nev\u0171 b\u00e9lgomb\u00e1b\u00f3l k\u00e9t \u00faj, fenil-dihidropir\u00e1n gy\u0171r\u0171t \u00e9s tetrahidrofur\u00e1n gy\u0171r\u0171v\u00e1zat tartalmaz\u00f3 spirociklusos poliketid sztereoizomer, a letenket\u00e1l A \u00e9s B izol\u00e1l\u00e1s\u00e1r\u00f3l sz\u00e1moltak be tengeri r\u00e1kokban. Antibakteri\u00e1lis \u00e9s daganatellenes aktivit\u00e1si vizsg\u00e1latok szinte semmilyen antibakteri\u00e1lis aktivit\u00e1st, de gyenge daganatellenes aktivit\u00e1st mutattak 40 \u03bc M-n\u00e1l; Xu \u00e9s munkat\u00e1rsai h\u00e9t \u00faj poliketid vegy\u00fcletet izol\u00e1ltak a Letendraea sp. 5XNZ4-2 tengeri eredet\u0171 gomb\u00e1b\u00f3l, nevezetesen a fomopsziketonokat D~G \u00e9s a letendronolokat A~C. K\u00f6z\u00fcl\u00fck a fomopsziketon E gyeng\u00e9bb aktivit\u00e1st mutatott a nitrog\u00e9n-oxid termel\u00e9s g\u00e1tl\u00e1s\u00e1ban lipopoliszachariddal aktiv\u00e1lt makrof\u00e1gokban. Kutat\u00f3csoportunk egy tavaszi homokmagb\u00f3l izol\u00e1lt endofita gomba, a Letendraea helminthicola A696 k\u00e9miai \u00f6sszet\u00e9tel\u00e9t, tumorellenes \u00e9s antibakteri\u00e1lis hat\u00e1s\u00e1t vizsg\u00e1lta.<\/p>\n<p>&nbsp;<\/p>\n<p>A Letendraea helminthicola gomba egy ritka mikrobafajhoz tartozik. Ez a cikk a negyedik jelent\u00e9s e gombafaj m\u00e1sodlagos anyagcsereterm\u00e9keir\u0151l. Ez a gombafaj diketopiperazinokat \u00e9s spirociklusos poliketideket termel. Ebben a tanulm\u00e1nyban nyolc monomer vegy\u00fcletet izol\u00e1ltak a tavaszi homokmagban \u00e9l\u0151 A696 endofita gomba ferment\u00e1ci\u00f3s leves\u00e9b\u0151l, gazdag\u00edtva a gomb\u00e1k e nemzets\u00e9g\u00e9nek m\u00e1sodlagos metabolitjainak t\u00edpusait. K\u00f6z\u00fcl\u00fck az 1. vegy\u00fclet egy \u00faj szeszkviterp\u00e9n vegy\u00fclet; a 2. vegy\u00fclet antioxid\u00e1ns \u00e9s az 1076 \u00e9s 1010 antioxid\u00e1nsok szint\u00e9zis\u00e9nek f\u0151 alapanyaga; a 3. \u00e9s 4. vegy\u00fclet mindkett\u0151 \u03b1-piranon szerkezet\u0171 vegy\u00fclet. A 3. vegy\u00fclet az els\u0151 term\u00e9szetes term\u00e9kekb\u0151l izol\u00e1lt \u03b1-piranon szerkezet\u0171 vegy\u00fclet, amelyet \u00e1ltal\u00e1ban a gibbepiron B-b\u0151l szintetiz\u00e1lnak; az 5., 6. \u00e9s 7. vegy\u00fclet mind kis molekul\u00e1j\u00fa arom\u00e1s benzolgy\u0171r\u0171s vegy\u00fclet; a 8. vegy\u00fclet ergoszterin, amelyet a gy\u00f3gyszerk\u00e9mi\u00e1ban a D2-vitamin prekurzorak\u00e9nt \u00e9s hormon\u00e1lis gy\u00f3gyszerek el\u0151\u00e1ll\u00edt\u00e1s\u00e1nak k\u00f6ztes term\u00e9kek\u00e9nt alkalmaznak. A bakt\u00e9rium nyers kivonata bizonyos antibakteri\u00e1lis \u00e9s tumorellenes aktivit\u00e1st mutatott, de az 1. vegy\u00fcletr\u0151l az aktivit\u00e1svizsg\u00e1lat sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy nem rendelkezik antibakteri\u00e1lis vagy tumorellenes aktivit\u00e1ssal. Val\u00f3sz\u00edn\u0171, hogy n\u00e9h\u00e1ny antibakteri\u00e1lis \u00e9s tumorellenes aktivit\u00e1ssal rendelkez\u0151 m\u00e1sodlagos metabolitot nem siker\u00fclt izol\u00e1lni a nyers kivonatb\u00f3l. Ez\u00e9rt a ferment\u00e1ci\u00f3s term\u00e9kek mennyis\u00e9ge alapj\u00e1n nagym\u00e9rt\u00e9k\u0171 ferment\u00e1ci\u00f3t lehet v\u00e9gezni az akt\u00edv m\u00e1sodlagos metabolitok kinyer\u00e9se \u00e9rdek\u00e9ben; A foly\u00e9kony ferment\u00e1ci\u00f3s folyamat ak\u00e1r 20 napig is eltartott, ami szint\u00e9n oka lehet n\u00e9h\u00e1ny szerkezetileg egyszer\u0171 alapanyagcsereterm\u00e9k el\u0151\u00e1ll\u00edt\u00e1s\u00e1nak a t\u00e1ptalajban, ami tanuls\u00e1gul szolg\u00e1l a j\u00f6v\u0151beli ferment\u00e1ci\u00f3s id\u0151tartamokhoz; M\u00e1sr\u00e9szt a vizsg\u00e1latok kimutatt\u00e1k, hogy a szeszkviterp\u00e9nek antibakteri\u00e1lis, r\u00e1kellenes, rovar\u00f6l\u0151 \u00e9s n\u00f6v\u00e9nyn\u00f6veked\u00e9st szab\u00e1lyoz\u00f3 tev\u00e9kenys\u00e9ggel rendelkeznek. A j\u00f6v\u0151ben m\u00e1s aktivit\u00e1si vizsg\u00e1latokat is el lehet v\u00e9gezni ezzel a vegy\u00fclettel, hogy felt\u00e1rj\u00e1k egy\u00e9b biol\u00f3giai aktivit\u00e1sait.<\/p>","protected":false},"excerpt":{"rendered":"<p>A Letendraea helminthicola A696 endofita gomba m\u00e1sodlagos metabolitjainak vizsg\u00e1lata tavaszi homokmagokban A k\u00ednai gy\u00f3gy\u00e1szati homokmag a Zingiberaceae n\u00f6v\u00e9nyek \u00e9rett term\u00e9se, amely sz\u00e9les k\u00f6rben elterjedt D\u00e9l-K\u00edn\u00e1ban, Laoszban, Vietnamban, Kambodzs\u00e1ban \u00e9s Thaif\u00f6ld\u00f6n. A Guangdong tartom\u00e1ny Yangchun v\u00e1ros\u00e1ban (Yangchun) termesztett homokmag a legh\u00edresebb. A tavaszi homokmagok [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on the secondary metabolites of the endophytic fungus Letendraea helminthicola A696 in spring sand kernels - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/a-letendraea-helminthicola-a696-endofita-gomba\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the secondary metabolites of the endophytic fungus Letendraea helminthicola A696 in spring sand kernels - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the secondary metabolites of the endophytic fungus Letendraea helminthicola A696 in spring sand kernels Chinese medicine sand kernel belongs to the mature fruit of Zingiberaceae plants, widely distributed in southern China, Laos, Vietnam, Cambodia, and Thailand. Yangchun sand kernels produced in Yangchun City, Guangdong Province are the most famous. Spring sand kernels have [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/hu\/a-letendraea-helminthicola-a696-endofita-gomba\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-15T18:35:27+00:00\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Szerz\u0151:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Becs\u00fclt olvas\u00e1si id\u0151\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 perc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/\",\"url\":\"https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/\",\"name\":\"Study on the secondary metabolites of the endophytic fungus Letendraea helminthicola A696 in spring sand kernels - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"datePublished\":\"2024-08-15T18:35:27+00:00\",\"dateModified\":\"2024-08-15T18:35:27+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/#breadcrumb\"},\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study on the secondary metabolites of the endophytic fungus Letendraea helminthicola A696 in spring sand kernels\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"hu\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tanulm\u00e1ny a m\u00e1sodlagos metabolitok az endofita gomba Letendraea helminthicola A696 a tavaszi homokmagok - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/hu\/a-letendraea-helminthicola-a696-endofita-gomba\/","og_locale":"hu_HU","og_type":"article","og_title":"Study on the secondary metabolites of the endophytic fungus Letendraea helminthicola A696 in spring sand kernels - China Chemical Manufacturer","og_description":"Study on the secondary metabolites of the endophytic fungus Letendraea helminthicola A696 in spring sand kernels Chinese medicine sand kernel belongs to the mature fruit of Zingiberaceae plants, widely distributed in southern China, Laos, Vietnam, Cambodia, and Thailand. Yangchun sand kernels produced in Yangchun City, Guangdong Province are the most famous. Spring sand kernels have [&hellip;]","og_url":"https:\/\/longchangextracts.com\/hu\/a-letendraea-helminthicola-a696-endofita-gomba\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-15T18:35:27+00:00","author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Szerz\u0151:":"longcha9","Becs\u00fclt olvas\u00e1si id\u0151":"3 perc"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/","url":"https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/","name":"Tanulm\u00e1ny a m\u00e1sodlagos metabolitok az endofita gomba Letendraea helminthicola A696 a tavaszi homokmagok - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"datePublished":"2024-08-15T18:35:27+00:00","dateModified":"2024-08-15T18:35:27+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/#breadcrumb"},"inLanguage":"hu","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/the-endophytic-fungus-letendraea-helminthicola-a696\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Study on the secondary metabolites of the endophytic fungus Letendraea helminthicola A696 in spring sand kernels"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"K\u00edna Vegyi Gy\u00e1rt\u00f3","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/9097"}],"collection":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/comments?post=9097"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/9097\/revisions"}],"predecessor-version":[{"id":9098,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/9097\/revisions\/9098"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/media?parent=9097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/categories?post=9097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/tags?post=9097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}