{"id":8918,"date":"2024-08-15T10:33:03","date_gmt":"2024-08-15T10:33:03","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8918"},"modified":"2024-08-15T10:33:03","modified_gmt":"2024-08-15T10:33:03","slug":"the-stem-of-niujiaogua","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/a-niujiaogua-torzse\/","title":{"rendered":"A Niujiaogua sz\u00e1r\u00e1nak k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek \u00e9s citotoxikus aktivit\u00e1s\u00e1nak vizsg\u00e1lata"},"content":{"rendered":"

A Niujiaogua sz\u00e1r\u00e1nak k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek \u00e9s citotoxikus aktivit\u00e1s\u00e1nak vizsg\u00e1lata
\nCalotropis gigantea (L.) Dry. ex Ait f. A t\u00f6r\u00f6tt b\u00e9l\u0171 f\u0171nek vagy \u00d6t kutya fekv\u0151 vir\u00e1gsz\u00edvnek is nevezett, az Asclepiadaceae csal\u00e1dba tartoz\u00f3 Calotropis nemzets\u00e9gbe tartoz\u00f3 n\u00f6v\u00e9ny. Els\u0151sorban K\u00edna, India, Vietnam, Sr\u00ed Lanka \u00e9s Mianmar egyes r\u00e9szein, valamint K\u00edna Yunnan, Hainan, Guangdong \u00e9s Sichuan tartom\u00e1nyaiban terjedt el. Alacsony fekv\u00e9s\u0171, napos lejt\u0151k\u00f6n, ny\u00edlt mez\u0151k\u00f6n \u00e9s tengerpartokon n\u0151. A Niujiaogua flegmaold\u00f3, asztmaold\u00f3, antibakteri\u00e1lis, antioxid\u00e1ns, gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s m\u00e9regtelen\u00edt\u0151 hat\u00e1s\u00fa. A bikadinnye vir\u00e1gai f\u00e1jdalomcsillap\u00edt\u00f3 hat\u00e1s\u00faak; a sz\u00e1r m\u00e1jv\u00e9d\u0151 hat\u00e1s\u00fa; a levelek hasmen\u00e9s elleni hat\u00e1s\u00faak; a tej sebgy\u00f3gyul\u00e1st el\u0151seg\u00edt\u0151 \u00e9s antibakteri\u00e1lis hat\u00e1s\u00fa. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a kroszk\u00e1n k\u00fcl\u00f6nb\u00f6z\u0151 k\u00e9miai \u00f6sszetev\u0151ket tartalmaz, t\u00f6bbek k\u00f6z\u00f6tt sz\u00edvglikozidokat, szteroidokat, triterpenoidokat \u00e9s flavonoidokat. Jelent\u0151s daganatellenes aktivit\u00e1sa miatt sz\u00e1mos tud\u00f3s izol\u00e1lta, tiszt\u00edtotta \u00e9s szerkezetileg azonos\u00edtotta a teh\u00e9nbors\u00f3 k\u00e9miai \u00f6sszetev\u0151it. A Niujiaogua n\u00f6v\u00e9ny k\u00e9miai alapjainak jobb tanulm\u00e1nyoz\u00e1sa \u00e9s biol\u00f3giai aktivit\u00e1s\u00e1nak tov\u00e1bbi jav\u00edt\u00e1sa \u00e9rdek\u00e9ben ez a tanulm\u00e1ny a Niujiaogua sz\u00e1r\u00e1nak k\u00e9miai \u00f6sszet\u00e9tel\u00e9t \u00e9s citotoxikus aktivit\u00e1s\u00e1t vizsg\u00e1lta. A Niujiaogua sz\u00e1r etanolos kivonat\u00e1nak etil-acet\u00e1t frakci\u00f3j\u00e1nak elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re k\u00fcl\u00f6nb\u00f6z\u0151 kromatogr\u00e1fi\u00e1s elv\u00e1laszt\u00e1si technik\u00e1kat alkalmaztunk, mint p\u00e9ld\u00e1ul szilikag\u00e9lt \u00e9s Sephadex LH-20-at, \u00e9s a vegy\u00fclet in vitro citotoxikus aktivit\u00e1s\u00e1t n\u00e9gyf\u00e9le tumorsejttel szemben hat\u00e1roztuk meg MTT-teszttel.<\/p>\n

T\u00edz vegy\u00fcletet izol\u00e1ltak a szarvast\u00f6k sz\u00e1r\u00e1b\u00f3l, amelyek k\u00f6z\u00fcl az 1., 3., 4. \u00e9s 6-8. vegy\u00fcletet izol\u00e1lt\u00e1k el\u0151sz\u00f6r ebb\u0151l a n\u00f6v\u00e9nyb\u0151l. Ezek k\u00f6z\u00fcl az 1-4 vegy\u00fcletek lign\u00e1nok, a 8-10 vegy\u00fcletek pedig fenolos vegy\u00fcletek. Az 1-10 vegy\u00fcletek citotoxikus aktivit\u00e1s\u00e1t n\u00e9gyf\u00e9le daganatt\u00edpussal szemben vizsg\u00e1lt\u00e1k, \u00e9s az eredm\u00e9nyek azt mutatt\u00e1k, hogy a 4. \u00e9s 5. vegy\u00fcleteknek k\u00fcl\u00f6nb\u00f6z\u0151 m\u00e9rt\u00e9k\u0171 citotoxikus aktivit\u00e1sa volt a n\u00e9gyf\u00e9le daganatsejttel szemben, az IC50 \u00e9rt\u00e9kek 12,37-49,29, illetve 0,29-0,98 \u03bc M k\u00f6z\u00f6tt mozogtak. A t\u00f6bbi vegy\u00fclet nem mutatott jelent\u0151s aktivit\u00e1st. Az irodalmi jelent\u00e9sek szerint a 4. vegy\u00fclet gyenge citotoxikus aktivit\u00e1ssal rendelkezik az SK-OV-3 hum\u00e1n petef\u00e9szekr\u00e1kos sejtvonallal szemben. Az 5. vegy\u00fclet, a fruktozid, a szarvast\u00f6k f\u0151 sz\u00edvglikozid komponense, amely a kivonat tartalm\u00e1nak t\u00f6bb mint 2,8%-j\u00e9t teszi ki, \u00e9s er\u0151s citotoxikus aktivit\u00e1ssal rendelkezik k\u00fcl\u00f6nb\u00f6z\u0151 tumorsejtekkel szemben. A leg\u00fajabb vizsg\u00e1latok kimutatt\u00e1k, hogy a fruktozid k\u00e9pes mitokondri\u00e1lis k\u00f6zvet\u00edt\u00e9s\u0171 apopt\u00f3zist induk\u00e1lni a melanomasejtekben, ami seg\u00edthet a melanoma megel\u0151z\u00e9s\u00e9ben. Ez arra utal, hogy a vegy\u00fcletnek sz\u00e1mos potenci\u00e1lis, m\u00e9g nem kifejlesztett, tov\u00e1bbi kutat\u00e1sra \u00e9rdemes hat\u00e1sa lehet.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Chemical Composition and Cytotoxic Activity of the Stem of Niujiaogua Calotropis gigantea (L.) Dry. ex Ait f. Also known as the Broken Intestine Grass or the Five Dog Lying Flower Heart, it is a plant of the Calotropis genus in the Asclepiadaceae family. It is mainly distributed in parts of China, India, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Chemical Composition and Cytotoxic Activity of the Stem of Niujiaogua - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/a-niujiaogua-torzse\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Chemical Composition and Cytotoxic Activity of the Stem of Niujiaogua - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Chemical Composition and Cytotoxic Activity of the Stem of Niujiaogua Calotropis gigantea (L.) 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