{"id":8807,"date":"2024-08-14T20:14:03","date_gmt":"2024-08-14T20:14:03","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8807"},"modified":"2024-08-14T20:14:03","modified_gmt":"2024-08-14T20:14:03","slug":"endophytic-fungus-phomopsis-prunorum-in-camellia-sinensis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/endofita-gomba-phomopsis-prunorum-a-camellia-sinensisben\/","title":{"rendered":"A Phomopsis prunorum endofita gomba m\u00e1sodlagos metabolitjainak \u00e9s \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1s\u00e1nak vizsg\u00e1lata a Camellia sinensisben."},"content":{"rendered":"

A Phomopsis prunorum endofita gomba m\u00e1sodlagos metabolitjainak \u00e9s \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1s\u00e1nak vizsg\u00e1lata a Camellia sinensisben.
\nA Phomopsis gomb\u00e1k a n\u00f6v\u00e9nyi patog\u00e9nek gyakori t\u00edpusai, amelyek s\u00falyos betegs\u00e9geket okozhatnak k\u00fcl\u00f6nb\u00f6z\u0151 n\u00f6v\u00e9nyekben; ek\u00f6zben e nemzets\u00e9g egyes fajai fontos endofita gomb\u00e1k is, amelyek a term\u00e9szetben a legt\u00f6bb n\u00f6v\u00e9nyben sz\u00e9les k\u00f6rben jelen vannak. A Phomopsis gomb\u00e1k, mint endofitikus gomb\u00e1k a n\u00f6v\u00e9nyekben, akt\u00edv m\u00e1sodlagos metabolitok sokf\u00e9le v\u00e1ltozat\u00e1t k\u00e9pesek el\u0151\u00e1ll\u00edtani, bele\u00e9rtve az \u03b1-piranont, terp\u00e9neket, alkaloidokat \u00e9s sejtlaz\u00edt\u00f3 szereket. Ezek a vegy\u00fcletek nemcsak farmakol\u00f3giai aktivit\u00e1st mutatnak, mint p\u00e9ld\u00e1ul gombaellenes, daganatellenes, neuroprotekt\u00edv \u00e9s \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00e1s, hanem sejtn\u00f6veked\u00e9s-szab\u00e1lyoz\u00f3k\u00e9nt is felhaszn\u00e1lhat\u00f3k. Sz\u00e9lesk\u00f6r\u0171 alkalmaz\u00e1si lehet\u0151s\u00e9geik vannak az orvostudom\u00e1ny \u00e9s a mez\u0151gazdas\u00e1g ter\u00fclet\u00e9n.
\nA Hypericum ascyron L. a Primulaceae csal\u00e1dba, a Hypericum nemzets\u00e9gbe tartoz\u00f3 n\u00f6v\u00e9ny. Gy\u00f3gyn\u00f6v\u00e9nyk\u00e9nt haszn\u00e1lj\u00e1k, v\u00e9rz\u00e9scsillap\u00edt\u00f3, f\u00e1jdalomcsillap\u00edt\u00f3, antibakteri\u00e1lis \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00fa. A Camellia sinensis k\u00e9miai \u00f6sszet\u00e9tel\u00e9r\u0151l m\u00e1r sz\u00fclettek jelent\u00e9sek, amelyek f\u0151k\u00e9nt flavonoidokat, terp\u00e9neket \u00e9s policiklusos poliizopr\u00e9n-szubsztitu\u00e1lt trifenilfenolokat tartalmaznak. A Camellia sinensis endofita gomb\u00e1inak m\u00e1sodlagos anyagcsereterm\u00e9keir\u0151l azonban kev\u00e9s jelent\u00e9s sz\u00fcletett. Kutat\u00f3csoportunk egy endofita gomb\u00e1t, a Phomopsis prunorumot (F4-3) a Shennongjia ter\u00fcleten l\u00e9v\u0151 Camellia sinensis n\u00f6v\u00e9nyek leveleib\u0151l nyert korai st\u00e1diumban. Kisl\u00e9pt\u00e9k\u0171 ferment\u00e1ci\u00f3 \u00e9s termeszt\u00e9s ut\u00e1n meg\u00e1llap\u00edtottuk, hogy a rizs ferment\u00e1ci\u00f3s term\u00e9kei a szerkezeti t\u00edpusok gazdag v\u00e1ltozatoss\u00e1g\u00e1t mutatt\u00e1k. Kor\u00e1bbi kutat\u00e1sok ezen a gomb\u00e1n P A prunorumban (F4-3) \u00faj mirha-szeszkviterp\u00e9neket \u00e9s izokumarinokat fedeztek fel, amelyek j\u00f3 aktivit\u00e1st mutattak a mez\u0151gazdas\u00e1gi patog\u00e9n bakt\u00e9riumokkal szemben. Ez a tanulm\u00e1ny tov\u00e1bb vizsg\u00e1lja a gomb\u00e1t P A prunorum (F4-3) rizsferment\u00e1ci\u00f3s term\u00e9keivel kapcsolatos kutat\u00e1sokat v\u00e9geztek, \u00e9s az izol\u00e1lt m\u00e1sodlagos metabolitok biol\u00f3giai aktivit\u00e1s\u00e1t \u00e9rt\u00e9kelt\u00e9k, hogy \u00faj szerkezeti t\u00edpusokkal \u00e9s jelent\u0151s farmakol\u00f3giai aktivit\u00e1ssal rendelkez\u0151 vegy\u00fcleteket fedezzenek fel.<\/p>\n

Ebben a tanulm\u00e1nyban szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1t, g\u00e9l oszlopkromatogr\u00e1fi\u00e1t \u00e9s f\u00e9lpreparat\u00edv HPLC-t haszn\u00e1ltak a P Hat m\u00e1sodlagos metabolitot izol\u00e1ltak a prunorumb\u00f3l (F4-3), k\u00f6zt\u00fck k\u00e9t \u00faj \u03b1-piranon vegy\u00fcletet \u00e9s k\u00e9t ismert dibenzo \u03b1-piranon vegy\u00fcletet, egy izokumarin vegy\u00fcletet \u00e9s egy alkaloid vegy\u00fcletet. Az 1. \u00e9s 2. \u03b1 - piranonvegy\u00fcletek oldall\u00e1ncszerkezete egyar\u00e1nt tartalmaz szomsz\u00e9dos dihidroxi fragmentumokat, \u00e9s a 4-6. vegy\u00fcleteket el\u0151sz\u00f6r izol\u00e1lt\u00e1k ebb\u0151l a gombafajb\u00f3l. A farmakol\u00f3giai aktivit\u00e1s \u00e9rt\u00e9kel\u00e9se azt mutatta, hogy csak a 3. vegy\u00fcletnek volt m\u00e9rs\u00e9kelt alfa-gl\u00fckozid\u00e1z g\u00e1tl\u00f3 hat\u00e1sa, m\u00edg az 1-6. vegy\u00fcletek nem mutattak jelent\u0151s antibakteri\u00e1lis aktivit\u00e1st. Az irodalmi jelent\u00e9sek szerint a 3. vegy\u00fclet bizonyos citotoxikus aktivit\u00e1st \u00e9s DPPH-gy\u00f6kfog\u00f3 aktivit\u00e1st is mutat (IC50 46,5 \u03bc M), \u00e9s gyenge antibakteri\u00e1lis aktivit\u00e1st mutat k\u00fcl\u00f6nb\u00f6z\u0151 n\u00f6v\u00e9nyi k\u00f3rokoz\u00f3kkal szemben. Ebben a vizsg\u00e1latban nem izol\u00e1ltak olyan vegy\u00fcleteket, amelyek k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek szerkezete hasonl\u00f3 a Camellia sinensis\u00e9hoz. Ennek oka az lehet, hogy a m\u00e1sodlagos metabolitok szint\u00e9zis\u00e9hez kapcsol\u00f3d\u00f3 sz\u00e1mos g\u00e9nklaszter eln\u00e9mul a norm\u00e1l laborat\u00f3riumi teny\u00e9szt\u00e9si k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt. A j\u00f6v\u0151ben k\u00eds\u00e9rleteket tesz\u00fcnk arra, hogy a bakt\u00e9riumt\u00f6rzsekben az eln\u00e9m\u00edtott g\u00e9nek kifejez\u0151d\u00e9s\u00e9t a t\u00e1ptalaj t\u00edpus\u00e1nak megv\u00e1ltoztat\u00e1s\u00e1val vagy k\u00e9miai epigenetikai m\u00f3dos\u00edt\u00f3k hozz\u00e1ad\u00e1s\u00e1val induk\u00e1ljuk a t\u00e1ptalajhoz, hogy n\u00f6velj\u00fck a m\u00e1sodlagos metabolitok szerkezet\u00e9nek v\u00e1ltozatoss\u00e1g\u00e1t \u00e9s jav\u00edtsuk az \u00faj \u00e9s akt\u00edv vegy\u00fcletek felfedez\u00e9s\u00e9nek val\u00f3sz\u00edn\u0171s\u00e9g\u00e9t.<\/p>","protected":false},"excerpt":{"rendered":"

Study on secondary metabolites and \u03b1 – glucosidase inhibitory activity of endophytic fungus Phomopsis prunorum in Camellia sinensis Phomopsis fungi are a common type of plant pathogen that can cause serious diseases in various crops; Meanwhile, some species within this genus are also important endophytic fungi, widely present in most plants in nature. Phomopsis fungi, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on secondary metabolites and \u03b1 - glucosidase inhibitory activity of endophytic fungus Phomopsis prunorum in Camellia sinensis - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/endofita-gomba-phomopsis-prunorum-a-camellia-sinensisben\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on secondary metabolites and \u03b1 - glucosidase inhibitory activity of endophytic fungus Phomopsis prunorum in Camellia sinensis - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on secondary metabolites and \u03b1 – glucosidase inhibitory activity of endophytic fungus Phomopsis prunorum in Camellia sinensis Phomopsis fungi are a common type of plant pathogen that can cause serious diseases in various crops; Meanwhile, some species within this genus are also important endophytic fungi, widely present in most plants in nature. 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