{"id":8759,"date":"2024-08-14T19:52:02","date_gmt":"2024-08-14T19:52:02","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8759"},"modified":"2024-08-14T19:52:02","modified_gmt":"2024-08-14T19:52:02","slug":"yunnan-guna-xiang","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/yunnan-guna-xiang\/","title":{"rendered":"A Yunnan Guna Xiang daganatellenes k\u00e9miai \u00f6sszetev\u0151inek vizsg\u00e1lata"},"content":{"rendered":"

A Yunnan Guna Xiang daganatellenes k\u00e9miai \u00f6sszetev\u0151inek vizsg\u00e1lata
\nA licsif\u00e9l\u00e9k csal\u00e1dj\u00e1ba tartoz\u00f3 Goniothalamus n\u00f6v\u00e9nyeknek mintegy 160 faja tal\u00e1lhat\u00f3 \u00c1zsia tr\u00f3pusi \u00e9s szubtr\u00f3pusi r\u00e9gi\u00f3iban. Ezt a n\u00f6v\u00e9nyfajt D\u00e9l-\u00c1zsia sz\u00e1mos orsz\u00e1g\u00e1ban reuma-, \u00f6d\u00e9ma- \u00e9s abortuszgy\u00f3gyszerk\u00e9nt, K\u00edna d\u00e9li tartom\u00e1nyaiban \u00e9s r\u00e9gi\u00f3iban pedig f\u00e1jdalomcsillap\u00edt\u00f3, m\u00e9regtelen\u00edt\u0151, rovar\u00f6l\u0151, v\u00e9rhas- \u00e9s mal\u00e1riaellenes szerk\u00e9nt haszn\u00e1lj\u00e1k. K\u00edn\u00e1ban a Gonna nemzets\u00e9ghez tartoz\u00f3 n\u00f6v\u00e9nyeknek 10 faja tal\u00e1lhat\u00f3, amelyek f\u0151k\u00e9nt Guangxi, Yunnan, Hainan \u00e9s Tajvan tartom\u00e1nyokban \u00e9s r\u00e9gi\u00f3kban terjednek el. Jelenleg hazai \u00e9s k\u00fclf\u00f6ldi tud\u00f3sok olyan komponenseket fedeztek fel a Colubrica nemzets\u00e9g n\u00f6v\u00e9nyeib\u0151l, mint a sztirol-lakton, alkaloidok, terp\u00e9nek, flavonoidok \u00e9s kumarin. K\u00f6z\u00fcl\u00fck a kumarin \u00e9s a sztirol-lakton a Colubrica nemzets\u00e9g n\u00f6v\u00e9nyeinek jellegzetes \u00f6sszetev\u0151i, amelyek er\u0151s daganatellenes aktivit\u00e1ssal rendelkeznek, \u00e9s a \"holnapi r\u00e1kellenes holnap csillagai\" n\u00e9ven ismertek.
\nA G. yunnanensis, m\u00e1s n\u00e9ven Yunnan Yunnanensis az Annonaceae csal\u00e1dba tartoz\u00f3, K\u00edn\u00e1ban endemikus n\u00f6v\u00e9nyfaj. A 350 m\u00e9teres tengerszint feletti magass\u00e1g\u00fa ter\u00fcleteken, t\u00f6bbnyire hegyi erd\u0151k alatt n\u0151, els\u0151sorban Yunnanban \u00e9s K\u00edna m\u00e1s r\u00e9szein elterjedt. Jelenleg nincsenek kutat\u00e1si jelent\u00e9sek a Yunnanxiang k\u00e9miai \u00f6sszet\u00e9tel\u00e9r\u0151l \u00e9s biol\u00f3giai aktivit\u00e1s\u00e1r\u00f3l. A Yunnanxiangban tal\u00e1lhat\u00f3 bioakt\u00edv anyagok felt\u00e1r\u00e1sa \u00e9rdek\u00e9ben a kutat\u00f3csoport tanulm\u00e1nyokat v\u00e9gzett a Yunnanxiang k\u00e9miai \u00f6sszet\u00e9tel\u00e9r\u0151l \u00e9s in vitro daganatellenes hat\u00e1sair\u00f3l, hogy tudom\u00e1nyos alapot biztos\u00edtson az \u00e9rt\u00e9kes vadon \u00e9l\u0151 n\u00f6v\u00e9nyi er\u0151forr\u00e1sok felhaszn\u00e1l\u00e1s\u00e1hoz \u00e9s a daganatellenes gy\u00f3gyszerek fejleszt\u00e9s\u00e9hez K\u00edn\u00e1ban.<\/p>\n

Ez a k\u00eds\u00e9rlet a Yunnan Konaxiangb\u00f3l sz\u00e1rmaz\u00f3 etanolos kivonat k\u00e9miai \u00f6sszet\u00e9tel\u00e9t \u00e9s in vitro tumorellenes aktivit\u00e1s\u00e1t vizsg\u00e1lta. Tizenkilenc vegy\u00fcletet izol\u00e1ltak \u00e9s azonos\u00edtottak, k\u00f6zt\u00fck alkaloidokat (1-9, 18), sztirol-laktonokat (10-12), flavonoidokat (13) \u00e9s triterpenoidokat (19). Valamennyi vegy\u00fcletet el\u0151sz\u00f6r izol\u00e1lt\u00e1k ebb\u0151l a n\u00f6v\u00e9nyb\u0151l, \u00e9s kilenc vegy\u00fclet citotoxikus aktivit\u00e1s\u00e1t vizsg\u00e1lt\u00e1k a HCC1806, HCT116 \u00e9s Hela hum\u00e1n tumorsejtvonalakon SRB-m\u00f3dszerrel. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a 7. \u00e9s 12. vegy\u00fcletek jelent\u0151s citotoxikus aktivit\u00e1st mutattak h\u00e1rom hum\u00e1n tumorsejtvonallal szemben, a 12. sztirol-lakton vegy\u00fclet a 7. aporfin-alkaloid vegy\u00fclethez \u00e9s a 13. flav\u00e1n vegy\u00fclethez k\u00e9pest jobb citotoxikus aktivit\u00e1st mutatott a h\u00e1rom hum\u00e1n tumorsejtvonallal szemben. A 12 vegy\u00fclet pedig el\u0151sz\u00f6r mutatott jelent\u0151s g\u00e1tl\u00f3 hat\u00e1st a HCC1806 \u00e9s HCT116 r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1ra, 5,2 \u00b1 0,7 \u00e9s 3,1 \u00b1 0,5 \u03bc M IC50 \u00e9rt\u00e9kkel.
\nA sztirol-laktonvegy\u00fcletek a Colubriaceae csal\u00e1dba tartoz\u00f3 n\u00f6v\u00e9nyek jellegzetes \u00f6sszetev\u0151i, \u00e9s sz\u00e9les k\u00f6rben jelen vannak a Colubriaceae nemzets\u00e9g n\u00f6v\u00e9nyeiben. A goniothalamin az els\u0151 sztirol-laktonvegy\u00fclet, amelyet Hlubucek \u00e9s Robertson izol\u00e1lt a Cryptocaryacalooneura k\u00e9rg\u00e9b\u0151l, \u00e9s egyben az els\u0151 sztirol-laktonvegy\u00fclet, amelyet a Goniothalamin nemzets\u00e9g n\u00f6v\u00e9nyeib\u0151l izol\u00e1ltak. A goniothalamint el\u0151sz\u00f6r embri\u00f3toxikus vegy\u00fcletk\u00e9nt fedezt\u00e9k fel, de k\u00e9s\u0151bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy ez a vegy\u00fclet j\u00f3 daganatellenes aktivit\u00e1ssal \u00e9s citotoxikus hat\u00e1ssal rendelkezik, \u00e9s jelent\u0151s hat\u00e1st fejt ki gyomorr\u00e1k (HGC-27), eml\u0151r\u00e1k (MCF-7 T47D\u3001MDA-MB-231) \u3001 leuk\u00e9mia (HL-60) eset\u00e9n, petef\u00e9szekr\u00e1k (Caov-3) \u00e9s m\u00e1s r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1ra jelent\u0151s g\u00e1tl\u00f3 hat\u00e1st fejt ki, \u00e9s a goniothalamin Ehrlich-tumoros egereknek t\u00f6rt\u00e9n\u0151 bead\u00e1sa ut\u00e1n nem \u00e9szleltek toxicit\u00e1sra utal\u00f3 jeleket, ami azt jelzi, hogy a goniothalamin j\u00f3 biokompatibilit\u00e1ssal rendelkezik, azaz mell\u00e9khat\u00e1sok n\u00e9lk\u00fcl g\u00e1tolja a tumor n\u00f6veked\u00e9s\u00e9t; A goniothalamin els\u0151sorban a r\u00e1kos sejtciklust szab\u00e1lyozza, \u00e9s oxidat\u00edv stresszv\u00e1laszon \u00e9s kaszp\u00e1z aktiv\u00e1l\u00e1son kereszt\u00fcl a r\u00e1kos sejtek apopt\u00f3zis\u00e1t id\u00e9zi el\u0151. Ebben a cikkben tal\u00e1lt\u00e1k meg el\u0151sz\u00f6r, hogy a goniothalamin (12) vegy\u00fclet jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal van a HCC1806 \u00e9s HCT116 r\u00e1kos sejtvonalak prolifer\u00e1ci\u00f3j\u00e1ra, ami k\u00eds\u00e9rleti bizony\u00edt\u00e9kot szolg\u00e1ltat a daganatellenes gy\u00f3gyszerek tervez\u00e9s\u00e9hez \u00e9s fejleszt\u00e9s\u00e9hez.
\n\u00d6sszefoglalva, ez a tanulm\u00e1ny elv\u00e9gezte az els\u0151 kutat\u00e1st a Yunnan GeNa Xiang k\u00e9miai \u00f6sszet\u00e9tel\u00e9r\u0151l \u00e9s tumorellenes aktivit\u00e1s\u00e1r\u00f3l, \u00e9s el\u0151zetesen tiszt\u00e1zta a Yunnan GeNa Xiang tumorellenes aktivit\u00e1s\u00e1nak farmakol\u00f3giai anyag\u00e1nak alapj\u00e1t, bizonyos k\u00eds\u00e9rleti alapot biztos\u00edtva a Yunnan GeNa Xiang fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz a tumorellenes ter\u00fcleten.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the anti-tumor chemical components of Yunnan Guna Xiang There are about 160 species of Goniothalamus plants in the family Lychee, distributed in tropical and subtropical regions of Asia. This plant species is commonly used as a rheumatism, edema, and abortion medicine in many countries in South Asia, and as an analgesic, detoxifying, insecticidal, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the anti-tumor chemical components of Yunnan Guna Xiang - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/yunnan-guna-xiang\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the anti-tumor chemical components of Yunnan Guna Xiang - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the anti-tumor chemical components of Yunnan Guna Xiang There are about 160 species of Goniothalamus plants in the family Lychee, distributed in tropical and subtropical regions of Asia. 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