{"id":8711,"date":"2024-08-14T19:20:56","date_gmt":"2024-08-14T19:20:56","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8711"},"modified":"2024-08-14T19:20:56","modified_gmt":"2024-08-14T19:20:56","slug":"streptomyces-ardus-ws-65090-and-their-biological-activities","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/streptomyces-ardus-ws-65090-es-biologiai-aktivitasuk\/","title":{"rendered":"A Streptomyces ardus WS-65090 \u00e1ltal termelt teleocidin vegy\u00fcletek \u00e9s biol\u00f3giai aktivit\u00e1suk vizsg\u00e1lata"},"content":{"rendered":"

A Streptomyces ardus WS-65090 \u00e1ltal termelt teleocidin vegy\u00fcletek \u00e9s biol\u00f3giai aktivit\u00e1suk vizsg\u00e1lata
\nA mikroorganizmusok nagy mennyis\u00e9g\u0171 vezet\u0151 vegy\u00fcletforr\u00e1st biztos\u00edtanak a gy\u00f3gyszerek \u00e9s peszticidek fejleszt\u00e9s\u00e9hez. A Streptomyces az aktinomicit\u00e1k egyik f\u0151 csoportja, amely v\u00e1ltozatos m\u00e1sodlagos metabolitszerkezettel \u00e9s jelent\u0151s biol\u00f3giai aktivit\u00e1ssal rendelkezik. Sz\u00e1mos antibiotikum \u00e9s potenci\u00e1lis gy\u00f3gyszerforr\u00e1s forr\u00e1sak\u00e9nt tartj\u00e1k sz\u00e1mon. Az ut\u00f3bbi \u00e9vekben a Streptomycesb\u0151l j\u00f3 biol\u00f3giai aktivit\u00e1s\u00fa metabolitokat fedeztek fel, mint p\u00e9ld\u00e1ul az aldgamycin P, egy \u00faj makrociklikus lipidvegy\u00fclet, amelyet a Streptomyces sp. KIB-K1-b\u0151l izol\u00e1ltak, \u00e9s amely 7,81 \u03bc g\/ml MIC-\u00e9rt\u00e9kkel jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal van a Staphylococcus aureusra. Az endosztemonin A-J vegy\u00fcletek \u00fajonnan jelentett term\u00e9szetes pirrol-2-karboxil\u00e1t-sz\u00e1rmaz\u00e9kok, amelyeket el\u0151sz\u00f6r izol\u00e1ltak \u00e9s azonos\u00edtottak a Streptomyces BS-1 t\u00f6rzsb\u0151l. Er\u0151s let\u00e1lis hat\u00e1st mutatnak a gyapot lev\u00e9ltetvek ellen, 72 \u00f3r\u00e1s LC50 \u00e9rt\u00e9k\u00fck 3,55-32,00 mg\/l k\u00f6z\u00f6tt mozog.
\nAz aktinomicit\u00e1k akt\u00edv metabolitjainak keres\u00e9se sor\u00e1n meg\u00e1llap\u00edtottuk, hogy a Streptomyces ardus WS65090 ferment\u00e1lt kivonata j\u00f3 rovar\u00f6l\u0151 hat\u00e1ssal rendelkezik. Akt\u00edv metabolitjainak tiszt\u00e1z\u00e1sa \u00e9rdek\u00e9ben izol\u00e1ltuk \u00e9s tiszt\u00edtottuk, \u00e9s n\u00e9h\u00e1ny teleocidin vegy\u00fcletet nyert\u00fcnk. A teleocidint el\u0151sz\u00f6r 1960-ban izol\u00e1lt\u00e1k toxikus anyagk\u00e9nt a mediterr\u00e1n Streptomyces mic\u00e9lium\u00e1nak metanolos kivonat\u00e1b\u00f3l. Egyedi indol-lakt\u00e1m v\u00e1zzal rendelkezik, A1, A2, B-1, B-2, B-3 \u00e9s B-46 sztereoizomerekkel, \u00e9s nagy figyelmet keltett egyedi szerkezete \u00e9s v\u00e1ltozatos biol\u00f3giai aktivit\u00e1sa miatt. Jelenleg k\u00fcl\u00f6nb\u00f6z\u0151 teleocidin szerkezet\u0171 vegy\u00fcleteket izol\u00e1ltak mikroorganizmusokb\u00f3l, mint p\u00e9ld\u00e1ul a lyngbyatoxin A~C, olivoretin A~C, 14-O - (N-acetilgl\u00fckozaminil) teleocidin A \u00e9s 2-oxo teleocidin A1. Ezek a vegy\u00fcletek fontos biol\u00f3giai aktivit\u00e1st mutatnak, mint p\u00e9ld\u00e1ul b\u0151rirrit\u00e1l\u00f3, tumorpromotorok, PKC-aktiv\u00e1torok \u00e9s citotoxikus aktivit\u00e1s. Az ebben a tanulm\u00e1nyban k\u00f6z\u00f6lt \u00faj teleocidin B-oszt\u00e1ly\u00fa anal\u00f3gok \u00e9s rovar\u00f6l\u0151 \u00e9s citotoxikus aktivit\u00e1suk gazdag\u00edtja az ilyen vegy\u00fcletek szerkezeti t\u00edpusait \u00e9s aktivit\u00e1s\u00e1t, valamint a Streptomyces akt\u00edv metabolitjainak t\u00edpusait, alapvet\u0151 adatokat szolg\u00e1ltatva a mez\u0151gazdas\u00e1gi kutat\u00e1sukhoz.<\/p>\n

\u00d6t teleocidin vegy\u00fcletet izol\u00e1ltak a Streptomyces ardus WS-65090 ferment\u00e1lt kivonat\u00e1b\u00f3l, amelyek mindegyike rovar\u00f6l\u0151 \u00e9s citotoxikus hat\u00e1s\u00fa. K\u00f6z\u00fcl\u00fck a 14-O-acetil-toleocidin B-2 (1) \u00faj vegy\u00fclet, a 14-O-acetil-toleocidin B-3 (2) pedig \u00faj term\u00e9szetes term\u00e9k, \u00e9s el\u0151sz\u00f6r dolgozt\u00e1k ki a nukle\u00e1ris m\u00e1gneses rezonancia spektrum\u00e1nak adatait. Az elm\u00falt \u00e9vekben ez az els\u0151 alkalom, hogy talajb\u00f3l sz\u00e1rmaz\u00f3 Streptomyces-t\u00f6rzsekb\u0151l izol\u00e1ltak olyan teleocidin B-t\u00edpus\u00fa vegy\u00fcleteket, amelyek rovar\u00f6l\u0151 hat\u00e1s\u00faak az \u0151szi p\u00e1nc\u00e9lf\u00e9rgek, a gyapottok-bolyv\u00e1k, a gy\u00e9m\u00e1ntmolyok \u00e9s a lev\u00e9ltetvek ellen. R\u00e1ad\u00e1sul ez a k\u00e9t \u00faj teleocidin-anal\u00f3g C-14-ben acetilcsoportot tartalmaz, \u00e9s rovar\u00f6l\u0151 hat\u00e1suk er\u0151sebb, mint a h\u00e1rom ismert vegy\u00fclet\u00e9. A citotoxikus aktivit\u00e1s k\u00eds\u00e9rleti eredm\u00e9nyei alapj\u00e1n bebizonyosodott, hogy a teleocidin anal\u00f3gok C-14-es poz\u00edci\u00f3j\u00e1ban l\u00e9v\u0151 acetilcsoport jelent\u0151s hat\u00e1ssal van biol\u00f3giai aktivit\u00e1sukra. A teleocidin vegy\u00fcletek biol\u00f3giai aktivit\u00e1sa els\u0151sorban a gy\u00f3gy\u00e1szati tev\u00e9kenys\u00e9gekre \u00f6sszpontos\u00edt. Az ebben a tanulm\u00e1nyban k\u00f6z\u00f6lt vegy\u00fcletek gazdag\u00edtj\u00e1k a teleocidin vegy\u00fcletek t\u00edpusait, b\u0151v\u00edtik biol\u00f3giai aktivit\u00e1sukat, \u00e9s felt\u00e1r\u00e1st ny\u00fajtanak a mez\u0151gazdas\u00e1gban v\u00e9gzett kutat\u00e1saikhoz.<\/p>","protected":false},"excerpt":{"rendered":"

Study on teleocidin compounds produced by Streptomyces ardus WS-65090 and their biological activities Microorganisms provide a large amount of lead compound resources for the development of drugs and pesticides. Streptomyces is a major group of actinomycetes, with diverse secondary metabolite structures and significant biological activity. It is considered a source of many antibiotics and potential […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on teleocidin compounds produced by Streptomyces ardus WS-65090 and their biological activities - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/streptomyces-ardus-ws-65090-es-biologiai-aktivitasuk\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on teleocidin compounds produced by Streptomyces ardus WS-65090 and their biological activities - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on teleocidin compounds produced by Streptomyces ardus WS-65090 and their biological activities Microorganisms provide a large amount of lead compound resources for the development of drugs and pesticides. 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