{"id":8662,"date":"2024-08-14T18:54:57","date_gmt":"2024-08-14T18:54:57","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8662"},"modified":"2024-08-14T18:54:57","modified_gmt":"2024-08-14T18:54:57","slug":"two-new-lignans-in-rhododendron-grandiflorum","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/ket-uj-lignan-a-rododendron-grandiflorumban\/","title":{"rendered":"K\u00e9t \u00faj lign\u00e1n a Rhododendron grandiflorumban"},"content":{"rendered":"

K\u00e9t \u00faj lign\u00e1n a Rhododendron grandiflorumban
\nA Rhododendron minutiflorum, m\u00e1s n\u00e9ven karcs\u00fa rododendron vagy karcs\u00fa gr\u00e1n\u00e1talma vir\u00e1g, a Rhododendron csal\u00e1dba tartoz\u00f3 Rhododendron L. n\u00f6v\u00e9ny. \u00c1ltal\u00e1ban 1120-1430 m tengerszint feletti magass\u00e1gban tal\u00e1lhat\u00f3 dombvid\u00e9ken, \u00e9s f\u0151k\u00e9nt K\u00edna Guangxi \u00e9s Guangdong tartom\u00e1nyaiban termesztik. A nemzets\u00e9g sz\u00e1mos n\u00f6v\u00e9nye nagy gy\u00f3gy\u00e1szati \u00e9s gazdas\u00e1gi \u00e9rt\u00e9kkel b\u00edr, mint p\u00e9ld\u00e1ul az R. molle, amely gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3 farmakol\u00f3giai hat\u00e1ssal rendelkezik, \u00e9s olyan betegs\u00e9gek kezel\u00e9s\u00e9re haszn\u00e1lhat\u00f3, mint a reum\u00e1s \u00edz\u00fcleti gyullad\u00e1s \u00e9s a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gek; az R. athopogonoide, egy \u00e1ltal\u00e1nosan haszn\u00e1lt tibeti gy\u00f3gyszer, amelynek k\u00f6h\u00f6g\u00e9st \u00e9s asztm\u00e1t enyh\u00edt\u0151, h\u0151tiszt\u00edt\u00f3 \u00e9s m\u00e9regtelen\u00edt\u0151 hat\u00e1sa van. A modern kromatogr\u00e1fi\u00e1s elv\u00e1laszt\u00e1si \u00e9s spektroszk\u00f3piai technik\u00e1k gyors fejl\u0151d\u00e9s\u00e9vel a Rhododendron n\u00f6v\u00e9nyek k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek \u00e9s farmakol\u00f3giai aktivit\u00e1s\u00e1nak kutat\u00e1sa folyamatosan m\u00e9ly\u00fcl \u00e9s rendszerez\u0151dik mind hazai, mind nemzetk\u00f6zi szinten. Az ut\u00f3bbi \u00e9vekben sz\u00e1mos szerkezetileg \u00fajszer\u0171 \u00e9s nagy aktivit\u00e1s\u00fa k\u00e9miai vegy\u00fcletet izol\u00e1ltak e nemzets\u00e9g n\u00f6v\u00e9nyeib\u0151l, k\u00f6zt\u00fck kumarinokat, lign\u00e1nokat, flavonoidokat \u00e9s terp\u00e9neket. Sz\u00e1mos vegy\u00fclet jelent\u0151s biol\u00f3giai aktivit\u00e1st mutat, p\u00e9ld\u00e1ul hipoglik\u00e9mi\u00e1s, tumorellenes, gyullad\u00e1scs\u00f6kkent\u0151, antibakteri\u00e1lis, rovar\u00f6l\u0151 \u00e9s antioxid\u00e1ns tulajdons\u00e1gokkal rendelkezik.<\/p>\n

A Rhododendron n\u00f6v\u00e9nyek hipoglik\u00e9mi\u00e1s hat\u00e1sa mindig is nagy aggodalommal t\u00f6lt\u00f6tte el a kutat\u00f3kat mind hazai, mind nemzetk\u00f6zi szinten. Choi \u00e9s munkat\u00e1rsai a R Rhododendron A sav \u00e9s a brachycarpumb\u00f3l izol\u00e1lt ursolsav er\u0151s g\u00e1tl\u00f3 hat\u00e1st mutatnak a kulcsfontoss\u00e1g\u00fa inzulin jel\u00e1tviv\u0151 enzimmel, a PTP1B-vel szemben, az IC50 \u00e9rt\u00e9kek (6,3 \u00b1 0,6), illetve (3,1 \u00b1 0,3) \u03bc mol\/L \u00e9rt\u00e9kek. Liao \u00e9s munkat\u00e1rsai: R A Capitalumb\u00f3l izol\u00e1lt\u00e1k a PTP1B g\u00e1tl\u00f3 hat\u00e1s\u00fa (-) - rodonoidok B \u00e9s (+) - rodonoidok B enantiomerp\u00e1rj\u00e1t, amelyek IC50 \u00e9rt\u00e9ke (43,56 \u00b1 8,53), illetve (30,38 \u00b1 13,41) \u03bc mol\/L volt. Az R-b\u0151l Az arboreumb\u00f3l izol\u00e1lt 3-O-acetilkurzorolsav jelent\u0151s g\u00e1tl\u00f3 hat\u00e1st mutatott az alfa-gl\u00fckozid\u00e1zzal szemben, az IC50 \u00e9rt\u00e9k 3,3 \u00b1 0,1 \u03bc mol\/L volt. Muhammad et al. felfedezte R A Schlippenbachii k\u00e9regb\u0151l sz\u00e1rmaz\u00f3 80% metanolos nyers kivonat etil-acet\u00e1t \u00e9s dikl\u00f3rmet\u00e1n kivonata hat\u00e9konyan g\u00e1tolja az \u03b1 - gl\u00fckozid\u00e1z aktivit\u00e1st \u00e9s cs\u00f6kkenti a v\u00e9r gl\u00fck\u00f3z koncentr\u00e1ci\u00f3j\u00e1t egerekben.<\/p>\n

A Xiaohua Rhododendron a Rhododendron nemzets\u00e9ghez tartozik, \u00e9s jelenleg nincsenek jelent\u00e9sek a Xiaohua Rhododendron k\u00e9miai \u00f6sszet\u00e9tel\u00e9r\u0151l \u00e9s farmakol\u00f3giai aktivit\u00e1s\u00e1r\u00f3l sem hazai, sem nemzetk\u00f6zi szinten. Ennek f\u00e9ny\u00e9ben ez a cikk a Rhododendron simsii 95% etanolos kivonat\u00e1nak etil-acet\u00e1t kivonata k\u00e9miai \u00f6sszet\u00e9tel\u00e9t vizsg\u00e1lta, \u00e9s az izol\u00e1lt monomer vegy\u00fcletek \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1s\u00e1t sz\u0171rte, annak \u00e9rdek\u00e9ben, hogy referenci\u00e1t \u00e9s tudom\u00e1nyos alapot ny\u00fajtson a Rhododendron simsii tov\u00e1bbi fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz.<\/p>\n

Ez a k\u00eds\u00e9rlet a Rhododendron simsii 95% etanolos kivonat\u00e1nak k\u00e9miai \u00f6sszet\u00e9tel\u00e9t \u00e9s in vitro \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 hat\u00e1s\u00e1t vizsg\u00e1lta. Kilenc vegy\u00fcletet izol\u00e1ltak \u00e9s azonos\u00edtottak, k\u00f6zt\u00fck lign\u00e1nokat, flavonoidokat \u00e9s fenolos vegy\u00fcleteket. K\u00f6z\u00fcl\u00fck az 1. vegy\u00fclet a term\u00e9szetes term\u00e9kekben viszonylag ritka benzofur\u00e1n t\u00edpus\u00fa lign\u00e1n, a 2. vegy\u00fclet egy \u00faj fenil-dihidronaftalin t\u00edpus\u00fa lign\u00e1n, a t\u00f6bbi vegy\u00fcletet pedig mindegyiket el\u0151sz\u00f6r izol\u00e1lt\u00e1k a Rhododendron simsii-b\u0151l. A 2. vegy\u00fclet kiv\u00e9tel\u00e9vel a PNPG-m\u00f3dszerrel vizsg\u00e1ltuk a fennmarad\u00f3 8 vegy\u00fclet \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 hat\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a 8. \u00e9s 9. vegy\u00fclet j\u00f3 \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 hat\u00e1ssal rendelkezik, \u00e9s a k\u00eds\u00e9rletb\u0151l levont k\u00f6vetkeztet\u00e9sek hasonl\u00f3ak voltak a m\u00e1s szakirodalomban k\u00f6z\u00f6ltekhez. Ez\u00e9rt felt\u00e9telezhet\u0151, hogy az apigenin \u00e9s a kaempferol fontos anyagi alapjai a Rhododendron simsii in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1nak. Ez a k\u00eds\u00e9rlet v\u00e9gezte az els\u0151 tanulm\u00e1nyt a Rhododendron fortunei k\u00e9miai \u00f6sszet\u00e9tel\u00e9r\u0151l \u00e9s \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1s\u00e1r\u00f3l, amely referenci\u00e1t ny\u00fajt a n\u00f6v\u00e9nyi k\u00e9miai er\u0151forr\u00e1sok \u00e9sszer\u0171 fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"

Two new lignans in Rhododendron grandiflorum Rhododendron minutiflorum, also known as slender rhododendron or slender pomegranate flower, is a plant of Rhododendron L. in the Rhododendron family. It is commonly found in hilly areas at an altitude of 1120-1430m and is mainly produced in Guangxi and Guangdong provinces in China. Many plants in this genus […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nTwo new lignans in Rhododendron grandiflorum - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/ket-uj-lignan-a-rododendron-grandiflorumban\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Two new lignans in Rhododendron grandiflorum - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Two new lignans in Rhododendron grandiflorum Rhododendron minutiflorum, also known as slender rhododendron or slender pomegranate flower, is a plant of Rhododendron L. in the Rhododendron family. 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