{"id":8575,"date":"2024-08-14T16:41:35","date_gmt":"2024-08-14T16:41:35","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8575"},"modified":"2024-08-14T16:41:35","modified_gmt":"2024-08-14T16:41:35","slug":"blueberry-leaf-polyphenols","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/afonya-level-polifenolok\/","title":{"rendered":"Az \u00e1fonyalev\u00e9l polifenolok in vitro g\u00e1tl\u00f3 hat\u00e1s\u00e1nak vizsg\u00e1lata az alfa-amil\u00e1zra \u00e9s az alfa-gl\u00fckozid\u00e1zra vonatkoz\u00f3an"},"content":{"rendered":"

Az \u00e1fonyalev\u00e9l polifenolok in vitro g\u00e1tl\u00f3 hat\u00e1s\u00e1nak vizsg\u00e1lata az alfa-amil\u00e1zra \u00e9s az alfa-gl\u00fckozid\u00e1zra vonatkoz\u00f3an
\nAz \u00e1fonya \u00e9des-savanyk\u00e1s \u00edz\u0171 kis bogy\u00f3s gy\u00fcm\u00f6lcs, amely friss fogyaszt\u00e1sra finom. Az Ericaceae csal\u00e1dba \u00e9s a Vaccinium nemzets\u00e9gbe tartoznak. A Csangbai-hegys\u00e9g, a Daxing'an-hegys\u00e9g \u00e9s az \u00e9szakkelet-k\u00ednai Xiaoxing'an-hegys\u00e9g erdeiben b\u0151s\u00e9ges vadon term\u0151 \u00e1fonya tal\u00e1lhat\u00f3. Az \u00e1fonya gazdag olyan vegy\u00fcletekben, mint a cukrok, terp\u00e9nek, aminosavak \u00e9s nagy mennyis\u00e9g\u0171 polifenol, amelyek magas t\u00e1p\u00e9rt\u00e9kkel \u00e9s eg\u00e9szs\u00e9g\u00fcgyi el\u0151ny\u00f6kkel rendelkeznek. Az ut\u00f3bbi \u00e9vekben egyre t\u00f6bb kutat\u00e1s foglalkozik a hat\u00f3anyagaival. Az \u00e1fonya term\u00e9s\u00e9hez \u00e9s vir\u00e1g\u00e1hoz k\u00e9pest az \u00e1fonya leveleinek magasabb a fenolos anyagtartalma. Jelenleg sz\u00e1mos tanulm\u00e1ny foglalkozik az \u00e1fonyalev\u00e9l polifenolok antioxid\u00e1ns kapacit\u00e1s\u00e1val, v\u00e9rnyom\u00e1scs\u00f6kkent\u0151 \u00e9s antibakteri\u00e1lis hat\u00e1saival, de kev\u00e9s a v\u00e9rcukorszint cs\u00f6kkent\u00e9s\u00e9re vonatkoz\u00f3 kutat\u00e1s. Napjainkban a cukorbetegs\u00e9g az emberi eg\u00e9szs\u00e9get fenyeget\u0151 egyik legfontosabb betegs\u00e9gg\u00e9 v\u00e1lt. Az alfa-amil\u00e1z \u00e9s az alfa-gl\u00fckozid\u00e1z el\u0151seg\u00edtheti a t\u00e1pl\u00e1l\u00e9k lebont\u00e1s\u00e1t a sz\u00e1jban, a gyomorban \u00e9s a belekben, ez\u00e1ltal gl\u00fck\u00f3z szabadul fel a v\u00e9r\u00e1ramba \u00e9s emelkedik a v\u00e9rcukorszint. A cukorbetegs\u00e9g kezel\u00e9s\u00e9re jelenleg a g\u00e1tl\u00f3k szed\u00e9se az els\u0151 v\u00e1laszt\u00e1s. A forgalomban l\u00e9v\u0151 k\u00e9miai gy\u00f3gyszerek hajlamosak az olyan mell\u00e9khat\u00e1sokra, mint a puffad\u00e1s \u00e9s az em\u00e9szt\u00e9si zavarok, ez\u00e9rt biztons\u00e1gosabb a g\u00e1tl\u00f3kat term\u00e9szetes anyagokb\u00f3l kinyerni. Kor\u00e1bbi tanulm\u00e1nyok arr\u00f3l sz\u00e1moltak be, hogy a n\u00f6v\u00e9nyi kivonatok polifenolokat, terpenoid sz\u00e1rmaz\u00e9kokat, poliszacharidokat, fenilpropanoidokat \u00e9s m\u00e1s vegy\u00fcleteket tartalmaznak, amelyek kiv\u00e1l\u00f3 \u03b1 - amil\u00e1z \u00e9s \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1st mutatnak. A polifenolok nagy potenci\u00e1llal rendelkeznek a cukorbetegs\u00e9g megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben. Liu \u00e9s munkat\u00e1rsai kimutatt\u00e1k, hogy a z\u00f6ld tea kivonatokban tal\u00e1lhat\u00f3 polifenolok g\u00e1tl\u00f3 hat\u00e1s\u00faak, \u00e9s k\u00e9pesek g\u00e1tolni a gl\u00fck\u00f3z felv\u00e9tel\u00e9t \u00e9s sz\u00e1ll\u00edt\u00e1s\u00e1t a Caco-2 b\u00e9lh\u00e1msejtek \u00e1ltal. Sun \u00e9s munkat\u00e1rsai molekul\u00e1ris dokkol\u00e1ssal felt\u00e1rt\u00e1k, hogy a polifenolok k\u00e9pesek az alfa-amil\u00e1z akt\u00edv hely\u00e9n l\u00e9v\u0151 aminosavmaradv\u00e1nyokhoz k\u00f6t\u0151dni, megv\u00e1ltoztatva az enzim molekul\u00e1ris konform\u00e1ci\u00f3j\u00e1t \u00e9s g\u00e1tolva a szubsztr\u00e1tokhoz val\u00f3 k\u00f6t\u0151d\u00e9s\u00e9t. Ez a cikk az \u00e1fonyalev\u00e9l polifenolok alfa-amil\u00e1zra \u00e9s alfa-gl\u00fckozid\u00e1zra gyakorolt g\u00e1tl\u00f3 hat\u00e1sait \u00e9s t\u00edpusait vizsg\u00e1lja, elm\u00e9leti alapot ny\u00fajtva az \u00e1fonyalev\u00e9llel kapcsolatos term\u00e9kek fejleszt\u00e9s\u00e9hez.<\/p>\n

Az e cikkben vizsg\u00e1lt \u00e1fonyalev\u00e9l polifenol-kivonat f\u0151 \u00f6sszetev\u0151i k\u00f6z\u00e9 tartozik a klorog\u00e9nsav, az 5,6,7,3',4' pentahidroperoxid, a kvercetin, az antocianinok stb. Az in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s \u00e9rt\u00e9kel\u00e9se azt mutatta, hogy az \u00e1fonyalev\u00e9l polifenolok j\u00f3 g\u00e1tl\u00f3 hat\u00e1ssal vannak az alfa-amil\u00e1zra \u00e9s az alfa-gl\u00fckozid\u00e1zra, \u00e9s a g\u00e1tl\u00f3 hat\u00e1s pozit\u00edvan korrel\u00e1l az \u00f6sszes fenoltartalommal. A h\u0151m\u00e9rs\u00e9klet \u00e9s a pH-\u00e9rt\u00e9k hat\u00e1s\u00e1t vizsg\u00e1lva az \u00e1fonyalev\u00e9l polifenolok g\u00e1tl\u00f3 hat\u00e1s\u00e1ra meg\u00e1llap\u00edtott\u00e1k, hogy az \u00e1fonyalev\u00e9l polifenolok viszonylag stabilak alacsony h\u0151m\u00e9rs\u00e9kleten (30-50 \u2103) \u00e9s enyh\u00e9n savas k\u00f6rnyezetben (pH 2,0-8,0 \u00e9s 3,0-5,0), \u00e9s k\u00e9pesek magas szinten fenntartani az \u03b1 - amil\u00e1z \u00e9s \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1st. Az \u00e1fonyalev\u00e9l polifenolok f\u00e9lmaxim\u00e1lis g\u00e1tl\u00f3 koncentr\u00e1ci\u00f3ja (IC50) az alfa-amil\u00e1zra \u00e9s az alfa-gl\u00fckozid\u00e1zra 10,926, illetve 7,276 \u03bc g\/ml volt. Ezenk\u00edv\u00fcl a kinetikai vizsg\u00e1latok azt mutatt\u00e1k, hogy mindk\u00e9t enzimre gyakorolt g\u00e1tl\u00e1suk vegyes, reverzibilis g\u00e1tl\u00e1s volt, nagyobb m\u00e9rt\u00e9k\u0171 verseng\u00e9ssel, mint nem verseng\u00e9ssel.
\n\u00d6sszefoglalva, az \u00e1fonyalevelek gazdagok polifenolokban, \u00e9s j\u00f3 in vitro \u03b1-amil\u00e1z \u00e9s \u03b1-gl\u00fckozid\u00e1z g\u00e1tl\u00f3 hat\u00e1ssal rendelkeznek, ami felt\u00e1rja az \u00e1fonyalev\u00e9l polifenolok potenci\u00e1lis hipoglik\u00e9mi\u00e1s hat\u00e1s\u00e1t, \u00e9s elm\u00e9leti alapot ny\u00fajt az \u00e1fonyalev\u00e9llel kapcsolatos term\u00e9kek fejleszt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the in vitro inhibitory activity of blueberry leaf polyphenols on alpha amylase and alpha glucosidase Blueberries are small berries with a sweet and sour taste that is delicious for fresh consumption. They belong to the Ericaceae family and the Vaccinium genus. There are abundant wild blueberries in the forests of Changbai Mountain, Daxing’an […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the in vitro inhibitory activity of blueberry leaf polyphenols on alpha amylase and alpha glucosidase - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/afonya-level-polifenolok\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the in vitro inhibitory activity of blueberry leaf polyphenols on alpha amylase and alpha glucosidase - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the in vitro inhibitory activity of blueberry leaf polyphenols on alpha amylase and alpha glucosidase Blueberries are small berries with a sweet and sour taste that is delicious for fresh consumption. 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