{"id":8235,"date":"2024-08-11T20:53:51","date_gmt":"2024-08-11T20:53:51","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8235"},"modified":"2024-08-11T20:53:51","modified_gmt":"2024-08-11T20:53:51","slug":"endophytic-fungus-fusarium-guttiforme-in-plants","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/endofita-gomba-fusarium-guttiforme-a-novenyekben\/","title":{"rendered":"A Fusarium guttiforme endofita gomba m\u00e1sodlagos metabolitjainak vizsg\u00e1lata n\u00f6v\u00e9nyekben"},"content":{"rendered":"

A Fusarium guttiforme endofita gomba m\u00e1sodlagos metabolitjainak vizsg\u00e1lata n\u00f6v\u00e9nyekben
\nAz endofita gomb\u00e1k a mikroorganizmusok azon csoportj\u00e1t jelentik, amelyek az eg\u00e9szs\u00e9ges n\u00f6v\u00e9nyi sz\u00f6vetekben \u00e9lnek, de nem okoznak n\u00f6v\u00e9nyi fert\u0151z\u00e9seket \u00e9s betegs\u00e9geket. Egyedi biol\u00f3giai tulajdons\u00e1gokkal rendelkeznek, k\u00f6lcs\u00f6nhat\u00e1sba l\u00e9pnek a gazdan\u00f6v\u00e9nyekkel, \u00e9s hasznukra v\u00e1lnak, valamint k\u00fcl\u00f6nb\u00f6z\u0151 fontos m\u00e1sodlagos anyagcsereterm\u00e9keket termelnek. A gy\u00f3gyszeriparban, a mez\u0151gazdas\u00e1gban \u00e9s az \u00e9lelmiszeriparban sz\u00e1mos biol\u00f3giai aktivit\u00e1ssal haszn\u00e1lhat\u00f3k.
\nA fuz\u00e1rium a talajban \u00e9s a n\u00f6v\u00e9nyi testekben sz\u00e9les k\u00f6rben elterjedt fonalas gombafaj. Az elm\u00falt \u00e9vekben sz\u00e1mos tud\u00f3s tanulm\u00e1nyozta a Fusarium gomb\u00e1k m\u00e1sodlagos metabolitjait, \u00e9s meg\u00e1llap\u00edtotta, hogy nemcsak h\u00e1rom f\u0151 gombatoxint k\u00e9pesek el\u0151\u00e1ll\u00edtani: fumonokat, trichotec\u00e9neket \u00e9s zearalenonokat, hanem jelent\u0151s biol\u00f3giai aktivit\u00e1ssal rendelkez\u0151 terp\u00e9neket, amidokat, kinonokat \u00e9s poliketonokat is. A vonatkoz\u00f3 szakirodalom felkutat\u00e1s\u00e1val meg\u00e1llap\u00edtott\u00e1k, hogy viszonylag kev\u00e9s kutat\u00e1s foglalkozik a Fusarium gutiforme endofita gomba n\u00f6v\u00e9nyekben el\u0151fordul\u00f3 m\u00e1sodlagos metabolitjaival. A Fusarium gutiforme metabolitok k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek tov\u00e1bbi gazdag\u00edt\u00e1sa \u00e9s a szil\u00e1rdtest-ferment\u00e1ci\u00f3 m\u00e1sodlagos metabolitjaikra gyakorolt hat\u00e1s\u00e1nak vizsg\u00e1lata \u00e9rdek\u00e9ben ez a tanulm\u00e1ny k\u00fcl\u00f6nb\u00f6z\u0151 kromatogr\u00e1fi\u00e1s elv\u00e1laszt\u00e1si m\u00f3dszereket \u00e9s modern spektroszk\u00f3piai technik\u00e1kat alkalmazott a Fusarium gutiforme endofitikus gomba \u00e1ltal ferment\u00e1lt rizs m\u00e1sodlagos metabolitjainak k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek vizsg\u00e1lat\u00e1ra. Ugyanakkor a kapott vegy\u00fcleteket in vitro gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s szempontj\u00e1b\u00f3l is vizsg\u00e1ltuk, azzal a c\u00e9llal, hogy \u00faj \u00e9s akt\u00edv vezet\u0151 molekul\u00e1kat fedezz\u00fcnk fel, \u00e9s gazdag\u00edtsuk a Fusarium nemzets\u00e9g m\u00e1sodlagos metabolitjait.<\/p>\n

 <\/p>\n

Ez a tanulm\u00e1ny az F. endofita bakt\u00e9riumokat vizsg\u00e1lta a n\u00f6v\u00e9nyekben H\u00e9t vegy\u00fcletet izol\u00e1ltak \u00e9s azonos\u00edtottak a Gutiforme \u00e1ltal ferment\u00e1lt rizs etil-acet\u00e1t frakci\u00f3j\u00e1b\u00f3l. K\u00f6z\u00fcl\u00fck az 1. vegy\u00fclet egy \u00faj, peroxidk\u00f6t\u00e9seket tartalmaz\u00f3 bifenilsz\u00e1rmaz\u00e9k, m\u00edg a 2-7. vegy\u00fcletek benzolsz\u00e1rmaz\u00e9kok, fenolsavak, szteroidok, ergoszterol \u00e9s furfurol vegy\u00fcletek, amelyeket mind el\u0151sz\u00f6r izol\u00e1ltak ebb\u0151l a gomb\u00e1b\u00f3l, nagyban gazdag\u00edtva a Fusarium nemzets\u00e9g m\u00e1sodlagos metabolitjainak szerkezeti v\u00e1ltozatoss\u00e1g\u00e1t. Ugyanakkor a legt\u00f6bb dimer vagy polimer sz\u00e1rmaz\u00e9k er\u0151s farmakol\u00f3giai aktivit\u00e1ssal \u00e9s stabilit\u00e1ssal rendelkezik, a dimer sz\u00e1rmaz\u00e9kokkal kapcsolatos tov\u00e1bbi kutat\u00e1sokat folytatva. Paik \u00e9s munkat\u00e1rsai egy sor benzolgy\u0171r\u0171s szerkezetet tartalmaz\u00f3 dimer sz\u00e1rmaz\u00e9kr\u00f3l sz\u00e1moltak be, amelyek k\u00f6z\u00fcl a ftal\u00e1t-\u00e9szter dimerek j\u00f3 szelektivit\u00e1ssal \u00e9s citotoxicit\u00e1ssal rendelkeznek az emberi m\u00e9hnyakr\u00e1k ellen, \u00e9s nincs citotoxikus hat\u00e1suk a norm\u00e1l m\u00e9hnyaksejtekre. Az alkil-, \u00e9szter-, \u00e9terk\u00f6t\u00e9sekkel stb. \u00f6sszekapcsolt artemizinin-dimerek gyakran nagyobb in vitro \u00e9s in vivo mal\u00e1riaellenes aktivit\u00e1ssal, alacsonyabb toxikus mell\u00e9khat\u00e1sokkal \u00e9s stabilabb fizikai-k\u00e9miai tulajdons\u00e1gokkal rendelkeznek, mint az egymagv\u00fa vegy\u00fcletek. Ezenk\u00edv\u00fcl kor\u00e1bbi jelent\u00e9sek kimutatt\u00e1k, hogy a benzolgy\u0171r\u0171k, fenolok \u00e9s szteroidok sz\u00e1rmaz\u00e9kai gyullad\u00e1scs\u00f6kkent\u0151, antioxid\u00e1ns, daganatellenes, antibakteri\u00e1lis \u00e9s egy\u00e9b aktivit\u00e1sokkal rendelkeznek. Ez\u00e9rt ez a cikk t\u00e1rgyalja F A Gutiforme-b\u00f3l izol\u00e1lt 1-7 vegy\u00fcletek gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t el\u0151zetesen in vitro \u00e9rt\u00e9kelt\u00e9k. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az 1. \u00e9s 2. vegy\u00fclet bizonyos NO-termel\u00e9sg\u00e1tl\u00f3 aktivit\u00e1st mutatott, 48,1 \u00e9s 46,6 \u03bc mol\/L IC50 \u00e9rt\u00e9kekkel, ami el\u0151zetesen tiszt\u00e1zta a F A guttiforme hat\u00f3anyag-alapja referenci\u00e1t ny\u00fajt a k\u00e9s\u0151bbi farmakol\u00f3giai k\u00eds\u00e9rletekhez, \u00e9s bizonyos tudom\u00e1nyos \u00e9rt\u00e9ket is biztos\u00edthat a Fusariummal kapcsolatos kutat\u00e1sokhoz.<\/p>","protected":false},"excerpt":{"rendered":"

Study on secondary metabolites of endophytic fungus Fusarium guttiforme in plants Endophytic fungi refer to a group of microorganisms that live in healthy plant tissues but do not cause plant infections and diseases. They have unique biological characteristics, interact and benefit with host plants, and produce various important secondary metabolites. They can be used in […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on secondary metabolites of endophytic fungus Fusarium guttiforme in plants - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/endofita-gomba-fusarium-guttiforme-a-novenyekben\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on secondary metabolites of endophytic fungus Fusarium guttiforme in plants - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on secondary metabolites of endophytic fungus Fusarium guttiforme in plants Endophytic fungi refer to a group of microorganisms that live in healthy plant tissues but do not cause plant infections and diseases. 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