{"id":8215,"date":"2024-08-11T20:21:08","date_gmt":"2024-08-11T20:21:08","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8215"},"modified":"2024-08-11T20:21:08","modified_gmt":"2024-08-11T20:21:08","slug":"celery-root","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/zellergyoker\/","title":{"rendered":"A zellergy\u00f6k\u00e9r etil-acet\u00e1t kivonat\u00e1nak k\u00e9miai \u00f6sszetev\u0151i \u00e9s citotoxikus aktivit\u00e1sa"},"content":{"rendered":"<p>A zellergy\u00f6k\u00e9r etil-acet\u00e1t kivonat\u00e1nak k\u00e9miai \u00f6sszetev\u0151i \u00e9s citotoxikus aktivit\u00e1sa<br \/>\nAz Apium graveolens L. az Apiaceae csal\u00e1dba tartoz\u00f3 egy- vagy k\u00e9t\u00e9ves l\u00e1gysz\u00e1r\u00fa n\u00f6v\u00e9ny. K\u00fcl\u00f6nb\u00f6z\u0151 termesztett fajt\u00e1i vannak, mint p\u00e9ld\u00e1ul a zeller \u00e9s a sz\u00e1r\u00edtott zeller, amelyek k\u00f6z\u00fcl a sz\u00e1r\u00edtott zeller a leggyakrabban haszn\u00e1lt gy\u00f3gy\u00e1szati c\u00e9lokra. Jelenleg a zeller k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek kutat\u00e1sa itthon \u00e9s k\u00fclf\u00f6ld\u00f6n els\u0151sorban a f\u00f6ld feletti r\u00e9szek sz\u00e1r\u00e1ra \u00e9s leveleire \u00f6sszpontos\u00edt, \u00e9s ezekb\u0151l izol\u00e1ltak \u00e9s azonos\u00edtottak k\u00fcl\u00f6nb\u00f6z\u0151 hat\u00f3anyagokat, k\u00f6zt\u00fck flavonoidokat, terp\u00e9neket \u00e9s kumarinokat. A f\u00f6ld alatti r\u00e9szekkel, k\u00fcl\u00f6n\u00f6sen a gy\u00f6kerekkel azonban kev\u00e9s kutat\u00e1s foglalkozik. B\u00e1r sz\u00e1mos n\u00e9pi gy\u00f3gym\u00f3d l\u00e9tezik a betegs\u00e9gek kezel\u00e9s\u00e9re sz\u00e1r\u00edtott zeller- \u00e9s z\u00f6lds\u00e9ggy\u00f6kerekkel, ezeknek nincs tudom\u00e1nyos elm\u00e9leti alapja. A kutat\u00f3csoport rem\u00e9li, hogy a zeller- \u00e9s karfiolgy\u00f6kerek farmakol\u00f3giai anyagalapj\u00e1t k\u00e9miai \u00f6sszetev\u0151ik m\u00e9lyrehat\u00f3 szisztematikus vizsg\u00e1lat\u00e1val felt\u00e1rja. Kor\u00e1bbi tanulm\u00e1nyokban h\u00e1rom vegy\u00fcletet izol\u00e1ltak \u00e9s azonos\u00edtottak a zeller gy\u00f6ker\u00e9b\u0151l. Ebben a tanulm\u00e1nyban az etil-acet\u00e1t frakci\u00f3 k\u00e9miai komponenseit tov\u00e1bb izol\u00e1lt\u00e1k \u00e9s tiszt\u00edtott\u00e1k, \u00e9s az izol\u00e1lt monomerek citotoxikus aktivit\u00e1s\u00e1t vizsg\u00e1lt\u00e1k, tudom\u00e1nyos alapot szolg\u00e1ltatva a zeller gy\u00f6kerek fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz.<\/p>\n<p>&nbsp;<\/p>\n<p>Ebben a cikkben 9 vegy\u00fcletet, k\u00f6zt\u00fck glikozidokat, kumarinokat, flavonoidokat, ftal\u00e1tokat \u00e9s egy\u00e9b vegy\u00fcleteket izol\u00e1ltak \u00e9s azonos\u00edtottak a zellergy\u00f6k\u00e9r ipari alkoholos kivonat\u00e1nak etil-acet\u00e1t kivonat\u00e1b\u00f3l. A 3., 4., 6., 7. \u00e9s 9. vegy\u00fcletet el\u0151sz\u00f6r izol\u00e1lt\u00e1k ebb\u0151l a n\u00f6v\u00e9nynemzets\u00e9gb\u0151l. Az 1-9 vegy\u00fcletek citotoxikus aktivit\u00e1s\u00e1t h\u00e1romf\u00e9le daganatt\u00edpussal szemben vizsg\u00e1lt\u00e1k, \u00e9s az eredm\u00e9nyek azt mutatt\u00e1k, hogy a 4. vegy\u00fclet k\u00fcl\u00f6nb\u00f6z\u0151 m\u00e9rt\u00e9k\u0171 citotoxikus aktivit\u00e1st mutatott mindh\u00e1romf\u00e9le daganatsejttel szemben. A 4. vegy\u00fclet er\u0151s citotoxikus aktivit\u00e1st mutatott az A549 hum\u00e1n t\u00fcd\u0151r\u00e1kos sejtvonallal szemben, az IC50 \u00e9rt\u00e9k 6,68 \u03bc mol\/l volt. Jelentett\u00e9k, hogy a 4. vegy\u00fclet j\u00f3 citotoxicit\u00e1ssal rendelkezik az MCF hum\u00e1n eml\u0151r\u00e1ksejtre \u00e9s a HepG2 hepat\u00f3ma sejtre is, 8,58 \u00e9s 4,76 \u03bc mol\/L IC50 \u00e9rt\u00e9kkel. Ez\u00e9rt a 4. vegy\u00fclet a zellergy\u00f6k\u00e9r r\u00e1kellenes gy\u00f3gyszer\u00e9nek potenci\u00e1lis hat\u00f3anyaga lehet, \u00e9s hat\u00e1smechanizmusa \u00e9s in vivo hat\u00e9konys\u00e1ga m\u00e9g tov\u00e1bbi m\u00e9lyrehat\u00f3 kutat\u00e1sokat ig\u00e9nyel.<\/p>","protected":false},"excerpt":{"rendered":"<p>Chemical constituents and cytotoxic activity of ethyl acetate extract from celery root Apium graveolens L. is an annual or biennial herbaceous plant in the family Apiaceae. There are various cultivated varieties such as celery and dry celery, with dry celery being the most commonly used for medicinal purposes. At present, research on the chemical composition [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Chemical constituents and cytotoxic activity of ethyl acetate extract from celery root - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/zellergyoker\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chemical constituents and cytotoxic activity of ethyl acetate extract from celery root - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Chemical constituents and cytotoxic activity of ethyl acetate extract from celery root Apium graveolens L. is an annual or biennial herbaceous plant in the family Apiaceae. 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There are various cultivated varieties such as celery and dry celery, with dry celery being the most commonly used for medicinal purposes. 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