{"id":8163,"date":"2024-08-11T19:48:37","date_gmt":"2024-08-11T19:48:37","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8163"},"modified":"2024-08-11T19:48:37","modified_gmt":"2024-08-11T19:48:37","slug":"pharmacological-activity-and-pharmacokinetics-of-capsaicin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/pharmacological-activity-and-pharmacokinetics-of-capsaicin\/","title":{"rendered":"A kapszaicin farmakol\u00f3giai aktivit\u00e1s\u00e1val \u00e9s farmakokinetik\u00e1j\u00e1val kapcsolatos kutat\u00e1si eredm\u00e9nyek"},"content":{"rendered":"

A kapszaicin farmakol\u00f3giai aktivit\u00e1s\u00e1val \u00e9s farmakokinetik\u00e1j\u00e1val kapcsolatos kutat\u00e1si eredm\u00e9nyek
\nA Capsicum annuum L. a Capsicum nemzets\u00e9ghez tartoz\u00f3, a Magnoliaceae csal\u00e1dba tartoz\u00f3 \u00e9vel\u0151 l\u00e1gysz\u00e1r\u00fa n\u00f6v\u00e9ny. Vil\u00e1gszerte sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k gy\u00f3gy- \u00e9s \u00e9tkez\u00e9si n\u00f6v\u00e9nyk\u00e9nt. Gy\u00f3gyhat\u00e1s\u00fa r\u00e9sze a term\u00e9s, amelynek k\u00f6z\u00e9pmeleg\u00edt\u0151 \u00e9s hideg\u0171z\u0151, qi-cs\u00f6kkent\u0151 \u00e9s em\u00e9szt\u00e9st el\u0151seg\u00edt\u0151 hat\u00e1sa van. A chilipaprika k\u00fcl\u00f6nb\u00f6z\u0151 hat\u00f3anyagokat tartalmaz, mint p\u00e9ld\u00e1ul kapszaicint, chili\u00e9sztereket \u00e9s karotinoidokat. A kapszaicin csal\u00e1dba els\u0151sorban a kapszaicin, dihidrokapszaicin, magas kapszaicin, magas dihidrokapszaicin, alacsony dihidrokapszaicin, kapszaicin\u00e9szterek, dihidrokapszaicin\u00e9szterek, alacsony dihidrokapszaicin\u00e9szterek, kapszaicin - \u03b2 - D-gl\u00fckopiran\u00f3z glikozidok, dihidrokapszaicin - \u03b2 - D-gl\u00fckopiran\u00f3z glikozidok stb. tartoznak (l\u00e1sd az 1. \u00e1br\u00e1t). A kapszaicin a chili magas tartalm\u00fa \u00e9s cs\u00edp\u0151s \u00f6sszetev\u0151je, amely farmakol\u00f3giai hat\u00e1sok sz\u00e9les sk\u00e1l\u00e1j\u00e1val rendelkezik, mint p\u00e9ld\u00e1ul f\u00e1jdalomcsillap\u00edt\u00e1s, antioxid\u00e1ci\u00f3, sz\u00edvizomv\u00e9delem, daganatellenes, termogenezis, fogy\u00e1s stb. A farmakol\u00f3giai hat\u00e1sok egy r\u00e9sze a tranziens receptor potenci\u00e1l vanilloid 1 (TRPV1) f\u00fcggv\u00e9nye. P\u00e9ld\u00e1ul 2020 j\u00falius\u00e1ban az Avericas Pharma Quenza (kapszaicin) 8% tapasz\u00e1t az amerikai \u00c9lelmiszer- \u00e9s Gy\u00f3gyszer\u00fcgyi Hat\u00f3s\u00e1g (FDA) enged\u00e9lyezte a feln\u0151tt l\u00e1bdiab\u00e9teszes perif\u00e9ri\u00e1s neurop\u00e1ti\u00e1val (DPN) kapcsolatos neurol\u00f3giai f\u00e1jdalom kezel\u00e9s\u00e9re \u00e9s enyh\u00edt\u00e9s\u00e9re Az id\u0151tartam legfeljebb 3 h\u00f3nap, ami m\u00e9rf\u00f6ldk\u0151nek sz\u00e1m\u00edt a neuralgi\u00e1val kapcsolatos neurop\u00e1ti\u00e1s f\u00e1jdalom 2009-es kezel\u00e9se ut\u00e1n.
\nEzenk\u00edv\u00fcl a kapszaicin csal\u00e1dba tartoz\u00f3 kapszaicin\u00e9szterek hasonl\u00f3 farmakol\u00f3giai tev\u00e9kenys\u00e9ggel rendelkeznek, de nem rendelkeznek cs\u00edp\u0151s irrit\u00e1l\u00f3 hat\u00e1s\u00faakkal. Ez arra utal, hogy mag\u00e1nak a kapszaicinnek a hi\u00e1nyoss\u00e1gait a kapszaicin anal\u00f3gok keres\u00e9s\u00e9vel vagy szint\u00e9zis\u00e9vel lehet kik\u00fcsz\u00f6b\u00f6lni, ami el\u0151ny\u00f6s az \u00faj gener\u00e1ci\u00f3s kapszaicin gy\u00f3gyszerek kifejleszt\u00e9se szempontj\u00e1b\u00f3l. Ez a cikk \u00e1ttekinti a kapszaicin szerkezet\u00e9t, farmakol\u00f3giai aktivit\u00e1s\u00e1t \u00e9s metabolikus kinetikai tulajdons\u00e1gait.<\/p>\n

A chili egy gy\u00f3gy- \u00e9s ehet\u0151 n\u00f6v\u00e9ny, amely a kapszaicin csal\u00e1d sz\u00e1mos \u00f6sszetev\u0151j\u00e9ben gazdag, \u00e9s vil\u00e1gszerte r\u00e9g\u00f3ta sz\u00e9les k\u00f6rben fogyasztj\u00e1k. A kapszaicin csal\u00e1d \u00f6sszetev\u0151i felkeltett\u00e9k a vegy\u00e9szek, farmakol\u00f3gusok \u00e9s biol\u00f3gusok \u00e9rdekl\u0151d\u00e9s\u00e9t \u00e9s sz\u00e9les k\u00f6r\u0171 figyelm\u00e9t. A kapszaicint sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k helyi f\u00e1jdalomcsillap\u00edt\u00f3k\u00e9nt, \u00e9s a kutat\u00e1sok kimutatt\u00e1k, hogy sz\u00e1mos farmakol\u00f3giai hat\u00e1sa van az antioxid\u00e1ns, tumorellenes, gyomor-b\u00e9lrendszeri betegs\u00e9gek \u00e9s az elh\u00edz\u00e1s g\u00e1tl\u00e1sa ter\u00e9n. A kapszaicin farmakol\u00f3giai aktivit\u00e1sa szorosan \u00f6sszef\u00fcgg farmakokinetikai tulajdons\u00e1gaival, p\u00e9ld\u00e1ul az adagol\u00e1ssal, a bead\u00e1s m\u00f3dj\u00e1val \u00e9s a felez\u00e9si id\u0151vel a k\u00fcl\u00f6nb\u00f6z\u0151 sz\u00f6vetekben. A tumorokra \u00e9s a gyomor-b\u00e9lrendszeri fek\u00e9lyekre gyakorolt kett\u0151s hat\u00e1sa szorosan \u00f6sszef\u00fcgg a bead\u00e1s d\u00f3zis\u00e1val. A kapszaicin alacsony d\u00f3zisai j\u00f3 ter\u00e1pi\u00e1s hat\u00e1st fejtenek ki a gyomorfek\u00e9lyek megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben. A kapszaicin hosszabb metabolikus felez\u00e9si ideje a t\u00fcd\u0151ben \u00e9s a b\u0151r\u00f6n azt jelenti, hogy a t\u00fcd\u0151re vagy a b\u0151rre gyakorolt hat\u00e1sa jobb lesz. A sziszt\u00e9m\u00e1s gy\u00f3gyszeres kezel\u00e9s f\u0151 kih\u00edv\u00e1sa azonban a kapszaicin metabolikus instabilit\u00e1sa \u00e9s r\u00f6vid felez\u00e9si ideje, \u00e9s jelenleg nincsenek sz\u00e1jon \u00e1t szedhet\u0151 vagy sziszt\u00e9m\u00e1san beadhat\u00f3 kapszaicin gy\u00f3gyszerek a piacon. A kapszaicinhez hasonl\u00f3 szerkezetek fizikai-k\u00e9miai tulajdons\u00e1gainak, biol\u00f3giai aktivit\u00e1s\u00e1nak \u00e9s metabolikus kinetik\u00e1j\u00e1nak elemz\u00e9se azt sugallja, hogy a kapszaicin \u00faj gener\u00e1ci\u00f3j\u00e1nak fejleszt\u00e9si ir\u00e1nya a kapszaicin csal\u00e1d m\u00e1s hasonl\u00f3 \u00f6sszetev\u0151inek szerkezeti m\u00f3dos\u00edt\u00e1sa vagy keres\u00e9se az olyan probl\u00e9m\u00e1k lek\u00fczd\u00e9se \u00e9rdek\u00e9ben, mint a kapszaicin r\u00f6vid felez\u00e9si ideje; A kapszaicin anal\u00f3gjainak szintetiz\u00e1l\u00e1sa \u00e9s aktivit\u00e1suk \u00e9s farmakokinetik\u00e1juk vizsg\u00e1lata, szerkezeti aktivit\u00e1suk \u00e9s szerkezeti tulajdons\u00e1gaik kapcsolat\u00e1nak elemz\u00e9se, \u00e9s v\u00e9g\u00fcl kapszaicin anal\u00f3gok el\u0151\u00e1ll\u00edt\u00e1sa minim\u00e1lis mell\u00e9khat\u00e1sokkal, er\u0151s aktivit\u00e1ssal \u00e9s hossz\u00fa felez\u00e9si id\u0151vel. Ez\u00e9rt a szerkezetileg \u00faj kapszaicin-anal\u00f3gok kifejleszt\u00e9se lehet a kapszaicin gy\u00f3gyszerek \u00faj gener\u00e1ci\u00f3j\u00e1nak kutat\u00e1si ir\u00e1nya.<\/p>","protected":false},"excerpt":{"rendered":"

Research progress on pharmacological activity and pharmacokinetics of capsaicin Capsicum annuum L. is a perennial herbaceous plant of the Magnoliaceae family, belonging to the genus Capsicum. It is widely used as a medicinal and edible plant worldwide. The medicinal part is the fruit, which has the effects of warming the middle and dispelling cold, reducing […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nResearch progress on pharmacological activity and pharmacokinetics of capsaicin - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/pharmacological-activity-and-pharmacokinetics-of-capsaicin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research progress on pharmacological activity and pharmacokinetics of capsaicin - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Research progress on pharmacological activity and pharmacokinetics of capsaicin Capsicum annuum L. is a perennial herbaceous plant of the Magnoliaceae family, belonging to the genus Capsicum. 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