{"id":8159,"date":"2024-08-11T19:46:48","date_gmt":"2024-08-11T19:46:48","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8159"},"modified":"2024-08-11T19:46:48","modified_gmt":"2024-08-11T19:46:48","slug":"a-new-phenolic-acid-glycoside-in-the-xylem-of-gallbladder-wood","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/egy-uj-fenolsav-glikozid-az-epeholyagfa-xilemajaban\/","title":{"rendered":"Egy \u00faj fenolsav-glikozid az epeh\u00f3lyagfa xil\u00e9mj\u00e9ben"},"content":{"rendered":"<p>A Nauclea officinalis (Pierre ex Pitard Merr. et Chun), m\u00e1s n\u00e9ven \u00e9benfa, hegyi medvehagyma, medvehagymafa stb. a Rubiaceae csal\u00e1d Nauclea L. nemzets\u00e9g\u00e9be tartoz\u00f3 n\u00f6v\u00e9ny. Els\u0151sorban Hainanban termesztik, sz\u00f3rv\u00e1nyosan Guangdongban, Guangxiban \u00e9s m\u00e1s helyeken is elterjedt. Ez az egyetlen \u0151shonos \u00e9benfa n\u00f6v\u00e9ny K\u00edn\u00e1ban. A Danmu Hainan tartom\u00e1ny jellegzetes Li gy\u00f3gyszere, \u00e9s egyike a Hainan tartom\u00e1nyban vizsg\u00e1lt legfontosabb hagyom\u00e1nyos Li gy\u00f3gyn\u00f6v\u00e9nyeknek. Keser\u0171 \u00edz\u0171 \u00e9s hideg term\u00e9szet\u0171, h\u0151elvezet\u0151, m\u00e9regtelen\u00edt\u0151, duzzanatcs\u00f6kkent\u0151 \u00e9s f\u00e1jdalomcsillap\u00edt\u00f3 hat\u00e1s\u00fa. A li emberek sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k megf\u00e1z\u00e1sra \u00e9s k\u00fcls\u0151 antibakteri\u00e1lis fert\u0151tlen\u00edt\u00e9sre. Napjainkban a klinikai gyakorlatban gyakran haszn\u00e1lj\u00e1k olyan betegs\u00e9gek kezel\u00e9s\u00e9re, mint a megf\u00e1z\u00e1s \u00e9s l\u00e1z, akut mandulagyullad\u00e1s, torokgyullad\u00e1s, h\u00f6rghurut \u00e9s t\u00fcd\u0151gyullad\u00e1s. F\u0151 \u00f6sszetev\u0151i alkaloidok, fenolsavak, pentaciklusos triterpenoidok \u00e9s flavonoidok. Modern farmakol\u00f3giai k\u00eds\u00e9rletek kimutatt\u00e1k, hogy az epeh\u00f3lyagfa gyullad\u00e1scs\u00f6kkent\u0151, sejtburj\u00e1nz\u00e1sg\u00e1tl\u00f3 \u00e9s gyomorsavszekr\u00e9ci\u00f3t g\u00e1tl\u00f3 hat\u00e1ssal rendelkezik. Jelenleg az epeh\u00f3lyagf\u00e1val kapcsolatos kutat\u00e1sok els\u0151sorban az alkaloid r\u00e9szre \u00f6sszpontos\u00edtanak, m\u00edg kevesebb figyelmet ford\u00edtanak a nem alkaloid r\u00e9szre, k\u00fcl\u00f6n\u00f6sen a pol\u00e1ris vegy\u00fcletek magas tartalm\u00e1ra (n-butanolos kivonatok) \u00e9s azok biol\u00f3giai aktivit\u00e1s\u00e1ra a klinikai epeh\u00f3lyagfa-k\u00e9sz\u00edtm\u00e9nyekben. Ebben a tanulm\u00e1nyban az epeh\u00f3lyag n-butanolos kivonat\u00e1b\u00f3l izol\u00e1ltak \u00e9s azonos\u00edtottak vegy\u00fcleteket, f\u0151k\u00e9nt fenolsavvegy\u00fcleteket. Kor\u00e1bbi jelent\u00e9sek szerint ezek a vegy\u00fcletek j\u00f3 daganatellenes \u00e9s hipoglik\u00e9mi\u00e1s hat\u00e1ssal rendelkeznek. Ez\u00e9rt az epeh\u00f3lyag gy\u00f3gy\u00e1szati r\u00e9szeinek xil\u00e9m\u00e1j\u00e1b\u00f3l sz\u00e1rmaz\u00f3 n-butanolos kivonat k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek \u00e9s aktivit\u00e1s\u00e1nak tov\u00e1bbi vizsg\u00e1lata \u00e9rdek\u00e9ben izol\u00e1lt\u00e1k \u00e9s szerkezetileg azonos\u00edtott\u00e1k, valamint vizsg\u00e1lt\u00e1k az \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1st \u00e9s a citotoxikus aktivit\u00e1st. A c\u00e9l az, hogy tudom\u00e1nyos alapot biztos\u00edtsunk e n\u00f6v\u00e9ny fejleszt\u00e9s\u00e9hez, felhaszn\u00e1l\u00e1s\u00e1hoz \u00e9s \u00faj felhaszn\u00e1l\u00e1si m\u00f3dok felfedez\u00e9s\u00e9hez.<\/p>\n<p>&nbsp;<\/p>\n<p>Az epeh\u00f3lyagfa gy\u00f3gy\u00e1szati r\u00e9sze a xil\u00e9ma, \u00e9s a gy\u00f3gyszeripari folyamatban a vizes extrakci\u00f3t els\u0151sorban az epeh\u00f3lyagfa kivonat\u00e1nak, mint gy\u00f3gy\u00e1szati r\u00e9sznek az el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra haszn\u00e1lj\u00e1k. Kor\u00e1bbi tanulm\u00e1nyok kimutatt\u00e1k, hogy az epeh\u00f3lyagfa f\u0151 \u00f6sszetev\u0151je az alkaloidok, de viszonylag kev\u00e9s kutat\u00e1s van m\u00e1s t\u00edpus\u00fa vegy\u00fcletekr\u0151l. Ez\u00e9rt az er\u0151sen pol\u00e1ros, nem alkaloid komponensek is tov\u00e1bbi vizsg\u00e1latra \u00e9rdemesek. Ebben a tanulm\u00e1nyban 15 vegy\u00fcletet izol\u00e1ltak az epeh\u00f3lyagfa xil\u00e9m\u00e1j\u00e1nak z\u00faz\u00e1s\u00e1val. Az 1-4. \u00e9s 9-14. vegy\u00fcletek fenolos vegy\u00fcletek, az 5-6. vegy\u00fcletek ciklikus \u00e9terterterp\u00e9nek, a 7. vegy\u00fclet ligninvegy\u00fclet, a 8. vegy\u00fclet szeszkviterp\u00e9nvegy\u00fclet, a 15. vegy\u00fclet pedig fenilpropanoid vegy\u00fclet volt. Az 1. vegy\u00fclet egy \u00faj vegy\u00fclet, az 1-4. \u00e9s 6-8. vegy\u00fcleteket pedig el\u0151sz\u00f6r izol\u00e1lt\u00e1k ebb\u0151l a n\u00f6v\u00e9nynemzets\u00e9gb\u0151l. Az in vitro aktivit\u00e1si sz\u0171r\u00e9si eredm\u00e9nyek azt mutatt\u00e1k, hogy a 3., 7., 8., 13. \u00e9s 14. vegy\u00fclet gyenge alfa-gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1st mutatott, \u00e9s valamennyi vegy\u00fcletnek nem volt citotoxikus aktivit\u00e1sa. E tanulm\u00e1ny eredm\u00e9nyei els\u0151k\u00e9nt vizsg\u00e1lt\u00e1k az epeh\u00f3lyagfa nagy pol\u00e1ros, nem alkaloid k\u00e9miai \u00f6sszetev\u0151inek \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00e1s\u00e1t \u00e9s citotoxikus aktivit\u00e1s\u00e1t, gazdag\u00edtva az epeh\u00f3lyagfa k\u00e9miai \u00f6sszetev\u0151inek sokf\u00e9les\u00e9g\u00e9t. Meg\u00e1llap\u00edtott\u00e1k, hogy gyenge \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1st mutattak, referenci\u00e1t biztos\u00edtva az epeh\u00f3lyagfa, a Hainanban jellemz\u0151 Li gy\u00f3gy\u00e1szat fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz, valamint \u00faj alkalmaz\u00e1sainak b\u0151v\u00edt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"<p>Nauclea officinalis (Pierre ex Pitard Merr. et Chun), also known as ebony, mountain bear gall, bear gall wood, etc., is a plant of the Rubiaceae family in the Nauclea L. genus. It is mainly produced in Hainan and sporadically distributed in Guangdong, Guangxi and other places. It is the only native ebony plant in China. [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A new phenolic acid glycoside in the xylem of Gallbladder wood - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/egy-uj-fenolsav-glikozid-az-epeholyagfa-xilemajaban\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new phenolic acid glycoside in the xylem of Gallbladder wood - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Nauclea officinalis (Pierre ex Pitard Merr. et Chun), also known as ebony, mountain bear gall, bear gall wood, etc., is a plant of the Rubiaceae family in the Nauclea L. genus. 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It is mainly produced in Hainan and sporadically distributed in Guangdong, Guangxi and other places. It is the only native ebony plant in China. 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