{"id":8143,"date":"2024-08-11T19:37:22","date_gmt":"2024-08-11T19:37:22","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8143"},"modified":"2024-08-11T19:37:22","modified_gmt":"2024-08-11T19:37:22","slug":"secondary-metabolites-and-antibacterial","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/secondary-metabolites-and-antibacterial\/","title":{"rendered":"A Streptomyces sp. KC17012 m\u00e1sodlagos metabolitjainak \u00e9s antibakteri\u00e1lis aktivit\u00e1s\u00e1nak vizsg\u00e1lata"},"content":{"rendered":"

A Streptomyces sp. KC17012 m\u00e1sodlagos metabolitjainak \u00e9s antibakteri\u00e1lis aktivit\u00e1s\u00e1nak vizsg\u00e1lata
\nA Streptomyces a Gram-pozit\u00edv bakt\u00e9riumok, a prokari\u00f3t\u00e1k, az Actinobacterales, a Streptomyces csal\u00e1d \u00e9s a Streptomyces nemzets\u00e9gbe tartozik. A Streptomyces fontos mikrobi\u00e1lis er\u0151forr\u00e1s, amely f\u0151k\u00e9nt olyan \u00f6kosziszt\u00e9m\u00e1kban fordul el\u0151, mint a talaj, az \u00f3ce\u00e1n \u00e9s az \u00e9desv\u00edz. Sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k a gy\u00f3gyszerkutat\u00e1sban, mez\u0151gazdas\u00e1gi rovar\u00f6l\u0151 szerekben, gyomirt\u00f3 szerekben \u00e9s m\u00e1s ter\u00fcleteken. A Streptomyces var\u00e1zslatos kreat\u00edv k\u00e9pess\u00e9ggel rendelkezik, hogy nagysz\u00e1m\u00fa szerkezetileg \u00fajszer\u0171 \u00e9s biol\u00f3giailag akt\u00edv m\u00e1sodlagos anyagcsereterm\u00e9ket \u00e1ll\u00edtson el\u0151, amelyek t\u00f6bbs\u00e9ge nitrog\u00e9ntartalm\u00fa vegy\u00fclet. A statisztik\u00e1k szerint a Streptomyces \u00e1ltal termelt m\u00e1sodlagos metabolitok az eddig felfedezett \u00f6sszes mikrobi\u00e1lis akt\u00edv term\u00e9k 2\/3-\u00e1t teszik ki. Az orvosi alkalmaz\u00e1sokban haszn\u00e1lt antibiotikumok t\u00f6bbnyire a Streptomyces metabolitjai, mint p\u00e9ld\u00e1ul az aminoglikozid antibiotikumok, amelyek d\u00f6nt\u0151 szerepet j\u00e1tszanak az orvosi \u00e9s mez\u0151gazdas\u00e1gi termel\u00e9sben. Az ut\u00f3bbi \u00e9vekben a k\u00f6z\u00f6ns\u00e9ges k\u00f6rnyezeti mikroorganizmusok kutat\u00e1s\u00e1nak egyre \u00e9rettebb\u00e9 v\u00e1l\u00e1s\u00e1val a k\u00fcl\u00f6nleges k\u00f6rnyezeti mikroorganizmusok, p\u00e9ld\u00e1ul a sz\u00e9ls\u0151s\u00e9ges k\u00f6rnyezetek, p\u00e9ld\u00e1ul az \u00f3ce\u00e1nok, a vulkanikus ny\u00edl\u00e1sok \u00e9s a sarkvid\u00e9kek, forr\u00f3 kutat\u00e1si t\u00e9m\u00e1v\u00e1 v\u00e1ltak. Li \u00e9s t\u00e1rsai Vibrio parahaemolyticus elleni vegy\u00fcleteket izol\u00e1ltak a tengeri Streptomyces HS-34-b\u0151l. Ye \u00e9s munkat\u00e1rsai k\u00e9t Streptomyces t\u00f6rzset izol\u00e1ltak Guangxi mangrove talaj\u00e1b\u00f3l, \u00e9s meg\u00e1llap\u00edtott\u00e1k, hogy mindk\u00e9t t\u00f6rzs m\u00e1sodlagos anyagcsereterm\u00e9kei j\u00f3 g\u00e1tl\u00f3 hat\u00e1ssal vannak a Staphylococcus aureusra; Zhou \u00e9s munkat\u00e1rsai a Geomycespannorum SA3-2-YM pol\u00e1ris gomba m\u00e1sodlagos anyagcsereterm\u00e9keib\u0151l tumorcitotoxikus hat\u00e1s\u00fa ciklikus dipeptideket fedeztek fel. A Streptomyces KC17012-t kutat\u00f3csoportunk a Dongchuan r\u00e9zb\u00e1nya talaj\u00e1b\u00f3l izol\u00e1lta. A t\u00f6rzs morfol\u00f3gi\u00e1ja \u00e9s jellemz\u0151i, valamint a 16SrRNS g\u00e9n szisztematikus evol\u00faci\u00f3s elemz\u00e9se alapj\u00e1n \u00faj t\u00f6rzsnek min\u0151s\u00fclt (GenBank sz\u00e1m: MW526995). Ez\u00e9rt kutat\u00f3csoportunk folytatja a Streptomyces spp. tanulm\u00e1nyoz\u00e1s\u00e1t A KC 17012 m\u00e9lyrehat\u00f3 kutat\u00e1s alatt \u00e1ll, amelynek c\u00e9lja m\u00e1sodlagos anyagcsereterm\u00e9keinek felt\u00e1r\u00e1sa \u00e9s a tov\u00e1bbi fejl\u0151d\u00e9s megalapoz\u00e1sa.<\/p>\n

 <\/p>\n

A Streptomyces var\u00e1zslatos kreat\u00edv funkci\u00f3kkal rendelkezik, \u00e9s m\u00e1sodlagos anyagcsereterm\u00e9keik gyakran jelent\u0151s fiziol\u00f3giai aktivit\u00e1ssal rendelkeznek. Ez a cikk izol\u00e1lta a Dongchuan r\u00e9zb\u00e1ny\u00e1b\u00f3l sz\u00e1rmaz\u00f3 Streptomyces KC17012 ferment\u00e1ci\u00f3s leves\u00e9t, \u00e9s 18 komponenst nyert, k\u00f6zt\u00fck f\u0151k\u00e9nt dipeptideket, indol-alkaloid-sz\u00e1rmaz\u00e9kokat, abszcizinsav-anal\u00f3gokat stb. Az 1. \u00e9s 10. vegy\u00fcleteket in vitro antibakteri\u00e1lis aktivit\u00e1s szempontj\u00e1b\u00f3l vizsg\u00e1lt\u00e1k, a MIC-\u00e9rt\u00e9kek 11, illetve 33 \u03bc mol\/l voltak. A t\u00f6bbi vegy\u00fclet nem mutatott aktivit\u00e1st. Az 1-4 vegy\u00fcletek magas tartalm\u00fa dipeptidkomponensek, m\u00edg a 3. vegy\u00fclet D-t\u00edpus\u00fa prolinb\u00f3l \u00e9s L-t\u00edpus\u00fa tirozinb\u00f3l \u00e1ll, amelyek a term\u00e9szetben ritka D-t\u00edpus\u00fa aminosavakat tartalmaz\u00f3 peptidanyagok. A 11-14 vegy\u00fcletek abszcizinsav (ABA) anal\u00f3gok \u00f6sszetev\u0151i. Az ABA fontos n\u00f6v\u00e9nyi hormon, amely d\u00f6nt\u0151 szerepet j\u00e1tszik a n\u00f6v\u00e9nyek n\u00f6veked\u00e9s\u00e9nek szab\u00e1lyoz\u00e1s\u00e1ban \u00e9s a sz\u00e9ls\u0151s\u00e9ges k\u00fcls\u0151 k\u00f6rnyezetnek val\u00f3 ellen\u00e1ll\u00e1sban. Az ABA el\u0151\u00e1ll\u00edt\u00e1si k\u00f6lts\u00e9gei azonban magasak, \u00e9s neh\u00e9z nagy mennyis\u00e9gben iparos\u00edtani, ez\u00e9rt a mikrobi\u00e1lis anyagcsere felhaszn\u00e1l\u00e1sa az ABA el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra sz\u00e9les alkalmaz\u00e1si ter\u00fcletet jelent. Ez a cikk a m\u00e1sodlagos metabolitok \u00e9s monomer komponensek antibakteri\u00e1lis aktivit\u00e1s\u00e1t vizsg\u00e1lja a Streptomyces KC17012 ferment\u00e1ci\u00f3s leves\u00e9ben, tudom\u00e1nyos hivatkoz\u00e1st ny\u00fajtva a vegy\u00fclet egy\u00e9b antibakteri\u00e1lis aktivit\u00e1sainak \u00e9s mechanizmusainak tov\u00e1bbi felt\u00e1r\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"

Study on secondary metabolites and antibacterial activity of Streptomyces sp. KC17012 Streptomyces belongs to the Gram positive bacteria, prokaryotes, Actinobacterales, Streptomyces family, and Streptomyces genus. Streptomyces is an important microbial resource that mainly exists in ecosystems such as soil, ocean, and freshwater. It is widely used in drug research, agricultural insecticides, herbicides, and other fields. […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on secondary metabolites and antibacterial activity of Streptomyces sp. 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