{"id":8121,"date":"2024-08-11T19:25:21","date_gmt":"2024-08-11T19:25:21","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8121"},"modified":"2024-08-11T19:25:21","modified_gmt":"2024-08-11T19:25:21","slug":"gouteng","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/gouteng\/","title":{"rendered":"Tanulm\u00e1ny a Talaromyces sp., egy endofita gomba m\u00e1sodlagos metabolitjair\u00f3l GoutengbenTanulm\u00e1ny a Talaromyces sp., egy endofita gomba m\u00e1sodlagos metabolitjair\u00f3l Goutengben"},"content":{"rendered":"<p>A Talaromyces sp., egy endofita gomba m\u00e1sodlagos metabolitjainak vizsg\u00e1lata Goutengben<br \/>\nAz Uncaria rhynchhophylla (Miq.) Miq Ex Havil. a Rubiaceae csal\u00e1dba, a Gentianaceae rendj\u00e9be tartoz\u00f3 t\u00fcsk\u00e9s n\u00f6v\u00e9ny. Nev\u00e9t a csom\u00f3pontjain tal\u00e1lhat\u00f3, lefel\u00e9 ir\u00e1nyul\u00f3 egyszer\u0171 vagy kett\u0151s kamp\u00f3kr\u00f3l kapta, \u00e9s gyakran haszn\u00e1lj\u00e1k gy\u00f3gyszerk\u00e9nt a sz\u00e1raz kamp\u00f3s sz\u00e1rakat \u00e9s \u00e1gakat. A gouteng n\u00f6v\u00e9ny h\u0151elvezet\u0151 \u00e9s m\u00e1jnyugtat\u00f3, sz\u00e9lcsendes\u00edt\u0151 \u00e9s idegnyugtat\u00f3 hat\u00e1s\u00fa. A modern farmakol\u00f3gia kimutatta, hogy a Gouteng nemzets\u00e9ghez tartoz\u00f3 n\u00f6v\u00e9nyek hat\u00e9konyak a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s k\u00f6zponti idegrendszeri betegs\u00e9gek kezel\u00e9s\u00e9ben, \u00e9s j\u00f3 eredm\u00e9nyeket mutattak a r\u00e1k kezel\u00e9s\u00e9ben is.<\/p>\n<p>A n\u00f6v\u00e9nyekben \u00e9l\u0151 endofita gomb\u00e1k hossz\u00fa t\u00e1v\u00fa koevol\u00faci\u00f3 r\u00e9v\u00e9n stabil szimbi\u00f3zisban \u00e9lnek gazdan\u00f6v\u00e9nyeikkel. Egyr\u00e9szt az endofita gomb\u00e1k a gazdan\u00f6v\u00e9nyb\u0151l t\u00e1panyagokat vehetnek fel saj\u00e1t n\u00f6veked\u00e9s\u00fckh\u00f6z; m\u00e1sr\u00e9szt az endofita gomb\u00e1k saj\u00e1t m\u00e1sodlagos anyagcsereterm\u00e9keik vagy jel\u00e1tvitel\u00fck r\u00e9v\u00e9n pozit\u00edv hat\u00e1st gyakorolhatnak a gazdan\u00f6v\u00e9nyekre. Az elm\u00falt \u00e9vekben sz\u00e1mos irodalmi besz\u00e1mol\u00f3ban sz\u00e1mos bioakt\u00edv monomer vegy\u00fcletet izol\u00e1ltak endofita gomb\u00e1k m\u00e1sodlagos anyagcsereterm\u00e9keib\u0151l. A term\u00e9szetes term\u00e9kek gomb\u00e1k anyagcser\u00e9j\u00e9n kereszt\u00fcl t\u00f6rt\u00e9n\u0151 kinyer\u00e9se jelent\u0151s el\u0151ny\u00f6kkel j\u00e1r a term\u00e9shozam, a gazdas\u00e1goss\u00e1g \u00e9s a k\u00f6rnyezetv\u00e9delem ter\u00e9n.<\/p>\n<p>A Talaromyces sp. 1.88E a Talaromyces gomb\u00e1k nemzets\u00e9g\u00e9be tartozik. A szakirodalmi jelent\u00e9sek sz\u00e1mos \u00faj v\u00e1zszerkezetet izol\u00e1ltak a Talaromyces sp. metabolitjaib\u00f3l, amelyek jelent\u0151s gyullad\u00e1scs\u00f6kkent\u0151, daganatellenes \u00e9s antibakteri\u00e1lis hat\u00e1s\u00fa vegy\u00fcletek. Ez a tanulm\u00e1ny a Goutengb\u0151l izol\u00e1lt Talaromyces sp.1.88E endofita gomb\u00e1ra \u00f6sszpontos\u00edt, \u00e9s rizskult\u00far\u00e1s t\u00e1ptalajt haszn\u00e1l ferment\u00e1ci\u00f3ra, hogy j\u00f3 biol\u00f3giai aktivit\u00e1s\u00fa monomer vegy\u00fcleteket izol\u00e1ljon ferment\u00e1ci\u00f3s term\u00e9keib\u0151l. Ez nagy jelent\u0151s\u00e9ggel b\u00edr az \u00faj gy\u00f3gyszerek sz\u0171r\u00e9se \u00e9s \u00faj gy\u00f3gyszerforr\u00e1sok kifejleszt\u00e9se szempontj\u00e1b\u00f3l.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Ebben a k\u00eds\u00e9rletben k\u00fcl\u00f6nb\u00f6z\u0151 kromatogr\u00e1fi\u00e1s m\u00f3dszereket alkalmaztak 8 vegy\u00fclet izol\u00e1l\u00e1s\u00e1ra a Talaromycessp.1.88E endofita gomba ferment\u00e1ci\u00f3s term\u00e9keib\u0151l Goutengben. K\u00f6z\u00fcl\u00fck az 1. vegy\u00fclet egy \u00faj vegy\u00fclet, a 2. vegy\u00fclet pedig az els\u0151 bejelentett NMR-adat. Az 1-8 vegy\u00fcletekkel gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s alfa-gl\u00fckozid\u00e1z aktivit\u00e1si vizsg\u00e1latokat v\u00e9gezt\u00fcnk, \u00e9s csak a 2. \u00e9s 6. vegy\u00fclet mutatott g\u00e1tl\u00f3 hat\u00e1st az alfa-gl\u00fckozid\u00e1z aktivit\u00e1sra. Az 5-8 vegy\u00fcletek mindegyike a mikorrhiza oszt\u00e1lyba tartoz\u00f3 vegy\u00fclet, \u00e9s a mikorrhiza vegy\u00fcletek szubsztituenseinek enyhe elt\u00e9r\u00e9sei jelent\u0151s hat\u00e1ssal vannak az aktivit\u00e1sukra. Csak a 6. vegy\u00fclet mutat gyenge g\u00e1tl\u00f3 hat\u00e1st az alfa-gl\u00fckozid\u00e1zra. Az egyetlen k\u00fcl\u00f6nbs\u00e9g a 6. vegy\u00fclet \u00e9s a 7. vegy\u00fclet k\u00f6z\u00f6tt az, hogy az A gy\u0171r\u0171 5. poz\u00edci\u00f3j\u00e1ban l\u00e9v\u0151 OH OCH3-ra v\u00e1ltozik, m\u00edg az 5. \u00e9s 8. vegy\u00fcletekben az A gy\u0171r\u0171 5. poz\u00edci\u00f3j\u00e1ban l\u00e9v\u0151 OH szint\u00e9n OCH3, ami arra utal, hogy az OH ebben a poz\u00edci\u00f3ban d\u00f6nt\u0151 szerepet j\u00e1tszhat az alfa-gl\u00fckozid\u00e1z aktivit\u00e1sban. \u00d6sszefoglalva, ez a tanulm\u00e1ny megalapozza a g\u00fatai endofita gomb\u00e1k ferment\u00e1ci\u00f3s term\u00e9keiben l\u00e9v\u0151 hat\u00f3anyagok tov\u00e1bbi felt\u00e1r\u00e1s\u00e1t. Az izol\u00e1lt monomer vegy\u00fcletek LPS induk\u00e1lt NO-termel\u00e9sre \u00e9s \u03b1 - gl\u00fckozid\u00e1z aktivit\u00e1sra gyakorolt g\u00e1tl\u00f3 hat\u00e1s\u00e1nak vizsg\u00e1lat\u00e1val RAW 264.7 sejtekben felt\u00e1rjuk a vegy\u00fcletek k\u00f6z\u00f6tti szerkezet-hat\u00e1s \u00f6sszef\u00fcgg\u00e9st, ami bizonyos referencia jelent\u0151s\u00e9get biztos\u00edt a term\u00e9szetes hat\u00f3anyagok fejleszt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"<p>Study on Secondary Metabolites of Talaromyces sp., an Endophytic Fungus in Gouteng Uncaria rhynchhophylla (Miq.) Miq Ex Havil. is a thorny plant belonging to the Gentianaceae order of the Rubiaceae family. It is named after the downward single or double hooks on its nodes, and is often used as medicine with dry hooked stems and [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on Secondary Metabolites of Talaromyces sp., an Endophytic Fungus in GoutengStudy on Secondary Metabolites of Talaromyces sp., an Endophytic Fungus in Gouteng - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/gouteng\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on Secondary Metabolites of Talaromyces sp., an Endophytic Fungus in GoutengStudy on Secondary Metabolites of Talaromyces sp., an Endophytic Fungus in Gouteng - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on Secondary Metabolites of Talaromyces sp., an Endophytic Fungus in Gouteng Uncaria rhynchhophylla (Miq.) 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Miq Ex Havil. is a thorny plant belonging to the Gentianaceae order of the Rubiaceae family. 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