{"id":8041,"date":"2024-08-11T18:34:05","date_gmt":"2024-08-11T18:34:05","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8041"},"modified":"2024-08-11T18:34:05","modified_gmt":"2024-08-11T18:34:05","slug":"chuanxinlian-lactone","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/chuanxinlian-lactone\/","title":{"rendered":"A csuanxinlian-lakton sz\u00e1rmaz\u00e9kainak szint\u00e9zis\u00e9ben \u00e9s aktivit\u00e1skutat\u00e1s\u00e1ban el\u00e9rt eredm\u00e9nyek"},"content":{"rendered":"

A csuanxinlian-lakton sz\u00e1rmaz\u00e9kainak szint\u00e9zis\u00e9ben \u00e9s aktivit\u00e1skutat\u00e1s\u00e1ban el\u00e9rt eredm\u00e9nyek
\nA hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer Androgram paniculata (Burm. F) Nees a Menispermaceae csal\u00e1dba tartoz\u00f3 n\u00f6v\u00e9ny, amely a sz\u00edv, a t\u00fcd\u0151, a vastagb\u00e9l \u00e9s a h\u00f3lyag meridi\u00e1njaihoz tartozik. Keser\u0171 \u00edz\u0171 \u00e9s hideg term\u00e9szet\u0171. H\u0151tiszt\u00edt\u00f3 \u00e9s m\u00e9regtelen\u00edt\u0151, v\u00e9rh\u0171t\u0151 \u00e9s karbunkulusokat megsz\u00fcntet\u0151 hat\u00e1sa van. Az andrografolid (molekul\u00e1ris k\u00e9plet C20H30O5, szerkezet\u00e9t az 1. \u00e1bra mutatja) egy feh\u00e9r, n\u00e9gyzet alak\u00fa krist\u00e1ly, az Andrographis paniculata gy\u00f3gyn\u00f6v\u00e9ny f\u0151 kivonata. A kutat\u00e1sok kimutatt\u00e1k, hogy a chuanxinlian-lakton sz\u00e1mos biol\u00f3giai aktivit\u00e1ssal rendelkezik, p\u00e9ld\u00e1ul fert\u0151z\u00e9sellenes, hepatoprotekt\u00edv \u00e9s epehajt\u00f3, r\u00e1kellenes, gyullad\u00e1scs\u00f6kkent\u0151, antibakteri\u00e1lis, mal\u00e1riaellenes, immunmodul\u00e1l\u00f3, sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gek elleni, v\u00edrusellenes stb. hat\u00e1s\u00fa. A klinikai gyakorlatban sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k, \u00e9s jelent\u0151s hat\u00e1sai vannak. Az irodalmi besz\u00e1mol\u00f3k szerint Boorsma csapata izol\u00e1lt el\u0151sz\u00f6r egy sz\u00edntelen krist\u00e1lyt a Houttuynia cordat\u00e1b\u00f3l, amelyet k\u00e9s\u0151bb Gorter csapata szerkezetileg egy laktonvegy\u00fcletk\u00e9nt azonos\u00edtott, \u00e9s andrografolidnak nevezett el. A chuanxinlian-lakton modern extrakci\u00f3s elj\u00e1r\u00e1sa gyakran ultrahangos extrakci\u00f3s m\u00f3dszert alkalmaz. Gao 2011-ben fejezte be el\u0151sz\u00f6r az andrografolid aszimmetrikus teljes szint\u00e9zis\u00e9t biomimetikus poli\u00e9n-cikliz\u00e1ci\u00f3val. A chuanxinlian-lakton egy biciklikus diterpenoid laktonvegy\u00fclet, amely egy transzfuzion\u00e1lt f\u00e9lciklikus alk\u00e1nv\u00e1z, amely k\u00e9t sz\u00e9k alak\u00fa fuzion\u00e1lt hexagon\u00e1lis gy\u0171r\u0171b\u0151l \u00e9s egy pentagon\u00e1lis laktongy\u0171r\u0171b\u0151l \u00e1ll. Egy C-3 szekunder hidroxilcsoporttal, egy C-19 primer hidroxilcsoporttal \u00e9s egy C-14 allyl szekunder hidroxilcsoporttal, valamint k\u00e9t extra ciklikus kett\u0151s k\u00f6t\u00e9ssel rendelkezik. Ezek a csoportok sz\u00e1mos akt\u00edv helyet biztos\u00edtanak a chuanxinlian-lakton szerkezet\u00e9nek m\u00f3dos\u00edt\u00e1s\u00e1hoz. A rossz v\u00edzold\u00e9konys\u00e1g \u00e9s stabilit\u00e1s miatt in vivo a chuanxinlian-lakton biol\u00f3giai hozz\u00e1f\u00e9rhet\u0151s\u00e9ge alacsony, ami korl\u00e1tozza klinikai alkalmaz\u00e1s\u00e1t. Jelenleg a klinikai gyakorlatban els\u0151sorban gyullad\u00e1scs\u00f6kkent\u0151 c\u00e9lokra haszn\u00e1lj\u00e1k. Az elm\u00falt \u00e9vekben a kutat\u00f3k az andrografolid eredend\u0151 tulajdons\u00e1ghib\u00e1in \u00e9s viszonylag akt\u00edv szerkezeti jellemz\u0151in alapul\u00f3 kiterjedt szerkezeti m\u00f3dos\u00edt\u00e1si \u00e9s aktivit\u00e1ssz\u0171r\u00e9si munk\u00e1t v\u00e9geztek, hogy hat\u00e9konyabb gy\u00f3gyszerjel\u00f6lteket fedezzenek fel. Ez a cikk els\u0151sorban a chuanxinlian laktonsz\u00e1rmaz\u00e9kok szint\u00e9zis\u00e9t \u00e9s aktivit\u00e1skutat\u00e1si el\u0151rehalad\u00e1s\u00e1t mutatja be n\u00e9gy szempontb\u00f3l: daganatellenes, gyullad\u00e1scs\u00f6kkent\u0151, antibakteri\u00e1lis \u00e9s v\u00edrusellenes.<\/p>\n

 <\/p>\n

A chuanxinlian-lakton-sz\u00e1rmaz\u00e9kok farmakol\u00f3giai aktivit\u00e1sok sz\u00e9les sk\u00e1l\u00e1j\u00e1val rendelkeznek, \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 kutat\u00f3csoportok m\u00e9g mindig elk\u00f6telezettek abban, hogy ezeket vezet\u0151 vegy\u00fcletekk\u00e9nt haszn\u00e1lj\u00e1k fel, hogy egy sor \u00faj, jobb aktivit\u00e1s\u00fa chuanxinlian-lakton-sz\u00e1rmaz\u00e9kot szintetiz\u00e1ljanak. Jelenleg a chuanxinlian-lakton m\u00f3dos\u00edt\u00e1si t\u00edpusai els\u0151sorban az \u00e9szteres\u00edt\u00e9sre, \u00e9teres\u00edt\u00e9sre, oxid\u00e1ci\u00f3ra, acil\u00e1l\u00e1sra, amid\u00e1l\u00e1sra, kett\u0151s k\u00f6t\u00e9s add\u00edci\u00f3ra, oxid\u00e1ci\u00f3ra, Michael-add\u00edci\u00f3s reakci\u00f3ra \u00e9s a hidroxilcsoportok intramolekul\u00e1ris cikliz\u00e1ci\u00f3s reakci\u00f3j\u00e1ra \u00f6sszpontos\u00edtanak. Az \u00fajonnan szintetiz\u00e1lt sz\u00e1rmaz\u00e9kmolekul\u00e1k viszonylag er\u0151s gyullad\u00e1scs\u00f6kkent\u0151, daganatellenes, antibakteri\u00e1lis \u00e9s v\u00edrusellenes aktivit\u00e1st mutatnak. K\u00f6z\u00fcl\u00fck a 69 vegy\u00fclet v\u00e1rhat\u00f3an a gyullad\u00e1s kezel\u00e9s\u00e9re alkalmas gy\u00f3gyszerjel\u00f6lt lesz j\u00f3 v\u00edzoldhat\u00f3s\u00e1ga \u00e9s alacsony citotoxicit\u00e1sa miatt, a 94a vegy\u00fcletet pedig v\u00e1rhat\u00f3an \u00faj antibakteri\u00e1lis gy\u00f3gyszerk\u00e9nt fejlesztik ki. A sz\u00e1rmaz\u00e9kmolekul\u00e1k hat\u00e1smechanizmusa azonban m\u00e9g mindig nagyr\u00e9szt tiszt\u00e1zatlan, ez\u00e9rt a legt\u00f6bb akt\u00edv sz\u00e1rmaz\u00e9kot m\u00e9g mindig j\u00f3l alkalmazz\u00e1k a klinikai gyakorlatban. Ez\u00e9rt a j\u00f6v\u0151beni sz\u00e1rmaz\u00e9kszint\u00e9zis \u00e9s aktivit\u00e1ssz\u0171r\u00e9si munk\u00e1k sor\u00e1n sz\u00e1m\u00edt\u00f3g\u00e9pes gy\u00f3gyszertervez\u00e9st \u00e9s m\u00e1s m\u00f3dszereket kell alkalmazni, aktivit\u00e1sellen\u0151rz\u00e9si k\u00eds\u00e9rletekkel kombin\u00e1lva, az akt\u00edv sz\u00e1rmaz\u00e9kmolekul\u00e1k c\u00e9lpontjainak tanulm\u00e1nyoz\u00e1s\u00e1ra \u00e9s felt\u00e1r\u00e1s\u00e1ra, a vegy\u00fcletek szerkezeti m\u00f3dos\u00edt\u00e1s\u00e1nak ir\u00e1ny\u00edt\u00e1s\u00e1ra, hogy t\u00f6bb sz\u00e1rmaz\u00e9kmolekula ker\u00fclhessen be a klinikai kutat\u00e1sba gy\u00f3gyszerjel\u00f6ltk\u00e9nt, s\u0151t \u00faj gy\u00f3gyszereket fejlesszenek ki klinikai alkalmaz\u00e1sra. \u00d6sszefoglalva, az \u00e9vek sor\u00e1n a k\u00fcl\u00f6nb\u00f6z\u0151 orsz\u00e1gok kutat\u00f3i soha nem hagyt\u00e1k abba a paeoniflorin sz\u00e1rmaz\u00e9kainak tanulm\u00e1nyoz\u00e1s\u00e1t. A kor\u00e1bbi kutat\u00e1si eredm\u00e9nyek alapj\u00e1n folyamatosan \u00faj utakat keresnek \u00faj paeoniflorin-sz\u00e1rmaz\u00e9kok szint\u00e9zis\u00e9re. Ezek a vizsg\u00e1latok szil\u00e1rd alapot teremtettek az andrografolidon mint vezet\u0151 vegy\u00fcleten alapul\u00f3 \u00faj gy\u00f3gyszerek kifejleszt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Progress in the synthesis and activity research of derivatives of Chuanxinlian lactone The traditional Chinese medicine Androgram paniculata (Burm. F) Nees is a plant in the family Menispermaceae, which belongs to the meridians of the heart, lungs, large intestine, and bladder. It has a bitter taste and a cold nature. It has the effects of […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nProgress in the synthesis and activity research of derivatives of Chuanxinlian lactone - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/chuanxinlian-lactone\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Progress in the synthesis and activity research of derivatives of Chuanxinlian lactone - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Progress in the synthesis and activity research of derivatives of Chuanxinlian lactone The traditional Chinese medicine Androgram paniculata (Burm. 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