{"id":8033,"date":"2024-08-11T17:56:20","date_gmt":"2024-08-11T17:56:20","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8033"},"modified":"2024-08-11T17:56:20","modified_gmt":"2024-08-11T17:56:20","slug":"the-sword-leaved-dragon-blood-tree","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/the-sword-leaved-dragon-blood-tree\/","title":{"rendered":"A Colletotrichum sp. B-152, a kardlevel\u0171 s\u00e1rk\u00e1nyv\u00e9rfa endofita gomb\u00e1j\u00e1nak m\u00e1sodlagos metabolitjainak vizsg\u00e1lata"},"content":{"rendered":"<p>A Colletotrichum sp. B-152, a kardlevel\u0171 s\u00e1rk\u00e1nyv\u00e9rfa endofita gomb\u00e1j\u00e1nak m\u00e1sodlagos metabolitjainak vizsg\u00e1lata<br \/>\nAz endofit\u00e1k olyan mikroorganizmusok csoportj\u00e1ra utalnak, amelyek eg\u00e9szs\u00e9ges n\u00f6v\u00e9nyi sz\u00f6vetekben \u00e9lnek, de nem okoznak fert\u0151z\u00e9seket vagy betegs\u00e9geket a gazdaszervezetben. Sz\u00e9les k\u00f6rben jelen vannak az eg\u00e9szs\u00e9ges n\u00f6v\u00e9nyi sz\u00f6vetekben, \u00e9s nemcsak gazdag m\u00e1sodlagos anyagcsereterm\u00e9kek szint\u00e9zis\u00e9t v\u00e9gz\u0151 g\u00e9ncsoportokat tartalmaznak, hanem k\u00fcl\u00f6nb\u00f6z\u0151 hat\u00f3anyagokat is termelnek. Jav\u00edthatj\u00e1k a n\u00f6v\u00e9nyek stresszel szembeni ellen\u00e1ll\u00f3 k\u00e9pess\u00e9g\u00e9t, p\u00e9ld\u00e1ul a s\u00f3t\u0171r\u00e9st, a sz\u00e1razs\u00e1gt\u0171r\u00e9st, a hidegt\u0171r\u00e9st \u00e9s a rovarokkal szembeni ellen\u00e1ll\u00e1st. Az endofita gomb\u00e1k sokf\u00e9le biol\u00f3giai aktivit\u00e1sa miatt a Colletotrichumot potenci\u00e1lis gy\u00f3gyszerjel\u00f6ltnek tekintik. A Colletotrichum nemzets\u00e9g sz\u00e1mos n\u00f6v\u00e9nyi endofitikus gomb\u00e1t tartalmaz, \u00e9s gazdag bioszintetikus g\u00e9nklaszter\u00e9nek k\u00f6sz\u00f6nhet\u0151en a Colletotrichum k\u00fcl\u00f6nb\u00f6z\u0151 metabolitok, p\u00e9ld\u00e1ul ciklikus foszfopeptidek, antrakinonok, izoft\u00e1lsav-laktonok \u00e9s piranonok fontos forr\u00e1s\u00e1v\u00e1 v\u00e1lt. A Colletotrichum k\u00fcl\u00f6nf\u00e9le kivonatai \u00e9s m\u00e1sodlagos metabolitjai antibakteri\u00e1lis aktivit\u00e1sr\u00f3l sz\u00e1moltak be.<br \/>\nA kutat\u00f3csoport a korai szakaszban meg\u00e1llap\u00edtotta, hogy a Liliaceae csal\u00e1dba tartoz\u00f3 Dracaena Vand. ex L. \u00e9s Dracaena cochinchinensis (Lour.) S. C. Chen level\u00e9nek sz\u00f6vet\u00e9b\u0151l izol\u00e1lt Colletotrichum sp. B-152 endofita gomba sz\u00e9les spektrum\u00fa antibakteri\u00e1lis aktivit\u00e1ssal rendelkezik. Ez\u00e9rt a m\u00e1sodlagos metabolitokat izol\u00e1ltuk \u00e9s tiszt\u00edtottuk, \u00e9s 18 patog\u00e9n indik\u00e1tor bakt\u00e9riumot v\u00e1lasztottunk ki c\u00e9lpontk\u00e9nt a kapott monomer vegy\u00fcletek antibakteri\u00e1lis aktivit\u00e1s\u00e1nak vizsg\u00e1lat\u00e1hoz, hogy felfedezz\u00fck a potenci\u00e1lis antibakteri\u00e1lis aktivit\u00e1ssal rendelkez\u0151 vegy\u00fcleteket. Ez nem csak referenci\u00e1t ny\u00fajt \u00faj term\u00e9szetes akt\u00edv vegy\u00fcletek felfedez\u00e9s\u00e9hez, hanem fontos jelent\u0151s\u00e9ggel b\u00edr a Colletotrichum nemzets\u00e9g m\u00e1sodlagos metabolitjainak \u00e9s funkcion\u00e1lis diverzit\u00e1s\u00e1nak gazdag\u00edt\u00e1sa szempontj\u00e1b\u00f3l is.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u00d6sszesen 9 vegy\u00fcletet izol\u00e1ltunk a Colletotrichum sp. B-152 endofita gomba m\u00e1sodlagos metabolitjaib\u00f3l, amelyet a kardlevel\u0171 s\u00e1rk\u00e1nyv\u00e9rf\u00e1b\u00f3l izol\u00e1ltunk \u00e9s konzerv\u00e1ltunk. A 2-4, 6, 7 \u00e9s 9 vegy\u00fcleteket el\u0151sz\u00f6r izol\u00e1ltuk a Colletotrichum nemzets\u00e9ghez tartoz\u00f3 gomb\u00e1b\u00f3l. A 2-hidroxi-4-metil-1-fenil-3-pentanont (1) jelentett\u00e9k el\u0151sz\u00f6r term\u00e9szetes term\u00e9kk\u00e9nt. Az antibakteri\u00e1lis aktivit\u00e1s eredm\u00e9nyei alapj\u00e1n az 5., 7. \u00e9s 8. vegy\u00fcletek szerkezetileg megegyeznek az azonos sorozatba tartoz\u00f3 vegy\u00fcletekkel, de elt\u00e9r\u0151 aktivit\u00e1st mutatnak, \u00e9s szerkezet-aktivit\u00e1s kapcsolatuk tov\u00e1bbi kutat\u00e1st \u00e9s ellen\u0151rz\u00e9st ig\u00e9nyel; a 2. vegy\u00fclet er\u0151sebb antibakteri\u00e1lis aktivit\u00e1st mutat az Acinetobacter baumannii ATCC 19606 ellen, mint az 1. vegy\u00fclet, ami \u00f6sszef\u00fcgghet a k\u00e9t vegy\u00fclet szerkezet\u00e9ben a 3. poz\u00edci\u00f3ban l\u00e9v\u0151 k\u00fcl\u00f6nb\u00f6z\u0151 szubsztituensekkel. Ezenk\u00edv\u00fcl kor\u00e1bbi vizsg\u00e1latok kimutatt\u00e1k, hogy az adenozin (4) in vitro influenza v\u00edrus (H1N1) elleni aktivit\u00e1st mutat; a (22E, 24R) - ergosta-7,22-di\u00e9n-3 \u03b2, 5 \u03b1, 6 \u03b2 - triol (5) er\u0151s g\u00e1tl\u00f3 hat\u00e1st mutat a gyomorr\u00e1k SGC-7901 sejtekkel szemben; A (4E, 8E) - N-D-2 '- hidroxipalmitoil-1-O - \u03b2 - D-glikokopir-anozil-9-metil-4,8-szfingadienin (6) herpes simplex v\u00edrus (HSV-1) elleni g\u00e1tl\u00f3 aktivit\u00e1sa 20-szorosa a pozit\u00edv hat\u00f3anyag\u00fa ribavirinnek, az enterov\u00edrus 71 (EV71) elleni g\u00e1tl\u00f3 aktivit\u00e1sa pedig 5-szerese a pozit\u00edv hat\u00f3anyag\u00fa ribavirinnek; A tuberosider (7) er\u0151s g\u00e1tl\u00f3 hat\u00e1ssal rendelkezik az MCF-7 hum\u00e1n eml\u0151r\u00e1ksejt \u00e9s az MDCK kutyavese sejt prolifer\u00e1ci\u00f3j\u00e1ra; (22E, 24R) -5 \u03b1, 8 \u03b1 - epidioxygeergosta-6,22-dien-3 \u03b2 - ol (8) bizonyos g\u00e1tl\u00f3 hat\u00e1ssal rendelkezik az A-549 eg\u00e9r t\u00fcd\u0151 adenokarcin\u00f3ma sejtvonalra. Ezek a vizsg\u00e1latok azt mutatj\u00e1k, hogy a Colletotrichum gomb\u00e1b\u00f3l izol\u00e1lt vegy\u00fcletek j\u00f3 antibakteri\u00e1lis, antivir\u00e1lis \u00e9s tumorellenes aktivit\u00e1ssal rendelkeznek, ami \u00faj bizony\u00edt\u00e9kot szolg\u00e1ltat \u00faj antibakteri\u00e1lis gy\u00f3gyszerek \u00e9s akt\u00edv term\u00e9szetes term\u00e9kek felfedez\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"<p>Study on Secondary Metabolites of Colletotrichum sp. B-152, an Endophytic Fungus of the Sword leaved Dragon Blood Tree Endophytes refer to a group of microorganisms that live in healthy plant tissues but do not cause host infections or diseases. They are widely present in healthy plant tissues and not only contain rich secondary metabolite synthesis [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on Secondary Metabolites of Colletotrichum sp. 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B-152, a kardlevel\u0171 s\u00e1rk\u00e1nyv\u00e9rfa endofita gomb\u00e1j\u00e1nak m\u00e1sodlagos metabolitjainak vizsg\u00e1lata - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/hu\/the-sword-leaved-dragon-blood-tree\/","og_locale":"hu_HU","og_type":"article","og_title":"Study on Secondary Metabolites of Colletotrichum sp. B-152, an Endophytic Fungus of the Sword leaved Dragon Blood Tree - China Chemical Manufacturer","og_description":"Study on Secondary Metabolites of Colletotrichum sp. B-152, an Endophytic Fungus of the Sword leaved Dragon Blood Tree Endophytes refer to a group of microorganisms that live in healthy plant tissues but do not cause host infections or diseases. 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