{"id":8003,"date":"2024-08-11T17:39:24","date_gmt":"2024-08-11T17:39:24","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8003"},"modified":"2024-08-11T17:39:24","modified_gmt":"2024-08-11T17:39:24","slug":"career","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/career\/","title":{"rendered":"Az aerob glikol\u00edzisen alapul\u00f3 term\u00e9szetes kis molekul\u00e1j\u00fa g\u00e1tl\u00f3kkal kapcsolatos kutat\u00e1si eredm\u00e9nyek"},"content":{"rendered":"<p>Az aerob glikol\u00edzisen alapul\u00f3 term\u00e9szetes kis molekul\u00e1j\u00fa g\u00e1tl\u00f3kkal kapcsolatos kutat\u00e1si eredm\u00e9nyek<br \/>\nA rosszindulat\u00fa daganatok m\u00e9g mindig fontos betegs\u00e9g, amely s\u00falyosan vesz\u00e9lyezteti az emberi \u00e9letet \u00e9s eg\u00e9szs\u00e9get. A daganatos sejtek abnorm\u00e1lis energia-anyagcsere jellemz\u0151ket mutatnak, \u00e9s oxig\u00e9nben gazdag k\u00f6rnyezetben is glikol\u00edzist haszn\u00e1lnak az energiaell\u00e1t\u00e1shoz. A tumorsejtekben az ATP mintegy 50%-je aerob glikol\u00edzis \u00fatj\u00e1n szintetiz\u00e1l\u00f3dik. A tumorsejtek nemcsak a glikol\u00edzis \u00fatvonal k\u00f6ztes term\u00e9keit haszn\u00e1lhatj\u00e1k fel a szintetikus anyagcsere nyersanyagainak biztos\u00edt\u00e1s\u00e1ra, hanem a glikol\u00edzis \u00fatvonal \u00e1ltal okozott lakt\u00e1tn\u00f6veked\u00e9s savas n\u00f6veked\u00e9si k\u00f6rnyezetet biztos\u00edthat a tumorsejtek sz\u00e1m\u00e1ra, ami el\u0151seg\u00edti a besz\u0171r\u0151d\u00e9s\u00fcket \u00e9s \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9s\u00fcket. A glikol\u00edzis aktivit\u00e1s\u00e1nak mechanizmusa a tumorsejtekben \u00f6sszetett, \u00e9s t\u00f6bb t\u00e9nyez\u0151 kombin\u00e1ci\u00f3ja okozza, bele\u00e9rtve a glikol\u00edzis sz\u00e1m\u00e1ra kedvez\u0151 transzmembr\u00e1n strukt\u00far\u00e1kat, a kulcsfontoss\u00e1g\u00fa glikol\u00edzis enzimek abnorm\u00e1lis metabolizmus\u00e1t, az onkog\u00e9nek \u00e9s jel\u00e1tviteli \u00fatvonalak abnorm\u00e1lis expresszi\u00f3j\u00e1t stb. A glikolitikus enzimek be\u00e1ll\u00edt\u00e1sa a legfontosabb \u00fatvonal a glikol\u00edzis aktivit\u00e1s\u00e1nak \u00e9s t\u00falterjed\u00e9s\u00e9nek fokoz\u00e1s\u00e1ra. Vizsg\u00e1latok kimutatt\u00e1k, hogy a gl\u00fck\u00f3ztranszporterek (GLUT) el\u0151seg\u00edthetik a gl\u00fck\u00f3z transzportj\u00e1t a sejtmembr\u00e1non, m\u00edg a piruv\u00e1t-dehidrogen\u00e1z-kin\u00e1z (PDK), a lakt\u00e1t-dehidrogen\u00e1z A (LDHA), a piruv\u00e1t-kin\u00e1z (PKM), a hexokin\u00e1z (HK) kulcsfontoss\u00e1g\u00fa sebess\u00e9gkorl\u00e1toz\u00f3 enzimek a glikol\u00edzis folyamat\u00e1ban, \u00e9s magasan expressz\u00e1l\u00f3dnak sz\u00e1mos rosszindulat\u00fa daganatban, p\u00e9ld\u00e1ul m\u00e1jr\u00e1kban, t\u00fcd\u0151r\u00e1kban \u00e9s eml\u0151r\u00e1kban. Ezenk\u00edv\u00fcl az aerob glikol\u00edzis g\u00e1tl\u00e1sa hat\u00e9konyan elnyomhatja a tumorsejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s el\u0151seg\u00edtheti a tumorsejtek apopt\u00f3zis\u00e1t; A hipoxia \u00e1ltal induk\u00e1lt metabolikus kapcsol\u00f3k megv\u00e1ltoztat\u00e1s\u00e1val \u00e9s ezen specifikus enzimek c\u00e9lzott megc\u00e9lz\u00e1s\u00e1val a tumorsejtek aktivit\u00e1s\u00e1nak cs\u00f6kkent\u00e9se \u00e9rdek\u00e9ben a Warburg-hat\u00e1s megford\u00edt\u00e1sa a daganatellenes kezel\u00e9s fontos \u00fatj\u00e1v\u00e1 v\u00e1lt.<br \/>\nA kutat\u00e1sok kimutatt\u00e1k, hogy a gl\u00fck\u00f3z transzporter (GLUT) csal\u00e1d mind a 14 tagja k\u00e9pes hex\u00f3zok \u00e9s poliolok sz\u00e1ll\u00edt\u00e1s\u00e1ra. A GLUT1-5 k\u00fcl\u00f6nb\u00f6z\u0151 sz\u00f6vetekben \u00e9s sejtt\u00edpusokban gl\u00fck\u00f3z- \u00e9s\/vagy frukt\u00f3ztranszporterk\u00e9nt m\u0171k\u00f6dik. Az aerob glikol\u00edzis metabolikus folyamata (l\u00e1sd az 1. \u00e1br\u00e1t) azt jelzi, hogy a legt\u00f6bb tumorban a hipoxi\u00e1s mikrok\u00f6rnyezet a GLUT1 magas expresszi\u00f3j\u00e1t induk\u00e1lhatja, ez\u00e1ltal n\u00f6velve a tumorsejtek gl\u00fck\u00f3zfelv\u00e9teli k\u00e9pess\u00e9g\u00e9t. Ez a folyamat az alapja annak, hogy a tumorsejtek Warburg-effektust produk\u00e1ljanak. A hexokin\u00e1z (HK) az els\u0151 sebess\u00e9gkorl\u00e1toz\u00f3 enzim a glikol\u00edzisben, m\u00edg a foszfofruktokin\u00e1z 1 (PFK1) a m\u00e1sodik sebess\u00e9gkorl\u00e1toz\u00f3 enzim a glikol\u00edzisben. Aktivit\u00e1s\u00e1t a foszfofruktokin\u00e1z-2\/frukt\u00f3z-2,6-difoszfat\u00e1z (PFKFB) szab\u00e1lyozza. Az acetoacet\u00e1t-kin\u00e1znak (PK) n\u00e9gy izoform\u00e1ja van, M1, M2, L \u00e9s R, \u00e9s a glikol\u00edzis harmadik sebess\u00e9gkorl\u00e1toz\u00f3 enzimje. A PKM2 sz\u00e9les k\u00f6rben fel\u00fclreprezent\u00e1lt a tumorsz\u00f6vetekben. A lakt\u00e1t-dehidrogen\u00e1z (LDH) pedig a glikol\u00edzis folyamat\u00e1nak utols\u00f3 l\u00e9p\u00e9s\u00e9t - a lakt\u00e1t \u00e9s a piruv\u00e1t k\u00f6z\u00f6tti \u00e1talakul\u00e1st - kataliz\u00e1lja. A tumorsejtek f\u0151k\u00e9nt a lakt\u00e1t-dehidrogen\u00e1z LDHA alt\u00edpus\u00e1t expressz\u00e1lj\u00e1k. A tumorokban az emelkedett LDHA nemcsak a glikol\u00edzist, hanem a lakt\u00e1t termel\u00e9s\u00e9t is el\u0151seg\u00edti, ez\u00e1ltal \u00e1tform\u00e1lja a tumor mikrok\u00f6rnyezet\u00e9t. Ez a cikk \u00f6sszefoglalja a fent eml\u00edtett feh\u00e9rj\u00e9k \u00e9s term\u00e9szetes kismolekul\u00e1s c\u00e9lzott g\u00e1tl\u00f3ik kutat\u00e1s\u00e1ban el\u00e9rt leg\u00fajabb eredm\u00e9nyeket \u00e9s hat\u00e1smechanizmusokat, referenci\u00e1t ny\u00fajtva a kapcsol\u00f3d\u00f3 ter\u00fclet kutat\u00e1s\u00e1hoz.<\/p>\n<p>&nbsp;<\/p>\n<p>Az aerob glikol\u00edzis, mint a tumorsejtekre jellemz\u0151 saj\u00e1tos energia-anyagcsere, nemcsak a tumorsejtek prolifer\u00e1ci\u00f3j\u00e1hoz biztos\u00edt energi\u00e1t \u00e9s anyagell\u00e1t\u00e1st, hanem a ferment\u00e1ci\u00f3s \u00fatvonal \u00e1ltal okozott lakt\u00e1tn\u00f6veked\u00e9s miatt savas n\u00f6veked\u00e9si k\u00f6rnyezetet is biztos\u00edt a tumorsejtek sz\u00e1m\u00e1ra, ami el\u0151seg\u00edti besziv\u00e1rg\u00e1sukat \u00e9s \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9s\u00fcket. Ez a cikk \u00f6sszefoglalja a megl\u00e9v\u0151 kutat\u00e1sokban tal\u00e1lt kismolekul\u00e1s inhibitorokat, amelyek a tumor glikol\u00edzis\u00e9nek term\u00e9szetes forr\u00e1sokb\u00f3l sz\u00e1rmaz\u00f3 kulcsenzimeit c\u00e9lozz\u00e1k, intuit\u00edv m\u00f3don t\u00fckr\u00f6zve szerkezet\u00fcket \u00e9s \u00faj \u00f6tleteket ny\u00fajtva a szerkezeti m\u00f3dos\u00edt\u00e1shoz, annak \u00e9rdek\u00e9ben, hogy inspir\u00e1ci\u00f3t ny\u00fajtson a term\u00e9szetes term\u00e9kekben l\u00e9v\u0151 tumorellenes hat\u00f3anyagok hat\u00e9konyabb fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz, a ford\u00edtott tumorok multidrog-rezisztenci\u00e1j\u00e1nak kialak\u00edt\u00e1s\u00e1hoz, a hagyom\u00e1nyos kemoter\u00e1pia hat\u00e9konys\u00e1g\u00e1nak jav\u00edt\u00e1s\u00e1hoz \u00e9s a tumor kemoter\u00e1pi\u00e1s gy\u00f3gyszerekkel szembeni \u00e9rz\u00e9kenys\u00e9g\u00e9nek fokoz\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"<p>Research progress on natural small molecule inhibitors based on aerobic glycolysis Malignant tumors are still an important disease that seriously threatens human life and health. Tumor cells exhibit abnormal energy metabolism characteristics, using glycolysis to provide energy even in an oxygen rich environment. Approximately 50% of ATP in tumor cells is synthesized through aerobic glycolysis. [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research progress on natural small molecule inhibitors based on aerobic glycolysis - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/career\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research progress on natural small molecule inhibitors based on aerobic glycolysis - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Research progress on natural small molecule inhibitors based on aerobic glycolysis Malignant tumors are still an important disease that seriously threatens human life and health. 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Tumor cells exhibit abnormal energy metabolism characteristics, using glycolysis to provide energy even in an oxygen rich environment. Approximately 50% of ATP in tumor cells is synthesized through aerobic glycolysis. 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