{"id":7523,"date":"2024-08-06T20:19:48","date_gmt":"2024-08-06T20:19:48","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7523"},"modified":"2024-08-06T20:19:48","modified_gmt":"2024-08-06T20:19:48","slug":"sophora-alopecuroides","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/sophora-alopecuroides\/","title":{"rendered":"A Sophora alopecuroides gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1nak \u00e9s mechanizmus\u00e1nak vizsg\u00e1lata a lipopoliszacharid \u00e1ltal kiv\u00e1ltott gyullad\u00e1sra RAW264.7 sejtekben"},"content":{"rendered":"

A Sophora alopecuroides gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1nak \u00e9s mechanizmus\u00e1nak vizsg\u00e1lata a lipopoliszacharid \u00e1ltal kiv\u00e1ltott gyullad\u00e1sra RAW264.7 sejtekben
\nA gyullad\u00e1s egy v\u00e9dekez\u0151 v\u00e1laszreakci\u00f3, amely akkor l\u00e9p fel, amikor a szervezetet k\u00e1ros bels\u0151 \u00e9s k\u00fcls\u0151 ingerek, p\u00e9ld\u00e1ul k\u00f3rokoz\u00f3k t\u00e1madj\u00e1k meg vagy fert\u0151zik meg. Immunv\u00e1laszt v\u00e1lt ki a szervezet v\u00e9delme \u00e9rdek\u00e9ben. Ha az immunrendszer t\u00falzottan vagy folyamatosan aktiv\u00e1l\u00f3dik, az egy sor gyullad\u00e1ssal kapcsolatos betegs\u00e9ghez vezethet, mint p\u00e9ld\u00e1ul reum\u00e1s \u00edz\u00fcleti gyullad\u00e1s, gyullad\u00e1sos b\u00e9lbetegs\u00e9g, daganatok stb., ami v\u00e9g\u00fcl tart\u00f3s vagy \u00e1tmeneti gyullad\u00e1st eredm\u00e9nyez. A makrof\u00e1gok k\u00f6zponti szerepet j\u00e1tszanak a gyullad\u00e1sos v\u00e1laszok elind\u00edt\u00e1s\u00e1ban, fenntart\u00e1s\u00e1ban \u00e9s enyh\u00edt\u00e9s\u00e9ben, \u00e9s tart\u00f3s felhalmoz\u00f3d\u00e1suk \u00e9s aktiv\u00e1ci\u00f3juk kr\u00f3nikus gyullad\u00e1sra utal. A lipopoliszacharid (LPS) k\u00e9pes aktiv\u00e1lni a makrof\u00e1gokat \u00e9s el\u0151seg\u00edteni a gyullad\u00e1sos medi\u00e1torok, p\u00e9ld\u00e1ul a tumor nekr\u00f3zis faktor alfa (TNF - \u03b1), interleukin-1 \u03b2 (IL-1 \u03b2), interleukin-6 (IL-6), nitrog\u00e9n-oxid (NO) stb. kiv\u00e1laszt\u00e1s\u00e1t. Ezeknek a gyullad\u00e1sos medi\u00e1toroknak a t\u00falzott felszabadul\u00e1sa szervi k\u00e1rosod\u00e1shoz \u00e9s kr\u00f3nikus betegs\u00e9gekhez vezethet. Az NF - \u03ba B fontos szerepet j\u00e1tszik az olyan folyamatok szab\u00e1lyoz\u00e1s\u00e1ban, mint a sejt apopt\u00f3zis \u00e9s a gyullad\u00e1sos v\u00e1lasz, \u00e9s fontos c\u00e9lpontja a gyullad\u00e1scs\u00f6kkent\u0151 ter\u00e1pi\u00e1nak.<\/p>\n

A Sophora alopecuroides L, m\u00e1s n\u00e9ven Sophora alopecuroides a h\u00fcvelyesek csal\u00e1dj\u00e1ba, a Sophora nemzets\u00e9gbe tartoz\u00f3 n\u00f6v\u00e9ny. \u00c9szaknyugat-K\u00edna \u00e9s K\u00f6z\u00e9p-\u00c1zsia k\u00fcl\u00f6nb\u00f6z\u0151 tartom\u00e1nyaiban elterjedt, \u00e9s h\u0151- \u00e9s m\u00e9regtelen\u00edt\u0151, f\u00e1jdalom- \u00e9s gyullad\u00e1scs\u00f6kkent\u0151, nedvess\u00e9gsz\u00e1r\u00edt\u00f3 \u00e9s v\u00e9rhasmegel\u0151z\u0151 funkci\u00f3val rendelkezik. K\u00edna \u00e9szaknyugati r\u00e9gi\u00f3j\u00e1ban fontos gy\u00f3gyn\u00f6v\u00e9ny. A Sophora alopecuroides els\u0151sorban alkaloidokat, flavonoidokat, szerves savakat, poliszacharidokat, ill\u00f3olajokat, szteroidokat, fenolokat \u00e9s egy\u00e9b \u00f6sszetev\u0151ket tartalmaz. Az alkaloidok gyullad\u00e1scs\u00f6kkent\u0151, r\u00e1kellenes, antibakteri\u00e1lis \u00e9s immunszab\u00e1lyoz\u00f3 hat\u00e1s\u00faak, a flavonoidok gyullad\u00e1scs\u00f6kkent\u0151, v\u00edrusellenes, antioxid\u00e1ns hat\u00e1s\u00faak, a poliszacharidok pedig immunszab\u00e1lyoz\u00f3 \u00e9s daganatellenes funkci\u00f3val rendelkeznek, amelyek hat\u00e9konyan jav\u00edthatj\u00e1k a szervezet immunit\u00e1s\u00e1t, \u00e9s fontos szerepet j\u00e1tszanak a daganatellenes \u00e9s immuner\u0151s\u00edt\u00e9sben. A fenti tanulm\u00e1nyok mind a Sophora alopecuroides egy bizonyos k\u00e9miai \u00f6sszet\u00e9tel\u0171 csoportj\u00e1n alapulnak, \u00e9s a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s a t\u00f6bbkomponens\u0171, t\u00f6bbc\u00e9l\u00fa \u00e9s t\u00f6bb \u00fatvonal\u00fa kombin\u00e1lt hat\u00e1sok jellemz\u0151ivel rendelkezik, amelyek alacsonyabb gy\u00f3gyszeradagokkal ugyanazt vagy m\u00e9g jobb ter\u00e1pi\u00e1s hat\u00e1st \u00e9rhetnek el, bele\u00e9rtve a hat\u00e9kony r\u00e9szkompatibilit\u00e1st \u00e9s a hat\u00e9kony \u00f6sszetev\u0151 kompatibilit\u00e1st. Ez\u00e9rt meg kell vizsg\u00e1lni, hogy a Sophora alopecuroides k\u00fcl\u00f6nb\u00f6z\u0151 k\u00e9miai \u00f6sszet\u00e9tel\u0171 csoportjai fokozhatj\u00e1k-e a hat\u00e9konys\u00e1got. Ez a cikk az LPS \u00e1ltal induk\u00e1lt RAW 264.7 sejteket gyullad\u00e1sos modellk\u00e9nt a Sophora alopecuroides gyullad\u00e1scs\u00f6kkent\u0151 gy\u00f3gyszerek sz\u0171r\u00e9s\u00e9re, \u00e9s felt\u00e1rja a hagyom\u00e1nyos v\u00edzbont\u00f3 kivonatot (WDE), a vizes ultrahangos kivonatot (WUE), a 75% etanolos reflux kivonatot (ERE), 75% etanolos ultrahangos kivonatot (EUE), valamint a Sophora alopecuroides teljes alkaloid-kivonat\u00e1t (TAE), teljes flavonoid-kivonat\u00e1t (TFE), teljes poliszacharid-kivonat\u00e1t (TPE) \u00e9s a k\u00fcl\u00f6nb\u00f6z\u0151 hat\u00e9kony r\u00e9szek kilenc kombin\u00e1ci\u00f3j\u00e1t. A gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s \u00e9s hat\u00e1smechanizmus (1:1:1, 1:2:2, 1:3:3, 2:1:2, 2:2:3, 2:3:1, 3:1:3, 3:2:1, 3:3:2, 3:3:2).<\/p>\n

\"\"\"\"\"\"\"\"\"\"
\nA makrof\u00e1gok r\u00e9szt vesznek a szervezet immunv\u00e1lasz\u00e1ban. LPS stimul\u00e1l\u00e1sakor a makrof\u00e1gok jel\u00e1tviteli utakat (pl. NF - \u03ba B) ind\u00edtanak el, amelyek el\u0151seg\u00edtik a pro-inflammatorikus medi\u00e1torok, pl. NO, TNF - \u03b1, IL-1 \u03b2, IL-6 stb. termel\u00e9s\u00e9t. Az NO t\u00falzott termel\u00e9se szorosan \u00f6sszef\u00fcgg a gyullad\u00e1s kialakul\u00e1s\u00e1val. A TNF - \u03b1 \u00e9s az IL-6 szintj\u00e9nek n\u00f6veked\u00e9se el\u0151seg\u00edtheti a sejtek \u00e1ltal t\u00f6rt\u00e9n\u0151 t\u00f6bb pro-inflammatorikus citokin kiv\u00e1laszt\u00e1s\u00e1t. Az IL-6 egy fontos pro-inflammatorikus citokin, amely a B-sejtek \u00e9s a T-sejtek aktiv\u00e1l\u00f3d\u00e1s\u00e1t induk\u00e1lhatja, \u00e9s r\u00e9szt vehet a szervezet immunv\u00e1lasz\u00e1ban. Az IL-1 \u03b2 akut vagy kr\u00f3nikus gyullad\u00e1sban felszab\u00e1lyoz\u00f3dik. A vizsg\u00e1lat eredm\u00e9nyei azt mutatt\u00e1k, hogy a RAW 264.7 LPS-kezel\u00e9st k\u00f6vet\u0151en a NO, TNF - \u03b1, IL-6 \u00e9s IL-1 \u03b2 felszabadul\u00e1sa jelent\u0151sen megn\u0151tt, ami egy in vitro gyullad\u00e1sos modell sikeres l\u00e9trehoz\u00e1s\u00e1t jelzi. A Sophora alopecuroides WDE, WUE, EUE, ERE \u00e9s ezek TAE, TFE, TPE mind k\u00e9pesek g\u00e1tolni a NO, TNF - \u03b1, IL-6 \u00e9s IL-1 \u03b2 termel\u0151d\u00e9s\u00e9t az LPS \u00e1ltal stimul\u00e1lt RAW 264.7 sejtekben, amelyek k\u00f6z\u00fcl a TFE, EUE, ERE A TAE g\u00e1tl\u00f3 hat\u00e1sa jelent\u0151sebb A TFE \u00e9s TPE k\u00fcl\u00f6nb\u00f6z\u0151 ar\u00e1ny\u00fa kever\u00e9se ut\u00e1n azt tal\u00e1ltuk, hogy k\u00fcl\u00f6nb\u00f6z\u0151 m\u00e9rt\u00e9kben k\u00e9pesek g\u00e1tolni a TNF - \u03b1 felszabadul\u00e1s\u00e1t. K\u00f6z\u00fcl\u00fck az 1:1:1 \u00e9s 1:1:2 kombin\u00e1ci\u00f3k kiv\u00e9tel\u00e9vel a t\u00f6bbi h\u00e9t kombin\u00e1ci\u00f3 jobb g\u00e1tl\u00f3 hat\u00e1ssal volt a TNF - \u03b1 felszabadul\u00e1s\u00e1ra, mint \u00f6nmagukban. A 2:1:2 kombin\u00e1ci\u00f3nak volt a legjobb g\u00e1tl\u00f3 hat\u00e1sa, ami jelent\u0151s szinergista hat\u00e1st mutatott.<\/p>\n

A Sophora alopecuroides gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1nak molekul\u00e1ris mechanizmus\u00e1nak felt\u00e1r\u00e1sa \u00e9rdek\u00e9ben ez a tanulm\u00e1ny WB-t haszn\u00e1lt az IkB \u03b1, NF - \u03ba B p65 \u00e9s a p-IkB \u03b1, p-NF - \u03ba B p65 kulcsfeh\u00e9rj\u00e9k expresszi\u00f3j\u00e1nak kimutat\u00e1s\u00e1ra az NF - \u03ba B jel\u00e1tviteli \u00fatvonalban. Az NF - \u03ba B a gyullad\u00e1s kulcsfontoss\u00e1g\u00fa szab\u00e1lyoz\u00f3 faktor, amely sz\u00e1mos kulcsfontoss\u00e1g\u00fa gyullad\u00e1sos medi\u00e1tor, p\u00e9ld\u00e1ul az IL-1 \u03b2, IL-6, TNF - \u03b1 stb. transzkripci\u00f3j\u00e1t k\u00e9pes szab\u00e1lyozni. Az LPS a TLR4 receptorokhoz k\u00f6t\u0151dve aktiv\u00e1lja az NF - \u03ba B jel\u00e1tviteli \u00fatvonalat, amely fontos l\u00e1ncszem a makrof\u00e1gok gyullad\u00e1sos medi\u00e1torok felszabad\u00edt\u00e1s\u00e1nak induk\u00e1l\u00e1s\u00e1ban. Amikor a sejteket stimul\u00e1lj\u00e1k, az NF - \u03ba B-hez k\u00f6t\u0151d\u0151 IkBa g\u00e1tl\u00f3 feh\u00e9rje az IkB \u03b1 kin\u00e1z hat\u00e1s\u00e1ra gyorsan foszforil\u00e1l\u00f3dik p-IkB \u03b1-v\u00e1, ami akt\u00edv p-NF - \u03ba B p65-\u00f6t szabad\u00edt fel a sejtmagba, ez\u00e1ltal el\u0151seg\u00edtve a gyullad\u00e1ssal kapcsolatos faktorok szint\u00e9zis\u00e9t \u00e9s szekr\u00e9ci\u00f3j\u00e1t. Az ut\u00f3bbi \u00e9vekben sz\u00e1mos jelent\u00e9s sz\u00fcletett az alkaloidok, flavonoidok \u00e9s poliszacharidok gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1sair\u00f3l. A vizsg\u00e1latok p\u00e9ld\u00e1ul azt tal\u00e1lt\u00e1k, hogy a Sophora flavescens alkaloidok k\u00e9pesek enyh\u00edteni az LPS \u00e1ltal kiv\u00e1ltott gyullad\u00e1st a RAW 264.7 makrof\u00e1gokban az IkB \u03b1 foszforil\u00e1ci\u00f3 \u00e9s a p-NF - \u03ba B p65 nukle\u00e1ris transzlok\u00e1ci\u00f3 g\u00e1tl\u00e1s\u00e1val. Zhao \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a Sophora flavescens \u00f6sszes alkaloidja az NF - \u03ba B aktiv\u00e1ci\u00f3 g\u00e1tl\u00e1s\u00e1val enyh\u00edtheti a dextr\u00e1n-szulf\u00e1t \u00e1ltal kiv\u00e1ltott vastagb\u00e9lgyullad\u00e1st. Vizsg\u00e1latok kimutatt\u00e1k, hogy a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban tal\u00e1lhat\u00f3 flavonoidok cs\u00f6kkenthetik az IkB \u03b1 \u00e9s p65 feh\u00e9rj\u00e9k foszforil\u00e1ci\u00f3s szintj\u00e9t az NF - \u03ba B jel\u00e1tviteli \u00fatvonalban, hogy gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1st fejtsenek ki. Li \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a Sophora flavescens teljes flavonoidjai a JAK2\/STAT3 jel\u00e1tviteli \u00fatvonal aktiv\u00e1ci\u00f3j\u00e1nak g\u00e1tl\u00e1s\u00e1val immunmodul\u00e1l\u00f3 hat\u00e1st fejthetnek ki a fek\u00e9lyes vastagb\u00e9lgyullad\u00e1sra, a Cistanche poliszacharidok pedig g\u00e1tolhatj\u00e1k a JAK2\/STAT3 jel\u00e1tviteli \u00fatvonal aktiv\u00e1ci\u00f3j\u00e1t. Az NF - \u03ba B MAPK \u00e9s a STAT3 aktiv\u00e1ci\u00f3j\u00e1t az LPS \u00e1ltal kiv\u00e1ltott gyullad\u00e1s g\u00e1tl\u00e1s\u00e1ra haszn\u00e1lj\u00e1k RAW 264.7 makrof\u00e1gokban, m\u00edg Qu \u00e9s munkat\u00e1rsai tanulm\u00e1nya kimutatta, hogy a Pinus koraiensisb\u0151l sz\u00e1rmaz\u00f3 poliszacharidok az Nrf2\/HO-1 jel\u00e1tviteli \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1val k\u00e9pesek g\u00e1tolni az LPS \u00e1ltal kiv\u00e1ltott gyullad\u00e1st. Jelenleg viszonylag kev\u00e9s kutat\u00e1s foglalkozik az alkaloidok, flavonoidok \u00e9s poliszacharidok kombin\u00e1ci\u00f3j\u00e1nak gyullad\u00e1sra gyakorolt hat\u00e1s\u00e1val. Ez a tanulm\u00e1ny azt tal\u00e1lta, hogy a Sophora alopecuroidesben l\u00e9v\u0151 TAE, TFE \u00e9s TPE kombin\u00e1ci\u00f3j\u00e1nak alkalmaz\u00e1sakor az NF - \u03ba B p65 \u00e9s IkB \u03b1 feh\u00e9rj\u00e9k foszforil\u00e1ci\u00f3ja jelent\u0151sen cs\u00f6kkent, \u00e9s a p-IkB \u03b1 \u00e9s a p-NF - \u03ba B p65 feh\u00e9rj\u00e9k expresszi\u00f3ja g\u00e1tolt. Ez azt jelzi, hogy a Sophora alopecuroides teljes biomassza, az \u00f6sszes flavonoidok \u00e9s az \u00f6sszes poliszacharidok kombin\u00e1ci\u00f3ja enyh\u00edtheti az LPS \u00e1ltal kiv\u00e1ltott gyullad\u00e1st a RAW 264.7 makrof\u00e1gokban az NF - \u03ba B \u00fatvonal aktiv\u00e1l\u00f3d\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val.<\/p>\n

\u00d6sszefoglalva, ez a tanulm\u00e1ny els\u0151sorban a Sophora alopecuroides hagyom\u00e1nyos WDE, WUE, EUE, ERE \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 hat\u00e9kony r\u00e9szeik TAE, TFE, TPE \u00e9s kilenc kombin\u00e1ci\u00f3 (1:1:1:1, 1:2:2, 1:3:3, 2:1:2, 2:2:3, 2:3:1, 3:1:3, 3:2:1, 3:3:2) gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t hasonl\u00edtotta \u00f6ssze in vitro. Meg\u00e1llap\u00edtottuk, hogy a TAE, TFE, TPE (2:1:2) kombin\u00e1ci\u00f3ja volt a legjobb g\u00e1tl\u00f3 hat\u00e1ssal az LPS \u00e1ltal kiv\u00e1ltott gyullad\u00e1sra a RAW 264.7 sejtekben, \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1st fejtett ki in vitro az NF - \u03ba B gyullad\u00e1sos \u00fatvonal aktiv\u00e1l\u00f3d\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val. Ez a k\u00eds\u00e9rlet csak a gyullad\u00e1scs\u00f6kkent\u0151 szerek sz\u0171r\u00e9s\u00e9t fejezte be sejtszinten, \u00e9s csak a Sophora alopecuroides k\u00fcl\u00f6nb\u00f6z\u0151 farmakol\u00f3giai r\u00e9szeinek kompatibilit\u00e1si kombin\u00e1ci\u00f3it vizsg\u00e1lta. Vannak azonban m\u00e9g olyan probl\u00e9m\u00e1k, mint a komplex k\u00e9miai \u00f6sszet\u00e9tel, a nem egy\u00e9rtelm\u0171 farmakol\u00f3giai \u00f6sszetev\u0151k \u00e9s a hat\u00e1sok anyagi alapja, amelyek tov\u00e1bbi kutat\u00e1st ig\u00e9nyelnek.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the anti-inflammatory effect and mechanism of Sophora alopecuroides on lipopolysaccharide induced inflammation in RAW264.7 cells Inflammation is a defensive response that occurs when the body is attacked or infected by harmful internal and external stimuli such as pathogens. It triggers an immune response to protect the body. When the immune system is excessively […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the anti-inflammatory effect and mechanism of Sophora alopecuroides on lipopolysaccharide induced inflammation in RAW264.7 cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/sophora-alopecuroides\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the anti-inflammatory effect and mechanism of Sophora alopecuroides on lipopolysaccharide induced inflammation in RAW264.7 cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the anti-inflammatory effect and mechanism of Sophora alopecuroides on lipopolysaccharide induced inflammation in RAW264.7 cells Inflammation is a defensive response that occurs when the body is attacked or infected by harmful internal and external stimuli such as pathogens. It triggers an immune response to protect the body. 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