{"id":7485,"date":"2024-08-06T20:06:46","date_gmt":"2024-08-06T20:06:46","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7485"},"modified":"2024-08-06T20:06:46","modified_gmt":"2024-08-06T20:06:46","slug":"colon-tumors","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/vastagbeldaganatok\/","title":{"rendered":"A Jolkinolid B mechanizmusa a vastagb\u00e9ldaganatok kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a k\u00eds\u00e9rleti kutat\u00e1s alapj\u00e1n"},"content":{"rendered":"

A Jolkinolid B mechanizmusa a vastagb\u00e9ldaganatok kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a k\u00eds\u00e9rleti kutat\u00e1s alapj\u00e1n
\nA vastagb\u00e9lr\u00e1k (CRC) a harmadik leggyakoribb rosszindulat\u00fa daganat a vil\u00e1gon, amely komoly vesz\u00e9lyt jelent az emberi eg\u00e9szs\u00e9gre. A vastagb\u00e9lr\u00e1k okozta hal\u00e1lesetek sz\u00e1ma 2015-ben el\u00e9rte a 774000-et. Az emberek \u00e9letm\u00f3dj\u00e1nak \u00e9s t\u00e1pl\u00e1lkoz\u00e1si szerkezet\u00e9nek \u00f3ri\u00e1si v\u00e1ltoz\u00e1sai miatt a vastagb\u00e9lr\u00e1k el\u0151fordul\u00e1si ar\u00e1nya \u00e9s hal\u00e1loz\u00e1si ar\u00e1nya \u00e9vr\u0151l \u00e9vre n\u0151. A vastagb\u00e9lr\u00e1k megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re ir\u00e1nyul\u00f3 kutat\u00e1s meger\u0151s\u00edt\u00e9se a r\u00e1k elleni k\u00fczdelem egyik fontos tartalma K\u00edn\u00e1ban. Egyre fontosabb\u00e1 v\u00e1lik a term\u00e9szetes er\u0151forr\u00e1sokb\u00f3l sz\u00e1rmaz\u00f3 olyan vezet\u0151 vegy\u00fcletek keres\u00e9se, amelyek k\u00e9pesek a vastagb\u00e9ldaganatokat megc\u00e9lozni \u00e9s el\u0151seg\u00edteni a tumorsejtek apopt\u00f3zis\u00e1t. A hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban a \"farkasbogy\u00f3\" hossz\u00fa m\u00faltra tekint vissza, \u00e9s a n\u00e9pi gy\u00f3gy\u00e1szatban gyakran haszn\u00e1lj\u00e1k a vastagb\u00e9lr\u00e1k kezel\u00e9s\u00e9re. Ez a gy\u00f3gyszer szerepel a K\u00ednai Gy\u00f3gyszerk\u00f6nyv 2020-as kiad\u00e1s\u00e1ban, \u00e9s az Euphorbia fis cheriana Steud \u00e9s az Euphorbia ebracteolata Hayata n\u00f6v\u00e9nyeknek az Euphorbiaceae csal\u00e1dba tartoz\u00f3 sz\u00e1r\u00edtott gy\u00f6kere. El\u0151sz\u00f6r a \"Shennong Materia Medica\"-ban jegyezt\u00e9k fel, \u00e9s f\u0151leg k\u00f6h\u00f6g\u00e9sre, felhalmoz\u00f3d\u00e1sok felold\u00e1s\u00e1ra, sebek, eg\u00e9relhal\u00e1s \u00e9s m\u00e9rgez\u00e9s eset\u00e9n haszn\u00e1lj\u00e1k. Az \u00e9szakkeleti n\u00e9pek a f\u0151zet\u00e9t vastagb\u00e9lr\u00e1k kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k. Kutat\u00e1sok kimutatt\u00e1k, hogy a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban haszn\u00e1lt \"farkasbogy\u00f3\" 47%-vel meghosszabb\u00edthatja a vastagb\u00e9lr\u00e1kban szenved\u0151 \u00e1llatok t\u00fal\u00e9l\u00e9si ar\u00e1ny\u00e1t.<\/p>\n

A farkasm\u00e9reg akt\u00edv m\u00e1sodlagos anyagcsereterm\u00e9kei f\u0151k\u00e9nt terpenoidok, amelyek tartalma b\u0151s\u00e9ges. K\u00eds\u00e9rleti csoportunk a farkasm\u00e9reg gy\u00f3gyn\u00f6v\u00e9nyforr\u00e1s\u00e1nak, az Euphorbia lanceolata sz\u00e1r\u00edtott gy\u00f6ker\u00e9b\u0151l a korai szakaszban szerkezetileg v\u00e1ltozatos diterp\u00e9neket izol\u00e1lt, mint p\u00e9ld\u00e1ul ent abiet\u00e1n, ros\u00e1n \u00e9s diterpenoid dimerek. K\u00f6z\u00fcl\u00fck az ent abiet\u00e1n diterp\u00e9n Jolkinolite B (szerkezet\u00e9t az 1. \u00e1bra mutatja) hat\u00e9konyan g\u00e1tolja az SW480 vastagb\u00e9l tumorsejt prolifer\u00e1ci\u00f3j\u00e1t (IC50=9,5 \u03bc mpl\/L), ami anyagi alapot ny\u00fajt a CRC kezel\u00e9s\u00e9hez, de a hat\u00e1smechanizmus m\u00e9g nem vil\u00e1gos. A kor\u00e1bbi kutat\u00e1sok alapjait figyelembe v\u00e9ve tervezz\u00fck, hogy a Jolkinolid B hat\u00f3anyag hat\u00e1smechanizmus\u00e1t a CRC kezel\u00e9s\u00e9ben in vitro sejtk\u00eds\u00e9rletekkel kombin\u00e1lt h\u00e1l\u00f3zati farmakol\u00f3giai m\u00f3dszerekkel felt\u00e1rjuk, k\u00eds\u00e9rleti bizony\u00edt\u00e9kot szolg\u00e1ltatva a k\u00e9s\u0151bbi gy\u00f3gyszerfejleszt\u00e9shez \u00e9s klinikai alkalmaz\u00e1sokhoz.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nA h\u00e1l\u00f3zati farmakol\u00f3gia nagym\u00e9rt\u00e9kben t\u00fckr\u00f6zheti a biomolekul\u00e1k \u00e9s a k\u00e9miai komponensek k\u00f6z\u00f6tti \u00f6sszetett k\u00f6lcs\u00f6nhat\u00e1sokat. A hat\u00e1s c\u00e9lpontj\u00e1nak h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1n kereszt\u00fcl t\u00f6rt\u00e9n\u0151 sz\u0171r\u00e9s\u00e9vel alapot teremthet a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s c\u00e9lzottabb kutat\u00e1s\u00e1hoz, tiszt\u00e1zhatja a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s optim\u00e1lis vegy\u00fcleteit \u00e9s hat\u00e1smechanizmusait. A hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat farkasbogy\u00f3 az Euphorbiaceae csal\u00e1dba tartoz\u00f3 Euphorbiaceae nemzets\u00e9ghez tartoz\u00f3 n\u00f6v\u00e9ny. Hat\u00e1sa a v\u00edz \u00e9s a v\u00e1lad\u00e9k eloszlat\u00e1sa, a felhalmoz\u00f3d\u00e1s lebont\u00e1sa \u00e9s a rovarok elpuszt\u00edt\u00e1sa. A kutat\u00e1si eredm\u00e9nyek azt mutatj\u00e1k, hogy a diterpenoidok a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat farkasbogy\u00f3 hat\u00f3anyag\u00e1nak alapj\u00e1t k\u00e9pezik, k\u00fcl\u00f6nb\u00f6z\u0151 biol\u00f3giai aktivit\u00e1sokkal, p\u00e9ld\u00e1ul daganatellenes, gyullad\u00e1scs\u00f6kkent\u0151, antibakteri\u00e1lis \u00e9s a multidrog-rezisztencia megford\u00edt\u00e1s\u00e1val. A hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban a farkasbogy\u00f3 hossz\u00fa m\u00faltra tekint vissza, \u00e9s a n\u00e9pi gy\u00f3gy\u00e1szatban gyakran haszn\u00e1lj\u00e1k a vastagb\u00e9lr\u00e1k kezel\u00e9s\u00e9re. Ennek alapj\u00e1n farmakol\u00f3giai mechanizmus el\u0151rejelz\u00e9st v\u00e9geznek. A hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat farkasbogy\u00f3 k\u00e9miai \u00f6sszetev\u0151inek kor\u00e1bbi kutat\u00e1sai alapj\u00e1n a farkasbogy\u00f3ban tal\u00e1lhat\u00f3 kiv\u00e1l\u00f3 vegy\u00fcletet, a Jolkinolid B-t in vitro citotoxikus aktivit\u00e1s sz\u0171r\u00e9sen \u00e9s in vivo biol\u00f3giai k\u00eds\u00e9rleteken kereszt\u00fcl vizsg\u00e1lt\u00e1k. A farkasbogy\u00f3ban tal\u00e1lhat\u00f3 kiv\u00e1l\u00f3 vegy\u00fclet, a Jolkinolid B c\u00e9lpontjai k\u00f6z\u00f6tti kapcsolat felt\u00e1r\u00e1s\u00e1ra egy Jolkinolid B-c\u00e9lpont h\u00e1l\u00f3zatot \u00e9p\u00edtett\u00fcnk, \u00e9s a c\u00e9lpontok funkcion\u00e1lis annot\u00e1ci\u00f3j\u00e1t g\u00e9nszinten v\u00e9gezt\u00fck el. Ez kutat\u00e1si alapot biztos\u00edt a Jolkinolid B t\u00f6bb c\u00e9lpontot \u00e9s t\u00f6bb \u00fatvonalat \u00e9rint\u0151 farmakol\u00f3giai mechanizmusaihoz.<\/p>\n

A Jolkinolide B-PPI k\u00f6lcs\u00f6nhat\u00e1si h\u00e1l\u00f3zat elemz\u00e9se azt mutatja, hogy a f\u0151 c\u00e9lpontok a STAT3, a MAPK8 \u00e9s a JUN, amelyeket a vonatkoz\u00f3 irodalmi kutat\u00e1sok meger\u0151s\u00edtettek; Ezek a c\u00e9lpontok jeleket tov\u00e1bb\u00edtanak a sejtfelsz\u00edni receptorokt\u00f3l a sejtmagban l\u00e9v\u0151 DNS-hez, r\u00e9szt vesznek olyan biol\u00f3giai folyamatokban, mint a sejthal\u00e1l \u00e9s a sejtciklus, valamint szab\u00e1lyozz\u00e1k a patol\u00f3giai folyamatokat, mint a gyullad\u00e1s \u00e9s a stresszv\u00e1lasz. A MAPK1 \u00e9s a MAPK3 a MAPK tagja. A STAT3 a MAPK \u00e1ltal aktiv\u00e1lhat\u00f3 transzkripci\u00f3s faktor, amely kulcsszerepet j\u00e1tszik sz\u00e1mos sejtfolyamatban, p\u00e9ld\u00e1ul a sejtn\u00f6veked\u00e9sben \u00e9s az apopt\u00f3zisban, r\u00e9szt vesz a daganatok kialakul\u00e1s\u00e1ban \u00e9s fejl\u0151d\u00e9s\u00e9ben. Ezenk\u00edv\u00fcl a STAT3 d\u00f6nt\u0151 fontoss\u00e1g\u00fa a TH17 seg\u00edt\u0151 T-sejtek differenci\u00e1l\u00f3d\u00e1s\u00e1ban, \u00e9s \u00f6sszef\u00fcgg\u00e9sbe hozhat\u00f3 az autoimmun betegs\u00e9gekkel, a visszat\u00e9r\u0151 fert\u0151z\u00e9sekkel \u00e9s m\u00e1s betegs\u00e9gekkel.<\/p>\n

A GO annot\u00e1ci\u00f3s eredm\u00e9nyek azt mutatj\u00e1k, hogy a Jolkinolite B legt\u00f6bb c\u00e9lpontja a sejtm\u00e1trixban \u00e9s a transzkripci\u00f3s komplexekben tal\u00e1lhat\u00f3, \u00e9s r\u00e9szt vesz a k\u00fcl\u00f6nb\u00f6z\u0151 stresszv\u00e1laszokban \u00e9s biol\u00f3giai folyamatokban a sejtekben. Ez az eredm\u00e9ny arra utal, hogy a Jolkinolite B r\u00e9szt vehet a legt\u00f6bb sejtes \u00e9lettev\u00e9kenys\u00e9g szab\u00e1lyoz\u00e1s\u00e1ban. A KEGG d\u00fas\u00edt\u00e1si elemz\u00e9s eredm\u00e9nyei azt mutatj\u00e1k, hogy a Jolkinolite B farmakol\u00f3giai hat\u00e1sai t\u00f6bb \u00fatvonal k\u00f6lcs\u00f6nhat\u00e1s\u00e1t foglalj\u00e1k magukban, bele\u00e9rtve az IL-17 jel\u00e1tviteli \u00fatvonalat, a PD-1 \/ PD-L1 jel\u00e1tviteli \u00fatvonalat \u00e9s a HIF-1 jel\u00e1tviteli \u00fatvonalat. A molekul\u00e1ris dokkol\u00e1si eredm\u00e9nyek azt mutatj\u00e1k, hogy a Jolkinolid B hidrog\u00e9n- \u00e9s hidrof\u00f3b k\u00f6lcs\u00f6nhat\u00e1sokat alak\u00edt ki a STAT3, MAPK8 \u00e9s JUN k\u00f6zponti feh\u00e9rj\u00e9kkel, stabil szerkezettel \u00e9s potenci\u00e1lis kutat\u00e1si \u00e9rt\u00e9kkel, ami bizony\u00edtja a Jolkinolid B t\u00f6bb c\u00e9lpontot \u00e9s t\u00f6bb \u00fatvonalat \u00e9rint\u0151 jellemz\u0151it a CRC kezel\u00e9s\u00e9ben.<\/p>\n

A daganatellenes gy\u00f3gyszerek f\u0151 hat\u00e1smechanizmusa a tumorsejtek apopt\u00f3zis\u00e1nak kiv\u00e1lt\u00e1sa, a sejtciklus g\u00e1tl\u00e1sa \u00e9s a migr\u00e1ci\u00f3 elnyom\u00e1sa. A k\u00eds\u00e9rleti eredm\u00e9nyek sejtszinten azt mutatt\u00e1k, hogy a Jolkinolite B jelent\u0151sen g\u00e1tolta a HCT116 sejtek prolifer\u00e1ci\u00f3j\u00e1t, el\u0151seg\u00edtette a sejtek apopt\u00f3zis\u00e1t \u00e9s g\u00e1tolta a sejtv\u00e1ndorl\u00e1st. Amikor a Bax nagym\u00e9rt\u00e9kben kifejez\u0151d\u00f6tt a sejtekben, a sejtek \u00e9rz\u00e9kenyek voltak a hal\u00e1ljelekre \u00e9s el\u0151seg\u00edtett\u00e9k az apopt\u00f3zist. Amikor a Bcl-2 nagym\u00e9rt\u00e9kben kifejez\u0151d\u00f6tt, a Bcl-2 heterodimert tudott k\u00e9pezni a Bax-szal, g\u00e1tolva a sejtek apopt\u00f3zis\u00e1t. Teh\u00e1t a Bax\/Bcl-2 ar\u00e1nya a sejtekben fontos szerepet j\u00e1tszik a sejtek apopt\u00f3zis \u00e9rz\u00e9kenys\u00e9g\u00e9nek meghat\u00e1roz\u00e1s\u00e1ban. Ez\u00e9rt a Western blot valid\u00e1ci\u00f3s k\u00eds\u00e9rletek sejtszinten azt mutatt\u00e1k, hogy a Jolkinolite B jelent\u0151sen felszab\u00e1lyozta a Bax\/Bcl-2 ar\u00e1ny\u00e1t, el\u0151seg\u00edtve az apopt\u00f3zist a HCT116 sejtekben. A h\u00e1l\u00f3zati farmakol\u00f3giai elemz\u00e9s eredm\u00e9nyei alapj\u00e1n a Jolkinolid B t\u00f6bb c\u00e9lponton \u00e9s \u00fatvonalon kereszt\u00fcl avatkozhat be a CRC-ben, \u00e9s daganatellenes aktivit\u00e1sa \u00f6sszef\u00fcgghet a Bax \u00e9s Bcl-2 apoptotikus g\u00e9nek expresszi\u00f3j\u00e1ra gyakorolt hat\u00e1s\u00e1val.<\/p>\n

A daganatok inv\u00e1zi\u00f3ja \u00e9s metaszt\u00e1zis\u00e1nak kialakul\u00e1sa \u00f6sszetett folyamat, amely mag\u00e1ban foglalja a sejtek k\u00f6z\u00f6tti k\u00f6lcs\u00f6nhat\u00e1sokat \u00e9s az extracellul\u00e1ris m\u00e1trix leboml\u00e1s\u00e1t. Az extracellul\u00e1ris m\u00e1trix lebont\u00e1sa a m\u00e1trixkomponenseket lebont\u00f3 enzimek szint\u00e9zis\u00e9t\u0151l \u00e9s aktiv\u00e1l\u00e1s\u00e1t\u00f3l f\u00fcgg. A m\u00e1trix metalloprotein\u00e1zok (MMP-k) a cinkf\u00fcgg\u0151 proteolitikus enzimek egy oszt\u00e1lya, amelyek szerkezeti homol\u00f3gi\u00e1val rendelkeznek. F\u0151 fiziol\u00f3giai funkci\u00f3juk az extracellul\u00e1ris m\u00e1trixkomponensek, p\u00e9ld\u00e1ul a kollag\u00e9n, a zselatin, az elasztin, a fibronectin \u00e9s a proteoglik\u00e1nok lebont\u00e1sa. Kutat\u00e1sok kimutatt\u00e1k, hogy a m\u00e1trix metalloprotein\u00e1z-3 (MMP-3) \u00e9s a m\u00e1trix metalloprotein\u00e1z-12 (MMP-12) d\u00f6nt\u0151 szerepet j\u00e1tszik a tumorsejtek \u00e1ltal k\u00f6zvet\u00edtett extracellul\u00e1ris m\u00e1trix lebont\u00e1s\u00e1ban, \u00e9s szorosan \u00f6sszef\u00fcgg a k\u00fcl\u00f6nb\u00f6z\u0151 rosszindulat\u00fa daganatok lehets\u00e9ges inv\u00e1zi\u00f3j\u00e1val, metaszt\u00e1zis\u00e1val \u00e9s progn\u00f3zis\u00e1val az emberben. Ez\u00e9rt a sejtek szintj\u00e9n v\u00e9gzett Western blot valid\u00e1ci\u00f3s k\u00eds\u00e9rletek azt mutatt\u00e1k, hogy a Jolkinolid B jelent\u0151sen cs\u00f6kkenti az MMP-2 \u00e9s az MMP-12 expresszi\u00f3j\u00e1t a tumor inv\u00e1zi\u00f3 \u00e9s metaszt\u00e1zis g\u00e1tl\u00e1sa \u00e9rdek\u00e9ben. A h\u00e1l\u00f3zati farmakol\u00f3giai elemz\u00e9s eredm\u00e9nyei alapj\u00e1n a Jolkinolid B t\u00f6bb c\u00e9lponton \u00e9s \u00fatvonalon kereszt\u00fcl avatkozhat be a CRC-ben, \u00e9s a tumorinv\u00e1zi\u00f3 \u00e9s metaszt\u00e1zis g\u00e1tl\u00e1sa \u00f6sszef\u00fcgghet az MMP-2 \u00e9s az MMP-12 expresszi\u00f3j\u00e1ra gyakorolt hat\u00e1s\u00e1val.<\/p>\n

\u00d6sszefoglalva, ez a tanulm\u00e1ny aktivit\u00e1ssz\u0171r\u00e9st, bioinformatikai \u00e9s molekul\u00e1ris dokkol\u00e1si technik\u00e1kat alkalmazott a Jolkinolid B mechanizmus\u00e1nak elemz\u00e9s\u00e9re a kolorekt\u00e1lis r\u00e1k (CRC) megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban l\u00e9v\u0151 farkasbogy\u00f3 Jolkinolid B hat\u00f3anyaga \u00e9s a kapcsol\u00f3d\u00f3 c\u00e9lfeh\u00e9rj\u00e9k, jel\u00e1tviteli \u00fatvonalak \u00e9s biol\u00f3giai funkci\u00f3k k\u00f6z\u00f6tti h\u00e1l\u00f3zati korrel\u00e1ci\u00f3 alapj\u00e1n. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a vegy\u00fclet a CRC-t t\u00f6bb c\u00e9lpont, \u00fatvonal \u00e9s biol\u00f3giai funkci\u00f3 seg\u00edts\u00e9g\u00e9vel kezeli, ir\u00e1nyt adva a Jolkinolid B mechanizmus\u00e1nak tov\u00e1bbi kutat\u00e1s\u00e1hoz a CRC megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben. Ennek f\u00e9ny\u00e9ben ez a projekt a j\u00f6v\u0151ben is folytatja a mechanizmus kutat\u00e1s\u00e1t a molekul\u00e1ris biol\u00f3giai \u00e9s a patofiziol\u00f3giai m\u00f3dszerek kombin\u00e1l\u00e1s\u00e1val.<\/p>","protected":false},"excerpt":{"rendered":"

Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research Colorectal cancer (CRC) is the third most common malignant tumor in the world, which is a serious threat to human health. In 2015, the number of deaths from colon cancer reached 774000. Because of the tremendous changes in […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nMechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/vastagbeldaganatok\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research Colorectal cancer (CRC) is the third most common malignant tumor in the world, which is a serious threat to human health. 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