{"id":7458,"date":"2024-08-06T19:58:27","date_gmt":"2024-08-06T19:58:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7458"},"modified":"2024-08-06T19:58:27","modified_gmt":"2024-08-06T19:58:27","slug":"jinlu","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/jinlu\/","title":{"rendered":"A Jinlu szilv\u00e1b\u00f3l sz\u00e1rmaz\u00f3 alfa-gl\u00fckozid\u00e1z inhibitor extrakci\u00f3ja, d\u00fas\u00edt\u00e1sa \u00e9s aktivit\u00e1s\u00e1nak vizsg\u00e1lata"},"content":{"rendered":"

A Jinlu szilv\u00e1b\u00f3l sz\u00e1rmaz\u00f3 alfa-gl\u00fckozid\u00e1z inhibitor extrakci\u00f3ja, d\u00fas\u00edt\u00e1sa \u00e9s aktivit\u00e1s\u00e1nak vizsg\u00e1lata
\nAz \u03b1 - gl\u00fckozid\u00e1z (AG) a cukorbetegs\u00e9ghez szorosan kapcsol\u00f3d\u00f3 enzim. K\u00e9pes a sz\u00e9nhidr\u00e1tokat gl\u00fck\u00f3zz\u00e1, frukt\u00f3zz\u00e1 \u00e9s galakt\u00f3zz\u00e1 metaboliz\u00e1lni, amelyek a szervezetben felsz\u00edv\u00f3dnak \u00e9s hasznos\u00edthat\u00f3k. \u03b1 - gl\u00fckozid\u00e1z inhibitor (AGI) k\u00e9pes blokkolni az AG \u00e9s a cukor kombin\u00e1ci\u00f3j\u00e1t \u00e9s az AG aktivit\u00e1s\u00e1nak kompetit\u00edv g\u00e1tl\u00e1s\u00e1val cs\u00f6kkenti az \u00e9homi v\u00e9rcukorszintet. Az elm\u00falt \u00e9vekben a cukorbetegek sz\u00e1m\u00e1nak n\u00f6veked\u00e9s\u00e9vel a k\u00ednai \u00e9s tibeti gy\u00f3gyszerek hat\u00e9kony \u00f6sszetev\u0151i fokozatosan n\u00f6vekedtek a cukorbetegs\u00e9g kezel\u00e9s\u00e9nek klinikai alkalmaz\u00e1s\u00e1ban. A term\u00e9szetes \u03b1 - gl\u00fckozid\u00e1z inhibitorok el\u0151nyei a stabil hat\u00e9konys\u00e1g, a biztons\u00e1g, a kis mell\u00e9khat\u00e1sok stb., az orvostudom\u00e1ny kutat\u00e1si ter\u00fclet\u00e9nek forr\u00f3 pontj\u00e1v\u00e1 v\u00e1lva.
\nA Potentilla fruticosa L. a r\u00f3zsaf\u00e9l\u00e9k (Rosaceae) csal\u00e1dj\u00e1ba \u00e9s a Potentilla nemzets\u00e9gbe tartoz\u00f3 lombhullat\u00f3 cserje, amely f\u0151k\u00e9nt a Csinghaji Tibeti-fenns\u00edk magasan fekv\u0151 ter\u00fcletein elterjedt. A Jin Lu Mei gy\u00f6kerei, sz\u00e1ra, levelei, vir\u00e1gai \u00e9s \u00e1gai er\u0151s farmakol\u00f3giai aktivit\u00e1ssal rendelkeznek. A leveleket \u00e1ltal\u00e1ban \u00e9lelmiszer- \u00e9s kozmetikai adal\u00e9kanyagk\u00e9nt haszn\u00e1lj\u00e1k, a gy\u00f6k\u00e9r- \u00e9s sz\u00e1rkivonatok pedig er\u0151s immunszab\u00e1lyoz\u00f3 tulajdons\u00e1gokkal rendelkeznek, er\u0151sebb hat\u00e1ssal, mint a Ci Wu Jia; Az \u00e1g kivonata ehet\u0151, \u00e9s in vitro k\u00eds\u00e9rletek kimutatt\u00e1k, hogy j\u00f3 hat\u00e1ssal van a koleszterin- \u00e9s v\u00e9rcukorszint cs\u00f6kkent\u00e9s\u00e9re a v\u00e9rben. Kutat\u00f3csoportunk kor\u00e1bbi, a Primulaceae k\u00e9miai \u00f6sszet\u00e9tel\u00e9re vonatkoz\u00f3 vizsg\u00e1latai kimutatt\u00e1k, hogy a Primulaceae-ban el\u0151sz\u00f6r izol\u00e1lt\u00e1k a kvercetin-7-O - \u03b2 - D-gl\u00fckuronid flavonoid vegy\u00fcletet, amely alfa-gl\u00fckozid\u00e1z g\u00e1tl\u00f3 hat\u00e1ssal rendelkezik.
\nA n\u00f6v\u00e9nyi flavonoidok elv\u00e1laszt\u00e1si \u00e9s tiszt\u00edt\u00e1si m\u00f3dszerei k\u00f6z\u00e9 els\u0151sorban a gyantaadszorpci\u00f3, a nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fia stb. tartozik. A gyantaadszorpci\u00f3s m\u00f3dszert sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k a flavonoidok d\u00fas\u00edt\u00e1s\u00e1ra a nagy fel\u00fclet, a nagy adszorpci\u00f3s kapacit\u00e1s, a j\u00f3 szelektivit\u00e1s, a hossz\u00fa gyanta \u00e9lettartam \u00e9s az alacsony m\u0171k\u00f6d\u00e9si k\u00f6lts\u00e9g el\u0151nyei miatt. Ez a tanulm\u00e1ny makropor\u00f3zus adszorpci\u00f3s gyanta (AB-8) m\u00f3dszert haszn\u00e1lt a Prunus mume-ban l\u00e9v\u0151 kvercetin-7-O - \u03b2 - D-gl\u00fckuronid vegy\u00fclet AG aktivit\u00e1s\u00e1nak d\u00fas\u00edt\u00e1s\u00e1ra \u00e9s g\u00e1tl\u00e1s\u00e1ra, elm\u00e9leti alapot ny\u00fajtva a term\u00e9szetes \u03b1 - gl\u00fckozid\u00e1z inhibitorok \u00e1tfog\u00f3 fejleszt\u00e9s\u00e9hez \u00e9s felhaszn\u00e1l\u00e1s\u00e1hoz a Prunus mume-ban.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nEz a cikk a tibeti Jin Lu Mei gy\u00f3gyszert tekinti kutat\u00e1si t\u00e1rgynak, \u00e9s a DAC-50 f\u00e9lig preparat\u00edv nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1t \u00e9s nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1t alkalmazza, hogy el\u0151sz\u00f6r izol\u00e1lja nagy tisztas\u00e1g\u00fa hipoglik\u00e9mi\u00e1s vegy\u00fcletet a Jin Lu Meib\u0151l. M\u00f3dszert dolgoztak ki a Quercetin-7-O - \u03b2 - D-gl\u00fckuronid monomer vegy\u00fcletek elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re a Jin Lu Meib\u0151l. A Jinlu Mei-ben jelen l\u00e9v\u0151 k\u00e9miai komponensek kivon\u00e1sa 75% etanol seg\u00edts\u00e9g\u00e9vel. Az extrakci\u00f3s oldatot AB-8 oszlopkromatogr\u00e1fi\u00e1val 0, 10%, 20%, 30%, 40% \u00e9s 50% vizes etanolos oldattal elv\u00e1lasztottuk \u00e9s szegment\u00e1ltuk. A vegy\u00fcleteket el\u0151zetesen polarit\u00e1suk alapj\u00e1n oszt\u00e1lyoztuk, \u00e9s a 20% AB-8 Jinlumei eluensben l\u00e9v\u0151 monomer vegy\u00fcleteket f\u0151leg a 20% AB-8 eluensben izol\u00e1ltuk \u00e9s \u00e1ll\u00edtottuk el\u0151.
\nA vegy\u00fclet szerkezeti elemz\u00e9se sor\u00e1n kider\u00fclt, hogy flavonoid vegy\u00fcletr\u0151l van sz\u00f3. A vegy\u00fclet aktivit\u00e1s kimutat\u00e1s\u00e1nak \u00e9s inhibitor t\u00edpus\u00e1nak azonos\u00edt\u00e1si eredm\u00e9nyei azt mutatt\u00e1k, hogy a kvercetin-7-O - \u03b2 - D-gl\u00fckuronid kompetit\u00edv inhibitor volt, a legmagasabb g\u00e1tl\u00e1si ar\u00e1ny 94,67% volt. Ez azt jelzi, hogy a vegy\u00fclet er\u0151s versenyk\u00e9pess\u00e9ggel rendelkezik az AG-hez val\u00f3 k\u00f6t\u0151d\u00e9sben, nagym\u00e9rt\u00e9kben cs\u00f6kkentve az AG cukrokhoz val\u00f3 k\u00f6t\u0151d\u00e9s\u00e9t, ami \u00f6sszhangban van a kor\u00e1bbi kutat\u00e1si eredm\u00e9nyekkel. A vegy\u00fclet \u00e9s az AG k\u00f6z\u00f6tti lehets\u00e9ges k\u00f6t\u0151d\u00e9si modellt sz\u00e1m\u00edt\u00f3g\u00e9pes molekul\u00e1ris dokkol\u00e1si m\u00f3dszerrel vizsg\u00e1ltuk, \u00e9s felt\u00e1rtuk a lehets\u00e9ges hat\u00e1smechanizmust. A vegy\u00fclet flavonoid sz\u00fcl\u0151magj\u00e1nak h\u00e1rom benzolgy\u0171r\u0171je \u03c0 - \u03c0 konjug\u00e1lt k\u00f6t\u00e9seken, \u03c0 - alkilk\u00f6t\u00e9seken, \u03c0 - \u03c3 konjug\u00e1lt k\u00f6t\u00e9seken, hidrog\u00e9nk\u00f6t\u00e9seken stb. kereszt\u00fcl stabil k\u00f6t\u00e9si \u00e1llapotot alak\u00edtott ki az AG feh\u00e9rjemarad\u00e9kokkal, ez\u00e1ltal cs\u00f6kkentve az \u00e9homi v\u00e9rcukorszintet. Ez a vegy\u00fclet j\u00f3 \u03b1 - gl\u00fckozid\u00e1z g\u00e1tl\u00f3 aktivit\u00e1ssal rendelkezik, ami azt jelzi, hogy a Jinlumei rendelkezik a cukorbetegs\u00e9g kezel\u00e9s\u00e9re szolg\u00e1l\u00f3 gy\u00f3gyszerek kifejleszt\u00e9s\u00e9nek lehet\u0151s\u00e9g\u00e9vel, \u00e9s tudom\u00e1nyos elm\u00e9leti alapot biztos\u00edt a Jinlumei hipoglik\u00e9mi\u00e1s gy\u00f3gyszer-\u00f6sszetev\u0151k kutat\u00e1s\u00e1hoz \u00e9s fejleszt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Extraction, Enrichment, and Activity Study of an Alpha Glucosidase Inhibitor from Jinlu Plum \u03b1 – glucosidase (AG) is an enzyme closely related to diabetes. It can metabolize carbohydrates into glucose, fructose and galactose that can be absorbed and utilized by the human body in the body. \u03b1 – glucosidase inhibitor (AGI) can block the combination […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExtraction, Enrichment, and Activity Study of an Alpha Glucosidase Inhibitor from Jinlu Plum - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/jinlu\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extraction, Enrichment, and Activity Study of an Alpha Glucosidase Inhibitor from Jinlu Plum - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Extraction, Enrichment, and Activity Study of an Alpha Glucosidase Inhibitor from Jinlu Plum \u03b1 – glucosidase (AG) is an enzyme closely related to diabetes. 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