{"id":7447,"date":"2024-08-06T19:55:48","date_gmt":"2024-08-06T19:55:48","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7447"},"modified":"2024-08-06T19:55:48","modified_gmt":"2024-08-06T19:55:48","slug":"huanglian-jiedu-tang","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/huanglian-jiedu-tang\/","title":{"rendered":"A Huanglian Jiedu Tang mechanizmus\u00e1nak felt\u00e1r\u00e1sa a vaszkul\u00e1ris demencia kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n"},"content":{"rendered":"

A Huanglian Jiedu Tang mechanizmus\u00e1nak felt\u00e1r\u00e1sa a vaszkul\u00e1ris demencia kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n
\nA vaszkul\u00e1ris demencia (VD) egy olyan kognit\u00edv diszfunkci\u00f3s szindr\u00f3ma, amelyet t\u00f6bb agyi \u00e9rrendszeri t\u00e9nyez\u0151 okoz, \u00e9s az Alzheimer-k\u00f3r ut\u00e1n a m\u00e1sodik legnagyobb demenciat\u00edpus. A felm\u00e9r\u00e9s azt mutatja, hogy a VD el\u0151fordul\u00e1si ar\u00e1nya a 65 \u00e9v feletti emberek k\u00f6r\u00e9ben a vil\u00e1gon 5%~10%. A n\u00e9pess\u00e9g el\u00f6reged\u00e9s\u00e9nek s\u00falyosbod\u00e1s\u00e1val a VD betegek sz\u00e1ma 2050-re v\u00e1rhat\u00f3an megh\u00e1romszoroz\u00f3dik, ami komoly vesz\u00e9lyt jelent a k\u00f6z\u00e9pkor\u00fa \u00e9s id\u0151s emberek eg\u00e9szs\u00e9g\u00e9re. Jelenleg a nyugati orvosl\u00e1sban nincs specifikus gy\u00f3gyszer a VD-re, \u00e9s a nyugati gy\u00f3gyszerek hossz\u00fa t\u00e1v\u00fa alkalmaz\u00e1sa s\u00falyos mell\u00e9khat\u00e1sokat okozhat. A hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9nyek el\u0151nye azonban a t\u00f6bbc\u00e9l\u00fa \u00e9s t\u00f6bbmechanizmus\u00fa hat\u00e1s, amely t\u00f6bbc\u00e9l\u00fa, t\u00f6bb \u00fatvonalon \u00e9s t\u00f6bb rendszerben t\u00f6rt\u00e9n\u0151 beavatkoz\u00e1ssal, minim\u00e1lis toxikus mell\u00e9khat\u00e1sokkal \u00e9s jelent\u0151s ter\u00e1pi\u00e1s hat\u00e1sokkal k\u00e9pes beavatkozni a VD komplex patogenezis\u00e9be.<\/p>\n

A modern t\u00e1rsadalom \u00fagy v\u00e9li, hogy az \"agyi meridi\u00e1n toxikus k\u00e1rosod\u00e1sa\" a VD egyik f\u0151 patogenezis\u00e9nek l\u00e9nyege, \u00e9s a f\u0151 kezel\u00e9si m\u00f3dszerek a t\u0171z tiszt\u00edt\u00e1sa \u00e9s a m\u00e9regtelen\u00edt\u00e9s. A Huanglian Jiedu Tang Ge Hong \"S\u00fcrg\u0151ss\u00e9gi formula a k\u00f6ny\u00f6ktartal\u00e9khoz\" c\u00edm\u0171 m\u0171v\u00e9b\u0151l sz\u00e1rmazik, \u00e9s a neve el\u0151sz\u00f6r a \"Secret Essentials of Outer Platform\" c\u00edm\u0171 k\u00f6nyvben jelent meg. Huanglian, Huangbai, Huangqin \u00e9s Gardenia \u00f6sszetev\u0151kb\u0151l \u00e1ll, \u00e9s a t\u0171z megtiszt\u00edt\u00e1s\u00e1nak \u00e9s m\u00e9regtelen\u00edt\u00e9s\u00e9nek reprezentat\u00edv formul\u00e1ja. A stroke ut\u00e1ni kognit\u00edv k\u00e1rosod\u00e1s a vaszkul\u00e1ris demencia egyik fontos \u00e1ga. Klinikai vizsg\u00e1latok kimutatt\u00e1k, hogy a Huanglian Jiedu Tang pozit\u00edv hat\u00e1ssal van a C-reakt\u00edv feh\u00e9rje, a neurospecifikus enol\u00e1z, a D-dimer \u00e9s a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s szindr\u00f3ma pontsz\u00e1maira a stroke ut\u00e1ni kognit\u00edv k\u00e1rosod\u00e1sban szenved\u0151 betegekn\u00e9l, \u00e9s jav\u00edthatja kognit\u00edv funkci\u00f3jukat; a Huanglian Jiedu Tang tiszt\u00edt\u00f3 hat\u00e1ssal van az \u00e1ltal\u00e1nos toxicit\u00e1s\u00e1ra, nem korl\u00e1toz\u00f3dik csak a h\u0151m\u00e9rgez\u00e9sre. K\u00eds\u00e9rleti eredm\u00e9nyek azt mutatt\u00e1k, hogy a Lianjiedu Tang jav\u00edthatja a szkopolamin \u00e1ltal kiv\u00e1ltott mem\u00f3riak\u00e9sz\u00edt\u00e9si zavarokkal k\u00fczd\u0151 egerek tanul\u00e1si \u00e9s mem\u00f3ria k\u00e9pess\u00e9geit. A mechanizmus az acetilkolin\u00e9szter\u00e1z (AchE) aktivit\u00e1s fokoz\u00e1s\u00e1val \u00e9s az acetilkolin\u00e9szter\u00e1z (ChAT) aktivit\u00e1s g\u00e1tl\u00e1s\u00e1val f\u00fcgghet \u00f6ssze. A hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9nyek jellemz\u0151je az integrit\u00e1s \u00e9s a sokf\u00e9les\u00e9g, \u00e9s a hagyom\u00e1nyos farmakol\u00f3giai m\u00f3dszerekkel neh\u00e9z \u00e9rt\u00e9kelni \u00f6sszetett hat\u00e1smechanizmusaikat. A h\u00e1l\u00f3zati farmakol\u00f3gia kutat\u00e1si koncepci\u00f3ja a rendszerszintr\u0151l \u00e9s a biol\u00f3giai h\u00e1l\u00f3zatok \u00e1tfog\u00f3 perspekt\u00edv\u00e1j\u00e1b\u00f3l kiindulva hangs\u00falyozza, amely szisztematikusan elemezheti a \"hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat \u00f6sszetev\u0151i, c\u00e9lpontjai, \u00fatvonalai \u00e9s a betegs\u00e9g c\u00e9lpontjai\" k\u00f6z\u00f6tti k\u00f6lcs\u00f6nhat\u00e1si kapcsolatot. A hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szati formul\u00e1k t\u00f6bb \u00f6sszetev\u0151je, c\u00e9lpontja \u00e9s \u00fatvonala k\u00f6z\u00f6tti k\u00f6lcs\u00f6nhat\u00e1si kapcsolatot mutathatja be, ami egybeesik a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat szindr\u00f3ma-megk\u00fcl\u00f6nb\u00f6ztet\u00e9s\u00e9nek \u00e9s kezel\u00e9s\u00e9nek \u00e1ltal\u00e1nos elk\u00e9pzel\u00e9s\u00e9vel.<\/p>\n

A Huanglian Jiedu Tang hat\u00e9kony \u00f6sszetev\u0151i \u00f6sszetettek \u00e9s t\u00f6bb c\u00e9lpontot tartalmaznak, de a Huanglian Jiedu Tang hat\u00e9kony \u00f6sszetev\u0151i \u00e9s mechanizmusa a VD kezel\u00e9s\u00e9ben m\u00e9g mindig nem vil\u00e1gos. Ez\u00e9rt ez a tanulm\u00e1ny h\u00e1l\u00f3zati farmakol\u00f3giai m\u00f3dszereket \u00e9s in vitro farmakol\u00f3giai valid\u00e1ci\u00f3t alkalmazott a Huanglian Jiedu Tang lehets\u00e9ges mechanizmus\u00e1nak vizsg\u00e1lat\u00e1ra \u00e9s felt\u00e1r\u00e1s\u00e1ra a VD kezel\u00e9s\u00e9ben, \u00e9s megvizsg\u00e1lta azt a tudom\u00e1nyos k\u00e9rd\u00e9st, hogy a Huanglian Jiedu Tang hogyan jav\u00edtja a VD-t, ami alapot ny\u00fajt a klinikai alkalmaz\u00e1s\u00e1hoz.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Megbesz\u00e9l\u00e9s \u00e9s k\u00f6vetkeztet\u00e9s: A hat\u00e9kony \u00f6sszetev\u0151 c\u00e9lh\u00e1l\u00f3zat azt mutatja, hogy a Huanglian Jiedu Tang a VD t\u00f6bbkomponens\u0171 \u00e9s t\u00f6bbc\u00e9l\u00fa kezel\u00e9s\u00e9nek jellemz\u0151ivel rendelkezik. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a berberin, a kvercetin, a ferulasav \u00e9s a genipozid a kulcsfontoss\u00e1g\u00fa hat\u00f3anyagok. A kutat\u00e1s meg\u00e1llap\u00edtotta, hogy a berberin jav\u00edthatja a tanul\u00e1st \u00e9s a mem\u00f3ri\u00e1t VD patk\u00e1nyokn\u00e1l a gyullad\u00e1sos kemokinek monocita kemoattrakt\u00e1ns protein-1 (MCP-1) \u00e9s a P38MAPK \u00fatvonal feh\u00e9rj\u00e9inek expresszi\u00f3j\u00e1nak g\u00e1tl\u00e1s\u00e1val a hippokampuszban. A kutat\u00e1sok kimutatt\u00e1k, hogy a kvercetin enyh\u00edtheti a VD patk\u00e1nyok tanul\u00e1si \u00e9s mem\u00f3riazavar\u00e1t, ami \u00f6sszef\u00fcgghet a nitrog\u00e9n-oxid (NO) tartalm\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel az agysz\u00f6vetben, a nitrog\u00e9n-oxid-szint\u00e1z (NOS) aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val, az agyi energiaanyagcsere el\u0151seg\u00edt\u00e9s\u00e9vel, az endotelin-1 (endotelin-1) \u00e9s a kalcitonin-g\u00e9nnel kapcsolatos peptid (CGRP) k\u00f6z\u00f6tti egyens\u00faly szab\u00e1lyoz\u00e1s\u00e1val \u00e9s a hemorheol\u00f3gia jav\u00edt\u00e1s\u00e1val. A kutat\u00e1sok kimutatt\u00e1k, hogy a ferulasav fokozhatja a kolinerg rendszer m\u0171k\u00f6d\u00e9s\u00e9t, az antioxid\u00e1ns aktivit\u00e1st \u00e9s szab\u00e1lyozhatja az izgalmi aminosavakat VD patk\u00e1nyokban, ez\u00e1ltal neuroprotekt\u00edv hat\u00e1st fejt ki. A kutat\u00e1sok kimutatt\u00e1k, hogy a genipozid enyh\u00edtheti a VD patk\u00e1nyok agyk\u00e9rgi \u00e9s hippokampusz neuronjainak apopt\u00f3zis\u00e1t \u00e9s nekr\u00f3zis\u00e1t.
\nA Huanglian Jiedu Tang hat\u00f3anyagainak a VD c\u00e9lpontokkal val\u00f3 keresztez\u00e9s\u00e9vel 105 gy\u00f3gyszerbetegs\u00e9ggel egy\u00fctt hat\u00f3 c\u00e9lg\u00e9nt kaptunk. A Huanglian Jiedu Tang h\u00e1rom legfontosabb c\u00e9lpontja a MAPK8, MAPK9 \u00e9s MAPK10. A MAPK8, MAPK9 \u00e9s MAPK10 JNK1, JNK2 \u00e9s JNK3 n\u00e9ven is ismert. Ezek a mitog\u00e9n aktiv\u00e1lt feh\u00e9rje kin\u00e1z MAPK jel\u00e1tviteli \u00fatvonal fontos tagjai, amelyek d\u00f6nt\u0151 szerepet j\u00e1tszanak a sejtek prolifer\u00e1ci\u00f3j\u00e1ban, differenci\u00e1l\u00f3d\u00e1s\u00e1ban, t\u00fal\u00e9l\u00e9s\u00e9ben \u00e9s apopt\u00f3zis\u00e1ban, \u00e9s szorosan kapcsol\u00f3dnak az Alzheimer-k\u00f3r megjelen\u00e9s\u00e9hez \u00e9s kialakul\u00e1s\u00e1hoz.
\nAz ebben a tanulm\u00e1nyban \u00e1tvizsg\u00e1lt KEGG jel\u00e1tviteli \u00fatvonalak k\u00f6z\u00fcl a MAPK jel\u00e1tviteli \u00fatvonalnak van a legmagasabb korrel\u00e1ci\u00f3ja a Huanglian Jiedu Tang hat\u00e9kony c\u00e9lpontjaival, amelyet a FoxO jel\u00e1tviteli \u00fatvonal k\u00f6vet. A kutat\u00e1sok kimutatt\u00e1k, hogy a JNK jel\u00e1tviteli \u00fatvonal, mint a klasszikus MAPK jel\u00e1tviteli \u00fatvonal fontos \u00f6sszetev\u0151je, d\u00f6nt\u0151 szerepet j\u00e1tszik a sejtek autof\u00e1gi\u00e1j\u00e1ban, az apopt\u00f3zisban, a gyullad\u00e1sos v\u00e1laszban, valamint az \u00e9rrendszeri demencia kialakul\u00e1s\u00e1ban \u00e9s fejl\u0151d\u00e9s\u00e9ben. A FoxO1 a Forkhead Box O (FoxO) transzkripci\u00f3s faktor csal\u00e1d f\u0151 k\u00e9pvisel\u0151je, amely els\u0151sorban a sejtprolifer\u00e1ci\u00f3t, a differenci\u00e1l\u00f3d\u00e1st, az autof\u00e1gi\u00e1t, az apopt\u00f3zist, az oxidat\u00edv stresszt, a DNS-k\u00e1rosod\u00e1st\/jav\u00edt\u00e1st \u00e9s m\u00e1s kapcsol\u00f3d\u00f3 mechanizmusokat szab\u00e1lyozza. A kutat\u00e1sok kimutatt\u00e1k, hogy az aktiv\u00e1lt JNK k\u00e9pes szab\u00e1lyozni a FoxO1 expresszi\u00f3j\u00e1t. A JNK el\u0151seg\u00edti a nukle\u00e1ris transzlok\u00e1ci\u00f3t \u00e9s cs\u00f6kkenti a transzkripci\u00f3s aktivit\u00e1st az\u00e1ltal, hogy n\u00f6veli a FoxO1 k\u00f6t\u0151d\u00e9s\u00e9t a 14-3-3 partnerfeh\u00e9rj\u00e9hez. Ebben a tanulm\u00e1nyban a VD patogenezis\u00e9vel kombin\u00e1lva az autof\u00e1gi\u00e1t, a gyullad\u00e1sos v\u00e1laszt, az oxidat\u00edv stresszv\u00e1laszt, a sejt apopt\u00f3zist \u00e9s a JNK \/ FoxO1 \u00fatvonalat sz\u0171rt\u00e9k ki, mint a Huanglian Jiedu Tang VD in vitro sejtk\u00eds\u00e9rletekbe val\u00f3 beavatkoz\u00e1s\u00e1nak lehets\u00e9ges mechanizmusait. E vizsg\u00e1lat eredm\u00e9nyei azt mutatj\u00e1k, hogy a Huanglian Jiedu Tang jelent\u0151sen g\u00e1tolni tudja a glutam\u00e1t \u00e1ltal kiv\u00e1ltott gyullad\u00e1sos \u00e9s oxidat\u00edv stresszv\u00e1laszokat PC12 sejtekben, ami a JNK \/ FoxO1 \u00fatvonal g\u00e1tl\u00e1s\u00e1hoz kapcsol\u00f3dhat, \u00f6sszhangban az irodalmi eredm\u00e9nyekkel. Az LC3-II, a Beclin-1 \u00e9s a P62 feh\u00e9rj\u00e9k r\u00e9szt vesznek az autof\u00e1gosz\u00f3m\u00e1k kialakul\u00e1s\u00e1ban, \u00e9s fontos indik\u00e1torfeh\u00e9rj\u00e9k az autof\u00e1gia m\u00e9r\u00e9s\u00e9hez. Az Atg k\u00e9pes szab\u00e1lyozni az autof\u00e1gi\u00e1t, \u00e9s egy sor szab\u00e1lyoz\u00f3 faktort tartalmaz, mint p\u00e9ld\u00e1ul az Atg1, Atg5, Atg6, Atg7 stb. Az autof\u00e1gia el\u0151rehaladt\u00e1val az LC3-I oldhat\u00f3 form\u00e1ja a citoplazm\u00e1ban az Atg7 hat\u00e1s\u00e1ra kovalensen k\u00f6t\u0151dik a foszfatidil-etanolaminhoz, LC3-II-t k\u00e9pezve, amely az autofagosz\u00f3ma membr\u00e1nj\u00e1hoz k\u00f6t\u0151dik \u00e9s el\u0151seg\u00edti az autof\u00e1gi\u00e1t. A vizsg\u00e1lat eredm\u00e9nyei azt mutatj\u00e1k, hogy a Huanglian Jiedu Tang k\u00e9pes cs\u00f6kkenteni a JNK, p-JNK, FoxO1, LC3II\/I, Beclin-1, Atg7, Kasp\u00e1z-3 \u00e9s Kasp\u00e1z-9 feh\u00e9rjeexpresszi\u00f3j\u00e1t, \u00e9s n\u00f6velni a p-FoxO1 \u00e9s P62 feh\u00e9rjeexpresszi\u00f3j\u00e1t. Ez arra utal, hogy a Huanglian Jiedu Tang g\u00e1tolhatja az autof\u00e1gi\u00e1t \u00e9s a sejtek apopt\u00f3zis\u00e1t a JNK\/FoxO1 \u00fatvonal elnyom\u00e1sa r\u00e9v\u00e9n, ami hasonl\u00f3 az irodalmi eredm\u00e9nyekhez.
\n\u00d6sszefoglalva, ez a tanulm\u00e1ny h\u00e1l\u00f3zati farmakol\u00f3giai \u00e9s k\u00eds\u00e9rleti ellen\u0151rz\u00e9si m\u00f3dszereket alkalmazott a Huanglian Jiedu Tang lehets\u00e9ges mechanizmus\u00e1nak felt\u00e1r\u00e1s\u00e1ra a VD kezel\u00e9s\u00e9ben. A levont k\u00f6vetkeztet\u00e9s az, hogy a Huanglian Jiedu Tang a JNK\/FoxO1 \u00fatvonal g\u00e1tl\u00e1s\u00e1val fejtheti ki ter\u00e1pi\u00e1s hat\u00e1s\u00e1t a VD-re, ez\u00e1ltal elnyomva a gyullad\u00e1st, az oxidat\u00edv stresszt, az autof\u00e1gi\u00e1t \u00e9s a sejt apopt\u00f3zist. Ez a tanulm\u00e1ny megalapozza a Huanglian Jiedu Tang hat\u00e9konys\u00e1g\u00e1t a VD kezel\u00e9s\u00e9ben, \u00e9s \u00faj \u00f6tleteket ny\u00fajt a Huanglian Jiedu Tang VD-re gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1ra vonatkoz\u00f3an is a j\u00f6v\u0151ben.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the mechanism of Huanglian Jiedu Tang in treating vascular dementia based on network pharmacology and experimental verification Vascular dementia (VD) is a cognitive dysfunction syndrome caused by multiple cerebrovascular factors, and is the second largest type of dementia after Alzheimer’s disease. The survey shows that the incidence rate of VD among people over 65 […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism of Huanglian Jiedu Tang in treating vascular dementia based on network pharmacology and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/huanglian-jiedu-tang\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of Huanglian Jiedu Tang in treating vascular dementia based on network pharmacology and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of Huanglian Jiedu Tang in treating vascular dementia based on network pharmacology and experimental verification Vascular dementia (VD) is a cognitive dysfunction syndrome caused by multiple cerebrovascular factors, and is the second largest type of dementia after Alzheimer’s disease. 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