{"id":7379,"date":"2024-08-06T19:39:02","date_gmt":"2024-08-06T19:39:02","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7379"},"modified":"2024-08-06T19:39:02","modified_gmt":"2024-08-06T19:39:02","slug":"huangqi-jianzhong-decoction","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/huangqi-jianzhong-fozet\/","title":{"rendered":"A b\u00fcd\u00f6s bazsar\u00f3zs\u00e1b\u00f3l sz\u00e1rmaz\u00f3 feniletanolos glikozidok azonos\u00edt\u00e1sa \u00e9s in vitro emberi t\u00fcd\u0151 adenokarcin\u00f3ma A549 sejtek elleni mechanizmus\u00e1nak vizsg\u00e1lata"},"content":{"rendered":"

A b\u00fcd\u00f6s bazsar\u00f3zs\u00e1b\u00f3l sz\u00e1rmaz\u00f3 feniletanolos glikozidok azonos\u00edt\u00e1sa \u00e9s in vitro emberi t\u00fcd\u0151 adenokarcin\u00f3ma A549 sejtek elleni mechanizmus\u00e1nak vizsg\u00e1lata
\nA t\u00fcd\u0151r\u00e1k a h\u00f6rg\u0151k ny\u00e1lkah\u00e1rty\u00e1j\u00e1n \u00e9s mirigyeiben el\u0151fordul\u00f3 rosszindulat\u00fa daganat. A Nemzeti R\u00e1kk\u00f6zpont \u00e1ltal szolg\u00e1ltatott adatok szerint 2022-ben a t\u00fcd\u0151r\u00e1k el\u0151fordul\u00e1si ar\u00e1nya K\u00edn\u00e1ban 10,6% lesz, a hal\u00e1loz\u00e1si ar\u00e1ny pedig 24%, ami az els\u0151 helyet jelenti a rosszindulat\u00fa daganatok hal\u00e1loz\u00e1si ar\u00e1ny\u00e1ban K\u00edn\u00e1ban, \u00e9s a n\u0151i betegek ar\u00e1nya \u00e9vr\u0151l \u00e9vre n\u0151, \u00e9s \u00e1ltal\u00e1ban fiatalabbak lesznek. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s, t\u00f6bbkomponens\u0171 \u00e9s t\u00f6bbc\u00e9l\u00fa el\u0151nyei miatt, k\u00e9sleltetheti a tumor progresszi\u00f3j\u00e1t, fokozhatja a tumorsejtek \u00e9rz\u00e9kenys\u00e9g\u00e9t a sug\u00e1r- \u00e9s kemoter\u00e1pi\u00e1ra, cs\u00f6kkentheti a m\u0171t\u00e9t ut\u00e1ni fert\u0151z\u00e9seket, \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 utakon kereszt\u00fcl minimaliz\u00e1lhatja a sug\u00e1r- \u00e9s kemoter\u00e1pia \u00e1ltal okozott mell\u00e9khat\u00e1sokat, ez\u00e1ltal el\u00e9rheti a tumor ki\u00fajul\u00e1s\u00e1nak \u00e9s \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9s\u00e9nek megel\u0151z\u00e9s\u00e9t \u00e9s kezel\u00e9s\u00e9t, valamint a hossz\u00fa t\u00e1v\u00fa stabil tumorokat. A Stinky Peony egy hat\u00e9kony hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer, amelyet a Hunan n\u00e9pi gy\u00f3gy\u00e1szatban fedeztek fel a rosszindulat\u00fa daganatok kezel\u00e9s\u00e9re, \u00e9s amelyet t\u00f6bb mint 40 \u00e9ves ism\u00e9telt klinikai \u00e9s tudom\u00e1nyos kutat\u00e1si gyakorlat sor\u00e1n v\u00e1lasztottak ki. A Stinky peony enyhe term\u00e9szet\u0171, cs\u00edp\u0151s \u00e9s keser\u0171 \u00edz\u0171, \u00e9s a \"sz\u00e9l \u00e9s nedvess\u00e9g eloszlat\u00e1sa, m\u00e9regtelen\u00edt\u00e9s \u00e9s a v\u00e9r pang\u00e1s\u00e1nak eloszlat\u00e1sa, a duzzanat \u00e9s a f\u00e1jdalom cs\u00f6kkent\u00e9se\" hat\u00e1s\u00fa. A Hunan r\u00e9gi\u00f3ban sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k a k\u00fcl\u00f6nb\u00f6z\u0151 daganatok, k\u00fcl\u00f6n\u00f6sen a t\u00fcd\u0151r\u00e1k kezel\u00e9s\u00e9ben. A b\u00fcd\u00f6s p\u00fcnk\u00f6sdi r\u00f3zsa hat\u00e9kony \u00f6sszetev\u0151i \u00e9s mechanizmusai a daganatellenes kezel\u00e9sben azonban m\u00e9g nem tiszt\u00e1zottak. A kutat\u00f3csoport el\u0151zetes k\u00eds\u00e9rletei sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy a Paeonia lactiflora gazdag feniletanolos glikozidokban \u00e9s j\u00f3 daganatellenes aktivit\u00e1ssal rendelkezik. Ebben a tanulm\u00e1nyban tov\u00e1bb azonos\u00edtjuk a Paeonia lactiflora feniletanolos glikozidjait, \u00e9s felt\u00e1rjuk az A549 sejtek prolifer\u00e1ci\u00f3j\u00e1nak in vitro g\u00e1tl\u00e1s\u00e1nak mechanizmus\u00e1t, hogy tov\u00e1bb tanulm\u00e1nyozzuk a Paeonia lactiflora feniletanolos glikozidjainak tumorellenes hat\u00e1s\u00e1t \u00e9s mechanizmus\u00e1t, \u00e9s megalapozzuk a hat\u00e9kony \u00e9s alacsony toxicit\u00e1s\u00fa hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9nyek kifejleszt\u00e9s\u00e9t.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"A t\u00fcd\u0151r\u00e1k a hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban a \"t\u00fcd\u0151halmoz\u00f3d\u00e1s\" \u00e9s a \"t\u00fcd\u0151k\u0151\" kateg\u00f3ri\u00e1j\u00e1ba tartoz\u00f3, a h\u00f6rg\u0151k ny\u00e1lkah\u00e1rty\u00e1j\u00e1n \u00e9s mirigyeiben el\u0151fordul\u00f3 rosszindulat\u00fa daganat. A kort\u00e1rs orvosszak\u00e9rt\u0151k \u00fagy v\u00e9lik, hogy a t\u00fcd\u0151r\u00e1k folyamatos n\u00f6veked\u00e9se a k\u00f6rnyezetszennyez\u00e9snek vagy a hossz\u00fa t\u00e1v\u00fa doh\u00e1nyz\u00e1snak k\u00f6sz\u00f6nhet\u0151, ami a m\u00e9rgez\u0151 k\u00f3rokoz\u00f3k felhalmoz\u00f3d\u00e1s\u00e1hoz vezet a t\u00fcd\u0151ben. A t\u00fcd\u0151 qi mozg\u00e1sa megszakad, \u00e9s a toxinok, a qi \u00e9s a v\u00e9r kombin\u00e1ci\u00f3ja id\u0151vel t\u00fcd\u0151felhalmoz\u00f3d\u00e1shoz vezet. A legalapvet\u0151bb k\u00f3ros mechanizmus a r\u00e1kos toxin, a flegma \u00e9s a v\u00e9r pang\u00e1sa, a hi\u00e1ny \u00e9s a felesleg kombin\u00e1ci\u00f3ja a f\u0151 k\u00f3ros v\u00e1ltoz\u00e1sok. Ouyang Qi professzor, a Hu Xiang Ouyang vegyes betegs\u00e9gek iskol\u00e1j\u00e1nak \u00f6r\u00f6k\u00f6se, a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s elismert gyakorl\u00f3ja, Ouyang Qi professzor tapasztalataira t\u00e1maszkodva a t\u00fcd\u0151r\u00e1k kezel\u00e9s\u00e9ben \u00e9s a m\u0171t\u00e9t ut\u00e1ni ki\u00fajul\u00e1s megel\u0151z\u00e9s\u00e9ben, \u00fagy v\u00e9lj\u00fck, hogy a t\u00fcd\u0151r\u00e1k etiol\u00f3gi\u00e1ja \u00e9s patogenezise a patog\u00e9n toxinok behatol\u00e1s\u00e1nak, az el\u00e9gtelen pozit\u00edv qi-nek k\u00f6sz\u00f6nhet\u0151, ami a t\u00fcd\u0151funkci\u00f3 elveszt\u00e9s\u00e9hez, a flegma felhalmoz\u00f3d\u00e1s\u00e1hoz \u00e9s a stagn\u00e1l\u00e1shoz vezet id\u0151vel, ami a qi \u00e9s a v\u00e9r yin \u00e9s yang hi\u00e1ny\u00e1t eredm\u00e9nyezi a szervezetben, ami v\u00e9g\u00fcl a t\u00fcd\u0151r\u00e1k kialakul\u00e1s\u00e1hoz vezet. A t\u00fcd\u0151r\u00e1k f\u0151 patogenezis\u00e9t a patog\u00e9n t\u00e9nyez\u0151k, mint p\u00e9ld\u00e1ul a k\u00f3rokoz\u00f3 t\u00e9nyez\u0151k, a flegma, a v\u00e9ralvad\u00e1s \u00e9s a toxinok felhalmoz\u00f3d\u00e1sa, valamint a qi stagn\u00e1l\u00e1sa \u00e9s a v\u00e9r pang\u00e1sa jellemzi. A kezel\u00e9s elve a v\u00e9r pang\u00e1s\u00e1nak m\u00e9regtelen\u00edt\u00e9se \u00e9s megsz\u00fcntet\u00e9se, a v\u00e1lad\u00e9k elt\u00e1vol\u00edt\u00e1sa \u00e9s a csom\u00f3k sz\u00e9toszlat\u00e1sa. A b\u00fcd\u00f6s bazsar\u00f3zsa a Clerodendrum bungei Steud, a Verbenaceae csal\u00e1dba tartoz\u00f3 n\u00f6v\u00e9ny sz\u00e1ra \u00e9s levele. K\u00edn\u00e1ban sz\u00e9les k\u00f6rben elterjedt, \u00e9s b\u0151s\u00e9ges gy\u00f3gy\u00e1szati forr\u00e1sokkal rendelkezik. Term\u00e9szete nyugodt, cs\u00edp\u0151s \u00e9s keserny\u00e9s \u00edz\u0171. Az \u0151si irodalom feljegyzi, hogy funkci\u00f3i: \"a sz\u00e9l \u00e9s a nedvess\u00e9g eloszlat\u00e1sa, a v\u00e9r pang\u00e1s\u00e1nak m\u00e9regtelen\u00edt\u00e9se \u00e9s eloszlat\u00e1sa, a duzzanat cs\u00f6kkent\u00e9se \u00e9s a f\u00e1jdalom enyh\u00edt\u00e9se\", ami \u00f6sszhangban van a t\u00fcd\u0151r\u00e1k eset\u00e9ben a \"v\u00e9r pang\u00e1s\u00e1nak m\u00e9regtelen\u00edt\u00e9se \u00e9s elt\u00e1vol\u00edt\u00e1sa, a v\u00e1lad\u00e9k elt\u00e1vol\u00edt\u00e1sa \u00e9s a csom\u00f3k eloszlat\u00e1sa\" kezel\u00e9si elv\u00e9vel. A kutat\u00e1sok kimutatt\u00e1k, hogy mind a b\u00fcd\u00f6s p\u00fcnk\u00f6sdi r\u00f3zsa vegy\u00fclet, mind a kivonata j\u00f3 daganatellenes aktivit\u00e1ssal rendelkezik, k\u00fcl\u00f6n\u00f6sen a legjobb daganatellenes aktivit\u00e1ssal a t\u00fcd\u0151r\u00e1k ellen. Az el\u0151zetes kutat\u00e1s sor\u00e1n a kutat\u00f3csoport t\u00f6bb folyad\u00e9kmin\u0151s\u00e9gi elemz\u00e9st v\u00e9gzett a b\u00fcd\u00f6s bazsar\u00f3zsa f\u0151zet\u00e9n \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 kivont \u00f6sszetev\u0151in, \u00e9s meg\u00e1llap\u00edtotta, hogy a b\u00fcd\u00f6s bazsar\u00f3zsa f\u0151 \u00f6sszetev\u0151i feniletanolos glikozidok, amelyek k\u00f6z\u00f6tt a f\u0151 \u00f6sszetev\u0151k a lev\u00e9lszer\u0171 \u00e9s heterog\u00e9n lev\u00e9lszer\u0171 glikozidok. K\u00eds\u00e9rleti sz\u0171r\u00e9s \u00e9s bizony\u00edt\u00e1s ut\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy a b\u00fcd\u00f6s bazsar\u00f3zsa feniletanolos glikozidjai j\u00f3 daganatellenes hat\u00e1ssal rendelkeznek. Ez\u00e9rt felt\u00e9telezhet\u0151, hogy a f\u0151k\u00e9nt lev\u00e9lszer\u0171 \u00e9s heterog\u00e9n lev\u00e9lszer\u0171 glikozidokb\u00f3l \u00e1ll\u00f3 feniletanolos glikozidok lehetnek a b\u00fcd\u00f6s bazsar\u00f3zsa tumorellenes hat\u00e1s\u00e1nak f\u0151 \u00f6sszetev\u0151i.<\/p>\n

Az EphA2 az Eph-csal\u00e1d, a receptor-tirozin-kin\u00e1zok (RKT-k) legnagyobb alcsal\u00e1dj\u00e1nak f\u0151 tagja, \u00e9s sz\u00e1mos rosszindulat\u00fa daganatban, k\u00fcl\u00f6n\u00f6sen a magas malignit\u00e1s\u00fa \u00e9s er\u0151s inv\u00e1zi\u00f3s \u00e9s metaszt\u00e1zisk\u00e9pess\u00e9g\u0171 tumorokban t\u00falterjed, \u00e9s r\u00e9szt vesz a t\u00fcd\u0151r\u00e1k inv\u00e1zi\u00f3j\u00e1ban \u00e9s metaszt\u00e1zis\u00e1ban. A kutat\u00e1sok azt tal\u00e1lt\u00e1k, hogy az EphA2 receptorok jelent\u0151sen expressz\u00e1l\u00f3dnak a t\u00fcd\u0151r\u00e1kos betegekben \u00e9s a t\u00fcd\u0151r\u00e1kos sejtvonalakban, \u00e9s min\u00e9l magasabb az expresszi\u00f3s szint, ann\u00e1l rosszabb a betegek progn\u00f3zisa. T\u00fcd\u0151r\u00e1ksz\u00f6vetekben az epiderm\u00e1lis n\u00f6veked\u00e9si faktor (EGFR) foszforil\u00e1lt EphA2 S897 mut\u00e1ci\u00f3j\u00e1t figyelt\u00e9k meg, \u00e9s a sejtmembr\u00e1non 19-es exon del\u00e9ci\u00f3t tal\u00e1ltak. Az EphA2 k\u00e9tf\u00e9le biol\u00f3giai hat\u00e1st fejt ki: ligandf\u00fcgg\u0151 \u00e9s ligandf\u00fcggetlen. Egyr\u00e9szt, amikor az EphrinA1 ligandum k\u00f6t\u0151dik az EphA2 receptorhoz, az EphA2 internaliz\u00e1ci\u00f3n megy kereszt\u00fcl, majd ubikvitin\u00e1ci\u00f3 r\u00e9v\u00e9n lebomlik; Ugyanakkor az EphA2-t a tirozinkin\u00e1z aktiv\u00e1lja foszforil\u00e1ci\u00f3ra, m\u00edg az EphA2 S897 helye defoszforil\u00e1l\u00f3dik, ez\u00e1ltal g\u00e1tolja az olyan jel\u00e1tviteli utakat, mint a PI3K\/ATK \u00e9s a Ras\/MAPK, \u00e9s ligandumf\u00fcgg\u0151 tumorellenes hat\u00e1st fejt ki. M\u00e1sr\u00e9szt, amikor az EphrinA1 ligandum alacsony expresszi\u00f3j\u00fa \u00e9s az EphA2 magas expresszi\u00f3j\u00fa, az EphA2 foszforil\u00e1l\u00f3dik \u00e9s aktiv\u00e1l\u00f3dik az S897-helyen kereszt\u00fcl, m\u00edg tirozin-foszforil\u00e1ci\u00f3s szintje cs\u00f6kken, ez\u00e1ltal aktiv\u00e1lva a PI3K\/ATK\/mTOR \u00e9s a Pyk2\/c-Src jel\u00e1tviteli utakat, ligandumf\u00fcggetlen tumorellenes hat\u00e1st kifejtve. A ligandt\u00f3l f\u00fcggetlen EphA2 jel\u00e1tvitel el\u0151seg\u00edtheti a tumor prolifer\u00e1ci\u00f3j\u00e1t \u00e9s metaszt\u00e1zis\u00e1t, fokozhatja a tumor gy\u00f3gyszerrezisztenci\u00e1j\u00e1t, \u00e9s fenntarthatja a tumor \u0151ssejt-szer\u0171 tulajdons\u00e1gait. L\u00e1that\u00f3, hogy az EphA2 kett\u0151s aktivit\u00e1ssal rendelkezik: ligandum aktiv\u00e1lta r\u00e1kellenes \u00e9s nem ligandum aktiv\u00e1lta r\u00e1kellenes aktivit\u00e1ssal, \u00e9s az EphA2 S897 hely\u00e9nek defoszforil\u00e1ci\u00f3ja vagy foszforil\u00e1ci\u00f3ja az a kapcsol\u00f3, amely a k\u00e9t ellent\u00e9tes biol\u00f3giai hat\u00e1st szab\u00e1lyozza. Az EphA2 S897 defoszforil\u00e1ci\u00f3ja az EphrinA1 ligandumhoz kapcsol\u00f3dik, m\u00edg az EphA2 S897 foszforil\u00e1ci\u00f3ja az ATK-hoz, amely a legkor\u00e1bbi \u00e9s elismert fontos t\u00e9nyez\u0151. Az ATK foszforil\u00e1ci\u00f3ja fontos t\u00e9nyez\u0151 az EphA2 faktor sejtmigr\u00e1ci\u00f3t \u00e9s inv\u00e1zi\u00f3t el\u0151seg\u00edt\u0151 hat\u00e1s\u00e1ban, m\u00edg az EphrinA1 ligandum EphrinA1-hez val\u00f3 k\u00f6t\u0151d\u00e9se g\u00e1tolja az ATK aktiv\u00e1l\u00f3d\u00e1s\u00e1t \u00e9s elnyomja a tumorsejtek migr\u00e1ci\u00f3j\u00e1t. Vannak jelent\u00e9sek arr\u00f3l, hogy az EphA2 egyszerre az ATK upstream negat\u00edv szab\u00e1lyoz\u00f3ja \u00e9s downstream effektorja. A PI3K\/ATK\/mTOR \u00fatvonal aktiv\u00e1l\u00e1sa, az EphrinA1s ligand hi\u00e1ny\u00e1val p\u00e1rosulva, az EphA2 tumorszuppresszorb\u00f3l pro tumorfaktorr\u00e1 alakul \u00e1t, amelyet az ATK foszforil\u00e1l \u00e9s el\u0151seg\u00edti a malignus tumor kialakul\u00e1s\u00e1t. A jelent\u00e9sek szerint az EphA2 a Wnt - \u03b2 - katenin \u00fatvonalon kereszt\u00fcl el\u0151seg\u00edti az EMT progresszi\u00f3j\u00e1t a gyomorr\u00e1kos sejtekben.<\/p>\n

A kutat\u00f3csoport kor\u00e1bbi kutat\u00e1sai kimutatt\u00e1k, hogy a b\u00fcd\u00f6s bazsar\u00f3zsa kivonata jelent\u0151sen cs\u00f6kkentheti az EMT-vel kapcsolatos Vimentin, Slug, Snail, Twist \u00e9s Cmyc faktorok expresszi\u00f3j\u00e1t t\u00fcd\u0151r\u00e1kban, \u00e9s g\u00e1tolja a t\u00fcd\u0151r\u00e1k EMT folyamat\u00e1t a Wnt - \u03b2 - catenin \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1val. Ebben a vizsg\u00e1latban azt tal\u00e1ltuk, hogy a Paeonia lactiflora feniletanolos glikozidok kivonatai jelent\u0151sen g\u00e1tolj\u00e1k az A549 sejtek prolifer\u00e1ci\u00f3j\u00e1t, migr\u00e1ci\u00f3j\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t, valamint elnyomj\u00e1k az EphA2, mTOR, p-mTOR, \u03b2 - katenin, GSK-3 \u03b2, P-GSK-3 \u03b2 \u00e9s P-ATK feh\u00e9rj\u00e9k expresszi\u00f3j\u00e1t. Ezek k\u00f6z\u00fcl k\u00fcl\u00f6n\u00f6sen jelent\u0151s a P-ATK downregul\u00e1ci\u00f3ja, \u00e9s az EphA2 feh\u00e9rje downregul\u00e1ci\u00f3ja az EphrinA1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozhatja. A b\u00fcd\u00f6s bazsar\u00f3zsa feniletanolos glikozid kivonata induk\u00e1lhatja az EphA2 k\u00f6t\u0151d\u00e9s\u00e9t az EphrinA1 ligandummal, el\u0151seg\u00edtheti a ligandum EphrinA1 f\u00fcgg\u0151 r\u00e1kellenes \u00fatvonalat, \u00e9s az EphA2, P-ATK, mTOR \u00e9s m\u00e1s t\u00e9nyez\u0151k g\u00e1tl\u00e1s\u00e1val, az EphA2\/ATK\/mTOR jel\u00e1tviteli \u00fatvonal blokkol\u00e1s\u00e1val tumorellenes hat\u00e1st fejthet ki. A P-EphA2 n\u00f6veked\u00e9se a ligandumf\u00fcgg\u0151s\u00e9gnek k\u00f6sz\u00f6nhet\u0151. B\u00e1r az EphA2 S897-es helye defoszforil\u00e1ci\u00f3n megy kereszt\u00fcl, az EphA2 tirozinkin\u00e1z foszforil\u00e1ci\u00f3val aktiv\u00e1l\u00f3dik, \u00edgy a teljes P-EphA2 felszab\u00e1lyoz\u00f3dhat. A daganatellenes mechanizmus azonban nagyon \u00f6sszetett, \u00e9s a tumorsejtek sors\u00e1t nem egyetlen \u00fatvonal hat\u00e1rozza meg. Ez a tanulm\u00e1ny k\u00eds\u00e9rleti bizony\u00edt\u00e9kot szolg\u00e1ltat a b\u00fcd\u00f6s bazsar\u00f3zsa tumorellenes molekul\u00e1ris mechanizmus\u00e1nak meghat\u00e1roz\u00e1s\u00e1hoz \u00e9s az EphA2 c\u00e9lpontokat c\u00e9lz\u00f3, rendk\u00edv\u00fcl hat\u00e9kony \u00e9s alacsony toxicit\u00e1s\u00fa hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerkivonatok kifejleszt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Identification of phenylethanolic glycosides from stinky peony and mechanism study of in vitro anti human lung adenocarcinoma A549 cells Lung cancer is a malignant tumor that occurs in the bronchial mucosa and glands. According to the data provided by the National Cancer Center, in 2022, the incidence rate of lung cancer in China will be […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nIdentification of phenylethanolic glycosides from stinky peony and mechanism study of in vitro anti human lung adenocarcinoma A549 cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/huangqi-jianzhong-fozet\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identification of phenylethanolic glycosides from stinky peony and mechanism study of in vitro anti human lung adenocarcinoma A549 cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Identification of phenylethanolic glycosides from stinky peony and mechanism study of in vitro anti human lung adenocarcinoma A549 cells Lung cancer is a malignant tumor that occurs in the bronchial mucosa and glands. 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