{"id":7370,"date":"2024-08-06T19:36:02","date_gmt":"2024-08-06T19:36:02","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7370"},"modified":"2024-08-06T19:36:02","modified_gmt":"2024-08-06T19:36:02","slug":"proliferation-migration","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/proliferation-migration\/","title":{"rendered":"A resveratrol hat\u00e1sa az endometrium r\u00e1kos HEC-1A sejtek prolifer\u00e1ci\u00f3j\u00e1ra, migr\u00e1ci\u00f3j\u00e1ra \u00e9s inv\u00e1zi\u00f3j\u00e1ra"},"content":{"rendered":"

A resveratrol hat\u00e1sa az endometrium r\u00e1kos HEC-1A sejtek prolifer\u00e1ci\u00f3j\u00e1ra, migr\u00e1ci\u00f3j\u00e1ra \u00e9s inv\u00e1zi\u00f3j\u00e1ra
\nAz endometrium karcin\u00f3ma (EC) a leggyakoribb daganat a n\u0151i reprodukt\u00edv traktusban, a m\u00e1sodik helyen \u00e1ll az eml\u0151r\u00e1k, a t\u00fcd\u0151r\u00e1k \u00e9s a vastagb\u00e9lr\u00e1k ut\u00e1n. A vil\u00e1gon \u00e9vente mintegy 380000 \u00faj endometriumr\u00e1kos eset fordul el\u0151, \u00e9s \u00e9vente mintegy 89000 ember hal meg endometriumr\u00e1kban, az el\u0151fordul\u00e1si ar\u00e1ny pedig \u00e9vr\u0151l \u00e9vre n\u0151. Jelenleg az endometriumr\u00e1k specifikus patogenezise m\u00e9g mindig nem tiszt\u00e1zott, \u00e9s kock\u00e1zati t\u00e9nyez\u0151i az elh\u00edz\u00e1shoz, a metabolikus szindr\u00f3m\u00e1hoz, a hiperlipid\u00e9mi\u00e1hoz, a cukorbetegs\u00e9ghez, a policiszt\u00e1s ov\u00e1rium szindr\u00f3m\u00e1hoz \u00e9s m\u00e1s olyan betegs\u00e9gekhez kapcsol\u00f3dnak, amelyek a magas \u00f6sztrog\u00e9nst\u00e1tusz \u00e1ltal okozott endometrium hiperpl\u00e1zi\u00e1hoz vezetnek. A korai endometriumr\u00e1k kezelhet\u0151 kiz\u00e1r\u00f3lag m\u0171t\u00e9ttel vagy adjuv\u00e1ns kemoradioter\u00e1pi\u00e1val kombin\u00e1lt m\u0171t\u00e9ttel, az 5 \u00e9ves teljes t\u00fal\u00e9l\u00e9si ar\u00e1ny 74% \u00e9s 91% k\u00f6z\u00f6tt van. Az el\u0151rehaladott vagy ki\u00fajult endometriumr\u00e1kkal diagnosztiz\u00e1lt betegek rossz progn\u00f3zissal \u00e9s alacsony t\u00fal\u00e9l\u00e9si ar\u00e1nnyal rendelkeznek, az \u00f6t\u00e9ves teljes t\u00fal\u00e9l\u00e9si ar\u00e1ny k\u00f6r\u00fclbel\u00fcl 15%. A hagyom\u00e1nyos ter\u00e1pi\u00e1k, mint a m\u0171t\u00e9t, a sug\u00e1rkezel\u00e9s, a kemoter\u00e1pia \u00e9s a c\u00e9lzott ter\u00e1pia k\u00f6lts\u00e9gesek \u00e9s s\u00falyos mell\u00e9khat\u00e1sokra hajlamosak. Az olyan probl\u00e9m\u00e1k megjelen\u00e9s\u00e9vel, mint a tumor ki\u00fajul\u00e1sa \u00e9s \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9s, valamint a kemoter\u00e1pi\u00e1s rezisztencia, s\u00fcrg\u0151sen sz\u00fcks\u00e9g van k\u00f6nnyen hozz\u00e1f\u00e9rhet\u0151, alacsony mell\u00e9khat\u00e1s\u00fa \u00e9s olcs\u00f3 alternat\u00edv gy\u00f3gyszerek megtal\u00e1l\u00e1s\u00e1ra az EK kezel\u00e9s\u00e9re. Ez\u00e9rt a tumorsejtek prolifer\u00e1ci\u00f3j\u00e1nak, migr\u00e1ci\u00f3j\u00e1nak \u00e9s inv\u00e1zi\u00f3j\u00e1nak bels\u0151 mechanizmusainak meg\u00e9rt\u00e9se nagy \u00e9rt\u00e9ket k\u00e9pvisel az EK-betegek kezel\u00e9s\u00e9re szolg\u00e1l\u00f3 \u00faj m\u00f3dszerek felt\u00e1r\u00e1s\u00e1ban.<\/p>\n

A piceatannol (PIC), amelynek k\u00e9miai k\u00e9plete C14H12O4, egy term\u00e9szetes polifenolos vegy\u00fclet, amely sz\u00e9les k\u00f6rben elterjedt olyan n\u00f6v\u00e9nyekben, mint a golgotavir\u00e1g, a golgotavir\u00e1g, a feh\u00e9r tea \u00e9s a jap\u00e1n tigrisvir\u00e1g. Kutat\u00e1sok kimutatt\u00e1k, hogy a PIC a rezveratrolhoz hasonl\u00f3an tumorellenes, gyullad\u00e1scs\u00f6kkent\u0151, antioxid\u00e1ns \u00e9s immunszab\u00e1lyoz\u00f3 hat\u00e1ssal rendelkezik, \u00e9s t\u00f6bbc\u00e9l\u00fa jelleg\u00e9nek k\u00f6sz\u00f6nhet\u0151en fontos szerepet j\u00e1tszik a r\u00e1k megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben. Egyes vizsg\u00e1latok kimutatt\u00e1k, hogy a PIC kemoprevent\u00edv hat\u00e1ssal rendelkezik, \u00e9s k\u00e9pes g\u00e1tolni a prosztatar\u00e1k, a vastagb\u00e9lr\u00e1k, az eml\u0151r\u00e1k, a t\u00fcd\u0151r\u00e1k, a melanoma, a limf\u00f3ma stb. migr\u00e1ci\u00f3j\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t. A Wnt\/\u03b2 - katenin jel\u00e1tviteli \u00fatvonal rendellenes aktiv\u00e1ci\u00f3ja el\u0151seg\u00edtheti a k\u00fcl\u00f6nb\u00f6z\u0151 rosszindulat\u00fa daganatok kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s szab\u00e1lyozhatja a sejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s differenci\u00e1l\u00f3d\u00e1s\u00e1t. A kutat\u00e1sok azt tal\u00e1lt\u00e1k, hogy a PIC a Wnt\/\u03b2 - katenin jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00f3jak\u00e9nt \u00e9s az apopt\u00f3zis induktorak\u00e9nt is m\u0171k\u00f6dhet a myel\u00f3ma sejtekben. Jelenleg nincsenek kutat\u00e1si jelent\u00e9sek a PIC endometrium r\u00e1kra kifejtett daganatellenes hat\u00e1s\u00e1r\u00f3l, \u00e9s az endometrium r\u00e1kos sejtek k\u00f6zvet\u00edt\u00e9s\u00e9nek mechanizmusa m\u00e9g mindig nem vil\u00e1gos. Ennek a k\u00eds\u00e9rletnek a c\u00e9lja a PIC el\u0151zetes tumorellenes mechanizmus\u00e1nak felt\u00e1r\u00e1sa az endometrium r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1ra, migr\u00e1ci\u00f3j\u00e1ra \u00e9s inv\u00e1zi\u00f3j\u00e1ra gyakorolt hat\u00e1s\u00e1nak megfigyel\u00e9s\u00e9vel, elm\u00e9leti \u00e9s k\u00eds\u00e9rleti alapot ny\u00fajtva az endometrium r\u00e1k kezel\u00e9s\u00e9re szolg\u00e1l\u00f3 \u00faj strat\u00e9gi\u00e1k keres\u00e9s\u00e9hez.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nAz epiteli\u00e1lis mesenchym\u00e1lis \u00e1tmenet (EMT) a tumoros \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9s d\u00f6nt\u0151 fontoss\u00e1g\u00fa folyamata, amely a sejteket er\u0151s v\u00e1ndorl\u00e1si \u00e9s invaz\u00edv embrion\u00e1lis programmal ruh\u00e1zza fel. Norm\u00e1lis k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt az EMT d\u00f6nt\u0151 szerepet j\u00e1tszik a sebgy\u00f3gyul\u00e1sban, m\u00edg k\u00f3ros esetekben el\u0151seg\u00edti a tumoros \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9st. A kutat\u00e1sok meger\u0151s\u00edtett\u00e9k, hogy az EMT r\u00e9szt vesz az endometri\u00e1lis r\u00e1kos daganatsejtek megjelen\u00e9s\u00e9ben, metaszt\u00e1zis\u00e1ban, antiapopt\u00f3zis\u00e1ban \u00e9s inv\u00e1zi\u00f3s folyamataiban. A kutat\u00e1sok kimutatt\u00e1k, hogy az ERK\/MAPK jel\u00e1tviteli \u00fatvonal \u00e9s a PI3K\/AKT\/mTOR jel\u00e1tviteli \u00fatvonal rendellenesen aktiv\u00e1l\u00f3dik az EC-ben. A sejtek norm\u00e1lisb\u00f3l rosszindulat\u00fav\u00e1 v\u00e1l\u00e1s\u00e1nak folyamata sor\u00e1n az EMT-t a PI3K\/AKT\/mTOR jel\u00e1tviteli \u00fatvonal szab\u00e1lyozza, m\u00edg a Wnt jel\u00e1tviteli \u00fatvonal EMT-t induk\u00e1l a tumorsejtekben, ez\u00e1ltal befoly\u00e1solja a tumor inv\u00e1zi\u00f3j\u00e1t \u00e9s metaszt\u00e1zis\u00e1t. Ebben a vizsg\u00e1latban azt tal\u00e1ltuk, hogy a PIC k\u00e9pes felszab\u00e1lyozni az epit\u00e9lszer\u0171 E-cdaherin marker expresszi\u00f3s szintj\u00e9t az endometriumr\u00e1k HEC-1A sejtekben, \u00e9s lefel\u00e9 szab\u00e1lyozza a transzkripci\u00f3t g\u00e1tl\u00f3 faktor Slug \u00e9s a Wnt jel\u00e1tviteli \u00fatvonal kulcsfontoss\u00e1g\u00fa effektor molekul\u00e1inak, a \u03b2 - kateninnek \u00e9s a CD44 feh\u00e9rj\u00e9knek az expresszi\u00f3s szintj\u00e9t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a PIC g\u00e1tolni tudja a Wnt jel\u00e1tviteli \u00fatvonalat, hogy EMT \u00e1talakul\u00e1st induk\u00e1ljon az endometrium r\u00e1kos sejtekben, ez\u00e1ltal elnyomja a HEC-1A sejtek migr\u00e1ci\u00f3j\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t.
\nA kutat\u00e1si jelent\u00e9sek azt mutatj\u00e1k, hogy a PIC k\u00e9pes visszafejl\u0151dni a daganatokban, apopt\u00f3zist induk\u00e1lni, valamint g\u00e1tolni az angiogenezist, az inv\u00e1zi\u00f3t, a migr\u00e1ci\u00f3t \u00e9s az \u00e1tt\u00e9tk\u00e9pz\u00e9st. Kor\u00e1bbi kutat\u00e1saink azt tal\u00e1lt\u00e1k, hogy a PIC k\u00e9pes g\u00e1tolni az MDA-MB-468 tripla negat\u00edv eml\u0151r\u00e1k sejtvonal prolifer\u00e1ci\u00f3j\u00e1t, blokkolni a sejtciklust \u00e9s apopt\u00f3zist induk\u00e1lni a Wnt\/\u03b2 - katenin jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val, \u00e9s j\u00f3 tripla negat\u00edv eml\u0151r\u00e1kellenes hat\u00e1ssal rendelkezik. Egy m\u00e1sik vizsg\u00e1lat kimutatta, hogy a PIC g\u00e1tolta az MCF-10A eml\u0151r\u00e1ksejtek metaszt\u00e1zis\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t a Hras \u00e1ltal induk\u00e1lt AKR foszforil\u00e1ci\u00f3, az MMP-2 \u00e9s a foszfatidil-inozitol-3-kin\u00e1z (PI3K) aktivit\u00e1s g\u00e1tl\u00e1s\u00e1val, valamint a foszfatidil-inozitol (3,4,5) - trifoszf\u00e1t (PI3K) expresszi\u00f3j\u00e1nak lefel\u00e9 t\u00f6rt\u00e9n\u0151 szab\u00e1lyoz\u00e1s\u00e1val, \u00e9s eml\u0151r\u00e1kellenes szerepet j\u00e1tszott. A vizsg\u00e1lat in vitro eredm\u00e9nyei azt mutatt\u00e1k, hogy a PIC jelent\u0151s, a gy\u00f3gyszer koncentr\u00e1ci\u00f3j\u00e1t\u00f3l f\u00fcgg\u0151 g\u00e1tl\u00f3 hat\u00e1ssal van a HEC-1A endometrium r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1ra, migr\u00e1ci\u00f3j\u00e1ra \u00e9s inv\u00e1zi\u00f3j\u00e1ra. A MAPK jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1sa \u00f6sszef\u00fcgg a daganatok kialakul\u00e1s\u00e1val \u00e9s fejl\u0151d\u00e9s\u00e9vel, \u00e9s r\u00e9szt vesz a sejtek n\u00f6veked\u00e9s\u00e9nek, differenci\u00e1l\u00f3d\u00e1s\u00e1nak, t\u00fal\u00e9l\u00e9s\u00e9nek \u00e9s hal\u00e1l\u00e1nak szab\u00e1lyoz\u00e1s\u00e1ban. Az Erk \u00e9s a p38MAPK feh\u00e9rj\u00e9k a MAPK jel\u00e1tviteli \u00fatvonal kulcsfontoss\u00e1g\u00fa effektor molekul\u00e1i. Yan \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a PIC g\u00e1tolja az Erk1\/2 \u00e9s Akt feh\u00e9rj\u00e9k foszforil\u00e1ci\u00f3j\u00e1t a MAPK \u00e9s AKT jel\u00e1tviteli \u00fatvonalak befoly\u00e1sol\u00e1s\u00e1val, ez\u00e1ltal elnyomja a RANKL induk\u00e1lta oszteoklaszt gener\u00e1ci\u00f3t \u00e9s csontreszorpci\u00f3t. Molekul\u00e1ris szinten ez a tanulm\u00e1ny tov\u00e1bb\u00e1 kimutatta, hogy a PIC k\u00e9pes g\u00e1tolni a prolifer\u00e1ci\u00f3val kapcsolatos Akt, Erk1\/2 \u00e9s p38MAPK feh\u00e9rj\u00e9k foszforil\u00e1ci\u00f3j\u00e1t a HEC-1A sejtekben, hat\u00e9konyan elnyomva az endometrium r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, migr\u00e1ci\u00f3j\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t.
\n\u00d6sszefoglalva, e vizsg\u00e1lat eredm\u00e9nyei azt mutatj\u00e1k, hogy a PIC hat\u00e9konyan g\u00e1tolja a HEC-1A endometrium r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, sejt apopt\u00f3zist induk\u00e1l, \u00e9s jelent\u0151sen cs\u00f6kkenti a HEC-1A sejtek migr\u00e1ci\u00f3s \u00e9s inv\u00e1zi\u00f3s k\u00e9pess\u00e9g\u00e9t. Mechanizmusa az Akt, Erk1\/2 \u00e9s p38MAPK foszforil\u00e1ci\u00f3j\u00e1nak g\u00e1tl\u00e1s\u00e1val f\u00fcgghet \u00f6ssze az Akt\/ERK\/MAPK jel\u00e1tviteli \u00fatvonalban, a \u03b2 - katenin, CD44 \u00e9s Slug inv\u00e1zi\u00f3s \u00e9s migr\u00e1ci\u00f3s feh\u00e9rj\u00e9k expresszi\u00f3s szintj\u00e9nek lefel\u00e9 ir\u00e1nyul\u00f3 szab\u00e1lyoz\u00e1s\u00e1val, valamint az E-cdaherin feh\u00e9rje expresszi\u00f3s szintj\u00e9nek felfel\u00e9 ir\u00e1nyul\u00f3 szab\u00e1lyoz\u00e1s\u00e1val. El\u0151zetesen meger\u0151s\u00edt\u00e9st nyert, hogy a PIC g\u00e1tl\u00f3 hat\u00e1ssal van az endometrium r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1ra, migr\u00e1ci\u00f3j\u00e1ra \u00e9s inv\u00e1zi\u00f3j\u00e1ra. Ez a k\u00eds\u00e9rlet azonban csak el\u0151zetes in vitro vizsg\u00e1latokat v\u00e9gzett sejtszinten, \u00e9s az endometrium r\u00e1kellenes hat\u00e1s\u00e1nak specifikus molekul\u00e1ris mechanizmusa m\u00e9g tov\u00e1bbi tiszt\u00e1z\u00e1sra szorul in vivo vizsg\u00e1latokkal.<\/p>","protected":false},"excerpt":{"rendered":"

The effect of resveratrol on proliferation, migration, and invasion of endometrial cancer HEC-1A cells Endometrial carcinoma (EC) is the most common tumor in the female reproductive tract, second only to breast cancer, lung cancer and colorectal cancer. In the world, there are about 380000 new cases of endometrial cancer every year, and about 89000 people […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nThe effect of resveratrol on proliferation, migration, and invasion of endometrial cancer HEC-1A cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/proliferation-migration\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The effect of resveratrol on proliferation, migration, and invasion of endometrial cancer HEC-1A cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The effect of resveratrol on proliferation, migration, and invasion of endometrial cancer HEC-1A cells Endometrial carcinoma (EC) is the most common tumor in the female reproductive tract, second only to breast cancer, lung cancer and colorectal cancer. 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