{"id":7309,"date":"2024-08-06T19:22:43","date_gmt":"2024-08-06T19:22:43","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7309"},"modified":"2024-08-06T19:22:43","modified_gmt":"2024-08-06T19:22:43","slug":"artesunate","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/artesunate\/","title":{"rendered":"Az artesun\u00e1tnak a TGF - \u03b2 \/ Smad \u00fatvonalon alapul\u00f3, a l\u00e9pfibr\u00f3zist enyh\u00edt\u0151 mechanizmusa 2 t\u00edpus\u00fa cukorbetegs\u00e9gben szenved\u0151 patk\u00e1nyokban"},"content":{"rendered":"

Az artesun\u00e1tnak a TGF - \u03b2 \/ Smad \u00fatvonalon alapul\u00f3, a l\u00e9pfibr\u00f3zist enyh\u00edt\u0151 mechanizmusa 2 t\u00edpus\u00fa cukorbetegs\u00e9gben szenved\u0151 patk\u00e1nyokban
\nA 2-es t\u00edpus\u00fa cukorbetegs\u00e9g (T2DM) kr\u00f3nikus anyagcsere-betegs\u00e9g. Mivel a T2DM el\u0151fordul\u00e1si ar\u00e1nya folyamatosan emelkedik, a T2DM a harmadik olyan kr\u00f3nikus betegs\u00e9gg\u00e9 v\u00e1lt, amely az emberi eg\u00e9szs\u00e9get vesz\u00e9lyezteti a vil\u00e1gon. Emellett a fiatalok k\u00f6r\u00e9ben az el\u0151fordul\u00e1si ar\u00e1ny \u00e9s a prevalencia vil\u00e1gszerte emelkedik. Ha nem kezelik id\u0151ben, egy sor s\u00falyos betegs\u00e9g \u00e9s c\u00e9lszervi k\u00e1rosod\u00e1s k\u00f6vetkezik be, ami megr\u00f6vid\u00edti a cukorbetegek \u00e9let\u00e9t. Amikor a T2DM betegek magas v\u00e9rcukorszintje oxidat\u00edv stresszt \u00e9s a gyullad\u00e1sos faktorok emelkedett szintj\u00e9t okozza, ez l\u00e9psejt apopt\u00f3zishoz \u00e9s immunrendszeri diszfunkci\u00f3hoz vezethet, ami v\u00e9g\u00fcl l\u00e9pk\u00e1rosod\u00e1shoz vezet. Ugyanakkor a t\u00falzott gyullad\u00e1sos v\u00e1lasz l\u00e9pfibr\u00f3zist okozhat, \u00e9s a kollag\u00e9nrostok prolifer\u00e1ci\u00f3ja tov\u00e1bb korl\u00e1tozhatja a l\u00e9p v\u00e9rell\u00e1t\u00e1s\u00e1t, visszaford\u00edthatatlan k\u00e1rosod\u00e1st okozva a betegeknek. Jelenleg azonban nincs hat\u00e9kony m\u00f3dszer a T2DM-betegek l\u00e9pk\u00e1rosod\u00e1s\u00e1nak \u00e9s fibr\u00f3zis\u00e1nak megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re. A transzform\u00e1l\u00f3 n\u00f6veked\u00e9si faktor b\u00e9ta (TGF - \u03b2) \u00e9s f\u0151 \u00fatvonala, a TGF - \u03b2\/Smad azonban szorosan \u00f6sszef\u00fcgg a fibr\u00f3zis progresszi\u00f3j\u00e1val. Tanulm\u00e1nyok kimutatt\u00e1k, hogy a TGF - \u03b2\/Smad fontos szab\u00e1lyoz\u00f3 szerepet j\u00e1tszik a k\u00fcl\u00f6nb\u00f6z\u0151 szervek, p\u00e9ld\u00e1ul a t\u00fcd\u0151fibr\u00f3zis, a vesefibr\u00f3zis, a m\u00e1jfibr\u00f3zis \u00e9s a hasny\u00e1lmirigy-fibr\u00f3zis fibr\u00f3zis\u00e1ban. Azonban kev\u00e9s hazai \u00e9s k\u00fclf\u00f6ldi jelent\u00e9s sz\u00f3l arr\u00f3l, hogy ez \u00f6sszef\u00fcgg-e a l\u00e9pfibr\u00f3zissal.
\nAz artesun\u00e1t (ART), egy k\u00ednai gy\u00f3gyn\u00f6v\u00e9nyb\u0151l, az artemizininb\u0151l kivont term\u00e9szetes szeszkviterp\u00e9n-lakton vegy\u00fclet, a mal\u00e1riaellenes szerek els\u0151 vonalbeli kezel\u00e9si gy\u00f3gyszere. Az elm\u00falt \u00e9vekben a kutat\u00e1sok azt is meg\u00e1llap\u00edtott\u00e1k, hogy az ART daganatellenes, immunszab\u00e1lyoz\u00f3, v\u00edrusellenes, fibr\u00f3zisellenes \u00e9s egy\u00e9b hat\u00e1sokkal is rendelkezik. A kutat\u00f3csoport korai kutat\u00e1sai sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy az ART nemcsak a cukorbeteg patk\u00e1nyok v\u00e9rcukorszintj\u00e9t k\u00e9pes cs\u00f6kkenteni, hanem megel\u0151z\u0151 hat\u00e1ssal van a ves\u00e9re, a t\u00fcd\u0151fibr\u00f3zisra \u00e9s az oxidat\u00edv stresszre is. Azt azonban, hogy az ART hat\u00e1ssal van-e a T2DM l\u00e9psz\u00f6vet\u00e9re \u00e9s annak fibr\u00f3zis\u00e1ra, nem vizsg\u00e1lt\u00e1k, \u00e9s az ezzel kapcsolatos mechanizmust sem t\u00e1rt\u00e1k fel. Ez\u00e9rt ebben a k\u00eds\u00e9rletben az ART hat\u00e1s\u00e1t figyelj\u00fck meg a T2DM patk\u00e1nyok l\u00e9p\u00e9nek szerkezet\u00e9re \u00e9s fibr\u00f3zis\u00e1ra egy T2DM patk\u00e1nymodell l\u00e9trehoz\u00e1s\u00e1val. \u00c9s felt\u00e1rni, hogy ez \u00f6sszef\u00fcgghet-e a TGF - \u03b2\/Smad \u00fatvonallal.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nA l\u00e9p az emberi szervezet legnagyobb immunszerve, \u00e9s funkci\u00f3i k\u00f6z\u00e9 tartozik els\u0151sorban a v\u00e9rsz\u0171r\u00e9s, a v\u00f6r\u00f6sv\u00e9rtestek, az antig\u00e9nek \u00e9s idegen testek \u00f6reged\u00e9se, valamint az immunv\u00e1lasz. A T2DM az anyagcsere-betegs\u00e9gek egy csoportja, \u00e9s a hossz\u00fa t\u00e1v\u00fa hiperglik\u00e9mia oxidat\u00edv stresszt \u00e9s t\u00f6bb szerv k\u00e1rosod\u00e1s\u00e1t okozhatja. Oxidat\u00edv stressz k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt a l\u00e9psz\u00f6vetben abnorm\u00e1lis citokinek termel\u0151dnek, ami a l\u00e9p megnagyobbod\u00e1s\u00e1hoz \u00e9s fibr\u00f3zishoz vezet, ami a betegekn\u00e9l l\u00e9pk\u00e1rosod\u00e1shoz vezet. Amikor a l\u00e9psz\u00f6vetben fibr\u00f3zis alakul ki, a k\u00f6zponti art\u00e9ria intim\u00e1ja megvastagszik \u00e9s a k\u00f6rnyez\u0151 kollag\u00e9nrostok prolifer\u00e1lnak, ami korl\u00e1tozza a l\u00e9p szinuszoidjainak t\u00e1gul\u00e1s\u00e1t \u00e9s a v\u00e9rt\u00e1rol\u00f3 funkci\u00f3 cs\u00f6kken\u00e9s\u00e9hez vezet, ami el\u00e9gtelen v\u00e9r\u00e1raml\u00e1st \u00e9s az eredeti \u00e9lettani funkci\u00f3k k\u00e1rosod\u00e1s\u00e1t eredm\u00e9nyezi. A kutat\u00f3csoport el\u0151zetes kutat\u00e1sai szerint a T2DM patk\u00e1nyok 50mg\/kg-os ART-koncentr\u00e1ci\u00f3 mellett hat\u00e9konyan k\u00e9pesek kifejteni a gy\u00f3gyszerhat\u00e1st an\u00e9lk\u00fcl, hogy m\u00e1jtoxicit\u00e1st okozn\u00e1nak. Ez\u00e9rt ezt hat\u00e1rozt\u00e1k meg a k\u00eds\u00e9rlet v\u00e9gs\u0151 koncentr\u00e1ci\u00f3jak\u00e9nt. Ebben a k\u00eds\u00e9rletben SD patk\u00e1nymodellt hoztak l\u00e9tre, \u00e9s pozit\u00edv kontrollk\u00e9nt a T2DM kezel\u00e9s\u00e9re \u00e1ltal\u00e1nosan haszn\u00e1lt gy\u00f3gyszert, a metformint haszn\u00e1lt\u00e1k. A HE-fest\u00e9s azt mutatta, hogy a T2DM-patk\u00e1nyok l\u00e9p\u00e9nek k\u00f6zponti art\u00e9ri\u00e1ja megvastagodott, \u00e9s a l\u00e9pzsin\u00f3r sz\u00e9le keskeny volt. A gy\u00f3gyszeres kezel\u00e9s ut\u00e1n a l\u00e9p szerkezete javult. A Masson-fest\u00e9s azt mutatta, hogy a DM csoportban a k\u00f6zponti art\u00e9ria \u00e9s v\u00e9na k\u00f6r\u00fcl a kollag\u00e9nrostok sz\u00e1ma megn\u00f6vekedett a CON csoporthoz k\u00e9pest, m\u00edg a k\u00e9k rostok lerak\u00f3d\u00e1sa minden gy\u00f3gyszeres csoportban cs\u00f6kkent, \u00e9s a k\u00fcl\u00f6nbs\u00e9g statisztikailag szignifik\u00e1ns volt, ami bizonyos m\u00e9rt\u00e9kig arra utal, hogy az ART v\u00e9d\u0151 hat\u00e1ssal van a l\u00e9p szerkezet\u00e9re \u00e9s a fibr\u00f3zisra.
\nA fibr\u00f3zis elve a szervparenchimasejtek elhal\u00e1s\u00e1nak patol\u00f3giai folyamata, amelyet a gyullad\u00e1s, az extracellul\u00e1ris m\u00e1trix (ECM) abnorm\u00e1lis n\u00f6veked\u00e9se \u00e9s t\u00falzott lerak\u00f3d\u00e1sa okoz a sz\u00f6vetekben, ami szint\u00e9n a T2DM gyakori t\u00fcnete, bele\u00e9rtve a vesefibr\u00f3zist, a t\u00fcd\u0151fibr\u00f3zist, a m\u00e1jfibr\u00f3zist stb. Min\u00e9l t\u00f6bb a rostos k\u00f6t\u0151sz\u00f6vet a sz\u00f6vetekben, ann\u00e1l k\u00f6nnyebben halnak el a sejtek, ami v\u00e9g\u00fcl szervi el\u00e9gtelens\u00e9ghez vezet. A fibr\u00f3zis mechanizmusa els\u0151sorban a TGF - \u03b2\/Smad \u00fatvonalhoz kapcsol\u00f3dik. A TGF - \u03b2 fontos t\u00e9nyez\u0151 a fibr\u00f3zisban, szab\u00e1lyozza a sejtn\u00f6veked\u00e9st \u00e9s az apopt\u00f3zist, bele\u00e9rtve h\u00e1rom alt\u00edpust. K\u00f6z\u00fcl\u00fck a TGF - \u03b2 1 rendelkezik a leger\u0151sebb aktivit\u00e1ssal, \u00e9s fontos szerepet j\u00e1tszik a fibr\u00f3zis folyamat\u00e1ban. Egyr\u00e9szt el\u0151seg\u00edti az ECM termel\u00e9s\u00e9t \u00e9s saj\u00e1t jel\u00e1tviteli \u00fatvonal\u00e1n kereszt\u00fcl induk\u00e1lja a fibr\u00f3zist. M\u00e1sr\u00e9szt g\u00e1tolhatja a m\u00e1trix metalloprotein\u00e1zok (MMP-k) termel\u00e9s\u00e9t \u00e9s el\u0151seg\u00edtheti a kollag\u00e9n n\u00f6veked\u00e9s\u00e9t, s\u00falyosb\u00edtva a fibr\u00f3zist. A rekombin\u00e1ns hum\u00e1n feh\u00e9rjecsal\u00e1d (smad csal\u00e1dtag) a TGF - \u03b2 egyik downstream kulcs receptor feh\u00e9rjecsal\u00e1dja, bele\u00e9rtve az aktiv\u00e1lt t\u00edpusokat, mint a Smad2, Smad3, Smad5, \u00e9s a g\u00e1tl\u00f3 t\u00edpusokat, bele\u00e9rtve f\u0151k\u00e9nt a smad7-et. A Smad7, mint a TGF - \u03b2 jel\u00e1tvitel kulcsfontoss\u00e1g\u00fa negat\u00edv szab\u00e1lyoz\u00f3ja, g\u00e1tolhatja a fibr\u00f3zist a receptoraktivit\u00e1s blokkol\u00e1s\u00e1val, a receptor degrad\u00e1ci\u00f3j\u00e1nak induk\u00e1l\u00e1s\u00e1val vagy a Smad2\/3-DNS k\u00f6t\u0151d\u00e9s zavar\u00e1s\u00e1val. Amikor cukorbetegekn\u00e9l sz\u00f6veti fibr\u00f3zis l\u00e9p fel, a TGF - \u03b2 1 expresszi\u00f3ja megn\u0151, \u00e9s specifikusan k\u00f6t\u0151dik a Smad2-hez \u00e9s Smad3-hoz. A Smad7 g\u00e1tolt, ami n\u00f6veli a jel\u00e1tvitelt a sejtmembr\u00e1nb\u00f3l a sejtmagba, \u00edgy aktiv\u00e1lja a downstream c\u00e9lg\u00e9nt a fibr\u00f3zis el\u0151seg\u00edt\u00e9se \u00e9rdek\u00e9ben. A kutat\u00e1sok azt mutatj\u00e1k, hogy amikor a TGF - \u03b2\/Smad \u00fatvonal aktiv\u00e1l\u00f3dik, a downstream c\u00e9lg\u00e9n, a kollag\u00e9n I is megn\u0151 a sz\u00f6vet lerak\u00f3d\u00e1s\u00e1ban, \u00edgy s\u00falyosb\u00edtva a sz\u00f6veti fibr\u00f3zis m\u00e9rt\u00e9k\u00e9t.
\nZhang \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a nagy d\u00f3zis\u00fa cink k\u00e9pes megel\u0151zni \u00e9s kezelni a l\u00e9pfibr\u00f3zist, \u00e9s a mechanizmusa a TGF - \u03b2, a kollag\u00e9n I \u00e9s az \u03b1 - simaizomaktin (\u03b1 - SMA) tartalm\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel \u00e9rhet\u0151 el a l\u00e9psz\u00f6vetben, ez\u00e1ltal n\u00f6velve az ECM lebont\u00e1s\u00e1t. Egyes tud\u00f3sok azt is meg\u00e1llap\u00edtott\u00e1k, hogy a TGF - \u03b2\/Smad jel\u00e1tviteli \u00fatvonal r\u00e9szt vesz a cukorbetegs\u00e9g c\u00e9lszervi fibr\u00f3zis\u00e1nak folyamat\u00e1ban. A kezel\u00e9s ut\u00e1n jav\u00edthatja a cukorbetegs\u00e9g c\u00e9lszervi fibr\u00f3zis\u00e1t a kollag\u00e9n I, TGF - \u03b2, Smad2, Smad3 expresszi\u00f3j\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel. Ebben a k\u00eds\u00e9rletben immunhisztok\u00e9mia, Western blot \u00e9s qRT PCR seg\u00edts\u00e9g\u00e9vel meg\u00e1llap\u00edtott\u00e1k, hogy a DM csoportba tartoz\u00f3 patk\u00e1nyok l\u00e9psz\u00f6vet\u00e9ben a TGF - \u03b2 1, Smad2 \u00e9s Kollag\u00e9n I tartalma szignifik\u00e1nsan magasabb volt, mint a CON csoport\u00e9, m\u00edg a Smad7 expresszi\u00f3ja cs\u00f6kkent. A TGF - \u03b2 1, a Smad2 \u00e9s a Kollag\u00e9n I feh\u00e9rje- \u00e9s mRNS-expresszi\u00f3s szintje szignifik\u00e1nsan cs\u00f6kkent, a Smad7 tartalma pedig szignifik\u00e1nsan n\u0151tt az egyes gy\u00f3gyszercsoportokban, a statisztikai k\u00fcl\u00f6nbs\u00e9gek \u00f6sszhangban voltak a fenti eredm\u00e9nyekkel.
\n\u00d6sszefoglalva, az ART nemcsak a T2DM-patk\u00e1nyok v\u00e9rcukorszintj\u00e9t cs\u00f6kkentheti, hanem nagyszer\u0171 kil\u00e1t\u00e1sokkal rendelkezik a T2DM-patk\u00e1nyok l\u00e9pindex\u00e9nek, l\u00e9ps\u00faly\u00e1nak \u00e9s l\u00e9pszerkezet\u00e9nek v\u00e1ltoz\u00e1saira is. Az is kider\u00fcl, hogy az ART-nek bizonyos szerepe van a T2DM-patk\u00e1nyok l\u00e9pfibr\u00f3zis\u00e1nak megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben, \u00e9s a kombin\u00e1lt csoport hat\u00e1sa jelent\u0151sebbnek t\u0171nik, \u00e9s a mechanizmusa a TGF - \u03b2 \/ Smad jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val is \u00f6sszef\u00fcgghet, ami elm\u00e9leti alapot ny\u00fajt a l\u00e9pk\u00e1rosod\u00e1s \u00e9s a l\u00e9pfibr\u00f3zis gy\u00f3gyszeres kezel\u00e9s\u00e9nek tanulm\u00e1nyoz\u00e1s\u00e1hoz a 2. t\u00edpus\u00fa cukorbeteg patk\u00e1nyokn\u00e1l.<\/p>","protected":false},"excerpt":{"rendered":"

The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF – \u03b2\/Smad Pathway Type 2 diabetes (T2DM) is a chronic metabolic disease. As the incidence rate of T2DM continues to rise, it has become the third chronic disease threatening human health in the world. In addition, the incidence rate and […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nThe Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF - \u03b2\/Smad Pathway - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/artesunate\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF - \u03b2\/Smad Pathway - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF – \u03b2\/Smad Pathway Type 2 diabetes (T2DM) is a chronic metabolic disease. As the incidence rate of T2DM continues to rise, it has become the third chronic disease threatening human health in the world. In addition, the incidence rate and […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/hu\/artesunate\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-06T19:22:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-35.jpg\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Szerz\u0151:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Becs\u00fclt olvas\u00e1si id\u0151\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 perc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/artesunate\/\",\"url\":\"https:\/\/longchangextracts.com\/artesunate\/\",\"name\":\"The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF - \u03b2\/Smad Pathway - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/artesunate\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/artesunate\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-35.jpg\",\"datePublished\":\"2024-08-06T19:22:43+00:00\",\"dateModified\":\"2024-08-06T19:22:43+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/artesunate\/#breadcrumb\"},\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/artesunate\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/artesunate\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-35.jpg\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-35.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/artesunate\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF – \u03b2\/Smad Pathway\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"hu\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"hu\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Az artesun\u00e1t mechanizmusa enyh\u00edti a l\u00e9p fibr\u00f3zist a 2. t\u00edpus\u00fa cukorbetegs\u00e9gben szenved\u0151 patk\u00e1nyokn\u00e1l a TGF - \u03b2 \/ Smad \u00fatvonalon - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/hu\/artesunate\/","og_locale":"hu_HU","og_type":"article","og_title":"The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF - \u03b2\/Smad Pathway - China Chemical Manufacturer","og_description":"The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF – \u03b2\/Smad Pathway Type 2 diabetes (T2DM) is a chronic metabolic disease. As the incidence rate of T2DM continues to rise, it has become the third chronic disease threatening human health in the world. In addition, the incidence rate and […]","og_url":"https:\/\/longchangextracts.com\/hu\/artesunate\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-06T19:22:43+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-35.jpg"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Szerz\u0151:":"longcha9","Becs\u00fclt olvas\u00e1si id\u0151":"7 perc"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/artesunate\/","url":"https:\/\/longchangextracts.com\/artesunate\/","name":"Az artesun\u00e1t mechanizmusa enyh\u00edti a l\u00e9p fibr\u00f3zist a 2. t\u00edpus\u00fa cukorbetegs\u00e9gben szenved\u0151 patk\u00e1nyokn\u00e1l a TGF - \u03b2 \/ Smad \u00fatvonalon - K\u00edna K\u00e9miai Gy\u00e1rt\u00f3","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/artesunate\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/artesunate\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-35.jpg","datePublished":"2024-08-06T19:22:43+00:00","dateModified":"2024-08-06T19:22:43+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/artesunate\/#breadcrumb"},"inLanguage":"hu","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/artesunate\/"]}]},{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/artesunate\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-35.jpg","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-35.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/artesunate\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF – \u03b2\/Smad Pathway"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"K\u00edna Vegyi Gy\u00e1rt\u00f3","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"hu","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/7309"}],"collection":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/comments?post=7309"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/7309\/revisions"}],"predecessor-version":[{"id":7319,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/posts\/7309\/revisions\/7319"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/media?parent=7309"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/categories?post=7309"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/hu\/wp-json\/wp\/v2\/tags?post=7309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}