{"id":7041,"date":"2024-08-06T18:24:00","date_gmt":"2024-08-06T18:24:00","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7041"},"modified":"2024-08-06T18:24:00","modified_gmt":"2024-08-06T18:24:00","slug":"honokiol-on-hif-1-%ce%b1-vegf-pathway-in-pc12-cells","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/honokiol-on-hif-1-%ce%b1-vegf-pathway-in-pc12-cells\/","title":{"rendered":"A honokiol szab\u00e1lyoz\u00f3 hat\u00e1s\u00e1nak felt\u00e1r\u00e1sa a HIF-1 \u03b1 - VEGF \u00fatvonalra a PC12 sejtekben h\u00e1l\u00f3zati farmakol\u00f3giai \u00e9s sejtk\u00eds\u00e9rletek alapj\u00e1n"},"content":{"rendered":"

A honokiol szab\u00e1lyoz\u00f3 hat\u00e1s\u00e1nak felt\u00e1r\u00e1sa a HIF-1 \u03b1 - VEGF \u00fatvonalra a PC12 sejtekben h\u00e1l\u00f3zati farmakol\u00f3giai \u00e9s sejtk\u00eds\u00e9rletek alapj\u00e1n
\nA Magnolia officinalis, mint Qi szab\u00e1lyoz\u00f3 gy\u00f3gyszer, amely k\u00e9pes kisz\u00e1r\u00edtani a nedvess\u00e9get, megsz\u00fcntetni a v\u00e1lad\u00e9kot \u00e9s enyh\u00edteni a felesleges Qi-t, az elm\u00falt \u00e9vekben sz\u00e9les k\u00f6rben tanulm\u00e1nyozt\u00e1k mind belf\u00f6ld\u00f6n, mind nemzetk\u00f6zi szinten. A Magnolia officinalis f\u0151 \u00f6sszetev\u0151i \u00e9s a magnolol a magas bioakt\u00edv fenolos vegy\u00fcletek egy oszt\u00e1lya, amelyek minim\u00e1lis toxicit\u00e1ssal \u00e9s farmakol\u00f3giai hat\u00e1sokkal rendelkeznek, mint p\u00e9ld\u00e1ul gyullad\u00e1scs\u00f6kkent\u0151, f\u00e1jdalomcsillap\u00edt\u00f3, tumorellenes \u00e9s patog\u00e9n mikroorganizmusok elleni hat\u00e1s. A honokiol fenol a v\u00e9r-agy g\u00e1ton kereszt\u00fcl bejuthat a k\u00f6zponti idegrendszerbe, \u00e9s k\u00f6zvetlen hat\u00e1st gyakorolhat az idegsz\u00f6vetre, \u00edgy \u00edg\u00e9retes gy\u00f3gyszer a neurol\u00f3giai betegs\u00e9gek kezel\u00e9s\u00e9re; M\u00e1sr\u00e9szt a honokiol ter\u00e1pi\u00e1s hat\u00e1ssal van sz\u00e1mos r\u00e1kos megbeteged\u00e9sre, p\u00e9ld\u00e1ul gyomorr\u00e1kra, t\u00fcd\u0151r\u00e1kra, m\u00e1jr\u00e1kra \u00e9s hasny\u00e1lmirigyr\u00e1kra is.
\nA HIF-1 \u03b1 expresszi\u00f3j\u00e1nak aktiv\u00e1l\u00e1sa el\u0151seg\u00edtheti az angiogenezist, a neuroprotektivit\u00e1st \u00e9s az idegi helyre\u00e1ll\u00edt\u00e1st, \u00e9s ez\u00e1ltal az agyi iszk\u00e9mi\u00e1s patk\u00e1nyok kezel\u00e9s\u00e9t. Ezenk\u00edv\u00fcl a HIF-1 a tumoros angiogenezis szab\u00e1lyoz\u00e1s\u00e1ban is kulcsfontoss\u00e1g\u00fa t\u00e9nyez\u0151, \u00e9s a magnolol g\u00e1tolja a HIF-\u00fatvonal \u00e9s a hipoxia \u00e1ltal k\u00f6zvet\u00edtett pro angiogenikus g\u00e9nek expresszi\u00f3j\u00e1t a legt\u00f6bb tumorban \u00e9s retina ischaemi\u00e1s betegs\u00e9gben. A fenti vizsg\u00e1latok arra utalnak, hogy a magnolol k\u00fcl\u00f6nb\u00f6z\u0151 \u00e1llapotokban t\u00f6rt\u00e9n\u0151 HIF-1 \u03b1 szab\u00e1lyoz\u00e1sa a farmakol\u00f3giai hat\u00e1sainak kulcsfontoss\u00e1g\u00fa mechanizmusa. Ez a tanulm\u00e1ny a \"HIF-1 \u03b1\"-t veszi kiindul\u00f3pontnak, \u00e9s h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t \u00e9s k\u00eds\u00e9rleti ellen\u0151rz\u00e9st haszn\u00e1l a honokiol szab\u00e1lyoz\u00f3 hat\u00e1sainak felt\u00e1r\u00e1s\u00e1ra a HIF-1 \u03b1 - VEGF \u00fatvonalra a PC12 sejtekben normoxikus \u00e9s hipoxikus k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt.<\/p>\n

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\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Normoxikus k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt a HIF-1 \u03b1 \u00e9s a VEGF expresszi\u00f3ja alacsony, de a magnolol ad\u00e1sa jelent\u0151sen el\u0151seg\u00edti a HIF-1 \u03b1 \u00e9s a VEGF feh\u00e9rj\u00e9k expresszi\u00f3j\u00e1t; Hipoxikus k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt a HIF-1 \u03b1 \u00e9s a VEGF magasan expressz\u00e1l\u00f3dik, \u00e9s a honokiol ad\u00e1sa jelent\u0151sen g\u00e1tolja a HIF-1 \u03b1 \u00e9s a VEGF expresszi\u00f3j\u00e1t. A honokiol k\u00fcl\u00f6nb\u00f6z\u0151 \u00e1llapotokban elt\u00e9r\u0151 szab\u00e1lyoz\u00f3 hat\u00e1st fejt ki a HIF-1 \u03b1-ra \u00e9s a VEGF-re, ami nagy jelent\u0151s\u00e9ggel b\u00edr a farmakol\u00f3giai mechanizmus\u00e1nak tanulm\u00e1nyoz\u00e1sa \u00e9s felhaszn\u00e1l\u00e1s\u00e1nak fejleszt\u00e9se szempontj\u00e1b\u00f3l. Ami azt illeti, hogy a honokiol hogyan befoly\u00e1solja a HIF-1 \u03b1 k\u00e9pz\u0151d\u00e9s\u00e9t \u00e9s leboml\u00e1s\u00e1t, a molekul\u00e1ris dokkol\u00e1s eredm\u00e9nyei azt mutatt\u00e1k, hogy a honokiol j\u00f3 k\u00f6t\u0151d\u00e9si aktivit\u00e1ssal rendelkezik k\u00e9t lebont\u00f3 enzimmel, a PHD-vel \u00e9s a VHL-lel. Azt azonban m\u00e9g mindig nem tudjuk tiszt\u00e1zni, hogy az adott lebont\u00f3 enzim aktiv\u00e1l\u00f3dik vagy g\u00e1tol\u00f3dik, ami szint\u00e9n egy olyan ir\u00e1ny, amelyet a j\u00f6v\u0151ben tanulm\u00e1nyozni kell.<\/p>\n

A h\u00e1l\u00f3zati farmakol\u00f3gia olyan rendszerbiol\u00f3giai m\u00f3dszerekkel v\u00e9gzett vizsg\u00e1lat, amely megk\u00f6nny\u00edtheti a gy\u00f3gyszerc\u00e9lpontok azonos\u00edt\u00e1s\u00e1t, \u00e9s sz\u00e9les k\u00f6rben alkalmazz\u00e1k a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s hat\u00f3anyagainak \u00e9s hat\u00e1smechanizmusainak el\u0151rejelz\u00e9s\u00e9ben. A kutat\u00e1s p\u00e9ld\u00e1ul \u00f6sszefoglalta a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s h\u00e1l\u00f3zatszab\u00e1lyoz\u00e1si mechanizmus\u00e1t az antidepressz\u00e1ns kezel\u00e9sben, \u00e9s az eredm\u00e9nyek azt mutatj\u00e1k, hogy a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s antidepressz\u00e1ns hat\u00e1st fejt ki a \"multi-target multi pathway\", a \"neuroendokrin immunh\u00e1l\u00f3zat\" \u00e9s a PI3K Akt jel\u00e1tviteli \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1n kereszt\u00fcl. A hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat daganatellenes h\u00e1l\u00f3zati farmakol\u00f3giai kutat\u00e1s\u00e1ban arr\u00f3l sz\u00e1moltak be, hogy a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat gyullad\u00e1scs\u00f6kkent\u0151, immunrendszer-ellenes, angiogenezis elleni, energiaanyagcsere-ellenes \u00e9s egy\u00e9b mechanizmusokon kereszt\u00fcl fejti ki daganatellenes hat\u00e1s\u00e1t. Ezen t\u00falmen\u0151en egyes tud\u00f3sok meg\u00e1llap\u00edtott\u00e1k, hogy a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s el\u0151seg\u00edti az idegsejtek n\u00f6veked\u00e9s\u00e9t \u00e9s prolifer\u00e1ci\u00f3j\u00e1t, \u00e9s g\u00e1tolja a sejtek apopt\u00f3zis\u00e1t a PI3K Akt \u00fatvonal, a HIF-1 \u00fatvonal \u00e9s a TNF \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1val, ez\u00e1ltal bizonyos szab\u00e1lyoz\u00f3 szerepet j\u00e1tszik a hipoxi\u00e1ban. A GO d\u00fas\u00edt\u00e1si elemz\u00e9s eredm\u00e9nyei tartalmazz\u00e1k a hipoxi\u00e1ra adott v\u00e1laszokat, a vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor stimul\u00e1ci\u00f3j\u00e1ra adott sejtv\u00e1laszokat, a gyullad\u00e1sos v\u00e1laszokat \u00e9s m\u00e1s biol\u00f3giai folyamatokat, amelyek kapcsolatban \u00e1llhatnak a hipoxia komplex patogenezis\u00e9vel. Ez azt jelzi, hogy a honokiol t\u00f6bb szinten \u00e9s \u00fatvonalon kereszt\u00fcl beavatkozhat a betegs\u00e9gek kialakul\u00e1s\u00e1ba \u00e9s fejl\u0151d\u00e9s\u00e9be. A KEGG d\u00fas\u00edt\u00e1si elemz\u00e9s eredm\u00e9nyei k\u00f6z\u00f6tt szerepel a HIF-1 \u00fatvonal, a VEGF \u00fatvonal, a PI3K Akt \u00fatvonal stb. A PI3K Akt \u00fatvonal foszforil\u00e1ci\u00f3n kereszt\u00fcl szab\u00e1lyozhatja a kapcsol\u00f3d\u00f3 feh\u00e9rj\u00e9ket, ez\u00e1ltal el\u0151seg\u00edtve a sejtn\u00f6veked\u00e9st \u00e9s g\u00e1tolva az apopt\u00f3zist. A HIF-1 \u00fatvonal megv\u00e1ltoztathatja a g\u00e9nexpresszi\u00f3t, hogy jav\u00edtsa a szervezet oxig\u00e9nell\u00e1t\u00e1si kapacit\u00e1s\u00e1t \u00e9s n\u00f6velje a v\u00e9rell\u00e1t\u00e1st az iszk\u00e9mi\u00e1s \u00e9s hipoxi\u00e1s k\u00f6rnyezethez val\u00f3 alkalmazkod\u00e1s \u00e9rdek\u00e9ben. A VEGF a HIF-1 \u03b1 egyik downstream c\u00e9lg\u00e9nje. Hipoxi\u00e1s k\u00f6r\u00fclm\u00e9nyek k\u00f6z\u00f6tt serkentheti a HIF-1 \u03b1 termel\u00e9s\u00e9t \u00e9s stabiliz\u00e1ci\u00f3j\u00e1t, \u00e9s elind\u00edthatja a VEGF transzkripci\u00f3j\u00e1t, ami a VEGF fokozott expresszi\u00f3j\u00e1t eredm\u00e9nyezi. Az al\u00e1bbiakban a depresszi\u00f3, az agyi iszk\u00e9mia \u00e9s a daganatos betegs\u00e9gek t\u00e1rgyal\u00e1s\u00e1ra \u00f6sszpontos\u00edtunk.
\nA HIF-1 \u03b1 - VEGF jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1sa fontos szerepet j\u00e1tszik a szinaptikus plaszticit\u00e1s el\u0151seg\u00edt\u00e9s\u00e9ben \u00e9s a depresszi\u00f3hoz hasonl\u00f3 viselked\u00e9s \u00e9s mem\u00f3riazavar hat\u00e9kony visszaford\u00edt\u00e1s\u00e1ban a CUMS-ben. Ezek k\u00f6z\u00fcl a hipoxia induk\u00e1lhat\u00f3 faktor-1 (HIF-1) egy olyan transzkripci\u00f3s faktor, amely a hipoxi\u00e1ra reag\u00e1l. Sejtes oxig\u00e9nreceptork\u00e9nt egy heterodimer, amely instabil alfa- \u00e9s b\u00e9ta-alegys\u00e9gekb\u0151l \u00e1ll, \u00e9s sz\u00e9les k\u00f6rben kifejez\u0151dik az emberi sejtekben. Vizsg\u00e1latok kimutatt\u00e1k, hogy a hipoxi\u00e1s prekondicion\u00e1l\u00e1s (HP) n\u00f6velheti a HIF-1 \u03b1 expresszi\u00f3j\u00e1t patk\u00e1nyok hippokampusz\u00e1ban, a hipotalamusz paraventrikul\u00e1ris magj\u00e1ban \u00e9s neokortex\u00e9ben. Vannak jelent\u00e9sek arr\u00f3l, hogy az intermitt\u00e1l\u00f3 hipoxia (IH) serkentheti a hippokampusz angiogenezis\u00e9t \u00e9s neurogenezis\u00e9t, \u00e9s jav\u00edthatja az agyi mem\u00f3riazavarokat. Ez\u00e9rt a HIF-1 \u03b1 jel\u00e1tviteli \u00fatvonal \u00edg\u00e9retes potenci\u00e1lis c\u00e9lpont a depresszi\u00f3 kezel\u00e9s\u00e9ben. A vaszkul\u00e1ris endot\u00e9l n\u00f6veked\u00e9si faktor (VEGF) nagy specificit\u00e1ssal rendelkezik az endot\u00e9lsejtek sz\u00e1m\u00e1ra, \u00e9s potenci\u00e1lisan neurotrofikus \u00e9s neuroprotekt\u00edv hat\u00e1ssal b\u00edr a k\u00f6zponti idegrendszerben. Kutat\u00e1sok kimutatt\u00e1k, hogy a VEGF befoly\u00e1solja a neuronok szinaptikus plaszticit\u00e1s\u00e1t, \u00e9s el\u0151seg\u00edtheti az axonok n\u00f6veked\u00e9s\u00e9t \u00e9s a neurogenezist. A VEGFR-2 (KDR) a VEGF sejtfelsz\u00edni receptora, amely szerepet j\u00e1tszik a tanul\u00e1sban \u00e9s a mem\u00f3ri\u00e1ban, mivel a VEGFR-2 receptor\u00e1n kereszt\u00fcl k\u00f6zvet\u00edti a hossz\u00fa t\u00e1v\u00fa javul\u00e1st, a plaszticit\u00e1s javul\u00e1s\u00e1t \u00e9s a kognit\u00edv funkci\u00f3k javul\u00e1s\u00e1t. \u00d6sszefoglalva, a HIF-1 \u03b1 - VEGF jel\u00e1tviteli \u00fatvonal aktiv\u00e1l\u00e1sa a depresszi\u00f3hoz hasonl\u00f3 viselked\u00e9s jav\u00edt\u00e1s\u00e1ra ir\u00e1nyul\u00f3, sokat kutatott strat\u00e9gia. Ezenk\u00edv\u00fcl az idegsejtekben a PI3K Akt \u00fatvonal szab\u00e1lyozhatja az idegsejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s differenci\u00e1l\u00f3d\u00e1s\u00e1t, valamint r\u00e9szt vesz az agyi v\u00e9r\u00e1raml\u00e1s szab\u00e1lyoz\u00e1s\u00e1ban \u00e9s a neuron\u00e1lis t\u00fal\u00e9l\u00e9s el\u0151seg\u00edt\u00e9s\u00e9ben, ami szorosan \u00f6sszef\u00fcgg a depresszi\u00f3 el\u0151fordul\u00e1s\u00e1val \u00e9s kialakul\u00e1s\u00e1val. A depresszi\u00f3 patogenezise a szinaptikus plaszticit\u00e1s zavar\u00e1hoz kapcsol\u00f3dik. A szinaptikus plaszticit\u00e1s v\u00e1ltoz\u00e1sai szorosan kapcsol\u00f3dnak a szinaptikus feh\u00e9rj\u00e9k kifejez\u0151d\u00e9s\u00e9hez. A PSD95 a posztszinaptikus s\u0171r\u0171 anyag (PSD) feh\u00e9rjecsal\u00e1d egyik t\u00edpusa, amely k\u00e9pes szab\u00e1lyozni a szinaptikus transzmisszi\u00f3t \u00e9s a szinaptikus funkci\u00f3t. A SYN1 a szinaptikus vezikul\u00e1k specifikus markerfeh\u00e9rje, amely t\u00fckr\u00f6zheti a szinapszisok sz\u00e1m\u00e1t, s\u0171r\u0171s\u00e9g\u00e9t \u00e9s eloszl\u00e1s\u00e1t. A PSD95 \u00e9s a SYN1 d\u00f6nt\u0151 szerepet j\u00e1tszik a jel\u00e1tvitel \u00e9s a szinaptikus plaszticit\u00e1s el\u0151seg\u00edt\u00e9s\u00e9ben, \u00e9s egyes antidepressz\u00e1ns gy\u00f3gyszerek jelent\u0151sen fokozhatj\u00e1k a szinaptikus plaszticit\u00e1st. Ez \u00f6sszhangban van a 2.8. \u00e9s 2.9. pont eredm\u00e9nyeivel, ahol a honokiol k\u00e9pes n\u00f6velni a PSD95 \u00e9s SYN1 feh\u00e9rj\u00e9k szintj\u00e9t, hogy fokozza a PC12 sejtek szinaptikus plaszticit\u00e1s\u00e1t.<\/p>\n

A fok\u00e1lis agyi iszk\u00e9mi\u00e1ban szenved\u0151 patk\u00e1nyok neurol\u00f3giai funkci\u00f3j\u00e1nak jav\u00edt\u00e1sa \u00f6sszef\u00fcgghet a HIF-1 \u03b1 - VEGF jel\u00e1tviteli \u00fatvonal expresszi\u00f3j\u00e1nak \u00e9s a szinaptikus plaszticit\u00e1s kialakul\u00e1s\u00e1nak el\u0151seg\u00edt\u00e9s\u00e9vel az agyi iszk\u00e9mi\u00e1t k\u00f6vet\u0151en. A tud\u00f3sok meg\u00e1llap\u00edtott\u00e1k, hogy az agyv\u00e9delem mechanizmusa a HIF-1 \u03b1 \u00e9s a downstream c\u00e9lg\u00e9nek, a VEGF \u00e9s az EPO fokozott expresszi\u00f3j\u00e1val f\u00fcgg \u00f6ssze. A magaslati hipoxia okozta agyi iszk\u00e9mia jav\u00edt\u00e1s\u00e1nak mechanizmusa szint\u00e9n a HIF-1 \u03b1 \u00fatvonal felszab\u00e1lyoz\u00e1s\u00e1hoz kapcsol\u00f3dik. A PI3K Akt \u00fatvonal aktiv\u00e1l\u00e1sa szint\u00e9n jav\u00edthatja a neurol\u00f3giai hi\u00e1nyoss\u00e1gokat, \u00e9s neuroprotekt\u00edv hat\u00e1st fejthet ki az agyi iszk\u00e9mia-reperf\u00fazi\u00f3s s\u00e9r\u00fcl\u00e9sben szenved\u0151 patk\u00e1nyokn\u00e1l. Ezenk\u00edv\u00fcl a HIF-1 \u03b1 - VEGF jel\u00e1tviteli \u00fatvonal fontos szerepet j\u00e1tszik a daganatok, k\u00fcl\u00f6n\u00f6sen a k\u00f6zponti idegrendszeri daganatok kialakul\u00e1s\u00e1ban \u00e9s fejl\u0151d\u00e9s\u00e9ben. A kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy a honokiol g\u00e1tolja a gli\u00f3ma sejtek prolifer\u00e1ci\u00f3j\u00e1t a HIF-1 \u03b1 \u00e9s a c\u00e9lg\u00e9njei, a VEGF \u00e9s a GLUT1 expresszi\u00f3j\u00e1nak cs\u00f6kkent\u00e9se r\u00e9v\u00e9n. \u00c1llatk\u00eds\u00e9rletekben n\u00e9h\u00e1ny tud\u00f3s meztelen egereket haszn\u00e1lt emberi vastagb\u00e9lr\u00e1ksejtek szil\u00e1rd tumormodellj\u00e9nek l\u00e9trehoz\u00e1s\u00e1ra. A magnolol sz\u00e1jon \u00e1t t\u00f6rt\u00e9n\u0151 bead\u00e1sa ut\u00e1n jelent\u0151sen g\u00e1tolja a tumor n\u00f6veked\u00e9s\u00e9t, \u00e9s mechanizmusa a HIF-1 \u03b1 - VEGF \u00fatvonal \u00e9s a PI3K Akt \u00fatvonal g\u00e1tl\u00e1s\u00e1hoz kapcsol\u00f3dik.<\/p>\n

\u00d6sszefoglalva, a magnolol k\u00fcl\u00f6nb\u00f6z\u0151 szab\u00e1lyoz\u00f3 hat\u00e1ssal van a HIF-1 \u03b1 - VEGF jel\u00e1tviteli \u00fatvonalra norm\u00e1l \u00e9s hipoxi\u00e1s k\u00f6rnyezetben. A houpo fenol t\u00f6bb \u00fatvonalon \u00e9s c\u00e9lponton kereszt\u00fcl kezelheti a depresszi\u00f3t, az agyi iszk\u00e9mi\u00e1t \u00e9s a daganatos betegs\u00e9geket, ami ir\u00e1nyt ad a houpo fenol mechanizmus\u00e1nak tov\u00e1bbi kutat\u00e1s\u00e1hoz e betegs\u00e9gek kezel\u00e9s\u00e9ben. Ezenk\u00edv\u00fcl megfigyelt\u00e9k a megj\u00f3solt molekul\u00e1ris dokkol\u00e1si sz\u00f6get \u00e9s a j\u00f3 dokkol\u00e1st a honokiol \u00e9s a HIF-1 \u03b1 lebont\u00f3 enzim k\u00f6z\u00f6tt. Ez a tanulm\u00e1ny folytatja annak felt\u00e1r\u00e1s\u00e1t, hogy a honokiol hogyan hat a HIF-1 \u03b1-ra molekul\u00e1ris biol\u00f3giai \u00e9s egy\u00e9b m\u00f3dszerek seg\u00edts\u00e9g\u00e9vel.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the regulatory effect of honokiol on HIF-1 \u03b1 – VEGF pathway in PC12 cells based on network pharmacology and cell experiments Magnolia officinalis, as a Qi regulating medicine that can dry dampness, eliminate phlegm, and relieve excess Qi, has been widely studied both domestically and internationally in recent years. The main components of Magnolia […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the regulatory effect of honokiol on HIF-1 \u03b1 - VEGF pathway in PC12 cells based on network pharmacology and cell experiments - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/honokiol-on-hif-1-\u03b1-vegf-pathway-in-pc12-cells\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the regulatory effect of honokiol on HIF-1 \u03b1 - VEGF pathway in PC12 cells based on network pharmacology and cell experiments - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the regulatory effect of honokiol on HIF-1 \u03b1 – VEGF pathway in PC12 cells based on network pharmacology and cell experiments Magnolia officinalis, as a Qi regulating medicine that can dry dampness, eliminate phlegm, and relieve excess Qi, has been widely studied both domestically and internationally in recent years. 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