{"id":6820,"date":"2024-08-06T14:47:50","date_gmt":"2024-08-06T14:47:50","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6820"},"modified":"2024-08-06T14:47:50","modified_gmt":"2024-08-06T14:47:50","slug":"corrugated-seeds","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/corrugated-seeds\/","title":{"rendered":"Hull\u00e1mos vet\u0151magok \u00e9s hamis\u00edtott term\u00e9keik k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek differenci\u00e1lt elemz\u00e9se \u00e9s sejtk\u00eds\u00e9rleti ellen\u0151rz\u00e9se metabolizmus alapj\u00e1n"},"content":{"rendered":"<p>Hull\u00e1mos vet\u0151magok \u00e9s hamis\u00edtott term\u00e9keik k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek differenci\u00e1lt elemz\u00e9se \u00e9s sejtk\u00eds\u00e9rleti ellen\u0151rz\u00e9se metabolizmus alapj\u00e1n<br \/>\nA hull\u00e1mos kagyl\u00f3k a kagyl\u00f3k csal\u00e1dj\u00e1ba tartoz\u00f3 Arca subcrinata Lischke, Arca granosa Linnaeus vagy Arca inflata Reeve kagyl\u00f3k. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban \u00e1ltal\u00e1nosan haszn\u00e1lt tengeri kagyl\u00f3k, amelyeknek a flegma cs\u00f6kkent\u0151, a v\u00e9r pang\u00e1s\u00e1t megsz\u00fcntet\u0151, a kem\u00e9nys\u00e9get l\u00e1gy\u00edt\u00f3, a csom\u00f3kat sz\u00e9toszlat\u00f3, valamint a savakat \u00e9s a f\u00e1jdalmat enyh\u00edt\u0151 hat\u00e1sa van. A hull\u00e1mos k\u00f6veket sz\u00e9les k\u00f6rben haszn\u00e1lj\u00e1k a klinikai gyakorlatban a gyomorbetegs\u00e9gek, p\u00e9ld\u00e1ul a gastrooesophagealis reflux, akut gyomorfek\u00e9ly, kr\u00f3nikus gyomorhurut \u00e9s gyomorfek\u00e9ly kezel\u00e9s\u00e9re; \u00c9s a pajzsmirigyr\u00e1k, pajzsmirigy csom\u00f3k, daganatok, fek\u00e9lyes vastagb\u00e9lgyullad\u00e1s, magas v\u00e9rnyom\u00e1s \u00e9s egy\u00e9b betegs\u00e9gek kezel\u00e9s\u00e9re.<br \/>\nA hull\u00e1mos kagyl\u00f3k k\u00fcl\u00f6nf\u00e9le eredeti gy\u00f3gyn\u00f6v\u00e9nyek, \u00e9s sz\u00e1mos hamis\u00edtott term\u00e9k is l\u00e9tezik, f\u0151k\u00e9nt bord\u00e1zott durva d\u00edsz\u00edtett kagyl\u00f3k, csom\u00f3s kagyl\u00f3k, cs\u00f3nakkagyl\u00f3k, g\u00f6mbkagyl\u00f3k \u00e9s sz\u0151r\u00f6s kagyl\u00f3k. Mint m\u00e1s kagyl\u00f3k hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerek, a hull\u00e1mos magvak k\u00e9miai \u00f6sszet\u00e9tele k\u00e9t f\u0151 kateg\u00f3ri\u00e1b\u00f3l \u00e1ll: szervetlen \u00e9s szerves komponensek. A f\u0151 szervetlen komponensek a szervetlen s\u00f3k, amelyek f\u0151k\u00e9nt kalcium-karbon\u00e1tb\u00f3l \u00e9s szervetlen nyomelemekb\u0151l \u00e1llnak. A K\u00ednai N\u00e9pk\u00f6zt\u00e1rsas\u00e1g gy\u00f3gyszerk\u00f6nyv\u00e9nek 2020-as kiad\u00e1sa szerint a kalcium-karbon\u00e1t (CaCO3) tartalma nem lehet kevesebb, mint 93,0%. A szerves anyagok f\u0151 \u00f6sszetev\u0151i a feh\u00e9rj\u00e9k, aminosavak, poliszacharidok stb. A szerves \u00f6sszetev\u0151k \u00e1ltal\u00e1ban a h\u00e9j sz\u00e1raz t\u00f6meg\u00e9nek k\u00f6r\u00fclbel\u00fcl 0,3%-5,0%-\u00e1t teszik ki. Az alacsony szerves tartalom \u00e9s a bonyolult szerkezet, valamint a kutat\u00e1si m\u00f3dszerek \u00e9s \u00f6tletek korl\u00e1tai miatt a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat kagyl\u00f3h\u00e9j farmakol\u00f3giai alapkutat\u00e1sa viszonylag gyenge, ami azt eredm\u00e9nyezi, hogy a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat jelenlegi min\u0151s\u00e9gi szabv\u00e1nyaiban a kagyl\u00f3h\u00e9j funkcion\u00e1lis \u00f6sszetev\u0151inek tartalm\u00e1ra vonatkoz\u00f3 speci\u00e1lis azonos\u00edt\u00e1si \u00e9s meghat\u00e1roz\u00e1si m\u00f3dszerek hi\u00e1nyoznak, ami megnehez\u00edti a bels\u0151 min\u0151s\u00e9g \u00e9rt\u00e9kel\u00e9s\u00e9t. A szerves \u00f6sszetev\u0151inek modern kutat\u00e1si m\u00f3dszerekkel t\u00f6rt\u00e9n\u0151 szisztematikus azonos\u00edt\u00e1sa \u00e9s elemz\u00e9se el\u0151felt\u00e9tele \u00e9s alapja az anyagi alapok tiszt\u00e1z\u00e1s\u00e1nak \u00e9s a min\u0151s\u00e9gi szabv\u00e1nyok jav\u00edt\u00e1s\u00e1nak. Ez a tanulm\u00e1ny a TM Wide Targeted Metabolomics technik\u00e1t haszn\u00e1lta, amely integr\u00e1lja a nem c\u00e9lzott (n\u00e9gys\u00e1vos rep\u00fcl\u00e9si id\u0151 t\u00f6megspektrometria, QTOF) \u00e9s a sz\u00e9les c\u00e9lzott metabolit kimutat\u00e1si technik\u00e1k (kvantitat\u00edv t\u00f6bbsz\u00f6r\u00f6s reakci\u00f3monitoroz\u00e1s, MRM) el\u0151nyeit. Ez a technika egyes\u00edti a nem c\u00e9lzott (nagy felbont\u00e1s\u00fa, sz\u00e9les lefedetts\u00e9g\u0171) \u00e9s a sz\u00e9les c\u00e9lzott (nagy \u00e9rz\u00e9kenys\u00e9g\u0171, pontos mennyis\u00e9gi meghat\u00e1roz\u00e1s) technik\u00e1t, \u00edgy alkalmas komplex mint\u00e1k elemz\u00e9s\u00e9re. A hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerek fajt\u00e1inak azonos\u00edt\u00e1sa a hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerek min\u0151s\u00e9gellen\u0151rz\u00e9s\u00e9nek kulcsa. A metabolomikai technol\u00f3gia hasonl\u00f3 anyagcsere-inform\u00e1ci\u00f3kkal alkalmazhat\u00f3 a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat min\u0151s\u00e9gellen\u0151rz\u00e9s\u00e9re. Az elm\u00falt \u00e9vekben a metabolizmus-technol\u00f3gi\u00e1t sz\u00e9les k\u00f6rben alkalmazt\u00e1k a hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerek min\u0151s\u00e9g\u00e9nek \u00f6sszehasonl\u00edt\u00f3 vizsg\u00e1lat\u00e1ban. Ez\u00e9rt ebben a tanulm\u00e1nyban a sz\u00e9les c\u00e9lpont\u00fa technol\u00f3gi\u00e1t haszn\u00e1lt\u00e1k a hull\u00e1mos kagyl\u00f3 \u00e9s a hamis\u00edtott term\u00e9keik, p\u00e9ld\u00e1ul a vastag bord\u00e1s kagyl\u00f3 metabolikus \u00f6sszetev\u0151inek \u00e1tfog\u00f3 elemz\u00e9s\u00e9re, hogy azonos\u00edts\u00e1k a k\u00fcl\u00f6nb\u00f6z\u0151 metabolitjaikat, \u00e9s potenci\u00e1lis min\u0151s\u00e9gi markereket keressenek. A kutat\u00e1sok kimutatt\u00e1k, hogy a hull\u00e1mos kagyl\u00f3k jelent\u0151s ter\u00e1pi\u00e1s hat\u00e1ssal vannak a pajzsmirigyr\u00e1kra. Ez a tanulm\u00e1ny a TPC-1 emberi pajzsmirigyr\u00e1kos sejtvonalat v\u00e1lasztotta ki, amely a hagyom\u00e1nyos hat\u00e9konys\u00e1g\u00e1hoz kapcsol\u00f3dik, hogy felt\u00e1rja n\u00e9h\u00e1ny differenci\u00e1lis metabolit farmakol\u00f3giai hat\u00e1s\u00e1t, megalapozva ezzel a hull\u00e1mos magvak farmakol\u00f3giai anyagalapj\u00e1nak \u00e9s min\u0151s\u00e9gi szabv\u00e1nyainak jav\u00edt\u00e1s\u00e1t.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6821\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-31.jpg\" alt=\"\" width=\"800\" height=\"277\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-31.jpg 800w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-31-768x266.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6822\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-29.jpg\" alt=\"\" width=\"700\" height=\"277\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6823\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-20.jpg\" alt=\"\" width=\"700\" height=\"365\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6824\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-181.png\" alt=\"\" width=\"700\" height=\"702\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-181.png 700w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-181-200x200.png 200w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6825\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-165.png\" alt=\"\" width=\"800\" height=\"606\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-165.png 800w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-165-768x582.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6826\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-150.png\" alt=\"\" width=\"700\" height=\"308\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6827\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-137.png\" alt=\"\" width=\"700\" height=\"370\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6828\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-125.png\" alt=\"\" width=\"800\" height=\"460\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-125.png 800w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-125-768x442.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6829\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-117.png\" alt=\"\" width=\"700\" height=\"270\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6830\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-8.jpg\" alt=\"\" width=\"800\" height=\"395\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-8.jpg 800w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-8-768x379.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6831\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-4.jpg\" alt=\"\" width=\"800\" height=\"226\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-4.jpg 800w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-4-768x217.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6832\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-70.png\" alt=\"\" width=\"800\" height=\"790\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-70.png 800w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-70-768x758.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-70-729x720.png 729w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6833\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-59.png\" alt=\"\" width=\"800\" height=\"846\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-59.png 800w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-59-768x812.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-59-681x720.png 681w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6834\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-45.png\" alt=\"\" width=\"700\" height=\"280\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6835\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-34.png\" alt=\"\" width=\"765\" height=\"362\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6836\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-26.png\" alt=\"\" width=\"789\" height=\"344\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-26.png 789w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-26-768x335.png 768w\" sizes=\"(max-width: 789px) 100vw, 789px\" \/><br \/>\nA hull\u00e1mos magvak farmakol\u00f3giai anyag\u00e1nak alapjaira \u00e9s hat\u00e1smechanizmus\u00e1ra vonatkoz\u00f3 kutat\u00e1sok gyeng\u00e9k. Ebben a tanulm\u00e1nyban el\u0151sz\u00f6r alkalmaztak sz\u00e9les c\u00e9lpont\u00fa metabolomikai technol\u00f3gi\u00e1t a hull\u00e1mos magvak \u00e9s hamis\u00edtott term\u00e9keik metabolikus \u00f6sszetev\u0151inek \u00e1tfog\u00f3 elemz\u00e9s\u00e9re, \u00e9s 22 kateg\u00f3ri\u00e1b\u00f3l \u00f6sszesen 1208 metabolitot mutattak ki. Els\u0151sorban aminosavakat \u00e9s metabolitjaikat, benzolt \u00e9s sz\u00e1rmaz\u00e9kait, heterociklusos vegy\u00fcleteket, szerves savakat \u00e9s sz\u00e1rmaz\u00e9kaikat, aldehideket, ketonokat, \u00e9sztereket, nukleotidokat \u00e9s metabolitjaikat stb. bele\u00e9rtve, az anyagi alapot el\u0151zetesen megvil\u00e1g\u00edtott\u00e1k.<br \/>\nA korai szakaszban a kutat\u00f3csoport \u00f6sszehasonl\u00edtotta a hagyom\u00e1nyos mutat\u00f3kat, mint p\u00e9ld\u00e1ul a kalcium-karbon\u00e1t-tartalom, a f\u0151zet Ca2+-tartalma, a v\u00edzben old\u00f3d\u00f3 kivonat tartalma, a vizes kivonat pH-\u00e9rt\u00e9ke \u00e9s a hull\u00e1mos magvak \u00e9s kevert term\u00e9keik teljes aminosavtartalma, \u00e9s az eredm\u00e9nyek nem mutattak jelent\u0151s k\u00fcl\u00f6nbs\u00e9geket; a differenci\u00e1l h\u0151elemz\u00e9st, r\u00f6ntgendiffrakci\u00f3t \u00e9s r\u00f6ntgenfluoreszcenci\u00e1t haszn\u00e1lt\u00e1k a szisztematikus \u00f6sszehasonl\u00edt\u00f3 elemz\u00e9shez, \u00e9s az eredm\u00e9nyek tov\u00e1bbra sem mutattak jelent\u0151s k\u00fcl\u00f6nbs\u00e9geket. Ez a tanulm\u00e1ny elemezte a hiteles \u00e9s hamis\u00edtott term\u00e9keinek metabolikus \u00f6sszetev\u0151it, bele\u00e9rtve \u00f6sszesen 1083 metabolikus komponenst \u00e9s 167 differenci\u00e1lis metabolitot, ami azt jelzi, hogy az egyes mint\u00e1k szerves \u00f6sszetev\u0151i azonosak voltak, de voltak k\u00fcl\u00f6nbs\u00e9gek is. A PCA \u00e9s a klaszterez\u0151 h\u0151t\u00e9rk\u00e9pek azt mutatt\u00e1k, hogy a h\u00e1rom hiteles eredeti minta egy\u00fcttesen csoportos\u00edthat\u00f3, m\u00edg a hamis\u00edtott term\u00e9kek k\u00fcl\u00f6n-k\u00fcl\u00f6n csoportos\u00edthat\u00f3k, ami azt jelzi, hogy a sz\u00e9les c\u00e9l\u00fa metabolikus elemz\u00e9si m\u00f3dszer j\u00f3 referencia\u00e9rt\u00e9kkel rendelkezik a hiteles \u00e9s hamis\u00edtott kagyl\u00f3s hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat azonos\u00edt\u00e1s\u00e1ra.<br \/>\nEbben a k\u00eds\u00e9rletben 72 nukleotidot \u00e9s metabolitjaikat, k\u00f6zt\u00fck N6 izopentenil-adenozint, adenozint stb. mutattak ki. A nukleozid anyagok fontos szerepet j\u00e1tszanak az \u00e1llati gy\u00f3gyszerek hat\u00e9konys\u00e1g\u00e1ban. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a nukleozid komponensek olyan hat\u00e1sokkal rendelkeznek, mint a h\u00f6rg\u0151k simaizomzat\u00e1nak relax\u00e1l\u00e1sa, antihisztaminok, asztmaellenes, antibakteri\u00e1lis, v\u00e9rlemezke-aggreg\u00e1ci\u00f3 elleni, k\u00f6zponti idegrendszer nyugtat\u00f3 \u00e9s g\u00f6rcsold\u00f3 hat\u00e1s. K\u00f6z\u00fcl\u00fck az N6 izopentenil-adenozin egy potenci\u00e1lis \u00fajonnan megjelen\u0151 r\u00e1kellenes gy\u00f3gyszer. A kutat\u00e1sok kimutatt\u00e1k, hogy 10 \u03bc mol\/L N6 izopentenil-adenozinnal t\u00f6rt\u00e9n\u0151 kezel\u00e9s ut\u00e1n 8 hum\u00e1n epiteli\u00e1lis r\u00e1kos sejtvonalban a klonog\u00e9n aktivit\u00e1s teljesen g\u00e1tolt. Az adenozin k\u00e9pes g\u00e1tolni a gyomorr\u00e1k MGC-803 sejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s el\u0151seg\u00edteni az apopt\u00f3zist, m\u00edg az endoplazmatikus retikulum stressz szerepet j\u00e1tszhat az adenozin \u00e1ltal kiv\u00e1ltott apopt\u00f3zisban. A sejt\u00e9rv\u00e9nyes\u00edt\u00e9si k\u00eds\u00e9rletek azt mutatt\u00e1k, hogy az N6 izopentenil-adenozin el\u0151seg\u00edtheti a sejtek apopt\u00f3zis\u00e1t \u00e9s g\u00e1tolhatja a sejtprolifer\u00e1ci\u00f3t az\u00e1ltal, hogy blokkolja a sejtciklust az S \u00e9s G2 f\u00e1zisban. Az N6 izopentenil-adenozin pedig jelent\u0151sen felszab\u00e1lyozott az autentikus term\u00e9kben, ami v\u00e1rhat\u00f3an potenci\u00e1lis min\u0151s\u00e9gi markerk\u00e9nt szolg\u00e1lhat a val\u00f3di \u00e9s a hamis\u00edtott hull\u00e1mpap\u00edrterm\u00e9kek megk\u00fcl\u00f6nb\u00f6ztet\u00e9s\u00e9re. Jelezve, hogy a nukleozid anyagok fontos \u00f6sszetev\u0151i lehetnek a hull\u00e1mos magvak \"v\u00e1lad\u00e9kot eloszlat\u00f3 \u00e9s a v\u00e9r pang\u00e1s\u00e1t megsz\u00fcntet\u0151, a kem\u00e9nys\u00e9get l\u00e1gy\u00edt\u00f3 \u00e9s a csom\u00f3kat eloszlat\u00f3\" farmakol\u00f3giai anyagalapj\u00e1nak.<br \/>\nEbben a k\u00eds\u00e9rletben 237 aminosavat \u00e9s metabolitjaikat, k\u00f6zt\u00fck 134 kis peptidet, k\u00f6zt\u00fck 12 ciklikus dipeptidet (CDP) mutattak ki. A modern kutat\u00e1sok kimutatt\u00e1k, hogy a CDP-k univerz\u00e1lis biol\u00f3giai aktivit\u00e1ssal \u00e9s er\u0151s daganatellenes hat\u00e1ssal rendelkeznek, \u00e9s g\u00e1tolj\u00e1k a k\u00fcl\u00f6nb\u00f6z\u0151 r\u00e1kos sejtek n\u00f6veked\u00e9s\u00e9t. A sejtprolifer\u00e1ci\u00f3s k\u00eds\u00e9rletek azt mutatt\u00e1k, hogy a ciklikus tirozinnak nem volt jelent\u0151s g\u00e1tl\u00f3 hat\u00e1sa a TPC-1 sejtek prolifer\u00e1ci\u00f3j\u00e1ra, \u00e9s a j\u00f6v\u0151ben tov\u00e1bbi vizsg\u00e1latokat kell v\u00e9gezni.<br \/>\nA hiteles term\u00e9kekben 40 metabolit tal\u00e1lhat\u00f3, a hamis\u00edtott term\u00e9kekben azonban nem. Ezek k\u00f6z\u00fcl az \u00f6sztradiol-benzo\u00e1t g\u00e1tl\u00f3 hat\u00e1ssal van az eml\u0151r\u00e1k kialakul\u00e1s\u00e1ra, \u00e9s hat\u00e1smechanizmusa az ER \u03b1 \u00e9s Er \u03b2 \u00f6sztrog\u00e9nreceptor szab\u00e1lyoz\u00e1s\u00e1hoz kapcsol\u00f3dik. A HC toxin jelent\u0151s prolifer\u00e1ci\u00f3ellenes hat\u00e1ssal van a hum\u00e1n eml\u0151r\u00e1k T47D sejtekre. A farnezil tioszalicilsav egy RAS \u00e9s eml\u0151s rapamicin c\u00e9lfeh\u00e9rje (mTOR) inhibitor, amely k\u00e9pes g\u00e1tolni a tumorsejtek n\u00f6veked\u00e9s\u00e9t \u00e9s prolifer\u00e1ci\u00f3j\u00e1t. Ez a h\u00e1rom anyag v\u00e1rhat\u00f3an a hull\u00e1mos\u00edtott anyagok potenci\u00e1lis min\u0151s\u00e9gjelz\u0151jek\u00e9nt szolg\u00e1lhat.<br \/>\nA hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat gyenge kutat\u00e1si alapjai, valamint a referenciaanyagok \u00e9s adatb\u00e1zisok hi\u00e1nya miatt a kagyl\u00f3k hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat\u00e1nak min\u0151s\u00e9gi elemz\u00e9se neh\u00e9zkes. A differenci\u00e1lis metabolitelemz\u00e9s sor\u00e1n meg\u00e1llap\u00edtott\u00e1k, hogy egyes metabolitok, mint p\u00e9ld\u00e1ul a ginkgolid \u00e9s az ox\u00e1lsav, f\u0151k\u00e9nt a n\u00f6v\u00e9nyekben fordulnak el\u0151. Tov\u00e1bbi vizsg\u00e1latokra van sz\u00fcks\u00e9g a val\u00f3di forr\u00e1saik meghat\u00e1roz\u00e1s\u00e1hoz. Ezt k\u00f6vet\u0151en a kimutatott komponenseket referenciastandardokkal kell meger\u0151s\u00edteni a min\u0151s\u00e9gi pontoss\u00e1g jav\u00edt\u00e1sa \u00e9rdek\u00e9ben.<\/p>","protected":false},"excerpt":{"rendered":"<p>Differential analysis of chemical composition and cell experiment verification of corrugated seeds and their counterfeit products based on metabolomics Corrugated clams are shells of the Arca subcrinata Lischke, Arca granosa Linnaeus, or Arca inflata Reeve, which belong to the family of clams. They are commonly used traditional Chinese medicine for marine shellfish and have the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Differential analysis of chemical composition and cell experiment verification of corrugated seeds and their counterfeit products based on metabolomics - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/corrugated-seeds\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Differential analysis of chemical composition and cell experiment verification of corrugated seeds and their counterfeit products based on metabolomics - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Differential analysis of chemical composition and cell experiment verification of corrugated seeds and their counterfeit products based on metabolomics Corrugated clams are shells of the Arca subcrinata Lischke, Arca granosa Linnaeus, or Arca inflata Reeve, which belong to the family of clams. 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