{"id":6743,"date":"2024-08-06T14:22:06","date_gmt":"2024-08-06T14:22:06","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6743"},"modified":"2024-08-06T14:22:06","modified_gmt":"2024-08-06T14:22:06","slug":"chisandra-chinensis-goji-berry","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/chisandra-chinensis-goji-berry\/","title":{"rendered":"GEO chip elemz\u00e9s kombin\u00e1lva a h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1val a Schisandra chinensis Goji bogy\u00f3 sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s elleni v\u00e9delem mechanizmus\u00e1nak felt\u00e1r\u00e1s\u00e1ra"},"content":{"rendered":"

GEO chip elemz\u00e9s kombin\u00e1lva a h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1val a Schisandra chinensis Goji bogy\u00f3 sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s elleni v\u00e9delem mechanizmus\u00e1nak felt\u00e1r\u00e1s\u00e1ra
\nA sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s (RILI) a sug\u00e1rter\u00e1pia vagy nukle\u00e1ris sziv\u00e1rg\u00e1s \u00e1ltal okozott m\u00e1jk\u00e1rosod\u00e1s egy t\u00edpusa, amely a m\u00e1jfunkci\u00f3 cs\u00f6kken\u00e9s\u00e9t, a m\u00e1jenzimek emelked\u00e9s\u00e9t \u00e9s a m\u00e1j egy\u00e9b k\u00e1rosod\u00e1s\u00e1t eredm\u00e9nyezi egy bizonyos mennyis\u00e9g\u0171 sug\u00e1rz\u00e1snak val\u00f3 kitetts\u00e9g ut\u00e1n. F\u00e9nymikroszk\u00f3pos vizsg\u00e1lat sor\u00e1n a m\u00e1jsz\u00f6vet korai patol\u00f3giai megnyilv\u00e1nul\u00e1sai k\u00f6z\u00e9 tartozik els\u0151sorban a m\u00e1jlebenyek k\u00f6zponti r\u00e9gi\u00f3j\u00e1nak pang\u00e1sa, a m\u00e1jsejtek \u00f6d\u00e9m\u00e1ja \u00e9s a gyullad\u00e1sos reakci\u00f3k. K\u00e9s\u0151i st\u00e1diumban fokozatosan m\u00e1jfibr\u00f3zis \u00e9s m\u00e1jzsugorod\u00e1s alakul ki, amelyek visszaford\u00edthatatlanok. A f\u0151 patogenezis mag\u00e1ban foglalja a mikrovaszkul\u00e1ris \u00e9s k\u00f6t\u0151sz\u00f6veti k\u00e1rosod\u00e1st, a t\u00falzott szabad gy\u00f6k\u00f6ket, a t\u00falzott autoimmun v\u00e1laszt \u00e9s a citokinek hat\u00e1s\u00e1t.<\/p>\n

A Schisandra Chinensis Fructus (SCF) a Schisandra chinensisre utal, amely meleg term\u00e9szet\u0171, \u00e9s j\u00f3 m\u00e1jv\u00e9d\u0151 hat\u00e1s\u00fanak bizonyult. Hat\u00e1smechanizmusa els\u0151sorban antioxid\u00e1ns \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 m\u00f3dszereken kereszt\u00fcl \u00e9rv\u00e9nyes\u00fcl. A Lycium barbarum (LF) semleges term\u00e9szet\u0171 \u00e9s farmakol\u00f3giai hat\u00e1sai bizony\u00edtottan t\u00e1pl\u00e1lj\u00e1k a m\u00e1jat \u00e9s a ves\u00e9ket. A kett\u0151 kombin\u00e1ci\u00f3ja hat\u00e9konyan v\u00e9d a m\u00e1jk\u00e1rosod\u00e1s ellen. Ez a cikk a GEO chipelemz\u00e9st, a h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t \u00e9s a molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1t haszn\u00e1lja a Goji bogy\u00f3kkal kombin\u00e1lt Schisandra chinensis potenci\u00e1lis hat\u00f3anyagainak, c\u00e9lpontjainak \u00e9s hat\u00e1smechanizmusainak el\u0151rejelz\u00e9s\u00e9re a RILI v\u00e9delm\u00e9ben, referenci\u00e1t ny\u00fajtva a tov\u00e1bbi m\u00e9lyrehat\u00f3 kutat\u00e1shoz \u00e9s klinikai alkalmaz\u00e1sokhoz.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"A sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s a m\u00e1j bizonyos d\u00f3zis\u00fa sug\u00e1rter\u00e1pia vagy nukle\u00e1ris sziv\u00e1rg\u00e1s sor\u00e1n a r\u00e1kos betegekn\u00e9l bek\u00f6vetkez\u0151 sug\u00e1rter\u00e1pia vagy nukle\u00e1ris sziv\u00e1rg\u00e1s sor\u00e1n a m\u00e1jat \u00e9r\u0151 sug\u00e1rterhel\u00e9sre utal. A korai megnyilv\u00e1nul\u00e1sok k\u00f6z\u00e9 tartozik a m\u00e1jsejtek \u00f6d\u00e9m\u00e1ja a m\u00e1j k\u00f6zponti lebenyeiben, amelyet perif\u00e9ri\u00e1s gyullad\u00e1sos reakci\u00f3k k\u00eds\u00e9rnek \u00e9s a m\u00e1jfunkci\u00f3t befoly\u00e1solj\u00e1k. K\u00e9s\u0151bb hajlamos m\u00e1jfibr\u00f3zis vagy m\u00e1jzsugor kialakul\u00e1s\u00e1ra. Az ut\u00f3bbi \u00e9vekben egyre t\u00f6bb kutat\u00e1s foglalkozik a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat m\u00e1jk\u00e1rosod\u00e1s elleni sug\u00e1rv\u00e9delemmel. A hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban nagy lehet\u0151s\u00e9gek rejlenek biztons\u00e1goss\u00e1ga, sz\u00e1jon \u00e1t t\u00f6rt\u00e9n\u0151 bead\u00e1s\u00e1nak k\u00e9nyelme, gyors felsz\u00edv\u00f3d\u00e1sa \u00e9s alacsony k\u00f6lts\u00e9ge miatt.
\nA Schisandra chinensis kiv\u00e1l\u00f3 m\u00e1jv\u00e9d\u0151 hat\u00e1ssal rendelkezik. A kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy a Schisandra t\u00f6bb mint 200 k\u00e9miai \u00f6sszetev\u0151t tartalmaz, f\u0151k\u00e9nt ill\u00e9kony terp\u00e9neket, lign\u00e1nokat, szerves savakat \u00e9s poliszacharidokat, amelyek gyullad\u00e1scs\u00f6kkent\u0151, antioxid\u00e1ns, immuner\u0151s\u00edt\u0151 \u00e9s anyagcsere-szab\u00e1lyoz\u00f3 tulajdons\u00e1gokkal rendelkeznek. Wang kutat\u00e1sai szerint a nyers Schisandra chinensis jav\u00edtotta az akut alkoholos zs\u00edrm\u00e1j kezel\u00e9s\u00e9t \u00e9s megel\u0151z\u00e9s\u00e9t a gyullad\u00e1sos faktorok cs\u00f6kkent\u00e9se, a zs\u00edrfelhalmoz\u00f3d\u00e1s cs\u00f6kkent\u00e9se, a CYP2E1 expresszi\u00f3j\u00e1nak cs\u00f6kkent\u00e9se \u00e9s az Nrf2\/ARE jel\u00e1tviteli \u00fatvonalak fokoz\u00e1sa r\u00e9v\u00e9n a m\u00e1jk\u00e1rosod\u00e1s elleni v\u00e9delem \u00e9rdek\u00e9ben. Zhu in vitro kutat\u00e1sai azt tal\u00e1lt\u00e1k, hogy a Schisandra poliszacharidok hat\u00e9konyan k\u00e9pesek a hidroxilgy\u00f6k\u00f6k, az 1,1-difenil-2-trinitrofenilhidrazin \u00e9s a szuperoxid-ionok elsz\u00edv\u00e1s\u00e1ra; In vivo k\u00eds\u00e9rletek azt tal\u00e1lt\u00e1k, hogy a Schisandra poliszacharidok enyh\u00edthetik a CCL4 \u00e1ltal kiv\u00e1ltott hepatocita h\u00f3lyagos degener\u00e1ci\u00f3 \u00e9s gyullad\u00e1sos v\u00e1lasz \u00e1ltal okozott m\u00e1jk\u00e1rosod\u00e1st. Yang kutat\u00e1sai szerint a Schisandra lign\u00e1nok v\u00e9d\u0151hat\u00e1st fejtenek ki az acetaminofen \u00e1ltal okozott m\u00e1jk\u00e1rosod\u00e1ssal szemben, els\u0151sorban az EGFR \u00e9s az LPCAT1 kapcsol\u00f3d\u00f3 feh\u00e9rj\u00e9k expresszi\u00f3j\u00e1nak szab\u00e1lyoz\u00e1s\u00e1val az ERBB jel\u00e1tviteli \u00fatvonalban, gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s antioxid\u00e1ns hat\u00e1st fejtve ki. Chen \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a Schisandra chinensis lign\u00e1nok cs\u00f6kkenthetik az AST \u00e9s ALT aktivit\u00e1s\u00e1t a sz\u00e9rumban, cs\u00f6kkenthetik a gyullad\u00e1sos faktorokat, mint p\u00e9ld\u00e1ul az IL-6 \u00e9s IL1 \u03b2, \u00e9s er\u0151s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1st fejtenek ki, ez\u00e1ltal v\u00e9delmet ny\u00fajtanak a m\u00e1jk\u00e1rosod\u00e1s ellen. Chen \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a Schisandra chinensisb\u0151l sz\u00e1rmaz\u00f3 poliszacharidok cs\u00f6kkenthetik a Bcl-2\/Bax ar\u00e1nyt \u00e9s a CASP3 aktiv\u00e1l\u00f3d\u00e1s\u00e1t, ez\u00e1ltal cs\u00f6kkentve a m\u00e1jsejtek apopt\u00f3zis\u00e1t.
\nA Goji bogy\u00f3 t\u00e1pl\u00e1lja a l\u00e9nyeget, jav\u00edtja a l\u00e1t\u00e1st, t\u00e1pl\u00e1lja a m\u00e1jat \u00e9s a ves\u00e9t stb. Gazdag poliszacharidokban, ill\u00f3olajokban, alkaloidokban, flavonoidokban \u00e9s egy\u00e9b \u00f6sszetev\u0151kben. A modern farmakol\u00f3giai kutat\u00e1sok kimutatt\u00e1k, hogy jav\u00edtja az immunit\u00e1st, antioxid\u00e1ns, m\u00e1jv\u00e9d\u0151 \u00e9s v\u00e9di a retin\u00e1t. Tian kutat\u00e1sai szerint a Lycium barbarum poliszacharidok k\u00e9pesek megakad\u00e1lyozni a feh\u00e9rje-tiolok redukci\u00f3j\u00e1t \u00e9s a SOD inaktiv\u00e1l\u00e1s\u00e1t, \u00e9s j\u00f3 antioxid\u00e1ns hat\u00e1ssal vannak az eg\u00e9rm\u00e1j mitokondri\u00e1lis sejtjeinek gamma-sug\u00e1rz\u00e1s \u00e1ltal gener\u00e1lt szabad gy\u00f6k\u00f6k \u00e1ltal okozott membr\u00e1nk\u00e1rosod\u00e1s\u00e1ra. A goji bogy\u00f3k \u00e9s a schisandra kombin\u00e1ci\u00f3ja jav\u00edtja a m\u00e1jv\u00e9delem hat\u00e9konys\u00e1g\u00e1t. Zhang kutat\u00e1sai szerint a Lycium barbarum poliszacharidok v\u00e9d\u0151 hat\u00e1st fejtenek ki a sug\u00e1rz\u00e1s \u00e1ltal kiv\u00e1ltott v\u00e9konyb\u00e9lk\u00e1rosod\u00e1sra, cs\u00f6kkentik az oxidat\u00edv reakci\u00f3kat \u00e9s n\u00f6velik a Bcl-2\/Bax ar\u00e1nyt, \u00edgy g\u00e1tolj\u00e1k a sejtek apopt\u00f3zis\u00e1t. Gao \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a goji bogy\u00f3 polifenolok m\u00e1jk\u00e1rosod\u00e1sban szenved\u0151 patk\u00e1nyoknak t\u00f6rt\u00e9n\u0151 adagol\u00e1sa fokozhatja az oxidat\u00edv funkci\u00f3t, \u00e9s a mechanizmus szerepet j\u00e1tszhat a m\u00e1jk\u00e1rosod\u00e1s cs\u00f6kkent\u00e9s\u00e9ben az Nrf2 \u00e9s a downstream feh\u00e9rj\u00e9k expresszi\u00f3j\u00e1nak n\u00f6vel\u00e9s\u00e9vel.
\nA PPI-h\u00e1l\u00f3zati elemz\u00e9s sor\u00e1n azonos\u00edtott k\u00f6zponti feh\u00e9rj\u00e9k k\u00f6z\u00e9 tartozik a CASP3, az EGFR \u00e9s az ESR1. A kaszp\u00e1zok (CASP) d\u00f6nt\u0151 szerepet j\u00e1tszanak a sejtek apopt\u00f3zis\u00e1nak szab\u00e1lyoz\u00e1s\u00e1ban, \u00e9s proapoptotikus jelekre v\u00e1laszul kaszk\u00e1dreakci\u00f3kat ind\u00edtanak el. A CASP3 a CASP egyik f\u0151 v\u00e9grehajt\u00f3 feh\u00e9rj\u00e9je, \u00e9s az apopt\u00f3zis minden sejtben bek\u00f6vetkezik. Fizikai, k\u00e9miai \u00e9s egy\u00e9b molekul\u00e1ris mechanizmusokon kereszt\u00fcl k\u00e9pes szab\u00e1lyozni a sejtn\u00f6veked\u00e9s \u00e9s a sejthal\u00e1l dinamikus egyens\u00faly\u00e1t. Cao \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a Schisandrin B g\u00e1tl\u00f3 hat\u00e1ssal van a sug\u00e1rz\u00e1s \u00e1ltal kiv\u00e1ltott apopt\u00f3zisra a Hacat sejtekben, \u00e9s mechanizmusa v\u00e9d\u0151 hat\u00e1st fejt ki az apoptotikus g\u00e9nek, p\u00e9ld\u00e1ul a CASP3, a P53 \u00e9s a P21 expresszi\u00f3j\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel. Duan kutat\u00e1sai szerint a goji bogy\u00f3 v\u00edz antioxid\u00e1ns hat\u00e1ssal van a besug\u00e1rzott egerekre, \u00e9s v\u00e9d\u0151hat\u00e1st fejt ki a CASP3 \u00e9s CASP6 expresszi\u00f3j\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel. A CASP3 r\u00e9szt vesz a sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s apopt\u00f3zis folyamat\u00e1ban, a CASP3 feh\u00e9rje szab\u00e1lyoz\u00e1s\u00e1val a Schisandra chinensis Goji bogy\u00f3ban l\u00e9v\u0151 akt\u00edv \u00f6sszetev\u0151k r\u00e9v\u00e9n, ez\u00e1ltal g\u00e1tolja a sejtek apopt\u00f3zis\u00e1t \u00e9s fenntartja a n\u00f6veked\u00e9s \u00e9s a hal\u00e1l k\u00f6z\u00f6tti dinamikus egyens\u00falyt. Az epiderm\u00e1lis n\u00f6veked\u00e9si faktor receptor (EGFR) az epiderm\u00e1lis n\u00f6veked\u00e9si faktor receptor csal\u00e1d tagja, sz\u00e9les k\u00f6rben elterjedt a h\u00e1msejtek, fibroblasztok \u00e9s gliasejtek felsz\u00edn\u00e9n, \u00e9s fontos szerepet j\u00e1tszik a sejtek n\u00f6veked\u00e9s\u00e9ben, prolifer\u00e1ci\u00f3j\u00e1ban \u00e9s differenci\u00e1l\u00f3d\u00e1s\u00e1ban. Li \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a Schisandrin A k\u00e9pes g\u00e1tolni a m\u00e1jsejtek apopt\u00f3zis\u00e1t \u00e9s el\u0151seg\u00edteni a m\u00e1jsejtek regener\u00e1ci\u00f3j\u00e1t a m\u00e1j reszekci\u00f3s m\u0171t\u00e9tet k\u00f6vet\u0151en az EGFR g\u00e9nexpresszi\u00f3j\u00e1nak n\u00f6vel\u00e9s\u00e9vel \u00e9s a P53 \u00e9s P21 apopt\u00f3zis g\u00e9nek expresszi\u00f3j\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel. Zhang kutat\u00e1sai szerint a Lycium barbarum poliszacharidok k\u00e9pesek szab\u00e1lyozni az EGFR expresszi\u00f3j\u00e1t \u00e9s a foszforil\u00e1lt feh\u00e9rje szintj\u00e9t, hogy jav\u00edts\u00e1k az oxidat\u00edv stressz \u00e1ltal okozott endot\u00e9lfunkci\u00f3s k\u00e1rosod\u00e1st, \u00e9s a hat\u00e1smechanizmusa a PI3K Akt jel\u00e1tviteli \u00fatvonalon kereszt\u00fcl t\u00f6rt\u00e9nhet. A Schisandra chinensis goji bogy\u00f3 hat\u00f3anyagai az EGFR-re hatva szab\u00e1lyozhatj\u00e1k az apopt\u00f3zis okozta sejtek sz\u00e1m\u00e1nak kiegyens\u00falyozatlans\u00e1g\u00e1t, \u00edgy a szervezetet a norm\u00e1lis fiziol\u00f3gi\u00e1s szint fel\u00e9 vezethetik. Az \u00f6sztrog\u00e9nreceptor 1 (ER1) a sejtmagban tal\u00e1lhat\u00f3, \u00e9s a hormonk\u00f6t\u00e9s, a DNS-k\u00f6t\u00e9s \u00e9s a transzkripci\u00f3s aktiv\u00e1l\u00e1s szempontj\u00e1b\u00f3l fontos szerkezeti dom\u00e9nekb\u0151l \u00e1ll. Zeng tanulm\u00e1nya meg\u00e1llap\u00edtotta, hogy a goji bogy\u00f3 vizes kivonata k\u00e9pes szab\u00e1lyozni a PC12 sejtek mRNS-expresszi\u00f3j\u00e1t, nemcsak az ESR1 felszab\u00e1lyoz\u00e1s\u00e1t, hanem a CASP3 expresszi\u00f3j\u00e1nak visszaszab\u00e1lyoz\u00e1s\u00e1t is, ami bizonyos referenci\u00e1t ny\u00fajt a goji bogy\u00f3 c\u00e9lpontjaira. Liu \u00e9s munkat\u00e1rsai kimutatt\u00e1k, hogy az ESR1 a NEDD4L\/CD71 jel\u00e1tviteli \u00fatvonalon kereszt\u00fcl g\u00e1tolhatja az ioniz\u00e1l\u00f3 sug\u00e1rz\u00e1s \u00e1ltal kiv\u00e1ltott vashal\u00e1lt az eml\u0151r\u00e1ksejtekben. Ha az ESR1 t\u00falterjed, jav\u00edthatja az eml\u0151r\u00e1kos betegek t\u00fal\u00e9l\u00e9si ar\u00e1ny\u00e1t. Az ESR1 ki\u00fct\u00e9se ut\u00e1n fokozza az ioniz\u00e1l\u00f3 sug\u00e1rz\u00e1s \u00e1ltal k\u00f6zvet\u00edtett vashi\u00e1nyt. Az ESR1 potenci\u00e1lis c\u00e9lpont lehet a RILI v\u00e9delm\u00e9ben.
\nEz a tanulm\u00e1ny megj\u00f3solta a Schisandra chinensis Goji bogy\u00f3 mechanizmus\u00e1t a RILI v\u00e9delm\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1n kereszt\u00fcl, \u00e9s a hat\u00f3anyag kulcsfontoss\u00e1g\u00fa feh\u00e9rje c\u00e9lpontjainak h\u00e1l\u00f3zati diagramj\u00e1t \u00e9p\u00edtette. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a kvercetin, a genistein \u00e9s a dezoxipurpurin csom\u00f3pontfok \u00e9rt\u00e9kei viszonylag magasak voltak, ami arra utal, hogy ezek a hat\u00f3anyagok fontos szerepet j\u00e1tszanak a RILI v\u00e9delm\u00e9ben. A 66 potenci\u00e1lis feh\u00e9rjec\u00e9lpont GO-funkci\u00f3 d\u00fas\u00edt\u00e1s\u00e1n \u00e9s KEGG-\u00fatvonal elemz\u00e9s\u00e9n kereszt\u00fcl felt\u00e9telezhet\u0151, hogy a Schisandra chinensis Wolfberry akt\u00edv \u00f6sszetev\u0151i szerepet j\u00e1tszhatnak a RILI v\u00e9delm\u00e9ben a k\u00e9miai karcinogenezis receptoraktiv\u00e1ci\u00f3, a lipid- \u00e9s art\u00e9ri\u00e1s \u00e9relmeszesed\u00e9s, a PI3K-Akt, a MAPK, az apopt\u00f3zis \u00e9s m\u00e1s jel\u00e1tviteli utak szab\u00e1lyoz\u00e1s\u00e1val. Ez a cikk integr\u00e1lja \u00e9s el\u0151rejelzi az adatokat. A korl\u00e1tozott mintam\u00e9ret miatt a kutat\u00e1s folyamatos elm\u00e9ly\u00edt\u00e9s\u00e9vel \u00fagy gondoljuk, hogy a predikt\u00edv elemz\u00e9s kiterjedtebb \u00e9s pontosabb eredm\u00e9nyeket fog hozni.
\nA GEO chipelemz\u00e9s, a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a molekul\u00e1ris dokkol\u00e1si technol\u00f3gia seg\u00edts\u00e9g\u00e9vel \u00e1tfog\u00f3 \u00e9s t\u00f6bbdimenzi\u00f3s vizsg\u00e1latot v\u00e9geztek a Schisandra chinensis Goji bogy\u00f3r\u00f3l, \u00e9s el\u0151zetesen megj\u00f3solt\u00e1k a Schisandra chinensis Goji bogy\u00f3 sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s elleni v\u00e9delmet biztos\u00edt\u00f3 mechanizmus\u00e1t. A schisandra chinensis farkasbogy\u00f3 hat\u00e9kony anyagalapja a sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s elleni v\u00e9delemre, amelyet a hat\u00f3anyag g\u00e9n c\u00e9lzott sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s h\u00e1l\u00f3zata el\u0151re jelzett, lehet a kvercetin, a daidzein \u00e9s a dezoxiszikonin, amelyek a k\u00e9miai karcinogenezis receptoraktiv\u00e1ci\u00f3, a lipidek \u00e9s az art\u00e9ri\u00e1s \u00e9relmeszesed\u00e9s szab\u00e1lyoz\u00e1s\u00e1val szerepet j\u00e1tszanak a sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s v\u00e9delm\u00e9ben, PI3K-Akt, MAPK, apopt\u00f3zis \u00e9s m\u00e1s jel\u00e1tviteli utak a CASP3, EFGR, ESR1 kulcsfontoss\u00e1g\u00fa c\u00e9lpontokon kereszt\u00fcl, ami azt jelzi, hogy a schisandra chinensis wolfberry szerepet j\u00e1tszik a sug\u00e1rz\u00e1s okozta m\u00e1jk\u00e1rosod\u00e1s v\u00e9delm\u00e9ben a \"t\u00f6bbkomponens\u0171\", \"t\u00f6bb c\u00e9lpont\" \u00e9s \"t\u00f6bb \u00fatvonal\" r\u00e9v\u00e9n, ami bizonyos referenciaalapot biztos\u00edthat a hat\u00e1smechanizmus \u00e9s a klinikai alkalmaz\u00e1s k\u00e9s\u0151bbi kutat\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"

GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury Radiation induced liver injury (RILI) is a type of liver damage caused by radiation therapy or nuclear leakage, which results in a decrease in liver function, an increase in liver enzymes, and other […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nGEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/chisandra-chinensis-goji-berry\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury - 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