{"id":6713,"date":"2024-08-06T14:11:51","date_gmt":"2024-08-06T14:11:51","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6713"},"modified":"2024-08-06T14:11:51","modified_gmt":"2024-08-06T14:11:51","slug":"ergothionein","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/ergothionein\/","title":{"rendered":"Az ergotionein antioxid\u00e1ns tulajdons\u00e1gainak \u00e9s az oxidat\u00edv stresszel \u00f6sszef\u00fcgg\u0151 betegs\u00e9gekbe val\u00f3 beavatkoz\u00e1s\u00e1nak kutat\u00e1si eredm\u00e9nyei"},"content":{"rendered":"<p>Az ergotioneinr\u0151l el\u0151sz\u00f6r 1909-ben sz\u00e1moltak be, amikor Tanret \u00e9s munkat\u00e1rsai a rozsszemeket puszt\u00edt\u00f3 anyarozsgomb\u00e1t tanulm\u00e1nyozva izol\u00e1ltak egy egyed\u00fcl\u00e1ll\u00f3 k\u00e9ntartalm\u00fa krist\u00e1lyos vegy\u00fcletet, a 2-merkapto-L-hisztidin-trimetilb\u00e9t\u00e1t. A vegy\u00fcletet ergotionein (ERG) n\u00e9vvel illett\u00e9k. Az ERG f\u0151k\u00e9nt egyes gomb\u00e1kban \u00e9s bakt\u00e9riumokban tal\u00e1lhat\u00f3 meg, \u00e9s az \u00e1llatok nem k\u00e9pesek maguk szintetiz\u00e1lni az ERG-t, ez\u00e9rt f\u0151k\u00e9nt t\u00e1pl\u00e1l\u00e9kforr\u00e1sokra t\u00e1maszkodnak. A kutat\u00e1sok meg\u00e1llap\u00edtott\u00e1k, hogy az ERG jelen van az eml\u0151s\u00f6k sz\u00f6veteiben \u00e9s szerveiben, p\u00e9ld\u00e1ul a szemgoly\u00f3ban, a sperm\u00e1ban \u00e9s a v\u00f6r\u00f6sv\u00e9rtestekben, a v\u00f6r\u00f6sv\u00e9rtestekben az ERG-tartalom k\u00f6r\u00fclbel\u00fcl 1-2 mmol\/l. A kutat\u00f3k \u00f6sszehasonl\u00edtott\u00e1k az ERG metabolikus eloszl\u00e1s\u00e1t nyulakban, kuty\u00e1kban \u00e9s macsk\u00e1kban, \u00e9s meg\u00e1llap\u00edtott\u00e1k, hogy az ERG f\u0151k\u00e9nt a m\u00e1jban, a v\u00f6r\u00f6sv\u00e9rtestekben \u00e9s a ves\u00e9kben oszlik el. Az ERG-t tartalmaz\u00f3 \u00e9lelmiszerek, mint p\u00e9ld\u00e1ul a boletus edulis, a sz\u0151r\u00f6s fej\u0171 \u00f6rd\u00f6gerny\u0151 \u00e9s a shiitake gomba fogyaszt\u00e1sa ut\u00e1n az ERG szintj\u00e9nek n\u00f6veked\u00e9se kimutathat\u00f3 a v\u00f6r\u00f6sv\u00e9rtestekben, az agyban, a m\u00e1jban, a ves\u00e9ben \u00e9s a szem sz\u00f6vet\u00e9ben.<\/p>\n<p>2005-ben egy tanulm\u00e1ny meg\u00e1llap\u00edtotta, hogy a rekombin\u00e1ns szerves kationtranszporter 1 (OCTN1) az ERG f\u0151 transzportere, amelynek transzporthat\u00e9konys\u00e1ga n\u00e9gyszer nagyobb, mint a matrin\u00e9, \u00e9s sz\u00e1zszor nagyobb, mint a karnitin\u00e9. OCTN1 knockout modell\u00e1llatokban az ERG hi\u00e1nyzik a sejtekb\u0151l \u00e9s a sz\u00f6vetekb\u0151l. A t\u00e1pl\u00e1l\u00e9kb\u00f3l sz\u00e1rmaz\u00f3 ERG in vivo felhalmoz\u00f3d\u00e1sa az OCTN1 jelenl\u00e9t\u00e9t\u0151l f\u00fcgg. Az ERG sz\u00f6vetekben val\u00f3 eloszl\u00e1s\u00e1nak k\u00fcl\u00f6nbs\u00e9ge az OCTN1 feh\u00e9rje expresszi\u00f3j\u00e1nak k\u00fcl\u00f6nbs\u00e9g\u00e9vel f\u00fcgg \u00f6ssze. Az ERG in vivo szintje szorosan \u00f6sszef\u00fcgg a hepatointestinalis betegs\u00e9gekkel, a neurodegenerat\u00edv betegs\u00e9gekkel, a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gekkel, a cukorbetegs\u00e9ggel \u00e9s a vesebetegs\u00e9gekkel. Ez a cikk \u00f6sszefoglalja az ERG fizikai-k\u00e9miai tulajdons\u00e1gait, antioxid\u00e1ns tulajdons\u00e1gait, valamint az oxidat\u00edv stresszel kapcsolatos betegs\u00e9gekre gyakorolt beavatkoz\u00e1si hat\u00e1sait \u00e9s mechanizmusait, hivatkoz\u00e1si alapot ny\u00fajtva az ergotamin v\u00e1ltozatos alkalmaz\u00e1s\u00e1hoz.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6714\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-249.png\" alt=\"\" width=\"359\" height=\"144\" \/>Az ERG, mint term\u00e9szetes antioxid\u00e1ns, m\u00e1s antioxid\u00e1nsokkal szemben bizonyos el\u0151ny\u00f6kkel rendelkezik, \u00e9s antioxid\u00e1ns funkci\u00f3ja miatt nagy ter\u00e1pi\u00e1s vagy megel\u0151z\u0151 potenci\u00e1llal rendelkezik sz\u00e1mos oxidat\u00edv stressz okozta betegs\u00e9g eset\u00e9ben. Sz\u00e1mos megoldatlan k\u00e9rd\u00e9s azonban korl\u00e1tozhatja az ERG tov\u00e1bbi alkalmaz\u00e1s\u00e1t. Jelenleg m\u00e9g mindig korl\u00e1tozott kutat\u00e1sok folynak az ERG betegs\u00e9gmegel\u0151z\u00e9sben \u00e9s -kezel\u00e9sben val\u00f3 felhaszn\u00e1l\u00e1s\u00e1r\u00f3l, \u00e9s nincs \u00e9rdemi tanulm\u00e1ny az ERG kezel\u00e9s d\u00f3zisa \u00e9s a betegs\u00e9g k\u00f6z\u00f6tti \u00f6sszef\u00fcgg\u00e9sr\u0151l; Nincs \u00e9rdemi kutat\u00e1s az \u00e9trendi gombakieg\u00e9sz\u00edt\u00e9s \u00e9s a fogyaszt\u00e1s k\u00f6z\u00f6tti \u00f6sszef\u00fcgg\u00e9sr\u0151l; Az ERG ehet\u0151 gomb\u00e1kkal val\u00f3 kieg\u00e9sz\u00edt\u00e9s\u00e9nek vizsg\u00e1lata sor\u00e1n a betegs\u00e9gek megel\u0151z\u00e9se \u00e9rdek\u00e9ben, b\u00e1r kimutatt\u00e1k, hogy ez a m\u00f3dszer bizonyos antioxid\u00e1ns \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1ssal rendelkezik, a gomb\u00e1k \u00f6sszetett \u00f6sszet\u00e9tele miatt neh\u00e9z c\u00e9lzottan meghat\u00e1rozni \u00e9s meghat\u00e1rozni a hat\u00e1sukat kifejt\u0151 anyagokat, \u00e9s csak nyomokban lehet ERG-t nyerni a gomb\u00e1k fogyaszt\u00e1s\u00e1val. Ez\u00e9rt az ERG szerepe az orvostudom\u00e1nyban \u00e9s a klinikai gyakorlatban tov\u00e1bbi felt\u00e1r\u00e1st ig\u00e9nyel. A betegs\u00e9gek megel\u0151z\u00e9s\u00e9nek kutat\u00e1s\u00e1ban, b\u00e1r kimutatt\u00e1k, hogy ez a m\u00f3dszer bizonyos antioxid\u00e1ns \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1ssal rendelkezik, a gomb\u00e1k \u00f6sszetett \u00f6sszet\u00e9tele miatt neh\u00e9z megc\u00e9lozni \u00e9s meghat\u00e1rozni a szerepet j\u00e1tsz\u00f3 anyagokat, \u00e9s csak nyomokban lehet ERG-t nyerni a gomba elfogyaszt\u00e1s\u00e1val. Ez\u00e9rt az ERG szerepe az orvostudom\u00e1nyban \u00e9s a klinikai gyakorlatban tov\u00e1bbi felt\u00e1r\u00e1st ig\u00e9nyel.<br \/>\nAz ERG nagy lehet\u0151s\u00e9geket rejt mag\u00e1ban az olyan ipar\u00e1gakban is, mint az \u00e9lelmiszeripar \u00e9s a kozmetika. A leg\u00fajabb tanulm\u00e1nyok kimutatt\u00e1k, hogy az ERG hossz\u00fa \u00e9lettartam\u00fa \u00e9lelmiszerk\u00e9nt felhaszn\u00e1lhat\u00f3 az \u00f6reged\u00e9s okozta k\u00e1rosod\u00e1sok egy r\u00e9sz\u00e9nek v\u00e9delm\u00e9re vagy jav\u00edt\u00e1s\u00e1ra, az UV \u00e1ltal kiv\u00e1ltott foto\u00f6reged\u00e9si k\u00e1rosod\u00e1sok \u00e9s az emberi b\u0151r melaninlerak\u00f3d\u00e1s\u00e1nak megel\u0151z\u00e9s\u00e9re, \u00e9s ez\u00e1ltal az \u00e9letmin\u0151s\u00e9g jav\u00edt\u00e1s\u00e1ra.<br \/>\nAz ERG mesters\u00e9ges szint\u00e9zise egy m\u00e1sik ter\u00fclet, amelyre \u00e9rdemes odafigyelni. Az ERG korai kivon\u00e1sa az ehet\u0151 gomb\u00e1k term\u0151test\u00e9b\u0151l magas k\u00f6lts\u00e9gekkel \u00e9s alacsony hozammal j\u00e1rt, ami alkalmatlann\u00e1 tette az ipari alkalmaz\u00e1sra. A k\u00e9miai extrakci\u00f3s m\u00f3dszerekkel \u00f6sszehasonl\u00edtva a jelenlegi, foly\u00e9kony ferment\u00e1ci\u00f3s bioszint\u00e9zis ehet\u0151 gomb\u00e1kb\u00f3l t\u00f6rt\u00e9n\u0151 el\u0151\u00e1ll\u00edt\u00e1s\u00e1nak el\u0151nye az alacsony k\u00f6lts\u00e9g, a nagy hozam \u00e9s a k\u00f6nny\u0171 m\u00e9retar\u00e1nyos termel\u00e9s, ami az ERG szint\u00e9zis technol\u00f3gi\u00e1j\u00e1nak fejleszt\u00e9si ir\u00e1nya lehet.<br \/>\nA megl\u00e9v\u0151 kutat\u00e1sok bebizony\u00edtott\u00e1k, hogy az ERG hatalmas alkalmaz\u00e1si lehet\u0151s\u00e9geket rejt mag\u00e1ban olyan ter\u00fcleteken, mint az orvostudom\u00e1ny, az \u00e9lelmiszeripar, az eg\u00e9szs\u00e9g\u00fcgy \u00e9s a kozmetika. K\u00fcl\u00f6n\u00f6sen az ERG mesters\u00e9ges szint\u00e9zis\u00e9ben el\u00e9rt \u00e1tt\u00f6r\u00e9s tette lehet\u0151v\u00e9 annak sz\u00e9les k\u00f6r\u0171 alkalmaz\u00e1s\u00e1t. Az ERG-vel kapcsolatos alap- \u00e9s alkalmazott kutat\u00e1sok azonban m\u00e9g mindig viszonylag gyeng\u00e9k, \u00e9s tov\u00e1bbi kutat\u00e1sokra van sz\u00fcks\u00e9g ahhoz, hogy tudom\u00e1nyos alapot biztos\u00edtsanak az alkalmaz\u00e1s\u00e1hoz.<\/p>","protected":false},"excerpt":{"rendered":"<p>Ergothionein was first reported in 1909 when Tanret et al. isolated a unique sulfur-containing crystal compound, 2-mercapto-L-histidine trimethylbetaine, while studying the ergot fungus that destroys rye grains. The compound was named ergothionein (ERG). ERG is mainly found in some fungi and bacteria, and animals cannot synthesize ERG themselves, relying mainly on food sources. Research has [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research progress on the antioxidant properties of ergothionein and its intervention in oxidative stress-related diseases - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/ergothionein\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research progress on the antioxidant properties of ergothionein and its intervention in oxidative stress-related diseases - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Ergothionein was first reported in 1909 when Tanret et al. isolated a unique sulfur-containing crystal compound, 2-mercapto-L-histidine trimethylbetaine, while studying the ergot fungus that destroys rye grains. 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The compound was named ergothionein (ERG). ERG is mainly found in some fungi and bacteria, and animals cannot synthesize ERG themselves, relying mainly on food sources. 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