{"id":6532,"date":"2024-08-06T12:27:57","date_gmt":"2024-08-06T12:27:57","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6532"},"modified":"2024-08-06T12:27:57","modified_gmt":"2024-08-06T12:27:57","slug":"huangbai","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/huangbai\/","title":{"rendered":"A Huangbai mechanizmus\u00e1nak felt\u00e1r\u00e1sa a k\u00f6szv\u00e9ny kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1s \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n"},"content":{"rendered":"

A Huangbai mechanizmus\u00e1nak felt\u00e1r\u00e1sa a k\u00f6szv\u00e9ny kezel\u00e9s\u00e9ben a h\u00e1l\u00f3zati farmakol\u00f3gia, a molekul\u00e1ris dokkol\u00e1s \u00e9s a k\u00eds\u00e9rleti ellen\u0151rz\u00e9s alapj\u00e1n
\nA k\u00f6szv\u00e9ny akut \u00e9s kr\u00f3nikus \u00edz\u00fcleti gyullad\u00e1s, amelyet a monon\u00e1trium-ur\u00e1t (MSU) csontokban \u00e9s \u00edz\u00fcletekben t\u00f6rt\u00e9n\u0151 lerak\u00f3d\u00e1sa okoz, \u00e9s amely k\u00f6zvetlen\u00fcl \u00f6sszef\u00fcgg a purin anyagcserezavarok \u00e9s\/vagy a cs\u00f6kkent h\u00fagysavkiv\u00e1laszt\u00e1s \u00e1ltal okozott hiperurik\u00e9mi\u00e1val (HUA); A f\u0151 megnyilv\u00e1nul\u00e1s a hiperurik\u00e9mia, amelyet akut \u00edz\u00fcleti gyullad\u00e1sos rohamok, k\u00f6szv\u00e9nyes tophik\u00e9pz\u0151d\u00e9s, \u00edz\u00fcleti deformit\u00e1sok, vese- \u00e9s egy\u00e9b szervi k\u00e1rosod\u00e1sok k\u00eds\u00e9rnek. A betegs\u00e9g k\u00e9s\u0151bbi st\u00e1dium\u00e1ban magas v\u00e9rnyom\u00e1s, hiperlipid\u00e9mia, metabolikus szindr\u00f3ma \u00e9s egy\u00e9b betegs\u00e9gek is el\u0151fordulhatnak. A k\u00f6szv\u00e9ny el\u0151fordul\u00e1si gyakoris\u00e1ga feln\u0151ttek k\u00f6r\u00e9ben \u00c1zsi\u00e1ban, Eur\u00f3p\u00e1ban \u00e9s \u00c9szak-Amerik\u00e1ban 0,68% \u00e9s 3,90% k\u00f6z\u00f6tt mozog, m\u00edg K\u00edn\u00e1ban 0,86% \u00e9s 2,20% k\u00f6z\u00f6tt, \u00e9vr\u0151l \u00e9vre n\u00f6vekv\u0151 tendenci\u00e1t mutat, \u00e9s a fiatalabb koroszt\u00e1lyok fel\u00e9 tend\u00e1l. A kutat\u00e1sok azt sugallj\u00e1k, hogy az MSU krist\u00e1ly aktiv\u00e1l\u00e1sa makrof\u00e1g NOD mint receptor h\u0151feh\u00e9rje dom\u00e9n t\u00e1rs\u00edtott feh\u00e9rje 3 (NLRP3) inflammasz\u00f3ma jel\u00e1tviteli \u00fatvonal felszabad\u00edt\u00f3 aktivit\u00e1sa interleukin-1 \u03b2 (IL-1 \u03b2) a k\u00f6szv\u00e9nyes artritisz k\u00f6zponti patog\u00e9n mechanizmusa; A k\u00f6szv\u00e9ny megel\u0151z\u00e9s\u00e9re \u00e9s kezel\u00e9s\u00e9re a klinikai gyakorlatban \u00e1ltal\u00e1nosan haszn\u00e1lt gy\u00f3gyszerek k\u00f6z\u00e9 tartoznak a nem szteroid gyullad\u00e1scs\u00f6kkent\u0151k, kolhicin, gl\u00fckokortikoidok stb. Alkalmaz\u00e1sukat azonban k\u00fcl\u00f6nb\u00f6z\u0151 mell\u00e9khat\u00e1sok \u00e9s klinikai ellenjavallatok korl\u00e1tozz\u00e1k. Ez\u00e9rt nagy jelent\u0151s\u00e9ggel b\u00edr az \u00faj gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s k\u00f6szv\u00e9nyellenes gy\u00f3gyszerek keres\u00e9se.<\/p>\n

A Phellodendron Chinensis Cortex (PCC) a Rutaceae csal\u00e1dba tartoz\u00f3 Phellodendron chinense Schneid sz\u00e1r\u00edtott k\u00e9rge. \u00c1ltal\u00e1ban \"Chuan Huangbai\" n\u00e9ven ismert, \u00e9s a h\u0151 \u00e9s a nedvess\u00e9g elt\u00e1vol\u00edt\u00e1s\u00e1ra, a t\u0171z megtiszt\u00edt\u00e1s\u00e1ra \u00e9s a g\u0151z elt\u00e1vol\u00edt\u00e1s\u00e1ra, m\u00e9regtelen\u00edt\u00e9sre \u00e9s a sebek kezel\u00e9s\u00e9re alkalmas. A modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy a Phellodendron Chinensis \u00e9s gy\u00f3gyn\u00f6v\u00e9nyes formul\u00e1ja gyullad\u00e1scs\u00f6kkent\u0151, f\u00e1jdalomcsillap\u00edt\u00f3, h\u00fagysavcs\u00f6kkent\u0151 \u00e9s k\u00f6szv\u00e9nyellenes hat\u00e1ssal rendelkezik, de k\u00f6szv\u00e9nyellenes anyag\u00e1nak alapja \u00e9s konkr\u00e9t mechanizmusa m\u00e9g mindig nem tiszt\u00e1zott. Ez a tanulm\u00e1ny h\u00e1l\u00f3zati farmakol\u00f3giai m\u00f3dszereket alkalmazott a Huangbai k\u00f6szv\u00e9ny elleni hat\u00f3anyagainak \u00e9s f\u0151 c\u00e9lpontjainak el\u0151rejelz\u00e9s\u00e9re, majd bioinformatikai m\u00f3dszerekkel feh\u00e9rje-feh\u00e9rje k\u00f6lcs\u00f6nhat\u00e1si h\u00e1l\u00f3zatokat (PPI) \u00e9p\u00edtett a Huangbai farmakol\u00f3giai mechanizmus\u00e1nak elemz\u00e9s\u00e9re. Ugyanakkor molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1t alkalmaznak a hat\u00f3anyagok potenci\u00e1lis c\u00e9lfeh\u00e9rj\u00e9khez val\u00f3 k\u00f6t\u0151d\u00e9s\u00e9nek ellen\u0151rz\u00e9s\u00e9re, \u00e9s az alapvet\u0151 k\u00e9miai \u00f6sszetev\u0151k k\u00f6szv\u00e9nyellenes hat\u00e1s\u00e1t in vitro k\u00eds\u00e9rletek alapj\u00e1n ellen\u0151rzik, \u00edgy felt\u00e1rj\u00e1k a Huangbai k\u00f6szv\u00e9nyellenes hat\u00e1s\u00e1nak lehets\u00e9ges anyagi alapjait \u00e9s mechanizmus\u00e1t. Ez a tanulm\u00e1ny gazdag\u00edtja az autentikus szecsu\u00e1ni gy\u00f3gyn\u00f6v\u00e9ny, a Huangbai farmakol\u00f3giai kutat\u00e1s\u00e1t, elm\u00e9leti alapot ny\u00fajtva a k\u00f6szv\u00e9ny \u00e9s sz\u00f6v\u0151dm\u00e9nyei megel\u0151z\u00e9s\u00e9hez \u00e9s kezel\u00e9s\u00e9hez, a Huangbai-t a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szati formul\u00e1k \u00f6sszetev\u0151jek\u00e9nt haszn\u00e1lva. Ugyanakkor szil\u00e1rd alapot teremt a Huangbai \u00e9s hat\u00f3anyagain alapul\u00f3 \u00faj, innovat\u00edv k\u00ednai gy\u00f3gy\u00e1szati gy\u00f3gyszerek kifejleszt\u00e9s\u00e9hez.<\/p>\n

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\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"A hagyom\u00e1nyos k\u00ednai orvosl\u00e1s hat\u00f3anyagainak h\u00e1l\u00f3zati diagramja a kulcsfontoss\u00e1g\u00fa c\u00e9lpontok ebben a tanulm\u00e1nyban azt mutatja, hogy a Phellodendron amurense-ben l\u00e9v\u0151 kvercetin, rutaecarpin, \u03b2-szitoszterin, stigmasterol \u00e9s dehidrotanszinon IIA hat\u00f3anyagok viszonylag magas \u00e9rt\u00e9kekkel rendelkeznek a h\u00e1l\u00f3zatban, ami azt jelzi, hogy ezek lehetnek a Phellodendron amurense farmakol\u00f3giai anyagai a k\u00f6szv\u00e9nyellenes hat\u00e1sok alapjai. A kvercetin a SIRT1 expresszi\u00f3j\u00e1nak felszab\u00e1lyoz\u00e1s\u00e1val \u00e9s az NLRP3 inflammasz\u00f3ma aktiv\u00e1ci\u00f3j\u00e1nak elfojt\u00e1s\u00e1val g\u00e1tolhatja a gyullad\u00e1sos k\u00e1rosod\u00e1st. XO-g\u00e1tl\u00f3k\u00e9nt is haszn\u00e1lhat\u00f3, \u00e9s \u00faj, k\u00f6szv\u00e9nyellenes hat\u00e1s\u00fa gy\u00f3gyszerk\u00e9nt fejleszthet\u0151. A Wu Zhuyu alkaloidok g\u00e1tolhatj\u00e1k a gyullad\u00e1st \u00e9s az oxidat\u00edv stresszt a JNK\/p38MAPK jel\u00e1tviteli \u00fatvonal elnyom\u00e1sa r\u00e9v\u00e9n; A kaszp\u00e1z-12 \u00e9s az NF - \u03ba B \u00fatvonalak egyidej\u0171 g\u00e1tl\u00e1sa jav\u00edtja a peritone\u00e1lis makrof\u00e1g apopt\u00f3zist \u00e9s a gyullad\u00e1sos v\u00e1laszt szeptikus egerekben. A \u03b2 - szitoszterin egy term\u00e9szetes n\u00f6v\u00e9nyi szterol \u00e9s antioxid\u00e1ns, amelyr\u0151l meg\u00e1llap\u00edtott\u00e1k, hogy cs\u00f6kkenti az LPS \u00e1ltal induk\u00e1lt gyullad\u00e1sos medi\u00e1torok, mint p\u00e9ld\u00e1ul az IL-1 \u03b2 \u00e9s a tumor nekr\u00f3zis faktor - \u03b1 (TNF - \u03b1) felszabadul\u00e1s\u00e1t. Mind a szitoszterin, mind a \u03b2-szitoszterin a n\u00f6v\u00e9nyi szterinek oszt\u00e1ly\u00e1ba tartozik, \u00e9s k\u00e9pes jelent\u0151sen cs\u00f6kkenteni az LPS \u00e1ltal induk\u00e1lt COX-2 \u00e9s iNOS g\u00e9nexpresszi\u00f3t, ami arra utal, hogy ezek a vegy\u00fcletek gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1st fejthetnek ki a gyullad\u00e1sos faktorok g\u00e9nexpresszi\u00f3j\u00e1nak \u00e9s felszabadul\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val. A dehidrotanszinon IIA, mint a tansinon IIA akt\u00edv metabolitj\u00e1nak gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s k\u00f6szv\u00e9nyellenes hat\u00e1sair\u00f3l eddig nem sz\u00e1moltak be. Zhou \u00e9s munkat\u00e1rsai kutat\u00e1sai szerint azonban a tanshinone IIA k\u00e9pes g\u00e1tolni az LPS \u00e1ltal kiv\u00e1ltott gyullad\u00e1st \u00e9s a kondrocita apopt\u00f3zist, \u00e9s jelent\u0151s ter\u00e1pi\u00e1s hat\u00e1ssal b\u00edr az \u00edz\u00fcleti gyullad\u00e1s gyullad\u00e1sos v\u00e1lasz\u00e1nak cs\u00f6kkent\u00e9s\u00e9ben \u00e9s az \u00edz\u00fcleti kondrocit\u00e1k v\u00e9delm\u00e9ben. Emellett cs\u00f6kkentheti a mitokondri\u00e1lis reakt\u00edv oxig\u00e9nfajok (ROS) termel\u00e9s\u00e9t az LPS \u00e1ltal stimul\u00e1lt makrof\u00e1gokban, g\u00e1tolhatja az NLRP3 inflammasz\u00f3ma aktiv\u00e1l\u00f3d\u00e1s\u00e1t, \u00e9s enyh\u00edtheti a k\u00f6szv\u00e9nyes gyullad\u00e1st.<\/p>\n

A PPI-h\u00e1l\u00f3zatelemz\u00e9s \u00e9s a KEGG \u00fatvonalak gazdagod\u00e1si elemz\u00e9se azt mutatta, hogy a Huangbai kulcsfontoss\u00e1g\u00fa c\u00e9lpontjai a k\u00f6szv\u00e9ny kezel\u00e9s\u00e9ben az AKT1, TNF, IL-6 stb., els\u0151sorban a PI3K Akt, MAPK \u00e9s m\u00e1s jel\u00e1tviteli \u00fatvonalak bevon\u00e1s\u00e1val. K\u00f6z\u00fcl\u00fck a PI3K\/Akt, mint a legink\u00e1bb d\u00fas\u00edtott jel\u00e1tviteli \u00fatvonal, fontos szerepet j\u00e1tszik a sejtprolifer\u00e1ci\u00f3, az apopt\u00f3zis, a gyullad\u00e1sos v\u00e1lasz \u00e9s az autof\u00e1gia szab\u00e1lyoz\u00e1s\u00e1ban. A magas h\u00fagysavszint aktiv\u00e1lhatja az AKT-PRAS40 jel\u00e1tviteli \u00fatvonalat, aktiv\u00e1lhatja az mTOR-t, ez\u00e1ltal g\u00e1tolhatja az autof\u00e1gi\u00e1t, n\u00f6velheti az IL-1 \u03b2 gyullad\u00e1sos faktor expresszi\u00f3j\u00e1t, \u00e9s megzavarhatja az IL-1 receptor antagonist\u00e1t (IL-Ra), s\u00falyosb\u00edtva a gyullad\u00e1sos v\u00e1laszt. Ez\u00e9rt az AKT1 fontos c\u00e9lpont lehet a k\u00f6szv\u00e9ny kezel\u00e9s\u00e9ben. A kutat\u00e1sok kimutatt\u00e1k, hogy az autof\u00e1gia g\u00e1tl\u00e1sa szorosan \u00f6sszef\u00fcgg az inflammasz\u00f3ma aktiv\u00e1ci\u00f3j\u00e1val \u00e9s az IL-1 \u03b2 transzkripci\u00f3j\u00e1nak felszab\u00e1lyoz\u00e1s\u00e1val. A MAPK jel\u00e1tviteli \u00fatvonal d\u00fasul\u00e1si szintje a m\u00e1sodik a PI3K\/Akt jel\u00e1tviteli \u00fatvonal ut\u00e1n, amely szorosan kapcsol\u00f3dik a k\u00fcl\u00f6nb\u00f6z\u0151 pro-inflammatorikus folyamatokhoz. Meger\u0151s\u00edt\u00e9st nyert, hogy az oldhat\u00f3 h\u00fagysav k\u00e9pes aktiv\u00e1lni a p38 MAPK-t \u00e9s az extracellul\u00e1ris jelszab\u00e1lyozott kin\u00e1zokat (ERK), tov\u00e1bb aktiv\u00e1lni az NF - \u03ba B \u00e9s az AP1 transzkripci\u00f3s faktorokat, \u00e9s felszab\u00e1lyozni az IL-1 \u03b2, IL-6 stb. gyullad\u00e1sos citokinek transzkripci\u00f3j\u00e1t. Ezenk\u00edv\u00fcl a MAPK-k, mint a TNF downstream jel\u00e1tviteli \u00fatvonalai, gyullad\u00e1sos kaszk\u00e1dreakci\u00f3kat k\u00f6zvet\u00edthetnek \u00e9s s\u00falyosb\u00edthatj\u00e1k a k\u00f6szv\u00e9nyt. \u00d6sszefoglalva, felt\u00e9telezz\u00fck, hogy a Huangbai aktiv\u00e1lhatja a PI3K\/Akt \u00fatvonalat az autof\u00e1gia beind\u00edt\u00e1sa \u00e9s t\u00f6bb jel\u00e1tviteli \u00fatvonal, p\u00e9ld\u00e1ul a MAPK-k szab\u00e1lyoz\u00e1sa \u00e9rdek\u00e9ben, hogy k\u00f6szv\u00e9nyellenes hat\u00e1st fejtsen ki (l\u00e1sd a 9. \u00e1br\u00e1t).<\/p>\n

Ez a tanulm\u00e1ny molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1t alkalmazott a Phellodendron amurense hat\u00f3anyagainak a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e1ltal el\u0151re jelzett k\u00f6t\u0151d\u00e9si k\u00e9pess\u00e9g\u00e9nek ellen\u0151rz\u00e9s\u00e9re a kulcsfontoss\u00e1g\u00fa c\u00e9lpontokhoz AKT1, TNF, IL-6, PPARG \u00e9s PTGS2. Meg\u00e1llap\u00edtottuk, hogy a hat\u00f3anyagok \u00e9s a kulcsfontoss\u00e1g\u00fa c\u00e9lpontok k\u00f6z\u00f6tti legalacsonyabb k\u00f6t\u00e9si energia -9,60 \u00e9s -6,10 kcal\/mol k\u00f6z\u00f6tt volt, f\u0151k\u00e9nt hidrog\u00e9nk\u00f6t\u00e9si k\u00f6lcs\u00f6nhat\u00e1sok r\u00e9v\u00e9n, ami er\u0151s k\u00f6t\u0151d\u00e9si k\u00e9pess\u00e9gre utal. A fenti kutat\u00e1si eredm\u00e9nyek alapj\u00e1n ez a tanulm\u00e1ny egy in vitro gyullad\u00e1sos modellt fogad el, amelyet az LPS \u00e9s az MSU kombin\u00e1ci\u00f3ja induk\u00e1l. A reprezentat\u00edv hat\u00f3anyagokat, mint a kvercetin, a rutaekarpin, a \u03b2 - szitoszterin \u00e9s a Phellodendron amurense jellegzetes \u00f6sszetev\u0151i, mint a Phellodendron amurense alkaloid\u00e1i \u00e9s a berberin, kiv\u00e1lasztott\u00e1k a k\u00e9s\u0151bbi sejtk\u00eds\u00e9rletekhez, hogy felt\u00e1rj\u00e1k \u00e9s sz\u0171rj\u00e9k az er\u0151s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00fa hat\u00f3anyagokat. Az ELISA-eredm\u00e9nyek azt mutatt\u00e1k, hogy a Wu Zhuyu alkaloid alacsonyabb koncentr\u00e1ci\u00f3ban is jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal volt a MSU \u00e1ltal induk\u00e1lt IL-1 \u03b2 \u00e9s IL-6 gyullad\u00e1sos faktorok felszabadul\u00e1s\u00e1ra, \u00e9s in vitro k\u00f6szv\u00e9nyellenes hat\u00e1sa jobb volt, mint a Huangbai min\u0151s\u00e9gi markerek - berberin \u00e9s Huangbai alkaloid -\u00e9. A fenti vizsg\u00e1latok azt jelzik, hogy a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e1ltal megj\u00f3solt hat\u00f3anyagok potenci\u00e1lis k\u00f6szv\u00e9nyellenes hat\u00f3anyagok lehetnek, amelyek \u00faj gy\u00f3gyszerk\u00e9nt vagy gy\u00f3gyszer-el\u0151anyagk\u00e9nt haszn\u00e1lhat\u00f3k a k\u00f6szv\u00e9nyellenes hagyom\u00e1nyos k\u00ednai orvosl\u00e1s k\u00e9s\u0151bbi kutat\u00e1saihoz.<\/p>\n

\u00d6sszefoglalva, ez a tanulm\u00e1ny felt\u00e1rta a Huangbai anyagi alapjait \u00e9s mechanizmus\u00e1t a k\u00f6szv\u00e9ny kezel\u00e9s\u00e9ben h\u00e1l\u00f3zati farmakol\u00f3gia, molekul\u00e1ris dokkol\u00e1si m\u00f3dszerek \u00e9s in vitro k\u00eds\u00e9rleti ellen\u0151rz\u00e9s seg\u00edts\u00e9g\u00e9vel. B\u00e1r a h\u00e1l\u00f3zati farmakol\u00f3gia interdiszciplin\u00e1ris alkalmaz\u00e1sok \u00e9s \u00e1tfog\u00f3 biol\u00f3giai h\u00e1l\u00f3zatelemz\u00e9s r\u00e9v\u00e9n el\u00e9rte a \"t\u00f6bbkomponens\u0171, t\u00f6bbc\u00e9l\u00fa \u00e9s t\u00f6bb \u00fatvonal\u00fa\" hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerek (vegy\u00fcletek) hat\u00e9kony el\u0151rejelz\u00e9s\u00e9t, m\u00e9g mindig vannak k\u00fcl\u00f6nb\u00f6z\u0151 megoldand\u00f3 probl\u00e9m\u00e1k, mint p\u00e9ld\u00e1ul a k\u00fcl\u00f6nb\u00f6z\u0151 adatb\u00e1zisokban l\u00e9v\u0151 egyenetlen inform\u00e1ci\u00f3k, az \u00f6sszetev\u0151k c\u00e9linform\u00e1ci\u00f3ihoz val\u00f3 korl\u00e1tozott hozz\u00e1f\u00e9r\u00e9s \u00e9s a t\u00f6bb hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer bizonytalan in vivo k\u00f6lcs\u00f6nhat\u00e1si mechanizmusai. A nyomon k\u00f6vet\u0151 kutat\u00f3csoport tov\u00e1bbi kutat\u00e1sokat fog v\u00e9gezni a k\u00f6szv\u00e9nyellenes hat\u00f3anyagaival \u00e9s mechanizmusaival kapcsolatban, bele\u00e9rtve a c\u00e9lpontokat, a jel\u00e1tviteli utakat \u00e9s a hat\u00f3anyagok in vivo k\u00eds\u00e9rleteit, annak \u00e9rdek\u00e9ben, hogy elm\u00e9leti alapot biztos\u00edtson a Huangbai klinikai alkalmaz\u00e1s\u00e1hoz a k\u00f6szv\u00e9ny megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben, \u00e9s szil\u00e1rd alapot teremtsen a Huangbai \u00e9s hat\u00f3anyagain alapul\u00f3 innovat\u00edv hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szat \u00faj gy\u00f3gyszerek kifejleszt\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the mechanism of Huangbai in treating gout based on network pharmacology, molecular docking, and experimental verification Gout is an acute and chronic arthritis caused by the deposition of monosodium urate (MSU) in bones and joints, which is directly related to hyperuricemia (HUA) caused by purine metabolism disorders and\/or reduced uric acid excretion; The main […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism of Huangbai in treating gout based on network pharmacology, molecular docking, and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/huangbai\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of Huangbai in treating gout based on network pharmacology, molecular docking, and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of Huangbai in treating gout based on network pharmacology, molecular docking, and experimental verification Gout is an acute and chronic arthritis caused by the deposition of monosodium urate (MSU) in bones and joints, which is directly related to hyperuricemia (HUA) caused by purine metabolism disorders and\/or reduced uric acid excretion; 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