{"id":6494,"date":"2024-08-06T12:21:17","date_gmt":"2024-08-06T12:21:17","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6494"},"modified":"2024-08-06T12:21:17","modified_gmt":"2024-08-06T12:21:17","slug":"luteolin-inhibits","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/luteolin-inhibits\/","title":{"rendered":"A riboszom\u00e1lis feh\u00e9rje S12 expresszi\u00f3j\u00e1nak luteolin \u00e1ltali negat\u00edv szab\u00e1lyoz\u00e1sa g\u00e1tolja az MDA-MB-231 sejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t"},"content":{"rendered":"<p>A riboszom\u00e1lis feh\u00e9rje S12 expresszi\u00f3j\u00e1nak luteolin \u00e1ltali negat\u00edv szab\u00e1lyoz\u00e1sa g\u00e1tolja az MDA-MB-231 sejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t<br \/>\nA luteolin (Lut) egy term\u00e9szetes flavonoid vegy\u00fclet, amely bizony\u00edtottan j\u00f3 daganatellenes hat\u00e1ssal rendelkezik in vitro \u00e9s in vivo tumork\u00eds\u00e9rletekben, p\u00e9ld\u00e1ul m\u00e1jr\u00e1kban \u00e9s eml\u0151r\u00e1kban. Ezenk\u00edv\u00fcl a Lut viszonylag alacsony citotoxicit\u00e1ssal rendelkezik a k\u00fcl\u00f6nb\u00f6z\u0151 tumorsejtek prolifer\u00e1ci\u00f3j\u00e1nak g\u00e1tl\u00e1s\u00e1ban \u00e9s apopt\u00f3zisuk kiv\u00e1lt\u00e1s\u00e1ban, ami potenci\u00e1lis daganatellenes gy\u00f3gyszerr\u00e9 teszi. A t\u00e9ma kor\u00e1bbi k\u00eds\u00e9rlete meger\u0151s\u00edtette, hogy a Lut a PETN expresszi\u00f3j\u00e1nak felszab\u00e1lyoz\u00e1s\u00e1val befoly\u00e1solhatja a PI3K\/Akt aktivit\u00e1s\u00e1t, majd g\u00e1tolja az eml\u0151r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t. Tekintettel azonban arra, hogy az eml\u0151r\u00e1k el\u0151fordul\u00e1sa \u00e9s kialakul\u00e1sa sz\u00e1mos szab\u00e1lyoz\u00e1si mechanizmussal rendelkezik, tov\u00e1bbra is tiszt\u00e1zatlan, hogy a Lutnak vannak-e m\u00e1s mechanizmusai az eml\u0151r\u00e1ksejtek prolifer\u00e1ci\u00f3j\u00e1nak g\u00e1tl\u00e1s\u00e1ra. A ribosz\u00f3m\u00e1lis feh\u00e9rje (RP) a ribosz\u00f3m\u00e1k egyik f\u0151 \u00f6sszetev\u0151je, amely r\u00e9szt vesz az intracellul\u00e1ris feh\u00e9rje bioszint\u00e9zis\u00e9ben, a transzkripci\u00f3ban, a transzl\u00e1ci\u00f3ban \u00e9s a sejtprolifer\u00e1ci\u00f3ban m\u00e1s szab\u00e1lyoz\u00f3 molekul\u00e1ris kapcsol\u00f3d\u00f3 r\u00e9gi\u00f3kban. K\u00fcl\u00f6nb\u00f6z\u0151 m\u00e9rt\u00e9k\u0171 abnorm\u00e1lis expresszi\u00f3t mutat vastagb\u00e9lr\u00e1kban, gyomorr\u00e1kban, m\u00e1jr\u00e1kban \u00e9s nyel\u0151cs\u0151r\u00e1kban. A riboszom\u00e1lis S12 feh\u00e9rje (RPS12) a m\u00e9hnyakr\u00e1kos betegekben magasan expressz\u00e1l\u00f3dik, m\u00edg norm\u00e1lis sz\u00f6vetekben viszonylag alacsony az expresszi\u00f3ja. Ezenk\u00edv\u00fcl az RPS12 a gyomorr\u00e1kos sz\u00f6vetekben is t\u00falreprezent\u00e1lt, \u00e9s el\u0151seg\u00edtheti a tumorsejtek \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9s\u00e9t. Az RPS12 g\u00e9n szab\u00e1lyoz\u00f3 szerepe az eml\u0151r\u00e1ksejtek prolifer\u00e1ci\u00f3j\u00e1ban azonban nem egy\u00e9rtelm\u0171en meghat\u00e1rozott. A C-Myc a ribosz\u00f3maszint\u00e9zis szab\u00e1lyoz\u00f3 t\u00e9nyez\u0151je. A fibroblasztok cDNS-mikroarray-elemz\u00e9s\u00e9vel meg\u00e1llap\u00edtott\u00e1k, hogy az RPS12 expresszi\u00f3s szintje a sejtekben kapcsolatban \u00e1llhat a c-Myc-cel. E tanulm\u00e1ny c\u00e9lja, hogy felt\u00e1rja a c-Myc \u00e9s az RPS12 mechanizmus\u00e1t az eml\u0151r\u00e1k MDA-MB-231 sejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t g\u00e1tl\u00f3 Lut folyamat\u00e1ban, annak \u00e9rdek\u00e9ben, hogy \u00faj \u00f6tleteket ny\u00fajtson a gy\u00f3gyszerek fejleszt\u00e9s\u00e9hez \u00e9s kiv\u00e1laszt\u00e1s\u00e1hoz az eml\u0151r\u00e1k klinikai kezel\u00e9s\u00e9ben.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6495\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-233.png\" alt=\"\" width=\"327\" height=\"348\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6496\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-194.png\" alt=\"\" width=\"658\" height=\"241\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6497\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-182.png\" alt=\"\" width=\"657\" height=\"491\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6498\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-161.png\" alt=\"\" width=\"659\" height=\"588\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6499\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-145.png\" alt=\"\" width=\"661\" height=\"521\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6500\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-131.png\" alt=\"\" width=\"663\" height=\"287\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6501\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-119.png\" alt=\"\" width=\"663\" height=\"320\" \/><br \/>\nAz orvosi szint gyors fejl\u0151d\u00e9se ellen\u00e9re az ut\u00f3bbi \u00e9vekben az eml\u0151r\u00e1k klinikai kezel\u00e9s\u00e9nek hat\u00e1sa m\u00e9g mindig gyenge. Ennek f\u0151 oka, hogy a daganat kialakul\u00e1sa \u00e9s a korai \u00e1tt\u00e9tk\u00e9pz\u0151d\u00e9s mechanizmusa nem egy\u00e9rtelm\u0171. A lut, egy term\u00e9szetes flavonoid vegy\u00fclet, g\u00e1tl\u00f3 hat\u00e1ssal van a k\u00fcl\u00f6nb\u00f6z\u0151 rosszindulat\u00fa daganatok kialakul\u00e1s\u00e1ra \u00e9s fejl\u0151d\u00e9s\u00e9re. B\u00e1r kutat\u00f3csoportunk kor\u00e1bban meger\u0151s\u00edtette a Lut eml\u0151r\u00e1ksejtek prolifer\u00e1ci\u00f3j\u00e1t g\u00e1tl\u00f3 hat\u00e1s\u00e1t, a specifikus mechanizmusa m\u00e9g nem tiszt\u00e1zott. Ebben a vizsg\u00e1latban azt tal\u00e1ltuk, hogy a Lut k\u00e9pes a PI3K\/Akt\/mTOR jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val lefel\u00e9 szab\u00e1lyozni a c-Myc expresszi\u00f3j\u00e1t, \u00e9s az RPS12 expresszi\u00f3j\u00e1nak negat\u00edv szab\u00e1lyoz\u00e1s\u00e1val g\u00e1tolja az eml\u0151r\u00e1k MDA-MB-231 sejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t. Ez tov\u00e1bb er\u0151s\u00edtette a Lut kil\u00e1t\u00e1sait az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben.<br \/>\nA ribosz\u00f3m\u00e1k a sejtek feh\u00e9rjeszint\u00e9zis\u00e9nek f\u0151 szervezetei, \u00e9s az eukari\u00f3ta ribosz\u00f3m\u00e1k k\u00f6r\u00fclbel\u00fcl 80 RP-t tartalmaznak. Az RP-k k\u00f3rosan felszab\u00e1lyozottak k\u00fcl\u00f6nb\u00f6z\u0151 tumorsejtekben, p\u00e9ld\u00e1ul a m\u00e9hnyakr\u00e1kban \u00e9s a gyomorr\u00e1kban, \u00e9s \u00f6sszef\u00fcgg\u00e9sbe hozhat\u00f3k a tumorsejtek prolifer\u00e1ci\u00f3j\u00e1val \u00e9s inv\u00e1zi\u00f3j\u00e1val. A kutat\u00e1sok kimutatt\u00e1k, hogy az RPS12 expresszi\u00f3s szintje a gyomorr\u00e1kos sejtekben jelent\u0151sen magasabb, mint a norm\u00e1l sejtekben, ami arra utal, hogy az RPS12 szerepet j\u00e1tszhat a gyomorr\u00e1k kialakul\u00e1s\u00e1ban \u00e9s fejl\u0151d\u00e9s\u00e9ben. Ez a tanulm\u00e1ny azt tal\u00e1lta, hogy az RPS12 az eml\u0151r\u00e1kos sejtvonalakban is nagym\u00e9rt\u00e9kben kifejez\u0151d\u00f6tt, ami \u00f6sszhangban van m\u00e1s daganatokkal. Amikor azonban az eml\u0151r\u00e1ksejteket Lut-kezel\u00e9sben r\u00e9szes\u00edtett\u00e9k, az RPS12 expresszi\u00f3s szintje jelent\u0151sen cs\u00f6kkent. Meger\u0151s\u00edt\u00e9st nyert, hogy az RPS12 is r\u00e9szt vett a Lut szab\u00e1lyoz\u00e1s\u00e1ban az eml\u0151r\u00e1ksejteken. Az RPS12 eml\u0151r\u00e1ksejtek migr\u00e1ci\u00f3j\u00e1ban \u00e9s inv\u00e1zi\u00f3j\u00e1ban bet\u00f6lt\u00f6tt szerep\u00e9nek tov\u00e1bbi tiszt\u00e1z\u00e1sa \u00e9rdek\u00e9ben az RPS12 csendes\u00edt\u00e9s\u00e9nek hat\u00e1s\u00e1t is vizsg\u00e1ltuk a sejtek inv\u00e1zi\u00f3j\u00e1ra \u00e9s migr\u00e1ci\u00f3j\u00e1ra. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az RPS12 csendes\u00edt\u00e9se jelent\u0151sen g\u00e1tolhatja az eml\u0151r\u00e1ksejtek inv\u00e1zi\u00f3j\u00e1t \u00e9s migr\u00e1ci\u00f3j\u00e1t. Ez azt is jelzi, hogy az RPS12 magas expresszi\u00f3ja az eml\u0151r\u00e1kban hozz\u00e1j\u00e1rulhat a tumor kialakul\u00e1s\u00e1hoz \u00e9s metaszt\u00e1zis kialakul\u00e1s\u00e1hoz. A c-Myc g\u00e9n jelenleg proto onkog\u00e9nk\u00e9nt ismert, amely hat\u00e9konyan k\u00e9pes el\u0151seg\u00edteni a sejtoszt\u00f3d\u00e1st \u00e9s a prolifer\u00e1ci\u00f3t, \u00e9s szorosan kapcsol\u00f3dik a k\u00fcl\u00f6nb\u00f6z\u0151 rosszindulat\u00fa daganatok kialakul\u00e1s\u00e1hoz \u00e9s fejl\u0151d\u00e9s\u00e9hez. A kutat\u00e1sok kimutatt\u00e1k, hogy vastagb\u00e9lr\u00e1kban a MicroRNS-184 g\u00e1tolhatja a vastagb\u00e9lr\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s el\u0151seg\u00edtheti a sejtek apopt\u00f3zis\u00e1t a c-Myc expresszi\u00f3s szintj\u00e9nek leszab\u00e1lyoz\u00e1s\u00e1val. Ezenk\u00edv\u00fcl a c-Myc hasonl\u00f3an el\u0151seg\u00edt\u0151 hat\u00e1ssal van a sejtprolifer\u00e1ci\u00f3ra a gyomorr\u00e1kos sejtekben is. Ez a tanulm\u00e1ny meg\u00e1llap\u00edtotta, hogy a c-Myc az eml\u0151r\u00e1kos sejtvonalakban is nagym\u00e9rt\u00e9kben expressz\u00e1l\u00f3dik, \u00e9s a c-Myc expresszi\u00f3j\u00e1nak lefel\u00e9 szab\u00e1lyoz\u00e1sa tov\u00e1bb g\u00e1tolhatja az RPS12 expresszi\u00f3j\u00e1t \u00e9s transzkripci\u00f3j\u00e1t a sejtekben, ami tov\u00e1bb g\u00e1tolhatja az eml\u0151r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t. Figyelembe v\u00e9ve a c-Myc m\u00e1s tumorsejtekben bet\u00f6lt\u00f6tt szerep\u00e9t, ism\u00e9t bebizonyosodott, hogy a Lut a c-Myc\/RPS12 expresszi\u00f3j\u00e1nak befoly\u00e1sol\u00e1s\u00e1val fejtheti ki hat\u00e1s\u00e1t.<br \/>\nA PI3K\/Akt egy enzimakt\u00edv intracellul\u00e1ris jel\u00e1tviteli \u00fatvonal, amely olyan folyamatokban vehet r\u00e9szt, mint a tumor n\u00f6veked\u00e9se \u00e9s differenci\u00e1l\u00f3d\u00e1sa. Vizsg\u00e1latok kimutatt\u00e1k, hogy a PI3K\/Akt jel\u00e1tviteli \u00fatvonal gyakran k\u00f3rosan aktiv\u00e1l\u00f3dik az eml\u0151r\u00e1ksejtek prolifer\u00e1ci\u00f3ja \u00e9s migr\u00e1ci\u00f3ja sor\u00e1n. Ebben a vizsg\u00e1latban mind az Akt-inhibitor LY294002-t, mind az mTOR-inhibitor rapamicint haszn\u00e1ltuk az mTOR \u00e9s az S6K foszforil\u00e1ci\u00f3s szintj\u00e9nek jelent\u0151s g\u00e1tl\u00e1s\u00e1ra. A rapamicinnek azonban nem volt jelent\u0151s hat\u00e1sa az Akt foszforil\u00e1ci\u00f3s szintj\u00e9re, mivel az mTOR a PI3K\/Akt downstream molekul\u00e1ja, \u00e9s ez\u00e9rt nincs hat\u00e1sa az Akt foszforil\u00e1ci\u00f3j\u00e1ra. Ezenk\u00edv\u00fcl a PI3K\/Ak \u00e9s az mTOR inhibitorok jelent\u0151sen cs\u00f6kkenthetik az RPS12 \u00e9s a c-Myc expresszi\u00f3j\u00e1t a sejtekben, ez\u00e1ltal g\u00e1tolva a sejtprolifer\u00e1ci\u00f3t. Ezek az eredm\u00e9nyek arra utalnak, hogy az RPS12 \u00e9s a c-Myc is a PI3K\/Akt\/mTOR jel\u00e1tviteli \u00fatvonal downstream molekul\u00e1i lehetnek, \u00e9s r\u00e9szt vesznek a Lut szab\u00e1lyoz\u00e1s\u00e1ban az eml\u0151r\u00e1ksejtek prolifer\u00e1ci\u00f3j\u00e1n \u00e9s migr\u00e1ci\u00f3j\u00e1n.<br \/>\n\u00d6sszefoglalva, a Lut g\u00e1tolhatja az eml\u0151r\u00e1k MDA-MB-231 sejtek prolifer\u00e1ci\u00f3j\u00e1t \u00e9s inv\u00e1zi\u00f3j\u00e1t a PI3K\/Akt\/mTOR jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val, ez\u00e1ltal lecs\u00f6kkentve a c-Myc expresszi\u00f3j\u00e1t, majd negat\u00edvan szab\u00e1lyozva az RPS12-t. Ezek az eredm\u00e9nyek arra utalnak, hogy az RPS12 \u00e9s a c-Myc potenci\u00e1lis c\u00e9lpontok lehetnek az eml\u0151r\u00e1k kezel\u00e9s\u00e9ben, \u00e9s a Lut az RPS12 \u00e9s a c-Myc expresszi\u00f3j\u00e1nak szab\u00e1lyoz\u00e1s\u00e1val tumorellenes szerepet j\u00e1tszhat. Ez \u00faj \u00f6tleteket ny\u00fajt az eml\u0151r\u00e1k klinikai kezel\u00e9s\u00e9hez.<\/p>","protected":false},"excerpt":{"rendered":"<p>Negative regulation of ribosomal protein S12 expression by luteolin inhibits proliferation and invasion of MDA-MB-231 cells Luteolin (Lut) is a natural flavonoid compound, which has been proved to have a good anti-tumor effect in in vitro and in vivo tumor experiments such as liver cancer and breast cancer. In addition, Lut has relatively low cytotoxicity [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Negative regulation of ribosomal protein S12 expression by luteolin inhibits proliferation and invasion of MDA-MB-231 cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/luteolin-inhibits\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Negative regulation of ribosomal protein S12 expression by luteolin inhibits proliferation and invasion of MDA-MB-231 cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Negative regulation of ribosomal protein S12 expression by luteolin inhibits proliferation and invasion of MDA-MB-231 cells Luteolin (Lut) is a natural flavonoid compound, which has been proved to have a good anti-tumor effect in in vitro and in vivo tumor experiments such as liver cancer and breast cancer. 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