{"id":6452,"date":"2024-08-06T12:11:32","date_gmt":"2024-08-06T12:11:32","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6452"},"modified":"2024-08-06T12:11:32","modified_gmt":"2024-08-06T12:11:32","slug":"acacetin-j8","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/acacetin-j8\/","title":{"rendered":"Molekul\u00e1ris dokkol\u00e1son alapul\u00f3 vizsg\u00e1lat az acacetin J8 endot\u00e9lsejtek prolifer\u00e1ci\u00f3s c\u00e9lpontjaira \u00e9s az apopt\u00f3zissal kapcsolatos sejtjel\u00e1tviteli \u00fatvonalakra gyakorolt g\u00e1tl\u00f3 hat\u00e1s\u00e1r\u00f3l"},"content":{"rendered":"<p>Molekul\u00e1ris dokkol\u00e1son alapul\u00f3 vizsg\u00e1lat az acacetin J8 endot\u00e9lsejtek prolifer\u00e1ci\u00f3s c\u00e9lpontjaira \u00e9s az apopt\u00f3zissal kapcsolatos sejtjel\u00e1tviteli \u00fatvonalakra gyakorolt g\u00e1tl\u00f3 hat\u00e1s\u00e1r\u00f3l<br \/>\nAz ak\u00e1ck\u00e9reg az Albizia julibrissin Durazz h\u00fcvelyes sz\u00e1r\u00edtott k\u00e9rge. \u00c9des \u00e9s enyhe \u00edze van, \u00e9s a gy\u00f3gyszerk\u00f6nyvek a depresszi\u00f3 enyh\u00edt\u00e9s\u00e9re, az elme megnyugtat\u00e1s\u00e1ra, a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a duzzanat cs\u00f6kkent\u00e9s\u00e9re alkalmas hat\u00e1sk\u00e9nt tartj\u00e1k sz\u00e1mon. Els\u0151sorban olyan t\u00fcnetek kezel\u00e9s\u00e9re haszn\u00e1lj\u00e1k, mint a nyugtalans\u00e1g, depresszi\u00f3, \u00e1lmatlans\u00e1g, t\u00fcd\u0151t\u00e1lyog, sebek \u00e9s es\u00e9sek okozta f\u00e1jdalom. A modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az ak\u00e1ck\u00e9reg nyers kivonata \u00e9s \u00f6sszes szaponinja in vivo \u00e9s in vitro g\u00e1tolja a tumorsejtek prolifer\u00e1ci\u00f3j\u00e1t. H\u00edres orvosok, mint p\u00e9ld\u00e1ul Zhu Liangchun, j\u00f3 klinikai eredm\u00e9nyeket \u00e9rtek el a t\u00fcd\u0151r\u00e1k kezel\u00e9s\u00e9ben olyan gy\u00f3gyszerekkel, mint az ak\u00e1ck\u00e9reg. A daganatos angiogenezis elleni aktivit\u00e1s ir\u00e1ny\u00edt\u00e1sa alatt a projekt el\u0151zetes munk\u00e1ja sor\u00e1n izol\u00e1lt\u00e1k \u00e9s tiszt\u00edtott\u00e1k az ak\u00e1c k\u00e9regb\u0151l a tumor angiogenezist g\u00e1tl\u00f3 hat\u00e9kony komponenseket \u00e9s hat\u00f3anyagokat, \u00e9s azonos\u00edtott\u00e1k hat\u00f3anyagukat, mint juliozid J8 (J8). A kutat\u00e1si eredm\u00e9nyek azt mutatt\u00e1k, hogy a J8 jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal van az endot\u00e9lsejtek prolifer\u00e1ci\u00f3j\u00e1ra. \u00c9s k\u00e9pes a sejtek apopt\u00f3zis\u00e1t el\u0151id\u00e9zni. Azonban m\u00e9g mindig nem vil\u00e1gos, hogyan szab\u00e1lyozza a jel\u00e1tvitelt a sejten k\u00edv\u00fclr\u0151l \u00e9s a sejtmembr\u00e1non, citoplazm\u00e1n kereszt\u00fcl a sejtmagba, hogy kifejtse hat\u00e1s\u00e1t, \u00e9s nincsenek kutat\u00e1si jelent\u00e9sek itthon \u00e9s k\u00fclf\u00f6ld\u00f6n. Ebben a tanulm\u00e1nyban molekul\u00e1ris dokkol\u00e1st alkalmaztunk in vitro sejtk\u00eds\u00e9rletekkel kombin\u00e1lva, hogy elemezz\u00fck a J8 endot\u00e9lsejt-prolifer\u00e1ci\u00f3ra gyakorolt g\u00e1tl\u00f3 hat\u00e1s\u00e1nak c\u00e9lpontjait \u00e9s az apopt\u00f3zissal kapcsolatos sejtjel\u00e1tviteli \u00fatvonalakat.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6453\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-230.png\" alt=\"\" width=\"368\" height=\"259\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6454\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-191.png\" alt=\"\" width=\"780\" height=\"620\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-191.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-191-768x610.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6455\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-179.png\" alt=\"\" width=\"775\" height=\"255\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-179.png 775w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-179-768x253.png 768w\" sizes=\"(max-width: 775px) 100vw, 775px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6456\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-158.png\" alt=\"\" width=\"367\" height=\"412\" \/>A J8 egy szaponin, amelyet az ak\u00e1c k\u00e9regb\u0151l izol\u00e1ltak. Kor\u00e1bbi tanulm\u00e1nyok szerint mind in vitro, mind in vivo g\u00e1tl\u00f3 hat\u00e1ssal van a tumor angiogenezis\u00e9re, \u00e9s endot\u00e9lsejt apopt\u00f3zist induk\u00e1lhat. Azonban az \u00fatvonal, amelyen kereszt\u00fcl a sejtek apopt\u00f3zis\u00e1t kiv\u00e1ltja, nem teljesen vil\u00e1gos. A J8 \u00e1ltal induk\u00e1lt endot\u00e9lsejt-apopt\u00f3zis mechanizmus\u00e1nak vizsg\u00e1lata \u00e9rdek\u00e9ben az irodalomban ismertetett extrakci\u00f3s, izol\u00e1l\u00e1si \u00e9s azonos\u00edt\u00e1si m\u00f3dszerek alkalmaz\u00e1s\u00e1val \u00faj mintat\u00e9teleket \u00e1ll\u00edtottunk el\u0151, \u00e9s kimutattuk aktivit\u00e1sukat. A J8 sejtekre gyakorolt hat\u00e1smechanizmus\u00e1nak vizsg\u00e1lat\u00e1hoz, hogy a J8 a sejtek belsej\u00e9be jut-e, vagy a sejtmembr\u00e1non l\u00e9v\u0151 felsz\u00edni feh\u00e9rj\u00e9kkel l\u00e9p-e k\u00f6lcs\u00f6nhat\u00e1sba, HPLC-t haszn\u00e1ltunk a J8 sejteken bel\u00fcli \u00e9s k\u00edv\u00fcli koncentr\u00e1ci\u00f3j\u00e1nak kimutat\u00e1s\u00e1ra. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy a J8 nem jut be az endot\u00e9lsejtek belsej\u00e9be, \u00e9s csak a sejtmembr\u00e1non l\u00e9v\u0151 felsz\u00edni feh\u00e9rj\u00e9kkel l\u00e9p k\u00f6lcs\u00f6nhat\u00e1sba. Annak \u00e9rdek\u00e9ben, hogy tov\u00e1bb vizsg\u00e1ljuk a k\u00f6lcs\u00f6nhat\u00e1s\u00e1t bizonyos feh\u00e9rj\u00e9kkel, a k\u00eds\u00e9rletben el\u0151sz\u00f6r molekul\u00e1ris dokkol\u00e1st alkalmaztak a membr\u00e1nfeh\u00e9rj\u00e9k FAS, FAS \u00e9s FAS, amelyek az apopt\u00f3zissal kapcsolatosak DR3\u3001DR4\u3001DR5\u3001TFR-1\uff0c \u00c9s azt tal\u00e1lt\u00e1k, hogy a J8 csak a FAS-hoz \u00e9s a VEGF-hez k\u00f6t\u0151dik j\u00f3l, amelyek a sejtprolifer\u00e1ci\u00f3val kapcsolatos feh\u00e9rj\u00e9k.<br \/>\nA vaszkul\u00e1ris endot\u00e9l n\u00f6veked\u00e9si faktor A VEGF egy rendk\u00edv\u00fcl specifikus pro-endot\u00e9l n\u00f6veked\u00e9si faktor, amely el\u0151seg\u00edtheti az endot\u00e9lsejtek prolifer\u00e1ci\u00f3j\u00e1t, migr\u00e1ci\u00f3j\u00e1t, az \u00e9rrendszeri permeabilit\u00e1s n\u00f6veked\u00e9s\u00e9t \u00e9s az angiogenezist. A VEGF aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1sa jelent\u0151sen g\u00e1tolhatja a daganatos erek kialakul\u00e1s\u00e1t, ez\u00e1ltal el\u00e9rve a daganatellenes kezel\u00e9s ter\u00e1pi\u00e1s c\u00e9lj\u00e1t. A szakirodalom arr\u00f3l sz\u00e1mol be, hogy az ak\u00e1ck\u00e9regb\u0151l sz\u00e1rmaz\u00f3 \u00f6sszes szaponinok jelent\u0151sen g\u00e1tolhatj\u00e1k a tumoros erek kialakul\u00e1s\u00e1t \u00e9s elnyomhatj\u00e1k a VEGF aktivit\u00e1s\u00e1t. A J8 az egyik szaponin, \u00e9s a molekul\u00e1ris dokkol\u00e1s \u00e9s az in vitro molekul\u00e1ris kimutat\u00e1s kimutatta, hogy a J8 k\u00e9pes k\u00f6t\u0151dni a VEGF-hez, ez\u00e1ltal g\u00e1tolja az endot\u00e9lsejtek prolifer\u00e1ci\u00f3j\u00e1t.<br \/>\nA modern molekul\u00e1ris \u00e9s sejtfarmakol\u00f3giai kutat\u00e1sok szerint a sejtek apopt\u00f3zis\u00e1nak jel\u00e1tvitel\u00e9t k\u00e9t \u00fatvonalra lehet osztani: exog\u00e9n \u00e9s endog\u00e9n (mitokondri\u00e1lis) \u00fatvonalakra. Az exog\u00e9n apoptotikus \u00fatvonalat az apopt\u00f3zisreceptorok k\u00f6zvet\u00edtik, mint p\u00e9ld\u00e1ul a TNF-a, TRAIL, FAS-L. A Fas-L a FAS-hoz k\u00f6t\u0151dve rekrut\u00e1lja \u00e9s \u00f6sszekapcsolja a FADD-t a sejt apopt\u00f3zis\u00e1nak elind\u00edt\u00e1s\u00e1hoz. A mitokondriumok az endog\u00e9n sejt apopt\u00f3zis szab\u00e1lyoz\u00f3 k\u00f6zpontja, amely a k\u00fcl\u00f6nb\u00f6z\u0151 jel\u00e1tviteli \u00fatvonalak alapj\u00e1n kaszp\u00e1zf\u00fcgg\u0151 \u00e9s nem kaszp\u00e1zf\u00fcgg\u0151 apoptotikus jel\u00e1tviteli \u00fatvonalakra oszthat\u00f3. A FADD k\u00f6t\u0151d\u00e9se a kaszp\u00e1z-8-hoz a kaszp\u00e1z-8 dimeriz\u00e1ci\u00f3j\u00e1hoz, azaz aktiv\u00e1ci\u00f3j\u00e1hoz vezethet. Az aktiv\u00e1lt kaszp\u00e1z-8 reaktiv\u00e1lja a kaszp\u00e1z-3\/9-et, ami a sejtek apopt\u00f3zis\u00e1t induk\u00e1lja. A nem kaszp\u00e1zf\u00fcgg\u0151 apoptotikus jel\u00e1tviteli \u00fatvonal els\u0151sorban az AIF \u00e9s az EnDOG felszabadul\u00e1s\u00e1val val\u00f3sul meg, mindkett\u0151 nagy mennyis\u00e9g\u0171 DNS-fragment\u00e1ci\u00f3t \u00e9s sejtapopt\u00f3zist induk\u00e1lhat. K\u00eds\u00e9rleti ellen\u0151rz\u00e9ssel meg\u00e1llap\u00edtott\u00e1k, hogy a J8 (2,5 \u03bc g\/ml) HUVEC sejtekhez t\u00f6rt\u00e9n\u0151 hozz\u00e1ad\u00e1sa ut\u00e1n a VEGF, a JNK \u00e9s m\u00e1s feh\u00e9rj\u00e9k expresszi\u00f3ja jelent\u0151sen lecs\u00f6kkent, m\u00edg az apopt\u00f3zissal kapcsolatos p-JNK, Bax \u00e9s EnDOG feh\u00e9rj\u00e9k expresszi\u00f3ja jelent\u0151sen felfel\u00e9 szab\u00e1lyoz\u00f3dott. A J8 nem volt jelent\u0151s hat\u00e1ssal a kaszp\u00e1z-3, kaszp\u00e1z-8 \u00e9s kaszp\u00e1z-9 expresszi\u00f3s szintj\u00e9re, \u00e9s el\u0151seg\u00edthette a JNK, egy stressz aktiv\u00e1lt feh\u00e9rje kin\u00e1z foszforil\u00e1ci\u00f3j\u00e1t. Az aktiv\u00e1lt JNK \u00fatvonal szab\u00e1lyozhatja az apopt\u00f3zissal kapcsolatos c\u00e9lg\u00e9nek kifejez\u0151d\u00e9s\u00e9t, ez\u00e1ltal sejt apopt\u00f3zist induk\u00e1lva. A Bax \u00e9s az EnDOG a JNK \u00fatvonal downstream c\u00e9lg\u00e9njei. J8-mal t\u00f6rt\u00e9n\u0151 kezel\u00e9s ut\u00e1n az expresszi\u00f3s szintj\u00fck is megn\u0151, ami arra utal, hogy a J8 a VEGF\/JNK \u00fatvonal aktivit\u00e1s\u00e1nak gyeng\u00edt\u00e9s\u00e9vel okozhat sejthal\u00e1lt. E tanulm\u00e1ny eredm\u00e9nyei azt sugallj\u00e1k, hogy a J8 el\u0151seg\u00edtheti az \u00e9rrendszeri endot\u00e9lsejtek apopt\u00f3zis\u00e1t a JNK jel\u00e1tviteli \u00fatvonal szab\u00e1lyoz\u00e1s\u00e1val, \u00f6tleteket adva m\u00e1s tud\u00f3sok j\u00f6v\u0151beli kutat\u00e1saihoz, \u00e9s \u00faj kutat\u00e1si gy\u00f3gyszereket k\u00edn\u00e1lva a tumor angiogenezis ter\u00e1pi\u00e1j\u00e1nak g\u00e1tl\u00e1s\u00e1ra. Ennek a tanulm\u00e1nynak azonban vannak bizonyos hi\u00e1nyoss\u00e1gai is, \u00e9s a JNK jel\u00e1tviteli \u00fatvonal el\u0151tt \u00e9s ut\u00e1n l\u00e9v\u0151 feh\u00e9rj\u00e9k \u00e1tfog\u00f3 kimutat\u00e1s\u00e1ra van sz\u00fcks\u00e9g a j\u00f6v\u0151beli kutat\u00e1sokban. Az in vitro sejtk\u00eds\u00e9rletek bizonyos elt\u00e9r\u00e9seket mutathatnak, \u00e9s a k\u00eds\u00e9rleti eredm\u00e9nyeket klinikai \u00e9s \u00e1llatk\u00eds\u00e9rletekben kell valid\u00e1lni.<br \/>\n\u00d6sszefoglalva, a J8 a VEGF-re hatva g\u00e1tolja a sejtprolifer\u00e1ci\u00f3t, m\u00edg a JNK jel\u00e1tviteli \u00fatvonal szab\u00e1lyoz\u00e1sa el\u0151seg\u00edti az \u00e9rrendszeri endot\u00e9lsejtek apopt\u00f3zis\u00e1t, \u00e9s az apopt\u00f3zis m\u00e9rt\u00e9ke jelent\u0151sen n\u0151 a koncentr\u00e1ci\u00f3 n\u00f6veked\u00e9s\u00e9vel.<\/p>","protected":false},"excerpt":{"rendered":"<p>Molecular docking based study on the inhibitory effect of acacetin J8 on endothelial cell proliferation targets and apoptosis related cell signaling pathways Acacia bark is the dried bark of the legume Albizia julibrissin Durazz. It has a sweet and mild taste, and is recorded in pharmacopoeia as having the effects of relieving depression, calming the [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Molecular docking based study on the inhibitory effect of acacetin J8 on endothelial cell proliferation targets and apoptosis related cell signaling pathways - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/acacetin-j8\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular docking based study on the inhibitory effect of acacetin J8 on endothelial cell proliferation targets and apoptosis related cell signaling pathways - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Molecular docking based study on the inhibitory effect of acacetin J8 on endothelial cell proliferation targets and apoptosis related cell signaling pathways Acacia bark is the dried bark of the legume Albizia julibrissin Durazz. 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