{"id":5799,"date":"2024-08-04T21:13:30","date_gmt":"2024-08-04T21:13:30","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5799"},"modified":"2024-08-04T21:13:30","modified_gmt":"2024-08-04T21:13:30","slug":"dactylosopogia-elegans","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/dactylosopogia-elegans\/","title":{"rendered":"A Dactylosopogia elegans, egy d\u00e9l-k\u00ednai-tengeri szivacs diterpenoid k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1nak vizsg\u00e1lata"},"content":{"rendered":"<p>A Dactylosopogia elegans, egy d\u00e9l-k\u00ednai-tengeri szivacs diterpenoid k\u00e9miai \u00f6sszet\u00e9tel\u00e9nek \u00e9s gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1nak vizsg\u00e1lata<br \/>\nAz \u00f3ce\u00e1n k\u00fcl\u00f6nleges \u00f6kol\u00f3giai k\u00f6rnyezete, p\u00e9ld\u00e1ul a nagy nyom\u00e1s, a magas s\u00f3tartalom, a hipoxia \u00e9s az alacsony f\u00e9nyviszonyok lehet\u0151v\u00e9 teszik a tengeri szervezetek sz\u00e1m\u00e1ra, hogy egyedi anyagcsere-mechanizmusokkal rendelkezzenek, \u00e9s ez\u00e1ltal szerkezetileg \u00fajszer\u0171 m\u00e1sodlagos anyagcsereterm\u00e9keket \u00e1ll\u00edtsanak el\u0151. A szivacsok a m\u00e1sodik legnagyobb tengeri \u00e9l\u0151l\u00e9nyek, \u00e9s az \u00f3ce\u00e1nban a term\u00e9szetes term\u00e9kek leggazdagabb forr\u00e1s\u00e1nak tekinthet\u0151k. A Dactylosongia nemzets\u00e9gbe tartoz\u00f3 szivacsok b\u0151s\u00e9gesen rendelkeznek bioakt\u00edv m\u00e1sodlagos anyagcsereterm\u00e9kekkel. A szakirodalomban ismertetett k\u00e9miai \u00f6sszet\u00e9tele ennek a szivacs nemzets\u00e9gnek els\u0151sorban szeszkviterp\u00e9n kinonokat\/hidrokinonokat, szeszkviterp\u00e9n savakat, diterp\u00e9neket, szteroidokat, szeszkviterp\u00e9neket \u00e9s m\u00e1s t\u00edpus\u00fa vegy\u00fcleteket tartalmaz, amelyek t\u00f6bbs\u00e9ge szeszkviterp\u00e9n kinonok\/hidrokinonok. Ezek a metabolitok sz\u00e1mos biol\u00f3giai aktivit\u00e1st mutatnak, p\u00e9ld\u00e1ul daganatellenes, angiogenezis elleni, antibakteri\u00e1lis, gyullad\u00e1scs\u00f6kkent\u0151, tripanosz\u00f3maellenes, mal\u00e1riaellenes \u00e9s antioxid\u00e1ns aktivit\u00e1st. Jelenleg a D-b\u0151l Viszonylag kev\u00e9s diterpenoid vegy\u00fcletet izol\u00e1ltak az elegans szivacsb\u00f3l, \u00e9s csak kev\u00e9s irodalom sz\u00e1molt be r\u00f3luk, p\u00e9ld\u00e1ul Yu et al. a D-b\u0151l \u00d6t \u00faj szeszkviterp\u00e9nt izol\u00e1ltak az elegans szivacsb\u00f3l.<\/p>\n<p>Ez a cikk a p\u00e1nc\u00e9lszivacs felhaszn\u00e1l\u00e1s\u00e1t t\u00e1rgyalja D Sz\u00e1mos tanulm\u00e1nyt v\u00e9geztek az elegancia k\u00e9miai \u00f6sszet\u00e9tel\u00e9vel kapcsolatban, amelyek c\u00e9lja szerkezetileg \u00fajszer\u0171 \u00e9s biol\u00f3giailag akt\u00edv vegy\u00fcletek felfedez\u00e9se, tengeri forr\u00e1sokb\u00f3l sz\u00e1rmaz\u00f3 term\u00e9szetes term\u00e9kek gazdag\u00edt\u00e1sa \u00e9s potenci\u00e1lis gy\u00f3gy\u00e1szati \u00e9rt\u00e9kkel rendelkez\u0151 vezet\u0151 vegy\u00fcletek felfedez\u00e9se.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5800\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-10.jpg\" alt=\"\" width=\"639\" height=\"355\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5801\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-162.png\" alt=\"\" width=\"366\" height=\"252\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5802\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-152.png\" alt=\"\" width=\"367\" height=\"148\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5803\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-136.png\" alt=\"\" width=\"360\" height=\"254\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5804\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-10.jpg\" alt=\"\" width=\"489\" height=\"352\" \/>Ez a cikk a d\u00e9l-k\u00ednai-tengeri Yongxing-szigetr\u0151l sz\u00e1rmaz\u00f3 D. szivacsot t\u00e1rgyalja Az elegans k\u00e9miai \u00f6sszet\u00e9tel\u00e9t tanulm\u00e1nyozt\u00e1k, \u00e9s 8 ritka szeszkviterp\u00e9nt izol\u00e1ltak, amelyek ehhez a szivacs nemzets\u00e9ghez tartoznak. Az 1. vegy\u00fclet egy \u00faj vegy\u00fclet, a 2-8. vegy\u00fcleteket pedig el\u0151sz\u00f6r izol\u00e1lt\u00e1k ebb\u0151l a szivacsb\u00f3l. A 2-8 vegy\u00fcletek Scalarane t\u00edpus\u00fa szeszkviterp\u00e9nek, amelyeket az irodalomban f\u0151k\u00e9nt olyan szivacsokb\u00f3l izol\u00e1ltak, mint a Hyatella sp., Phyllospongia sp., Dysidia sp. \u00e9s Lendenfeldia sp. Az el egans szivacsokb\u00f3l izol\u00e1lt Scalarane t\u00edpus\u00fa szeszkviterp\u00e9neket most el\u0151sz\u00f6r izol\u00e1lt\u00e1k a D Az el egans szivacsokb\u00f3l izol\u00e1lt Scalarane t\u00edpus\u00fa szeszkviterp\u00e9nek kapcsolatban \u00e1llhatnak a t\u00e1pl\u00e1l\u00e9kl\u00e1nccal vagy e szivacsok szimbi\u00f3zisaival. Meghat\u00e1roztuk 8 vegy\u00fclet g\u00e1tl\u00e1si ar\u00e1ny\u00e1t a RAW 264.7 makrof\u00e1gokb\u00f3l lipopoliszacharid (LPS) \u00e1ltal induk\u00e1lt NO felszabadul\u00e1sra egerekben. Annak \u00e9rdek\u00e9ben, hogy a gyullad\u00e1scs\u00f6kkent\u0151 \u00e9rt\u00e9kel\u00e9s sor\u00e1n elker\u00fclj\u00fck a vizsg\u00e1lt vegy\u00fcletek RAW 264.7 sejtekre gyakorolt citotoxicit\u00e1s\u00e1t, CCK-8 kimutat\u00e1sra is sor ker\u00fclt. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az 1., 3. \u00e9s 4. vegy\u00fcletek 10 \u03bc mol\/L eset\u00e9n j\u00f3 NO-g\u00e1tl\u00f3 hat\u00e1ssal rendelkeztek, 65,5%, 48,5%, illetve 46,0% g\u00e1tl\u00e1si r\u00e1t\u00e1val, \u00e9s nem voltak citotoxikusak a RAW 264,7 sejteken. Ezek a vegy\u00fcletek potenci\u00e1lis \u00e9rt\u00e9kkel b\u00edrhatnak a gyullad\u00e1scs\u00f6kkent\u0151 ter\u00e1pi\u00e1ban, de a gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1sban szerepet j\u00e1tsz\u00f3 specifikus mechanizmusok tov\u00e1bbi kutat\u00e1sokat ig\u00e9nyelnek.<\/p>","protected":false},"excerpt":{"rendered":"<p>Study on the diterpenoid chemical composition and anti-inflammatory activity of Dactylosopogia elegans, a sponge from the South China Sea The special ecological environment of the ocean, such as high pressure, high salinity, hypoxia, and low light, enables marine organisms to have unique metabolic mechanisms, thereby producing structurally novel secondary metabolites. Sponges are the second largest [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on the diterpenoid chemical composition and anti-inflammatory activity of Dactylosopogia elegans, a sponge from the South China Sea - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/dactylosopogia-elegans\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the diterpenoid chemical composition and anti-inflammatory activity of Dactylosopogia elegans, a sponge from the South China Sea - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the diterpenoid chemical composition and anti-inflammatory activity of Dactylosopogia elegans, a sponge from the South China Sea The special ecological environment of the ocean, such as high pressure, high salinity, hypoxia, and low light, enables marine organisms to have unique metabolic mechanisms, thereby producing structurally novel secondary metabolites. 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