{"id":5666,"date":"2024-08-04T20:27:06","date_gmt":"2024-08-04T20:27:06","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5666"},"modified":"2024-08-04T20:27:06","modified_gmt":"2024-08-04T20:27:06","slug":"scutellaria-baicalensis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/hu\/scutellaria-baicalensis\/","title":{"rendered":"A Scutellaria baicalensis hat\u00e9kony \u00f6sszetev\u0151inek mechanizmus\u00e1nak \u00e9s hat\u00e9konys\u00e1g\u00e1nak vizsg\u00e1lata az alkoholos m\u00e1jbetegs\u00e9gre a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a molekul\u00e1ris dokkol\u00e1s alapj\u00e1n"},"content":{"rendered":"

A Scutellaria baicalensis hat\u00e9kony \u00f6sszetev\u0151inek mechanizmus\u00e1nak \u00e9s hat\u00e9konys\u00e1g\u00e1nak vizsg\u00e1lata az alkoholos m\u00e1jbetegs\u00e9gre a h\u00e1l\u00f3zati farmakol\u00f3gia \u00e9s a molekul\u00e1ris dokkol\u00e1s alapj\u00e1n
\nAz alkoholos m\u00e1jbetegs\u00e9gek (ALD) sz\u00e9les klinikai sz\u00f6vettani spektrumot \u00f6lelnek fel, bele\u00e9rtve a korai, egyszer\u0171 hepatikus steat\u00f3zist, valamint a k\u00f6z\u00e9p- \u00e9s k\u00e9s\u0151i st\u00e1dium\u00fa alkoholos hepatitist, a m\u00e1jfibr\u00f3zist \u00e9s az alkoholos cirr\u00f3zist. Az ALD jelenlegi legjobb megel\u0151z\u00e9si \u00e9s kezel\u00e9si m\u00f3dszere m\u00e9g mindig az alkoholt\u00f3l val\u00f3 tart\u00f3zkod\u00e1s, \u00e9s a kortikoszteroidok klinikai alkalmaz\u00e1sa csak r\u00e9szben enyh\u00edti a t\u00fcneteket \u00e9s r\u00f6vid t\u00e1v\u00fa t\u00fal\u00e9l\u00e9si el\u0151ny\u00f6ket biztos\u00edt. Jelenleg nincsenek megfelel\u0151 specifikus gy\u00f3gyszerek a klinikai gyakorlatban. Az ALD etiol\u00f3gi\u00e1ja, patogenezise \u00e9s klinikai megnyilv\u00e1nul\u00e1sai szerint a hagyom\u00e1nyos k\u00ednai orvosl\u00e1s az ALD-t h\u00e1rom szakaszra osztja: a \"borstagn\u00e1l\u00e1s\" korai szakasza, amelyet a nedvess\u00e9g \u00e9s a h\u0151 okoz, a \"borf\u00fcgg\u0151s\u00e9g\" k\u00f6z\u00e9ps\u0151 szakasza, amelyet a qi stagn\u00e1l\u00e1sa \u00e9s a v\u00e9r pang\u00e1sa okoz, \u00e9s a \"borstagn\u00e1l\u00e1s\" k\u00e9s\u0151i szakasza, amelyet a pozit\u00edv qi hi\u00e1nya okoz. A kezel\u00e9si m\u00f3dszerek a k\u00fcl\u00f6nb\u00f6z\u0151 szakaszokban elt\u00e9r\u0151ek. A korai szakaszban a f\u0151 hangs\u00faly a m\u00e1j megnyugtat\u00e1s\u00e1n \u00e9s a depresszi\u00f3 enyh\u00edt\u00e9s\u00e9n, a h\u0151 \u00e9s a nedvess\u00e9g tiszt\u00edt\u00e1s\u00e1n van. A k\u00f6z\u00e9ps\u0151 szakaszban a f\u0151 hangs\u00faly a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9n \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9n van. A k\u00e9s\u0151bbi szakaszban a f\u0151 hangs\u00faly a l\u00e9p er\u0151s\u00edt\u00e9s\u00e9re, valamint a m\u00e1j \u00e9s a ves\u00e9k t\u00e1pl\u00e1l\u00e1s\u00e1ra helyez\u0151dik.
\nA Scutellaria Radix a Scutellaria baicalensis, a Lamiaceae csal\u00e1dba tartoz\u00f3 n\u00f6v\u00e9ny sz\u00e1r\u00edtott gy\u00f6kere. A hagyom\u00e1nyos k\u00ednai orvosl\u00e1sban a h\u0151tiszt\u00edt\u00f3 kateg\u00f3ri\u00e1ba tartozik, \u00e9s h\u0151- \u00e9s nedvess\u00e9gtiszt\u00edt\u00f3, t\u0171ztiszt\u00edt\u00f3 \u00e9s m\u00e9regtelen\u00edt\u0151, v\u00e9rz\u00e9scsillap\u00edt\u00f3 \u00e9s vet\u00e9l\u00e9smegel\u0151z\u0151 hat\u00e1s\u00fa. J\u00f3l haszn\u00e1lhat\u00f3 az ALD kezel\u00e9s\u00e9re a korai \u00e9s a k\u00f6z\u00e9ps\u0151 szakaszban. Ugyanakkor a Scutellaria baicalensis m\u00e1jv\u00e9delm\u00e9r\u0151l sz\u00f3l\u00f3 vonatkoz\u00f3 vizsg\u00e1latokkal kombin\u00e1lva meg\u00e1llap\u00edthat\u00f3, hogy a Scutellaria baicalensis \u00e9s hat\u00f3anyagai v\u00e9dik a m\u00e1jsejteket \u00e9s cs\u00f6kkentik a m\u00e1j k\u00f3ros k\u00e1rosod\u00e1s\u00e1nak m\u00e9rt\u00e9k\u00e9t az oxidat\u00edv stresszv\u00e1lasz g\u00e1tl\u00e1s\u00e1val, a gyullad\u00e1sos faktorok besziv\u00e1rg\u00e1s\u00e1nak elfojt\u00e1s\u00e1val, a m\u00e1jsejtek apopt\u00f3zis\u00e1nak cs\u00f6kkent\u00e9s\u00e9vel \u00e9s a lipidanyagcsere szab\u00e1lyoz\u00e1s\u00e1val. A Huangqin farmakol\u00f3giai anyag\u00e1nak alapja, hat\u00e1smechanizmusa \u00e9s mechanizmusa az ALD megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben azonban m\u00e9g nem tiszt\u00e1zott. Ez a tanulm\u00e1ny h\u00e1l\u00f3zati farmakol\u00f3gi\u00e1t, molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1t \u00e9s in vitro sejtk\u00eds\u00e9rleteket haszn\u00e1lt a Scutellaria baicalensis hat\u00f3anyagainak \u00e9s megfelel\u0151 hat\u00e1s\u00fatjainak el\u0151zetes felt\u00e1r\u00e1s\u00e1ra az ALD megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben, annak \u00e9rdek\u00e9ben, hogy hivatkoz\u00e1si alapot ny\u00fajtson a Scutellaria baicalensis \u00e9s hat\u00f3anyagainak m\u00e9lyrehat\u00f3 kutat\u00e1s\u00e1hoz, \u00faj gy\u00f3gyszerek fejleszt\u00e9s\u00e9hez \u00e9s klinikai alkalmaz\u00e1s\u00e1hoz az ALD megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben.<\/p>\n

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\nA hepatitis B \u00e9s C megel\u0151z\u00e9se \u00e9s kezel\u00e9se ter\u00e9n K\u00edn\u00e1ban el\u00e9rt tart\u00f3san j\u00f3 eredm\u00e9nyek, valamint a gazdas\u00e1g gyors fejl\u0151d\u00e9se \u00e9s az alkoholkult\u00fara sz\u00e9les k\u00f6r\u0171 elterjed\u00e9se alapj\u00e1n az ALD \u00e1ltal okozott m\u00e1jzsugorod\u00e1s, m\u00e1jsejtes karcin\u00f3ma \u00e9s m\u00e9g a beteghal\u00e1loz\u00e1sok ar\u00e1nya is tov\u00e1bb fog n\u0151ni. A hagyom\u00e1nyos k\u00ednai orvosi rendszerben nincs az \"alkoholos m\u00e1jbetegs\u00e9g\" fogalma, de klinikai megnyilv\u00e1nul\u00e1sai, etiol\u00f3gi\u00e1ja \u00e9s patogenezise szerint oszt\u00e1lyozhat\u00f3, \u00e9s megfelelhet az \"alkoholbetegs\u00e9gnek\", \"alkoholos s\u00e9r\u00fcl\u00e9snek\", \"alkoholf\u00fcgg\u0151s\u00e9gnek\", \"alkoholos s\u00e1rgas\u00e1gnak\" stb. A kezel\u00e9si m\u00f3dszerek k\u00f6z\u00e9 tartozik els\u0151sorban a l\u00e9p \u00e9s a gyomor er\u0151s\u00edt\u00e9se, a m\u00e1j megnyugtat\u00e1sa \u00e9s az epe\u00e1raml\u00e1s el\u0151seg\u00edt\u00e9se, a h\u0151 \u00e9s a nedvess\u00e9g elt\u00e1vol\u00edt\u00e1sa, valamint a zavaross\u00e1g megsz\u00fcntet\u00e9se. A Scutellaria baicalensis hagyom\u00e1nyos k\u00ednai gy\u00f3gyszer a h\u0151tiszt\u00edt\u00f3 \u00e9s nedvess\u00e9gsz\u00e1r\u00edt\u00f3 gy\u00f3gyszerek kateg\u00f3ri\u00e1j\u00e1ba tartozik. Jelenleg a Scutellaria baicalensis-t els\u0151sorban az ALD korai \u00e9s k\u00f6z\u00e9ps\u0151 szakasz\u00e1ban alkalmazz\u00e1k. A Scutellaria baicalensis farmakol\u00f3giai anyagalapja, hat\u00e1s\u00fatja \u00e9s mechanizmusa az ALD megel\u0151z\u00e9s\u00e9ben \u00e9s kezel\u00e9s\u00e9ben azonban m\u00e9g nem vil\u00e1gos, ez\u00e9rt bizonyos kutat\u00e1si \u00e9rt\u00e9kkel b\u00edr.<\/p>\n

A h\u00e1l\u00f3zati farmakol\u00f3giai technik\u00e1k alkalmaz\u00e1s\u00e1val meg\u00e1llap\u00edthat\u00f3, hogy a feh\u00e9rje k\u00f6lcs\u00f6nhat\u00e1si h\u00e1l\u00f3zatok kulcsfontoss\u00e1g\u00fa c\u00e9lpontjai az SRC, az AKT1 \u00e9s a PIK3R1. Ez a h\u00e1rom prote\u00e1z szerkezetileg aktiv\u00e1l\u00f3dhat szinte minden r\u00e1kt\u00edpusban az upstream jel\u00e1tviteli molekul\u00e1k aktiv\u00e1l\u00e1sa vagy az \u00fatvonal komponenseinek mut\u00e1ci\u00f3i r\u00e9v\u00e9n. K\u00f6z\u00fcl\u00fck az SRC, mint az els\u0151k\u00e9nt felfedezett r\u00e1kkelt\u0151 g\u00e9n, sz\u00e1mos jel\u00e1tviteli \u00fatvonalban r\u00e9szt vesz a downstream c\u00e9lfeh\u00e9rj\u00e9k foszforil\u00e1ci\u00f3j\u00e1ban. K\u00fcl\u00f6nb\u00f6z\u0151 \u00fatvonalakon szab\u00e1lyozza a sejtek t\u00fal\u00e9l\u00e9s\u00e9t, adh\u00e9zi\u00f3j\u00e1t, prolifer\u00e1ci\u00f3j\u00e1t, motilit\u00e1s\u00e1t \u00e9s angiogenezis\u00e9t. Ezenk\u00edv\u00fcl az SRC konstitut\u00edv aktivit\u00e1sa el\u0151seg\u00edtheti \u00e9s fenntarthatja a gyullad\u00e1s \u00e9s a sejtanyagcsere \u00e1tprogramoz\u00e1s\u00e1t is, ez\u00e1ltal szinkroniz\u00e1lva a tumoros mikrok\u00f6rnyezet kialakul\u00e1s\u00e1val \u00e9s akt\u00edvan fenntartva a tumor n\u00f6veked\u00e9s\u00e9t. Az AKT1, mint a PI3K\/AKT jel\u00e1tviteli \u00fatvonal k\u00f6zponti tagja, a foszfatidil-inozitol-3-kin\u00e1z (PI3K) szab\u00e1lyoz\u00f3 alegys\u00e9g alfa (p85-ALPHA) k\u00f3dol\u00f3 PIK3R1 \u00e1ltal aktiv\u00e1lhat\u00f3. Az ebben a tanulm\u00e1nyban szerepl\u0151 feh\u00e9rje-feh\u00e9rje k\u00f6lcs\u00f6nhat\u00e1s PPI diagramj\u00e1val kombin\u00e1lva ism\u00e9t meger\u0151s\u00edtheti a kett\u0151 k\u00f6z\u00f6tti szoros upstream \u00e9s downstream kapcsolatot.<\/p>\n

A KEGG d\u00fas\u00edt\u00e1ssal kapott 20 legjobb jel\u00e1tviteli \u00fatvonal k\u00f6z\u00fcl a legt\u00f6bb a \"karcinogenezis \u00fatvonal\u00e1hoz\" tartozik, ami azt jelzi, hogy a Scutellaria baicalensis els\u0151sorban a m\u00e1jsejtek karcinogenezis\u00e9nek megel\u0151z\u00e9s\u00e9vel vagy g\u00e1tl\u00e1s\u00e1val kezeli az ALD-t. Az EGFR, mint az ErbB csal\u00e1d tipikus tirozin-kin\u00e1z receptora, nagym\u00e9rt\u00e9kben kifejez\u0151dik a m\u00e1jban. Alkoholfogyaszt\u00e1s ut\u00e1n az EGFR aktiv\u00e1l\u00f3dhat az angiotenzin II-hez \u00e9s annak AT1R receptor\u00e1hoz val\u00f3 k\u00f6t\u0151d\u00e9s felt\u00e9tele mellett. Ugyanakkor az EGFR a Ras-Raf-1-MAP2K\/MEK-MAPK\/ERK sejtszign\u00e1l\u00fatvonal csom\u00f3pontjak\u00e9nt m\u0171k\u00f6dhet, serkentve a PIK3R1 feh\u00e9rje rendellenes expresszi\u00f3j\u00e1t \u00e9s befoly\u00e1solva a PI3K\/AKT jel\u00e1tviteli \u00fatvonalat. A PI3K\/AKT jel\u00e1tviteli \u00fatvonal szorosan kapcsol\u00f3dik sz\u00e1mos gyullad\u00e1sos betegs\u00e9ghez, \u00e9s a tumorok egyik kulcsfontoss\u00e1g\u00fa jel\u00e1tviteli \u00fatvonal\u00e1nak tekinthet\u0151. Kor\u00e1bbi tanulm\u00e1nyok meger\u0151s\u00edtett\u00e9k, hogy a Scutellaria baicalensis el\u0151seg\u00edtheti a p-PI3K, p-Akt \u00e9s Glut2 foszforil\u00e1ci\u00f3j\u00e1t az IRS1, PI3K, Akt2 \u00e9s Glut2 mRNS expresszi\u00f3j\u00e1nak felszab\u00e1lyoz\u00e1s\u00e1val, ez\u00e1ltal lek\u00fczdve a PI3K \/ Akt inzulin jel\u00e1tviteli \u00fatvonal k\u00e1rosod\u00e1s\u00e1t \u00e9s akt\u00edvan jav\u00edtva a hepatitist. Az ALD patog\u00e9n t\u00e9nyez\u0151it \u00f6sszehasonl\u00edtva meg\u00e1llap\u00edthat\u00f3, hogy a sz\u00edv- \u00e9s \u00e9rrendszeri betegs\u00e9gekhez (CVD) hasonl\u00f3an mag\u00e1ban foglalja a gyullad\u00e1st, az adipokineket, a b\u00e9lmikrobi\u00f3ta dysbiosis\u00e1t, az oxidat\u00edv stresszt \u00e9s a pszichol\u00f3giai stresszt. Egyes tanulm\u00e1nyok azt is kimutatt\u00e1k, hogy az ALD \u00e9s a CVD k\u00f6z\u00f6tt k\u00f6zvetlen kapcsolat van, \u00e9s a m\u00e1j-sz\u00edv tengely fogalm\u00e1t terjesztett\u00e9k el\u0151, \u00e9s ezzel a tanulm\u00e1nynyal kombin\u00e1lva a lipid \u00e9s az ateroszkler\u00f3zis jel\u00fatjainak sz\u0171r\u00e9s\u00e9t, ami arra utal, hogy az ALD kezel\u00e9s\u00e9nek nem csak mag\u00e1ra a m\u00e1jra kell \u00f6sszpontos\u00edtania, hanem figyelembe kell vennie a kardiovaszkul\u00e1ris hat\u00e1s\u00e1t is.<\/p>\n

A molekul\u00e1ris dokkol\u00e1sban a k\u00f6t\u00e9si energi\u00e1kat \u00f6sszehasonl\u00edtva meg\u00e1llap\u00edthat\u00f3, hogy a resveratrol lehet a Scutellaria baicalensis egyik kulcsfontoss\u00e1g\u00fa hat\u00f3anyaga az ALD kezel\u00e9s\u00e9re. A shanjiangsu sz\u00e9les k\u00f6rben jelen van a gy\u00f6mb\u00e9rn\u00f6v\u00e9nyekben, \u00e9s farmakol\u00f3giai k\u00eds\u00e9rletek igazolt\u00e1k r\u00e1kellenes, antioxid\u00e1ns, gyullad\u00e1scs\u00f6kkent\u0151 \u00e9s endotheljav\u00edt\u00f3 hat\u00e1s\u00e1t. Az emberi szervezet els\u0151sorban a mikroszom\u00e1lis CYP2E1-re t\u00e1maszkodik az alkohol metabolizmus\u00e1ban, amelynek sor\u00e1n nagy mennyis\u00e9g\u0171 k\u00f6ztes term\u00e9k, p\u00e9ld\u00e1ul acetaldehid \u00e9s reakt\u00edv oxig\u00e9nfajok (ROS) keletkeznek. Az acetaldehid egyr\u00e9szt feh\u00e9rj\u00e9kkel \u00e9s DNS-sel k\u00e9pezhet adduktokat, k\u00f6zvetlen\u00fcl karcinog\u00e9n toxicit\u00e1st fejtve ki. M\u00e1sr\u00e9szt a ROS-ok felhalmoz\u00f3d\u00e1sa v\u00e1ltoz\u00e1sokat okozhat a DNS szerkezet\u00e9ben \u00e9s funkci\u00f3j\u00e1ban, ami a sejtciklus zavaraihoz vezethet, \u00e9s befoly\u00e1solhatja a g\u00e9n\u00e1t\u00edr\u00e1st, a transzl\u00e1ci\u00f3t \u00e9s m\u00e1s funkci\u00f3kat, ez\u00e1ltal elind\u00edtva vagy el\u0151seg\u00edtve a sejtek karcinogenezis\u00e9t. A kutat\u00e1sok kimutatt\u00e1k, hogy a resveratrol jelz\u0151molekulak\u00e9nt k\u00e9pes aktiv\u00e1lni a kapcsol\u00f3d\u00f3 \u00fatvonalakat, hat\u00e9konyan g\u00e1tolva a sejtkarcinogenezist, mik\u00f6zben a ROS-okat tiszt\u00edtja. In vitro sejtk\u00eds\u00e9rletekkel kombin\u00e1lva meg\u00e1llap\u00edthat\u00f3, hogy a hegyi gy\u00f6mb\u00e9r kivonat k\u00fcl\u00f6nb\u00f6z\u0151 koncentr\u00e1ci\u00f3inak bead\u00e1sa ut\u00e1n az alkohol \u00e1ltal kiv\u00e1ltott m\u00e1jsejtk\u00e1rosod\u00e1s hat\u00e9konyan cs\u00f6kkenthet\u0151, \u00e9s a kapcsol\u00f3d\u00f3 biok\u00e9miai mutat\u00f3k, az ALT \u00e9s AST is jelent\u0151sen javulnak. A MAD \u00e9s a SOD eredm\u00e9nyeivel kombin\u00e1lva ez arra utal, hogy a resveratrol a SOD enzimaktivit\u00e1s\u00e1nak n\u00f6vel\u00e9s\u00e9vel fejtheti ki hat\u00e1s\u00e1t a m\u00e1j oxidat\u00edv stresszv\u00e1lasz\u00e1nak g\u00e1tl\u00e1sa \u00e9rdek\u00e9ben. Antioxid\u00e1ns hat\u00e1sa azonban messze elmaradhat a r\u00e1kellenes hat\u00e1s\u00e1t\u00f3l, ez\u00e9rt tov\u00e1bbi k\u00eds\u00e9rleti kutat\u00e1sokra van sz\u00fcks\u00e9g.<\/p>\n

\u00d6sszefoglalva, ez a k\u00eds\u00e9rlet el\u0151zetesen megj\u00f3solta a Scutellaria baicalensis 27 hat\u00f3anyag\u00e1t a h\u00e1l\u00f3zati farmakol\u00f3gia seg\u00edts\u00e9g\u00e9vel, ami azt jelzi, hogy egyetlen hagyom\u00e1nyos k\u00ednai gy\u00f3gyszerk\u00e9sz\u00edtm\u00e9nyt is lehet kism\u00e9ret\u0171 vegy\u00fcletnek tekinteni. Ek\u00f6zben a Scutellaria baicalensis 27 hat\u00f3anyaga 257 g\u00e9nc\u00e9lponton kereszt\u00fcl gyakorolhat ter\u00e1pi\u00e1s hat\u00e1st az ALD-re, amelyek k\u00f6z\u00f6tt a legfontosabb f\u0151 c\u00e9lpontok k\u00f6z\u00e9 tartozik az SRC, AKT1, PIK3R1 stb. A KEGG jel\u00fatvonalak gazdagod\u00e1si elemz\u00e9se azt sugallta, hogy a Scutellaria baicalensis Georgi szerepet j\u00e1tszhat az ALD-ben a r\u00e1kot, a PI3K Akt jel\u00fatvonalat, a lipid \u00e9s az ateroszkler\u00f3zist \u00e9s m\u00e1s jel\u00fatvonalakat \u00e9rint\u0151 \u00fatvonalakon kereszt\u00fcl. A molekul\u00e1ris dokkol\u00e1si technol\u00f3gi\u00e1n kereszt\u00fcl, a h\u00e1l\u00f3zati farmakol\u00f3gia eredm\u00e9nyeinek ellen\u0151rz\u00e9se sor\u00e1n a Scutellaria baicalensis ALD kezel\u00e9s\u00e9re a leghat\u00e9konyabb \u00f6sszetev\u0151nek a kaempferol bizonyult. In vitro sejtk\u00eds\u00e9rleteken kereszt\u00fcl meg\u00e1llap\u00edthat\u00f3, hogy a hegyi gy\u00f6mb\u00e9rkivonat jelent\u0151sen jav\u00edthatja a BRL 3A patk\u00e1nym\u00e1jsejtek alkohol \u00e1ltal kiv\u00e1ltott k\u00e1rosod\u00e1si \u00e1llapot\u00e1t. E k\u00eds\u00e9rlet eredm\u00e9nyei n\u00e9mi elm\u00e9leti alapot ny\u00fajthatnak az ALD Scutellaria baicalensis-szel t\u00f6rt\u00e9n\u0151 kezel\u00e9s\u00e9hez, de a Scutellaria baicalensis ALD kezel\u00e9s\u00e9ben a Scutellaria baicalensis specifikus hat\u00e1smechanizmus\u00e1nak tov\u00e1bbi felt\u00e1r\u00e1sa m\u00e9g sz\u00e1mos farmakol\u00f3giai mechanizmusk\u00eds\u00e9rletet ig\u00e9nyel.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the mechanism and efficacy verification of effective components of Scutellaria baicalensis on alcoholic liver disease based on network pharmacology and molecular docking Alcoholic liver diseases (ALD) have a wide clinical histological spectrum, including early simple hepatic steatosis, as well as mid to late stage alcoholic hepatitis, liver fibrosis, and alcoholic cirrhosis. The current best […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism and efficacy verification of effective components of Scutellaria baicalensis on alcoholic liver disease based on network pharmacology and molecular docking - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/hu\/scutellaria-baicalensis\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism and efficacy verification of effective components of Scutellaria baicalensis on alcoholic liver disease based on network pharmacology and molecular docking - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism and efficacy verification of effective components of Scutellaria baicalensis on alcoholic liver disease based on network pharmacology and molecular docking Alcoholic liver diseases (ALD) have a wide clinical histological spectrum, including early simple hepatic steatosis, as well as mid to late stage alcoholic hepatitis, liver fibrosis, and alcoholic cirrhosis. 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